A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb.
paper
Cited
Public
Unavailable
- Authors
- Duvoisin, R M; Zhang, C; Ramonell, K
- Year
- 1995
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 7722646
- DOI
- 10.1523/JNEUROSCI.15-04-03075.1995
- PMCID
- PMC6577763
A novel metabotropic glutamate receptor, mGluR8, was identified by screening a mouse retina cDNA library. This receptor is most related to mGluR4, mGluR7, and mGluR6 (74%, 74%, and 70% identical amino acid residues, respectively). Similar to these receptors, stimulation by L-glutamate or L-2-amino-4-phosphonobutyrate (L-APB) of Chinese hamster ovary (CHO) cells stably transfected with mGluR8 result in the inhibition of forskolin-stimulated adenylyl cyclase. In situ hybridization studies revealed a strong expression of the mGluR8 gene in the olfactory bulb, accessory olfactory bulb, and mammillary body. A weaker expression was found in the retina, and in scattered cells in the cortex and hindbrain. During development, the distribution of mGluR8 expression was more widespread. These results extend the diversity of metabotropic glutamate receptors in the CNS. Because at least two APB receptors are expressed in the retina, the use of this drug to block selectively the ON pathway needs to be reconsidered. The pharmacology and expression of mGluR8 in mitral/tufted cells suggest it could be a presynaptic receptor modulating glutamate release by these cells at their axon terminals in the entorhinal cortex.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | 2009 | 18618593 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors. | Ostenrath AM et al. | β | 2025 | β |
| Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts. | Mielecki D et al. | β | 2024 | β |
| Metabotropic glutamate receptors-guardians and gatekeepers in neonatal hypoxic-ischemic brain injury. | Mielecki D et al. | β | 2024 | β |
| mGlu4R, mGlu7R, and mGlu8R allosteric modulation for treating acute and chronic neurodegenerative disorders. | Domin H et al. | β | 2024 | β |
| Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity. | Nabit BP et al. | β | 2024 | β |
| A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina. | Jo A et al. | β | 2023 | β |
| Dye coupling of horizontal cells in the primate retina. | Pan F et al. | β | 2023 | β |
| Genome-wide association study reveals genetic loci and candidate genes for meat quality traits in a four-way crossbred pig population. | Wang H et al. | β | 2023 | β |
| Glutamate receptor endocytosis and signaling in neurological conditions. | Yadav P et al. | β | 2023 | β |
| Roles of metabotropic glutamate receptor 8 in neuropsychiatric and neurological disorders. | Mao LM et al. | β | 2023 | β |
| Saccharin and aspartame excite rat retinal neurons. | Yang J et al. | β | 2023 | β |
| Targeting mGluR group III for the treatment of neurodegenerative diseases. | Rabeh N et al. | β | 2023 | β |
| Transcriptional regulation of NRF1 on metabotropic glutamate receptors in a neonatal hypoxicβischemic encephalopathy rat model. | Wang D et al. | β | 2023 | β |
| Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes <i>Grm8a</i> and <i>Grm8b</i> Display Distinct Behavioral Phenotypes in Zebrafish Larvae (<i>Danio rerio</i>). | LΓΌffe TM et al. | β | 2022 | β |
| Astrocytes in Neural Circuits: Key Factors in Synaptic Regulation and Potential Targets for Neurodevelopmental Disorders. | Liu X et al. | β | 2021 | β |
| International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors. | Gregory KJ et al. | β | 2021 | β |
| The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment-A Narrative Review. | Kryszkowski W et al. | β | 2021 | β |
| Regulation of Glutamatergic Activity via Bidirectional Activation of Two Select Receptors as a Novel Approach in Antipsychotic Drug Discovery. | CieΕlik P et al. | β | 2020 | β |
| Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum. | Katona L et al. | β | 2020 | β |
| Targeting Vesicular Glutamate Transporter Machinery: Implications on Metabotropic Glutamate Receptor 5 Signaling and Behavior. | Ibrahim KS et al. | β | 2020 | β |
| Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors. | Okubo M et al. | β | 2019 | β |
| Role of Metabotropic Glutamate Receptors in Neurological Disorders. | Crupi R et al. | β | 2019 | β |
| Regulation of Excitatory Amino Acid Transmission in the Retina: Studies on Neuroprotection. | Opere CA et al. | β | 2018 | β |
| Metabotropic glutamate receptors and neurodegenerative diseases. | Ribeiro FM et al. | β | 2017 | β |
| Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca<sup>2</sup>. | Zou J et al. | β | 2017 | β |
| Selective agonism of mGlu8 receptors by (S)-3,4-dicarboxyphenylglycine does not affect sleep stages in the rat. | Cavas M et al. | β | 2017 | β |
