A novel family of mammalian taste receptors.
paper
Cited
Public
Unavailable
- Authors
- Adler, E; Hoon, M A; Mueller, K L; Chandrashekar, J; Ryba, N J; Zuker, C S
- Year
- 2000
- Journal
- Cell
- PMID
- 10761934
- DOI
- 10.1016/s0092-8674(00)80705-9
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia. These candidate taste receptors (T2Rs) are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. Notably, a single taste receptor cell expresses a large repertoire of T2Rs, suggesting that each cell may be capable of recognizing multiple tastants. T2Rs are exclusively expressed in taste receptor cells that contain the G protein alpha subunit gustducin, implying that they function as gustducin-linked receptors. In the accompanying paper, we demonstrate that T2Rs couple to gustducin in vitro, and respond to bitter tastants in a functional expression assay.
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| Title | Year | PMID |
|---|---|---|
| Genetic analysis of the maximum drinks phenotype. | 2005 | 16451582 |
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| Chemosensory bitter taste receptors (T2Rs) are activated by multiple antibiotics. | Jaggupilli A et al. | β | 2019 | β |
| Conducting Nanomaterial Sensor Using Natural Receptors. | Kwon OS et al. | β | 2019 | β |
| Detection thresholds for quinine, PTC, and PROP measured using taste strips. | Cavazzana A et al. | β | 2019 | β |
| Differential long-term regulation of TAS2R14 by structurally distinct agonists. | Woo JA et al. | β | 2019 | β |
| Dual binding mode of "bitter sugars" to their human bitter taste receptor target. | Fierro F et al. | β | 2019 | β |
| Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/Ξ²-catenin signaling in adult mice. | Gaillard D et al. | β | 2019 | β |
| Insights on modulators in perception of taste modalities: a review. | Deepankumar S et al. | β | 2019 | β |
| Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring. | Song L et al. | β | 2019 | β |
| Molecular control limiting sensitivity of sweet taste neurons in <i>Drosophila</i>. | Chen HL et al. | β | 2019 | β |
| Next-Gen Approaches to Flavor-Related Metabolism. | Zhu G et al. | β | 2019 | β |
| Parabrachial Complex: A Hub for Pain and Aversion. | Chiang MC et al. | β | 2019 | β |
| Rats are unable to discriminate quinine from diverse bitter stimuli. | Martin LE et al. | β | 2019 | β |
| Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals. | Ohla K et al. | β | 2019 | β |
| Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity. | Sarnelli G et al. | β | 2019 | β |
| Taste receptor function. | TΓΆle JC et al. | β | 2019 | β |
| The Functional and Neurobiological Properties of Bad Taste. | Schier LA et al. | β | 2019 | β |
| Therapeutic potential of ectopic olfactory and taste receptors. | Lee SJ et al. | β | 2019 | β |
| The role of GPCRs in bone diseases and dysfunctions. | Luo J et al. | β | 2019 | β |
| The senses of the choroid plexus. | Santos CRA et al. | β | 2019 | β |
| Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA. | Douglas JE et al. | β | 2019 | β |
| Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine. | Luo M et al. | β | 2019 | β |
| Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device. | Zhang H et al. | β | 2019 | β |
| A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health. | Chamoun E et al. | β | 2018 | β |
| Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors. | Behrens M et al. | β | 2018 | β |
| Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae. | Yoshida R et al. | β | 2018 | β |
| Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. | Hwang LD et al. | β | 2018 | β |
| Current Status and Future Perspectives in Flavor Research: Highlights of the 11th Wartburg Symposium on Flavor Chemistry & Biology. | Hofmann T et al. | β | 2018 | β |
| Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). | Schroer AB et al. | β | 2018 | β |
| Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells. | Prandi S et al. | β | 2018 | β |
| Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. | Tung NT et al. | β | 2018 | β |
| Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. | Xue AY et al. | β | 2018 | β |
| Innate and acquired tolerance to bitter stimuli in mice. | Mura E et al. | β | 2018 | β |
| Interactions of Gut Endocrine Cells withΒ EpitheliumΒ and Neurons. | Liddle RA | β | 2018 | β |
| Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits. | Kok BP et al. | β | 2018 | β |
| Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential. | Pluskal T et al. | β | 2018 | β |
| Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense. | Dalesio NM et al. | β | 2018 | β |
| Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10. | Stern L et al. | β | 2018 | β |
| Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway. | Patel NN et al. | β | 2018 | β |
| Salivary proteins alter taste-guided behaviors and taste nerve signaling in rat. | Martin LE et al. | β | 2018 | β |
| Self-reported Smoking Status, TAS2R38 Variants, and Propylthiouracil Phenotype: An Exploratory Crowdsourced Cohort Study. | Baker AN et al. | β | 2018 | β |
| SERS-fluorescence bimodal nanoprobes for in vitro imaging of fatty acid responsive receptor GPR120. | Xiao L et al. | β | 2018 | β |
| Tastant-Evoked Arc Expression in the Nucleus of the Solitary Tract and Nodose/Petrosal Ganglion of the Mouse Is Specific for Bitter Compounds. | TΓΆle J et al. | β | 2018 | β |
| Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. | An SS et al. | β | 2018 | β |
| Taste Perception of Antidesma bunius Fruit and Its Relationships to Bitter Taste Receptor Gene Haplotypes. | Risso D et al. | β | 2018 | β |
| The bioelectronic nose and tongue using olfactory and taste receptors: Analytical tools for food quality and safety assessment. | Son M et al. | β | 2018 | β |
| The mouthfeel of white wine. | Gawel R et al. | β | 2018 | β |
| Vertebrate Bitter Taste Receptors: Keys for Survival in Changing Environments. | Behrens M et al. | β | 2018 | β |
| You Are What You (First) Eat. | Buchanan KL et al. | β | 2018 | β |
| Activation of bitter taste receptors in pulmonary nociceptors sensitizes TRPV1 channels through the PLC and PKC signaling pathway. | Gu QD et al. | β | 2017 | β |
| Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis. | Fierro F et al. | β | 2017 | β |
| A Matter of Taste: Lineage-Specific Loss of Function of Taste Receptor Genes in Vertebrates. | Antinucci M et al. | β | 2017 | β |
| Analysis of the expression of human bitter taste receptors in extraoral tissues. | Jaggupilli A et al. | β | 2017 | β |
| Caffeine Bitterness is Related to Daily Caffeine Intake and Bitter Receptor mRNA Abundance in Human Taste Tissue. | Lipchock SV et al. | β | 2017 | β |
| Characterization of GPCRs in extracellular vesicle (EV). | Medapati MR et al. | β | 2017 | β |
| From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. | Cheled-Shoval S et al. | β | 2017 | β |
| Genetic Labeling of Car4-expressing Cells Reveals Subpopulations of Type III Taste Cells. | Lossow K et al. | β | 2017 | β |
| Genomic evidence of bitter taste in snakes and phylogenetic analysis of bitter taste receptor genes in reptiles. | Zhong H et al. | β | 2017 | β |
| On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System. | Kokabu S et al. | β | 2017 | β |
| Perception of odors and tastes in autism spectrum disorders: A systematic review of assessments. | Boudjarane MA et al. | β | 2017 | β |
| Probing the Evolutionary History of Human Bitter Taste Receptor Pseudogenes by Restoring Their Function. | Risso D et al. | β | 2017 | β |
| Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling. | Spector AC et al. | β | 2017 | β |
| Taste buds: cells, signals and synapses. | Roper SD et al. | β | 2017 | β |
| Taste receptors and gustatory associated G proteins in channel catfish, Ictalurus punctatus. | Gao S et al. | β | 2017 | β |
| Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease. | Douglas JE et al. | β | 2017 | β |
| [Taste signal transduction and the role of taste receptors in the regulation of microbial infection]. | Yangyu L et al. | β | 2017 | β |
| The expression of bitter taste receptors in mesenteric, cerebral and omental arteries. | Chen JG et al. | β | 2017 | β |
| The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds. | Verbeurgt C et al. | β | 2017 | β |
| The repertoire of bitter taste receptor genes in canids. | Shang S et al. | β | 2017 | β |
| The Role of Cholecystokinin in Peripheral Taste Signaling in Mice. | Yoshida R et al. | β | 2017 | β |
| The Taste of Caffeine. | Poole RL et al. | β | 2017 | β |
| The taste of toxicity: A quantitative analysis of bitter and toxic molecules. | Nissim I et al. | β | 2017 | β |
| Whole transcriptome profiling of taste bud cells. | Sukumaran SK et al. | β | 2017 | β |
| Ξ²-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. | Gaillard D et al. | β | 2017 | β |
| Activation of human bitter taste receptors by polymethoxylated flavonoids. | Kuroda Y et al. | β | 2016 | β |
| A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. | Greer PL et al. | β | 2016 | β |
| Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms. | Lewandowski BC et al. | β | 2016 | β |
| Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to Ξ²-glycosides. | Imai H et al. | β | 2016 | β |
| Application of isothermal titration calorimeter for screening bitterness-suppressing molecules of quinine. | Zhang Y et al. | β | 2016 | β |
| A role for airway taste receptor modulation in the treatment of upper respiratory infections. | Douglas JE et al. | β | 2016 | β |
| Bitter taste receptors: Extraoral roles in pathophysiology. | Shaik FA et al. | β | 2016 | β |
| BitterX: a tool for understanding bitter taste in humans. | Huang W et al. | β | 2016 | β |
| Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods. | Batenburg AM et al. | β | 2016 | β |
| Chemosensory epithelial cells in the urethra: sentinels of the urinary tract. | Deckmann K et al. | β | 2016 | β |
| Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. | Lossow K et al. | β | 2016 | β |
| Copy Number Variation in TAS2R Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics. | Roudnitzky N et al. | β | 2016 | β |
| Development of delayed bitterness and effect of harvest date in stored juice from two complex citrus hybrids. | Raithore S et al. | β | 2016 | β |
| Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. | Nolden AA et al. | β | 2016 | β |
| Distribution of Ξ±-transducin and Ξ±-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract. | Mazzoni M et al. | β | 2016 | β |
| Docking and Molecular Dynamics of Steviol Glycoside-Human Bitter Receptor Interactions. | Acevedo W et al. | β | 2016 | β |
| Duplex Bioelectronic Tongue for Sensing Umami and Sweet Tastes Based on Human Taste Receptor Nanovesicles. | Ahn SR et al. | β | 2016 | β |
| Elucidating concepts in drug design through taste with natural and artificial sweeteners. | Lipchock JM et al. | β | 2016 | β |
| Exploring Ethnic Differences in Taste Perception. | Williams JA et al. | β | 2016 | β |
| Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells. | WΓΆlfle U et al. | β | 2016 | β |
| Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule. | Gaida MM et al. | β | 2016 | β |
| Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. | Latorre R et al. | β | 2016 | β |
| Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations. | Su Y et al. | β | 2016 | β |
| Humans Can Taste Glucose Oligomers Independent of the hT1R2/hT1R3 Sweet Taste Receptor. | Lapis TJ et al. | β | 2016 | β |
| Mechanism of fat taste perception: Association with diet and obesity. | Liu D et al. | β | 2016 | β |
| Multidimensional Evaluation of Endogenous and Health Factors Affecting Food Preferences, Taste and Smell Perception. | Guido D et al. | β | 2016 | β |
| Regulation of Adipogenesis by Quinine through the ERK/S6 Pathway. | Ning X et al. | β | 2016 | β |
| Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells. | Gaida MM et al. | β | 2016 | β |
| Sweet Structural Signatures Unveiled in Ketohexoses. | BermΓΊdez C et al. | β | 2016 | β |
| Synthesis of rebaudioside A from stevioside and their interaction model with hTAS2R4 bitter taste receptor. | Singla R et al. | β | 2016 | β |
| The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity. | Avau B et al. | β | 2016 | β |
| Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione. | Karanewsky DS et al. | β | 2016 | β |
| Understanding Biofilms in Chronic Sinusitis. | Tajudeen BA et al. | β | 2016 | β |
| Ξ²2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. | Kim D et al. | β | 2016 | β |
| A Butter Aroma Recombinate Activates Human Class-I Odorant Receptors. | Geithe C et al. | β | 2015 | β |
| A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. | Sandau MM et al. | β | 2015 | β |
| An alternative laboratory designed to address ethical concerns associated with traditional TAS2R38 student genotyping. | LaBonte ML et al. | β | 2015 | β |
| A novel cholinergic epithelial cell with chemosensory traits in the murine conjunctiva. | Wiederhold S et al. | β | 2015 | β |
| Association between individual response to food taste and gastroesophageal symptoms. | Shibata T et al. | β | 2015 | β |
| Birds Generally Carry a Small Repertoire of Bitter Taste Receptor Genes. | Wang K et al. | β | 2015 | β |
| Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts. | Gu F et al. | β | 2015 | β |
| CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span. | Hellekant G et al. | β | 2015 | β |
| Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. | Foster SR et al. | β | 2015 | β |
| Chemosensory receptor specificity and regulation. | Dalton RP et al. | β | 2015 | β |
| Children's perceptions about medicines: individual differences and taste. | Mennella JA et al. | β | 2015 | β |
| Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131. | Soultanova A et al. | β | 2015 | β |
| Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. | Malki A et al. | β | 2015 | β |
| Cre-Mediated Recombination in Tas2r131 Cells-A Unique Way to Explore Bitter Taste Receptor Function Inside and Outside of the Taste System. | Voigt A et al. | β | 2015 | β |
| Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia. | Ansoleaga B et al. | β | 2015 | β |
| Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. | Wauson EM et al. | β | 2015 | β |
| Electrogustometry and contact endoscopy findings in patients with head and neck malignancies treated with chemotherapy, radiotherapy, or radiochemotherapy. | Pavlidis P et al. | β | 2015 | β |
| Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes. | WΓΆlfle U et al. | β | 2015 | β |
| Expression of bitter taste receptor Tas2r105 in mouse kidney. | Liu X et al. | β | 2015 | β |
| GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell. | Park J et al. | β | 2015 | β |
| G protein-coupled receptors in cardiac biology: old and new receptors. | Foster SR et al. | β | 2015 | β |
| Inference of gorilla demographic and selective history from whole-genome sequence data. | McManus KF et al. | β | 2015 | β |
| Involvement of the gut chemosensory system in the regulation of colonic anion secretion. | Kuwahara A | β | 2015 | β |
| Molecular mechanisms of taste recognition: considerations about the role of saliva. | FΓ‘biΓ‘n TK et al. | β | 2015 | β |
| On the connection between nonmonotonic taste behavior and molecular conformation in solution: The case of rebaudioside-A. | Chopade PD et al. | β | 2015 | β |
| Promiscuity and selectivity of bitter molecules and their receptors. | Di Pizio A et al. | β | 2015 | β |
| Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques. | Suzuki-Hashido N et al. | β | 2015 | β |
| Reception of Aversive Taste. | Lunceford BE et al. | β | 2015 | β |
| Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception. | Roudnitzky N et al. | β | 2015 | β |
| Role of G protein-coupled orphan receptors in intestinal inflammation: novel targets in inflammatory bowel diseases. | Wasilewski A et al. | β | 2015 | β |
| Snooker structure-based pharmacophore model explains differences in agonist and blocker binding to bitter receptor hTAS2R39. | Roland WS et al. | β | 2015 | β |
| Sweet taste receptor signaling network: possible implication for cognitive functioning. | Welcome MO et al. | β | 2015 | β |
| Targeting G protein coupled receptor-related pathways as emerging molecular therapies. | Ghanemi A | β | 2015 | β |
| TAS2R bitter taste receptors regulate thyroid function. | Clark AA et al. | β | 2015 | β |
| Taste perception, associated hormonal modulation, and nutrient intake. | Loper HB et al. | β | 2015 | β |
| Taste receptors in innate immunity. | Lee RJ et al. | β | 2015 | β |
| Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone. | Maurer S et al. | β | 2015 | β |
| The neural representation of taste quality at the periphery. | Barretto RP et al. | β | 2015 | β |
| The pharmacology of bitter taste receptors and their role in human airways. | Devillier P et al. | β | 2015 | β |
| The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity. | Workman AD et al. | β | 2015 | β |
| The sweetness and bitterness of childhood: Insights from basic research on taste preferences. | Mennella JA et al. | β | 2015 | β |
| Tight junctions in Gerbil von Ebner's gland: horseradish peroxidase and freeze-fracture studies. | Huang AY et al. | β | 2015 | β |
| Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight. | Ciullo DL et al. | β | 2015 | β |
| Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation. | Roura E et al. | β | 2015 | β |
| Age-related differences in bitter taste and efficacy of bitter blockers. | Mennella JA et al. | β | 2014 | β |
| A physiologic role for serotonergic transmission in adult rat taste buds. | Jaber L et al. | β | 2014 | β |
| Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. | Deckmann K et al. | β | 2014 | β |
| Chaperoning G protein-coupled receptors: from cell biology to therapeutics. | Tao YX et al. | β | 2014 | β |
| Constitutive activity of bitter taste receptors (T2Rs). | Pydi SP et al. | β | 2014 | β |
| Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. | Vegezzi G et al. | β | 2014 | β |
| Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. | Li D et al. | β | 2014 | β |
| Differential evolutionary constraints in the evolution of chemoreceptors: a murine and human case study. | D'Oliveira Albanus R et al. | β | 2014 | β |
| Diverse contributions of Tas1r2/Tas2rs within the rat and mouse soft palate to sweet and bitter neural responses. | Tomonari H et al. | β | 2014 | β |
