Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.
- Authors
- Foroud, Tatiana; Wetherill, Leah Flury; Dick, Danielle M; Hesselbrock, Victor; Nurnberger, John I; Kramer, John; Tischfield, Jay; Schuckit, Marc; Bierut, Laura J; Xuei, Xiaoling; Edenberg, Howard J
- Year
- 2007
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 17850222
- DOI
- 10.1111/j.1530-0277.2007.00505.x
OBJECTIVE: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. METHODS: Single nucleotide polymophisms (SNPs) were genotyped in a sample of 219 multiplex alcohol-dependent families of European American descent from the Collaborative Study on the Genetics of Alcoholism (COGA). Family-based tests of association were performed to evaluate the evidence of association between the 18 SNPs distributed throughout COMT, including the functional Val158Met polymorphism, and the phenotypes of alcohol dependence, early onset alcohol dependence, habitual smoking, and comorbid alcohol dependence and habitual smoking. RESULTS: No significant, consistent evidence of association was found with alcohol dependence, early onset alcohol dependence, habitual smoking or the comorbid phenotype. There was no evidence that the functional Val158Met polymorphism, previously reported to be associated with these phenotypes, was associated with any of them. CONCLUSION: Despite the substantial size of this study, we did not find evidence to support an association between alcohol dependence or habitual smoking and variation in COMT.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol Use Disorder: Neurobiology and Therapeutics. | Yang W et al. | — | 2022 | → |
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| Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats. | McCane AM et al. | — | 2018 | → |
| Environmental risks outweigh dopaminergic genetic risks for alcohol use and abuse from adolescence through early adulthood. | Coley RL et al. | — | 2017 | → |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | — | 2017 | → |
| Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. | Celorrio D et al. | — | 2016 | → |
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| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | — | 2014 | → |
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