| Functional Dissociation of Group III Metabotropic Glutamate Receptors Revealed by Direct Comparison between the Behavioral Profiles of Knockout Mouse Lines. | Goddyn H et al. | β | 2015 | β |
| Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety. | Raber J et al. | β | 2015 | β |
| Therapeutic potential of group III metabotropic glutamate receptor ligands in pain. | Acher F et al. | β | 2015 | β |
| AΞ² selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer's disease. | Gu Z et al. | β | 2014 | β |
| Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential. | Mercier MS et al. | β | 2014 | β |
| Dopamine modulates the off pathway in light-adapted mouse retina. | Yang J et al. | β | 2013 | β |
| Haploinsufficiency of VGluT1 but not VGluT2 impairs extinction of spatial preference and response suppression. | Callaerts-Vegh Z et al. | β | 2013 | β |
| Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). | Haug MF et al. | β | 2013 | β |
| Regulation of the brain-gut axis by group III metabotropic glutamate receptors. | Julio-Pieper M et al. | β | 2013 | β |
| Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning. | Mukherjee S et al. | β | 2013 | β |
| "mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling. | Dhingra A et al. | β | 2012 | β |
| Selective activation of group III metabotropic glutamate receptor subtypes produces different patterns of Ξ³-aminobutyric acid immunoreactivity and glutamate release in the retina. | GuimarΓ£es-Souza EM et al. | β | 2012 | β |
| Analyses of porcine public SNPs in coding-gene regions by re-sequencing and phenotypic association studies. | Li X et al. | β | 2011 | β |
| Metabotropic glutamate receptors: from the workbench to the bedside. | Nicoletti F et al. | β | 2011 | β |
| mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. | Gosnell HB et al. | β | 2011 | β |
| Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. | Duvoisin RM et al. | β | 2011 | β |
| Acute pharmacological modulation of mGluR8 reduces measures of anxiety. | Duvoisin RM et al. | β | 2010 | β |
| Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function. | Jian K et al. | β | 2010 | β |
| Metabotropic glutamate receptors: physiology, pharmacology, and disease. | Niswender CM et al. | β | 2010 | β |
| Metabotropic glutamate receptors: their therapeutic potential in anxiety. | Spooren W et al. | β | 2010 | β |
| Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses. | Quraishi S et al. | β | 2010 | β |
| Sex-dependent cognitive phenotype of mice lacking mGluR8. | Duvoisin RM et al. | β | 2010 | β |
| The effect of mGlu8 deficiency in animal models of psychiatric diseases. | Fendt M et al. | β | 2010 | β |
| Activation switch in the transmembrane domain of metabotropic glutamate receptor. | Yanagawa M et al. | β | 2009 | β |
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | Chen AC et al. | β | 2009 | β |
| Metabotropic receptors for glutamate and GABA in pain. | Goudet C et al. | β | 2009 | β |
| Band 4.1 proteins are expressed in the retina and interact with both isoforms of the metabotropic glutamate receptor type 8. | Rose M et al. | β | 2008 | β |
| Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions. | Torarinsson E et al. | β | 2008 | β |
| Metabotropic glutamate 1 receptor: current concepts and perspectives. | Ferraguti F et al. | β | 2008 | β |
| The possible involvement of metabotropic glutamate receptors in schizophrenia. | Krivoy A et al. | β | 2008 | β |
| Antagonism of group III metabotropic glutamate receptors results in impairment of LTD but not LTP in the hippocampal CA1 region, and prevents long-term spatial memory. | Altinbilek B et al. | β | 2007 | β |
| Distribution of group-III metabotropic glutamate receptors in the retina. | Quraishi S et al. | β | 2007 | β |
| Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. | Robbins MJ et al. | β | 2007 | β |
| Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons. | Kim YT et al. | β | 2007 | β |
| Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina. | Joselevitch C et al. | β | 2007 | β |
| The trick of the tail: protein-protein interactions of metabotropic glutamate receptors. | Enz R | β | 2007 | β |
| Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. | Li W et al. | β | 2006 | β |
| Metabotropic glutamate receptors. | Ferraguti F et al. | β | 2006 | β |
| Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury. | Movsesyan VA et al. | β | 2006 | β |
| Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex. | Kim HH et al. | β | 2006 | β |
| 2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid. | Johnson RL et al. | β | 2005 | β |
| Changes in glutamate receptor function in synaptic input to the superficial superior colliculus (SSC) with aging and in retinal degeneration in the Royal College of Surgeons (RCS) rat. | Pothecary CA et al. | β | 2005 | β |