| Endogenous gustatory responses and gene expression profile of stably proliferating human taste cells isolated from fungiform papillae. | Hochheimer A et al. | β | 2014 | β |
| Extrasensory perception: odorant and taste receptors beyond the nose and mouth. | Foster SR et al. | β | 2014 | β |
| Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade. | Hayakawa T et al. | β | 2014 | β |
| Genetics of taste receptors. | Bachmanov AA et al. | β | 2014 | β |
| Genetic taste blindness to bitter and body composition in childhood: a Mendelian randomization design. | Bouthoorn SH et al. | β | 2014 | β |
| Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution. | Risso D et al. | β | 2014 | β |
| Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study. | Mfuna Endam L et al. | β | 2014 | β |
| Identification of novel compounds for human bitter taste receptors. | Ji M et al. | β | 2014 | β |
| Identifying flavor preference subgroups. Genetic basis and related eating behavior traits. | TΓΆrnwall O et al. | β | 2014 | β |
| Induction of salivary proteins modifies measures of both orosensory and postingestive feedback during exposure to a tannic acid diet. | Torregrossa AM et al. | β | 2014 | β |
| Insights into the origin of nematode chemosensory GPCRs: putative orthologs of the Srw family are found across several phyla of protostomes. | Krishnan A et al. | β | 2014 | β |
| Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds. | Feng P et al. | β | 2014 | β |
| Massive losses of taste receptor genes in toothed and baleen whales. | Feng P et al. | β | 2014 | β |
| Molecular basis of taste sense: involvement of GPCR receptors. | Cygankiewicz AI et al. | β | 2014 | β |
| Multiplex minisequencing screening for PTC genotype associated with bitter taste perception. | Sagong B et al. | β | 2014 | β |
| Nature and nurture in children's food preferences. | Fildes A et al. | β | 2014 | β |
| Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India. | Hussain R et al. | β | 2014 | β |
| PTC bitter taste genetic polymorphism, food choices, physical growth in body height and body fat related traits among adolescent girls from Kangra Valley, Himachal Pradesh (India). | Sharma K et al. | β | 2014 | β |
| Sinonasal solitary chemosensory cells "taste" the upper respiratory environment to regulate innate immunity. | Lee RJ et al. | β | 2014 | β |
| Taste bud homeostasis in health, disease, and aging. | Feng P et al. | β | 2014 | β |
| The loss of taste genes in cetaceans. | Zhu K et al. | β | 2014 | β |
| Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes. | Behrens M et al. | β | 2014 | β |
| Vampire bats exhibit evolutionary reduction of bitter taste receptor genes common to other bats. | Hong W et al. | β | 2014 | β |
| A case study on the association of variation of bitter-taste receptor gene TAS2R38 with the height, weight and energy intake in Japanese female college students. | Inoue H et al. | β | 2013 | β |
| Activation of the hTAS2R14 human bitter-taste receptor by (-)-epigallocatechin gallate and (-)-epicatechin gallate. | Yamazaki T et al. | β | 2013 | β |
| Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. | Allen AL et al. | β | 2013 | β |
| Bitter taste receptor research comes of age: from characterization to modulation of TAS2Rs. | Behrens M et al. | β | 2013 | β |
| Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. | Liggett SB | β | 2013 | β |
| Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding. | Marchiori A et al. | β | 2013 | β |
| Different phenolic compounds activate distinct human bitter taste receptors. | Soares S et al. | β | 2013 | β |
| Electrochemical impedance spectrum frequency optimization of bitter taste cell-based sensors. | Hui GH et al. | β | 2013 | β |
| Extracellular potentials recording in intact taste epithelium by microelectrode array for a taste sensor. | Liu Q et al. | β | 2013 | β |
| Functional characterization of bitter-taste receptors expressed in mammalian testis. | Xu J et al. | β | 2013 | β |
| Functional diversification of taste cells in vertebrates. | Matsumoto I et al. | β | 2013 | β |
| Gustatory neural pathways revealed by genetic tracing from taste receptor cells. | Matsumoto I | β | 2013 | β |
| Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. | Lipchock SV et al. | β | 2013 | β |
| Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. | Thalmann S et al. | β | 2013 | β |
| Modifying bitterness in functional food systems. | Gaudette NJ et al. | β | 2013 | β |
| Oral and extra-oral taste perception. | Yamamoto K et al. | β | 2013 | β |
| Peptide regulators of peripheral taste function. | Dotson CD et al. | β | 2013 | β |
| Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. | Jing F et al. | β | 2013 | β |
| Taste perception: from the tongue to the testis. | Li F | β | 2013 | β |
| The bad taste of medicines: overview of basic research on bitter taste. | Mennella JA et al. | β | 2013 | β |
| The cells and circuitry for itch responses in mice. | Mishra SK et al. | β | 2013 | β |
| The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. | Born S et al. | β | 2013 | β |
| Transgenic labeling of higher order neuronal circuits linked to phospholipase C-Ξ²2-expressing taste bud cells in medaka fish. | Ieki T et al. | β | 2013 | β |
| Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk. | Schembre SM et al. | β | 2013 | β |
| 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). | Tan J et al. | β | 2012 | β |
| A nociceptive signaling role for neuromedin B. | Mishra SK et al. | β | 2012 | β |
| Behavioral analysis of Drosophila transformants expressing human taste receptor genes in the gustatory receptor neurons. | Adachi R et al. | β | 2012 | β |
| Bitter taste stimuli induce differential neural codes in mouse brain. | Wilson DM et al. | β | 2012 | β |
| Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. | Li F et al. | β | 2012 | β |
| Diapause specific gene expression in the eggs of multivoltine silkworm Bombyx mori, identified by suppressive subtractive hybridization. | Sasibhushan S et al. | β | 2012 | β |
| Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes). | Hayakawa T et al. | β | 2012 | β |
| Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats. | Sekine H et al. | β | 2012 | β |
| Evaluation of the suppressive effect on bitter taste of gluconate. | Narukawa M et al. | β | 2012 | β |
| Expression analysis of taste signal transduction molecules in the fungiform and circumvallate papillae of the rhesus macaque, Macaca mulatta. | Ishimaru Y et al. | β | 2012 | β |
| Extraoral bitter taste receptors as mediators of off-target drug effects. | Clark AA et al. | β | 2012 | β |
| Functional diversity of bitter taste receptor TAS2R16 in primates. | Imai H et al. | β | 2012 | β |
| Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice. | Voigt A et al. | β | 2012 | β |
| GΞ±-gustducin is extensively coexpressed with sweet and bitter taste receptors in both the soft palate and fungiform papillae but has a different functional significance. | Tomonari H et al. | β | 2012 | β |
| Human psychometric and taste receptor responses to steviol glycosides. | Hellfritsch C et al. | β | 2012 | β |
| Identification of bitterness-masking compounds from cheese. | Homma R et al. | β | 2012 | β |
| Immunohistochemical detection of TAS2R38 protein in human taste cells. | Behrens M et al. | β | 2012 | β |
| Improvement of the bitter taste of drugs by complexation with cyclodextrins: applications, evaluations and mechanisms. | Arima H et al. | β | 2012 | β |
| Mechanisms for sweetness. | Fernstrom JD et al. | β | 2012 | β |
| Mechanisms of taste bud cell loss after head and neck irradiation. | Nguyen HM et al. | β | 2012 | β |
| Nanomaterial-based biosensor as an emerging tool for biomedical applications. | Lee SH et al. | β | 2012 | β |
| Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal. | Treesukosol Y et al. | β | 2012 | β |
| Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. | Hirai R et al. | β | 2012 | β |
| Patterns of immunoreactivity specific for gustducin and for NCAM differ in developing rat circumvallate papillae and their taste buds. | Iwasaki S et al. | β | 2012 | β |
| Peripheral chemosensing system for tastants and nutrients. | Iwatsuki K et al. | β | 2012 | β |
| Recent advances in gut nutrient chemosensing. | Nguyen CA et al. | β | 2012 | β |
| Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis. | Lipchock SV et al. | β | 2012 | β |
| Sense of taste in the gastrointestinal tract. | Iwatsuki K et al. | β | 2012 | β |
| Soy peptides enhance heterologous membrane protein productivity during the exponential growth phase of Saccharomyces cerevisiae. | Ito K et al. | β | 2012 | β |
| Strategies and tools for preventing neurotoxicity: to test, to predict and how to do it. | Llorens J et al. | β | 2012 | β |
| TAS2R activation promotes airway smooth muscle relaxation despite Ξ²(2)-adrenergic receptor tachyphylaxis. | An SS et al. | β | 2012 | β |
| Taste preferences. | Galindo MM et al. | β | 2012 | β |
| Taste receptor signalling - from tongues to lungs. | Kinnamon SC | β | 2012 | β |
| "Tasting" the airway lining fluid. | Krasteva G et al. | β | 2012 | β |
| A gustotopic map of taste qualities in the mammalian brain. | Chen X et al. | β | 2011 | β |
| A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans. | Aoki R et al. | β | 2011 | β |
| Attempt to develop taste bud models in three-dimensional culture. | Nishiyama M et al. | β | 2011 | β |
| B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion. | Ishii A et al. | β | 2011 | β |
| Behavioral and ecological consequences of sex-based differences in gustatory anatomy in Cebus apella. | Muchlinski MN et al. | β | 2011 | β |
| "Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures. | Kim TH et al. | β | 2011 | β |
| Chemosense for luminal environment in the large intestine. | Kaji I et al. | β | 2011 | β |
| Citric acid and quinine share perceived chemosensory features making oral discrimination difficult in C57BL/6J mice. | Treesukosol Y et al. | β | 2011 | β |
| Different tastants and low-caloric sweeteners induce differential effects on the release of satiety hormones. | Geraedts MC et al. | β | 2011 | β |
| Diversification of bitter taste receptor gene family in western chimpanzees. | Sugawara T et al. | β | 2011 | β |
| Establishment of a new cell-based assay to measure the activity of sweeteners in fluorescent food extracts. | Toda Y et al. | β | 2011 | β |
| Establishment of clonal cell lines of taste buds from a p53(-/-) mouse tongue. | Sako H et al. | β | 2011 | β |
| Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. | Narukawa M et al. | β | 2011 | β |
| Expression of taste receptors in solitary chemosensory cells of rodent airways. | Tizzano M et al. | β | 2011 | β |
| Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. | Roudnitzky N et al. | β | 2011 | β |
| Glossopharyngeal nerve transection impairs unconditioned avoidance of diverse bitter stimuli in rats. | Geran LC et al. | β | 2011 | β |
| Gustatory and extragustatory functions of mammalian taste receptors. | Behrens M et al. | β | 2011 | β |
| Hypothesis/review: the structural basis of sweetness perception of sweet-tasting plant proteins can be deduced from sequence analysis. | Wintjens R et al. | β | 2011 | β |
| Identification of a novel gene, anorexia, regulating feeding activity via insulin signaling in Drosophila melanogaster. | Ryuda M et al. | β | 2011 | β |
| Improvement of some physicochemical properties of arundic acid, (R)-(-)-2-propyloctanonic acid, by complexation with hydrophilic cyclodextrins. | Miyamoto Y et al. | β | 2011 | β |
| Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. | Robery S et al. | β | 2011 | β |
| Mutually exclusive expression of GΞ±ia and GΞ±14 reveals diversification of taste receptor cells in zebrafish. | Ohmoto M et al. | β | 2011 | β |
| My life with nature. | Adler J | β | 2011 | β |
| New insights into the characteristics of sweet and bitter taste receptors. | Temussi PA | β | 2011 | β |
| Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues. | Onoda K et al. | β | 2011 | β |
| Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. | Greene TA et al. | β | 2011 | β |
| Reduction of bitterness of antihistaminic drugs by complexation with Ξ²-cyclodextrins. | Ono N et al. | β | 2011 | β |
| Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception. | Iguchi N et al. | β | 2011 | β |
| Selection on the human bitter taste gene, TAS2R16, in Eurasian populations. | Li H et al. | β | 2011 | β |
| Sensing via intestinal sweet taste pathways. | Young RL | β | 2011 | β |
| Signatures of natural selection in a primate bitter taste receptor. | Wooding S | β | 2011 | β |
| Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. | Roland WS et al. | β | 2011 | β |
| Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies. | Dai W et al. | β | 2011 | β |
| Sweet and umami taste: natural products, their chemosensory targets, and beyond. | Behrens M et al. | β | 2011 | β |
| TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps. | Lucock M et al. | β | 2011 | β |
| Taste bud cells of adult mice are responsive to Wnt/Ξ²-catenin signaling: implications for the renewal of mature taste cells. | Gaillard D et al. | β | 2011 | β |
| Taste isn't just for taste buds anymore. | Finger TE et al. | β | 2011 | β |
| The discovery and mechanism of sweet taste enhancers. | Li X et al. | β | 2011 | β |
| The functional role of the T1R family of receptors in sweet taste and feeding. | Treesukosol Y et al. | β | 2011 | β |
| The gustatory and olfactory systems during infancy: implications for development of feeding behaviors in the high-risk neonate. | Lipchock SV et al. | β | 2011 | β |
| The molecular and cellular basis of bitter taste in Drosophila. | Weiss LA et al. | β | 2011 | β |
| TRPV1-lineage neurons are required for thermal sensation. | Mishra SK et al. | β | 2011 | β |
| Value and pitfalls in iodine fortification and supplementation in the 21st century. | Speeckaert MM et al. | β | 2011 | β |
| Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. | Mishra SK et al. | β | 2010 | β |
| Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. | Deshpande DA et al. | β | 2010 | β |
| Calcium signaling in taste cells: regulation required. | Medler KF | β | 2010 | β |
| Capsaicin receptors are colocalized with sweet/bitter receptors in the taste sensing cells of circumvallate papillae. | Moon YW et al. | β | 2010 | β |
| Carbonic anhydrase IV mediates the fizz of carbonated beverages. | Dunkel A et al. | β | 2010 | β |
| Evolutionary adaptations to dietary changes. | Luca F et al. | β | 2010 | β |
| Evolution of the sweet taste receptor gene Tas1r2 in bats. | Zhao H et al. | β | 2010 | β |
| Genetic tracing of the neural pathway for bitter taste in t2r5-WGA transgenic mice. | Ohmoto M et al. | β | 2010 | β |
| Gustatory signaling in the periphery: detection, transmission, and modulation of taste information. | Niki M et al. | β | 2010 | β |
| Gut chemosensing: interactions between gut endocrine cells and visceral afferents. | Raybould HE | β | 2010 | β |
| Identification of non-taster Japanese macaques for a specific bitter taste. | Suzuki N et al. | β | 2010 | β |
| Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. | BiarnΓ©s X et al. | β | 2010 | β |
| Involvement of the calcium-sensing receptor in human taste perception. | Ohsu T et al. | β | 2010 | β |
| Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells. | Shindo Y et al. | β | 2010 | β |
| Modulation of bitter taste perception by a small molecule hTAS2R antagonist. | Slack JP et al. | β | 2010 | β |
| Molecular and cellular designs of insect taste receptor system. | Isono K et al. | β | 2010 | β |
| Molecular gastronomy: a new emerging scientific discipline. | Barham P et al. | β | 2010 | β |
| Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. | Tizzano M et al. | β | 2010 | β |
| Neural architecture of the primary gustatory center of Drosophila melanogaster visualized with GAL4 and LexA enhancer-trap systems. | Miyazaki T et al. | β | 2010 | β |
| New insights into the signal transmission from taste cells to gustatory nerve fibers. | Yoshida R et al. | β | 2010 | β |
| NMDA receptor in intestinal enteroendocrine cell, STC-1. | Fukunaga Y et al. | β | 2010 | β |
| Oligomerization of TAS2R bitter taste receptors. | Kuhn C et al. | β | 2010 | β |
| Oral and extraoral bitter taste receptors. | Behrens M et al. | β | 2010 | β |
| Rewiring the gustatory system: specificity between nerve and taste bud field is critical for normal salt discrimination. | Spector AC et al. | β | 2010 | β |
| ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampus. | Sharma RK et al. | β | 2010 | β |
| Structural requirements of bitter taste receptor activation. | Brockhoff A et al. | β | 2010 | β |
| The cell biology of taste. | Chaudhari N et al. | β | 2010 | β |
| The molecular receptive ranges of human TAS2R bitter taste receptors. | Meyerhof W et al. | β | 2010 | β |
| The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. | Reed DR et al. | β | 2010 | β |
| The sour taste of a proton current. | Frings S | β | 2010 | β |
| The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells. | Le NevΓ© B et al. | β | 2010 | β |
| An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. | Mace OJ et al. | β | 2009 | β |
| A taste of the Drosophila gustatory receptors. | Montell C | β | 2009 | β |
| Bitter-responsive brainstem neurons: characteristics and functions. | Travers SP et al. | β | 2009 | β |
| Bitter-responsive gustatory neurons in the rat parabrachial nucleus. | Geran LC et al. | β | 2009 | β |
| Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. | Matsumura S et al. | β | 2009 | β |
| Common sense about taste: from mammals to insects. | Yarmolinsky DA et al. | β | 2009 | β |
| Discrimination of taste qualities among mouse fungiform taste bud cells. | Yoshida R et al. | β | 2009 | β |
| Dynamic evolution of bitter taste receptor genes in vertebrates. | Dong D et al. | β | 2009 | β |
| Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. | Young RL et al. | β | 2009 | β |
| Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae. | Sugawara T et al. | β | 2009 | β |
| Fluorescence patterns from supramolecular polymer assembly and disassembly for sensing metallo- and nonmetalloproteins. | GonzΓ‘lez DC et al. | β | 2009 | β |
| Genetic variation in taste and its influence on food selection. | Garcia-Bailo B et al. | β | 2009 | β |
| Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes. | Hevezi P et al. | β | 2009 | β |
| Glucose, epithelium, and enteric nervous system: dialogue in the dark. | Pfannkuche H et al. | β | 2009 | β |
| Gustation in fish: search for prototype of taste perception. | Yasuoka A et al. | β | 2009 | β |
| Identification of the key bitter compounds in our daily diet is a prerequisite for the understanding of the hTAS2R gene polymorphisms affecting food choice. | Hofmann T | β | 2009 | β |
| Linking peripheral taste processes to behavior. | Spector AC et al. | β | 2009 | β |
| Mammalian bitter taste perception. | Behrens M et al. | β | 2009 | β |
| Modeling and simulation of ion channels and action potentials in taste receptor cells. | Chen P et al. | β | 2009 | β |
| [Molecular cloning and evolutionary analysis of hog badger bitter taste receptor T2R2 gene]. | XU HL et al. | β | 2009 | β |
| Molecular mechanisms of taste transduction in vertebrates. | Ishimaru Y | β | 2009 | β |
| Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates. | Grus WE et al. | β | 2009 | β |
| pH-Dependent inhibition of the human bitter taste receptor hTAS2R16 by a variety of acidic substances. | Sakurai T et al. | β | 2009 | β |
| Positive selection drives the evolution of bat bitter taste receptor genes. | Zhou Y et al. | β | 2009 | β |
| Primary processes in sensory cells: current advances. | Frings S | β | 2009 | β |
| Recognition of organic compounds in aqueous solutions by chemiluminescence on an array of catalytic nanoparticles. | Kong H et al. | β | 2009 | β |
| Responses of the hamster chorda tympani nerve to sucrose+acid and sucrose+citrate taste mixtures. | Formaker BK et al. | β | 2009 | β |
| Ric-8A, a Galpha protein guanine nucleotide exchange factor potentiates taste receptor signaling. | Fenech C et al. | β | 2009 | β |
| Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine. | Kaji I et al. | β | 2009 | β |
| Signalling mechanisms in mouse bitter responsive taste cells. | Narukawa M et al. | β | 2009 | β |
| Sweet, bitter and umami receptors: a complex relationship. | Temussi PA | β | 2009 | β |
| Symposium overview: Impact of bitter taste on human nutrition and health. | Meyerhof W | β | 2009 | β |
| Synaptophysin as a probable component of neurotransmission occurring in taste receptor cells. | Asano-Miyoshi M et al. | β | 2009 | β |
| Taste receptor cell-based biosensor for taste specific recognition based on temporal firing. | Chen P et al. | β | 2009 | β |
| Taste, visceral information and exocrine reflexes with glutamate through umami receptors. | San Gabriel A et al. | β | 2009 | β |
| The neuropeptides CCK and NPY and the changing view of cell-to-cell communication in the taste bud. | Herness S et al. | β | 2009 | β |
| The taste of carbonation. | Chandrashekar J et al. | β | 2009 | β |
| The trigemino-cardiac reflex: an update of the current knowledge. | Schaller B et al. | β | 2009 | β |
| Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. | Matsunami H et al. | β | 2009 | β |
| Transient receptor potential (TRP) channels and taste sensation. | Ishimaru Y et al. | β | 2009 | β |
| [7-aminoactinomycin as a fluorescent probe for DNA unwinding and denaturation]. | Bitekhtina MA et al. | β | 2008 | β |
| Astringency: mechanisms and perception. | Bajec MR et al. | β | 2008 | β |
| Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. | Nagatomo K et al. | β | 2008 | β |
| Central and peripheral regulation of food intake and physical activity: pathways and genes. | Lenard NR et al. | β | 2008 | β |
| Construction of a taste-blind medaka fish and quantitative assay of its preference-aversion behavior. | Aihara Y et al. | β | 2008 | β |
| Cracking taste codes by tapping into sensory neuron impulse traffic. | Frank ME et al. | β | 2008 | β |
| Cytokeratin 14 is expressed in immature cells in rat taste buds. | Asano-Miyoshi M et al. | β | 2008 | β |
| Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. | Sternini C et al. | β | 2008 | β |
| Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation. | King CT et al. | β | 2008 | β |
| Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue. | Tizzano M et al. | β | 2008 | β |
| Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae. | Feng XH et al. | β | 2008 | β |
| Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. | Doyle GA et al. | β | 2008 | β |
| Food ingredients and cognitive performance. | le Coutre J et al. | β | 2008 | β |
| G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. | Shindo Y et al. | β | 2008 | β |
| Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells. | Ohmoto M et al. | β | 2008 | β |
| Genomic drift and copy number variation of chemosensory receptor genes in humans and mice. | Nozawa M et al. | β | 2008 | β |
| Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin. | Shigemura N et al. | β | 2008 | β |
| Immunohistochemical localization of cystic fibrosis transmembrane regulator and clara cell secretory protein in taste receptor cells of rat circumvallate papillae. | Merigo F et al. | β | 2008 | β |
| Impact of genetic and environmental determinants of taste with food preferences in older adults. | Navarro-Allende A et al. | β | 2008 | β |
| Modification of the bitterness of caffeine | Keast RSJ | β | 2008 | β |
| Modulation of taste sensitivity by GLP-1 signaling. | Shin YK et al. | β | 2008 | β |
| SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. | Jeon TI et al. | β | 2008 | β |
| Structural diversity of G protein-coupled receptors and significance for drug discovery. | LagerstrΓΆm MC et al. | β | 2008 | β |
| The brain, appetite, and obesity. | Berthoud HR et al. | β | 2008 | β |
| The Caenorhabditis chemoreceptor gene families. | Thomas JH et al. | β | 2008 | β |
| The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity. | Nei M et al. | β | 2008 | β |
| The taste of sugars. | McCaughey SA | β | 2008 | β |
| Tonic activity of Galpha-gustducin regulates taste cell responsivity. | Clapp TR et al. | β | 2008 | β |
| Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. | Hisatsune C et al. | β | 2007 | β |
| A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. | Keast RS et al. | β | 2007 | β |