| Coupling of metabotropic glutamate receptor 8 to N-type Ca2+ channels in rat sympathetic neurons. | Guo J et al. | β | 2005 | β |
| Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level. | Marabese I et al. | β | 2005 | β |
| Glutamate transporter studies reveal the pruning of metabotropic glutamate receptors and absence of AMPA receptor desensitization at mature calyx of Held synapses. | Renden R et al. | β | 2005 | β |
| Immunoreactivity for the group III receptor subtype mGluR4a in the visual layers of the rat superior colliculus. | Puente N et al. | β | 2005 | β |
| Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. | Duvoisin RM et al. | β | 2005 | β |
| Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. | Ferraguti F et al. | β | 2005 | β |
| Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development. | Lacey CJ et al. | β | 2005 | β |
| Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. | Tang Z et al. | β | 2005 | β |
| A novel constitutively active mutation in the second cytoplasmic loop of metabotropic glutamate receptor. | Yamashita T et al. | β | 2004 | β |
| Characterization of receptors for glutamate and GABA in retinal neurons. | Yang XL | β | 2004 | β |
| Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus. | Bough KJ et al. | β | 2004 | β |
| Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system. | Simeone TA et al. | β | 2004 | β |
| Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS). | Rudolf G et al. | β | 2004 | β |
| Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. | Takaki H et al. | β | 2004 | β |
| Tonic activity of metabotropic glutamate receptors is involved in developmental modification of short-term plasticity in the neocortex. | Chen HX et al. | β | 2004 | β |
| Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes. | Enz R et al. | β | 2003 | β |
| Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells. | Robbins J et al. | β | 2003 | β |
| Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro. | Turner JP et al. | β | 2003 | β |
| Group III metabotropic glutamate receptors as autoreceptors in the cerebellar cortex. | Lorez M et al. | β | 2003 | β |
| Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. | Croci C et al. | β | 2003 | β |
| Increased c-Fos expression in the centromedial nucleus of the thalamus in metabotropic glutamate 8 receptor knockout mice following the elevated plus maze test. | Linden AM et al. | β | 2003 | β |
| Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. | Higashida H et al. | β | 2003 | β |
| Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons. | Netzeband JG et al. | β | 2002 | β |
| Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor. | Linden AM et al. | β | 2002 | β |
| Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets. | Tong Q et al. | β | 2002 | β |
| Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells. | KnΓΆpfel T et al. | β | 2002 | β |
| Modulation of lateral perforant path excitatory responses by metabotropic glutamate 8 (mGlu8) receptors. | Zhai J et al. | β | 2002 | β |
| Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways. | Iacovelli L et al. | β | 2002 | β |
| Neuroprotective activity of metabotropic glutamate receptor ligands. | Flor PJ et al. | β | 2002 | β |
| Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype. | Gerlai R et al. | β | 2002 | β |
| Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG. | Pothecary CA et al. | β | 2002 | β |
| The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. | Enz R | β | 2002 | β |
| The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. | MillΓ‘n C et al. | β | 2002 | β |
| The metabotropic glutamate receptor mGluR7b binds to the catalytic gamma-subunit of protein phosphatase 1. | Enz R | β | 2002 | β |
| Changes in metabotropic glutamate receptor expression following spinal cord injury. | Mills CD et al. | β | 2001 | β |
| Development of retinal ganglion cell structure and function. | Sernagor E et al. | β | 2001 | β |
| Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. | Tamaru Y et al. | β | 2001 | β |
| Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate. | Yip PK et al. | β | 2001 | β |
| Glutamate receptors and nociception: implications for the drug treatment of pain. | Fundytus ME | β | 2001 | β |
| Immunoreactivity for the group III metabotropic glutamate receptor subtype mGluR4a in the superficial laminae of the rat spinal dorsal horn. | Azkue JJ et al. | β | 2001 | β |
| Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. | Sansig G et al. | β | 2001 | β |
| Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat. | Mills CD et al. | β | 2001 | β |
| Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. | Bruno V et al. | β | 2001 | β |
| Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina. | Hirano AA et al. | β | 2000 | β |
| Developmental changes in the neurotransmitter regulation of correlated spontaneous retinal activity. | Wong WT et al. | β | 2000 | β |
| Differential distribution of metabotropic glutamate receptor subtype mRNAs in the thalamus of the rat. | LourenΓ§o Neto F et al. | β | 2000 | β |
| Distribution of G-protein alpha subunits and neurotransmitter activation of g(alphai) and g(alphaq) in the brain of the lobster Homarus americanus. | McClintock TS et al. | β | 2000 | β |
| Expression of metabotropic glutamate receptors mRNA in the thalamus and brainstem of monoarthritic rats. | LourenΓ§o Neto F et al. | β | 2000 | β |
| Group III metabotropic glutamate receptors modulate long-term depression in the hippocampal CA1 region of two rat strains in vivo. | Manahan-Vaughan D | β | 2000 | β |
| Immunocytochemical localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of the rat. | BenΓtez R et al. | β | 2000 | β |
| Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. | Stinehelfer S et al. | β | 2000 | β |
| Ligands for glutamate receptors: design and therapeutic prospects. | BrΓ€uner-Osborne H et al. | β | 2000 | β |
| Localization of metabotropic glutamate receptor type 2 in the human brain. | Phillips T et al. | β | 2000 | β |
| Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus. | Richardson-Burns SM et al. | β | 2000 | β |
| Methylmalonic and propionic acids increase the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors. | de Mattos-Dutra A et al. | β | 2000 | β |
| Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. | De Colle C et al. | β | 2000 | β |
| Protein phosphatase 1 and 2A inhibitors prolong the switch in the control of glutamate release by group I metabotropic glutamate receptors: characterization of the inhibitory pathway. | Sistiaga A et al. | β | 2000 | β |
| Synaptic control of motoneuronal excitability. | Rekling JC et al. | β | 2000 | β |
| Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process. | Bessis AS et al. | β | 2000 | β |
| Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. | Malherbe P et al. | β | 1999 | β |
| Decreased sensitivity to Group III mGluR agonists in the lateral perforant path following kindling. | Klapstein GJ et al. | β | 1999 | β |
| Developmental expression of the group III metabotropic glutamate receptor mGluR4a in the medial nucleus of the trapezoid body of the rat. | Elezgarai I et al. | β | 1999 | β |
| Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. | Montague AA et al. | β | 1999 | β |
| Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala. | Keele NB et al. | β | 1999 | β |
| Distinct subtypes of metabotropic glutamate receptors mediate differential actions on excitability of spinal respiratory motoneurons. | Dong XW et al. | β | 1999 | β |
| Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord. | Berthele A et al. | β | 1999 | β |
| Evidence of metabotropic glutamate receptor subtypes found on catfish horizontal and bipolar retinal neurons. | Gafka AC et al. | β | 1999 | β |
| Expression and functional analysis of glutamate receptors in glial cells. | Condorelli DF et al. | β | 1999 | β |
| Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia. | Bradley SR et al. | β | 1999 | β |
| Immunohistological studies of metabotropic glutamate receptor subtype 6-deficient mice show no abnormality of retinal cell organization and ganglion cell maturation. | Tagawa Y et al. | β | 1999 | β |
| Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia. | Kosinski CM et al. | β | 1999 | β |
| Metabotropic glutamate receptor 2/3 immunoreactivity in the developing rat cerebellar cortex. | Meguro R et al. | β | 1999 | β |
| Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity. | HΓΆlscher C et al. | β | 1999 | β |
| mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats. | Schools GP et al. | β | 1999 | β |
| Modulation of synaptic transmission and differential localisation of mGlus in cultured hippocampal autapses. | Bushell TJ et al. | β | 1999 | β |
| Modulation of the intracellular calcium concentration in photoreceptor terminals by a presynaptic metabotropic glutamate receptor. | Koulen P et al. | β | 1999 | β |
| Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp DD et al. | β | 1999 | β |
| Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors. | Vetter P et al. | β | 1999 | β |
| Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro. | McCaffery B et al. | β | 1999 | β |
| Activity-dependent regulation of [Ca2+]i in avian cochlear nucleus neurons: roles of protein kinases A and C and relation to cell death. | Zirpel L et al. | β | 1998 | β |
| Alpha subunit of Go localizes in the dendritic tips of ON bipolar cells. | Vardi N | β | 1998 | β |
| Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. | Corti C et al. | β | 1998 | β |