| A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. | Jiao Y et al. | β | 2007 | β |
| Behavioral genetics and taste. | Boughter JD et al. | β | 2007 | β |
| Cellular mechanisms in taste buds. | Suzuki T | β | 2007 | β |
| [Changed taste perception in patients with eating disorders]. | WΓΆckel L et al. | β | 2007 | β |
| Characterization of ligands for fish taste receptors. | Oike H et al. | β | 2007 | β |
| Claudin-based permeability barriers in taste buds. | Michlig S et al. | β | 2007 | β |
| Combinatorial co-expression of pheromone receptors, V2Rs. | Silvotti L et al. | β | 2007 | β |
| Cycloheximide: no ordinary bitter stimulus. | Hettinger TP et al. | β | 2007 | β |
| Do G protein-coupled receptors expressed in human lingual epithelium interact with HPV11? | DurzyΕski L et al. | β | 2007 | β |
| Effects of two bitter substances on olfactory conditioning in the moth Heliothis virescens. | JΓΈrgensen K et al. | β | 2007 | β |
| Electrophysiological characterization of responses from gustatory receptor neurons of sensilla chaetica in the moth Heliothis virescens. | JΓΈrgensen K et al. | β | 2007 | β |
| Expression of T1Rs and gustducin in palatal taste buds of mice. | Stone LM et al. | β | 2007 | β |
| Functional characterization of human bitter taste receptors. | Sainz E et al. | β | 2007 | β |
| Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. | Wang JC et al. | β | 2007 | β |
| Generation and modulation of chemosensory behaviors in C. elegans. | Sengupta P | β | 2007 | β |
| GPR expression in the rat taste bud relating to fatty acid sensing. | Matsumura S et al. | β | 2007 | β |
| Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. | Behrens M et al. | β | 2007 | β |
| Immunohistochemical identification of cells expressing steroidogenic enzymes cytochrome P450scc and P450 aromatase in taste buds of rat circumvallate papillae. | Toyoshima K et al. | β | 2007 | β |
| Individual differences in perceived bitterness predict liking of sweeteners. | Kamerud JK et al. | β | 2007 | β |
| Intestinal STC-1 cells respond to five basic taste stimuli. | Saitoh O et al. | β | 2007 | β |
| Signal transduction and information processing in mammalian taste buds. | Roper SD | β | 2007 | β |
| Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. | Pronin AN et al. | β | 2007 | β |
| Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. | Mace OJ et al. | β | 2007 | β |
| Taste and pheromone perception in the fruit fly Drosophila melanogaster. | Ebbs ML et al. | β | 2007 | β |
| Taste receptor genes. | Bachmanov AA et al. | β | 2007 | β |
| Taste receptor signaling in the mammalian gut. | Rozengurt E et al. | β | 2007 | β |
| The G protein-coupled receptor subset of the rat genome. | Gloriam DE et al. | β | 2007 | β |
| The G-protein coupling properties of the human sweet and amino acid taste receptors. | Sainz E et al. | β | 2007 | β |
| The neural processing of taste. | Lemon CH et al. | β | 2007 | β |
| The sweet taste receptor: a single receptor with multiple sites and modes of interaction. | Temussi P | β | 2007 | β |
| Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides. | Tian F et al. | β | 2007 | β |
| Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene. | Aihara Y et al. | β | 2007 | β |
| TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. | Kaske S et al. | β | 2007 | β |
| [Adverse drug reactions and oral disorders]. | Kawaguchi M et al. | β | 2006 | β |
| Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. | Oike H et al. | β | 2006 | β |
| Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. | Chen MC et al. | β | 2006 | β |
| Cell communication in taste buds. | Roper SD | β | 2006 | β |
| Cell lineage and differentiation in taste buds. | Miura H et al. | β | 2006 | β |
| Cellular identification of water gustatory receptor neurons and their central projection pattern in Drosophila. | Inoshita T et al. | β | 2006 | β |
| Characterizing bitterness: identification of key structural features and development of a classification model. | Rodgers S et al. | β | 2006 | β |
| Coding channels for taste perception: information transmission from taste cells to gustatory nerve fibers. | Yoshida R et al. | β | 2006 | β |
| Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. | Rozengurt N et al. | β | 2006 | β |
| Computational studies of ligand-receptor interactions in bitter taste receptors. | Miguet L et al. | β | 2006 | β |
| Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. | Shi P et al. | β | 2006 | β |
| Diverse tastes: Genetics of sweet and bitter perception. | Reed DR et al. | β | 2006 | β |
| Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates. | Niimura Y et al. | β | 2006 | β |
| Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans. | Conte C et al. | β | 2006 | β |
| Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. | Hinrichs AL et al. | β | 2006 | β |
| Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues. | Kiuchi S et al. | β | 2006 | β |
| Group IIA phospholipase A(2) is coexpressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae. | Oike H et al. | β | 2006 | β |
| Heterogeneous distribution of taste cells in facial and vagal nerve-innervated taste buds. | Eram M et al. | β | 2006 | β |
| Independent evolution of bitter-taste sensitivity in humans and chimpanzees. | Wooding S et al. | β | 2006 | β |
| Influence of response variability on the coding performance of central gustatory neurons. | Lemon CH et al. | β | 2006 | β |
| Insect odor and taste receptors. | Hallem EA et al. | β | 2006 | β |
| I want a new drug: G-protein-coupled receptors in drug development. | Schlyer S et al. | β | 2006 | β |
| Keynote review: allosterism in membrane receptors. | Gao ZG et al. | β | 2006 | β |
| Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. | Bartel DL et al. | β | 2006 | β |
| Pattern-based discrimination of enantiomeric and structurally similar amino acids: an optical mimic of the mammalian taste response. | Folmer-Andersen JF et al. | β | 2006 | β |
| Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. | Wooding S | β | 2006 | β |
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