| Deafferentation up-regulates the expression of the mGlu1a metabotropic glutamate receptor protein in the olfactory bulb. | Casabona G et al. | β | 1998 | β |
| Developmental regulation of group III metabotropic glutamate receptors modulating adenylate cyclase activity in the avian retina. | Sampaio LF et al. | β | 1998 | β |
| Differential expression of the metabotropic glutamate receptor mGluR1alpha by neurons and axons in the cochlear nucleus: in situ hybridization and immunohistochemistry. | Bilak SR et al. | β | 1998 | β |
| Differential localization of the mRNAs for the pertussis toxin insensitive G-protein alpha sub-units Gq, G11, and Gz in the rat brain, and regulation of their expression after striatal deafferentation. | Friberg IK et al. | β | 1998 | β |
| Diversity of glutamate receptors in the mammalian retina. | BrandstΓ€tter JH et al. | β | 1998 | β |
| Glutamate receptors in the mammalian central nervous system. | Ozawa S et al. | β | 1998 | β |
| Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. | Wu S et al. | β | 1998 | β |
| Immunocytochemical localization of the mGluR1b metabotropic glutamate receptor in the rat hypothalamus. | Mateos JM et al. | β | 1998 | β |
| Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies. | Phillips T et al. | β | 1998 | β |
| Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia. | Testa CM et al. | β | 1998 | β |
| Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. | Fisher K et al. | β | 1998 | β |
| In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats. | Fundytus ME et al. | β | 1998 | β |
| Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. | Tallaksen-Greene SJ et al. | β | 1998 | β |
| Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro. | Wigmore MA et al. | β | 1998 | β |
| Metabotropic glutamate receptors in the plasticity of excitatory responses in the hippocampus. Clinical impact. | Merlin LR | β | 1998 | β |
| Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: a light and electron microscopic immunohistochemical study in the rat. | Wada E et al. | β | 1998 | β |
| Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. | Michaelis EK | β | 1998 | β |
| Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures. | Schaffhauser H et al. | β | 1998 | β |
| Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. | Francesconi A et al. | β | 1998 | β |
| Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors. | Kubo Y et al. | β | 1998 | β |
| Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines. | Kingston AE et al. | β | 1998 | β |
| Synthesis and biological activity of glutamic acid derivatives. | Receveur JM et al. | β | 1998 | β |
| The group III metabotropic glutamate receptor agonist, l-AP4, reduces EPSPs in some layers of rat visual cortex. | Jin X et al. | β | 1998 | β |
| The metabotropic glutamate receptor 1 is not involved in the facilitation of glutamate release in cerebrocortical nerve terminals. | Sistiaga A et al. | β | 1998 | β |
| Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist. | Abdul-Ghani AS et al. | β | 1997 | β |
| Arginine-481 mutation abolishes ligand-binding of the AMPA-selective glutamate receptor channel alpha1-subunit. | Kawamoto S et al. | β | 1997 | β |
| Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists. | Fundytus ME et al. | β | 1997 | β |
| Block of theta-burst-induced long-term potentiation by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning. | HΓΆlscher C et al. | β | 1997 | β |
| Characterization of metabotropic glutamate receptors in rat C6 glioma cells. | Albasanz JL et al. | β | 1997 | β |
| Characterization of the inward current induced by metabotropic glutamate receptor stimulation in rat ventromedial hypothalamic neurones. | Lee K et al. | β | 1997 | β |
| Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. | Laurie DJ et al. | β | 1997 | β |
| Developmentally regulated gene expression of all eight metabotropic glutamate receptors in hypothalamic suprachiasmatic and arcuate nuclei--a PCR analysis. | Ghosh PK et al. | β | 1997 | β |
| Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. | LujΓ‘n R et al. | β | 1997 | β |
| Evidence for functional metabotropic glutamate receptors in the dorsal cochlear nucleus. | Molitor SC et al. | β | 1997 | β |
| Expression of a novel splice variant of human mGluR1 in the cerebellum. | Makoff AJ et al. | β | 1997 | β |
| Expression of eight metabotropic glutamate receptor subtypes during neuronal differentiation of P19 embryocarcinoma cells: a study by RT-PCR and in situ hybridization. | Heck S et al. | β | 1997 | β |
| Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus. | Kerner JA et al. | β | 1997 | β |
| Glutamatergic deafferentation of olfactory bulb modulates the expression of mGluR1a mRNA. | Ferraris N et al. | β | 1997 | β |
| Group 1 and 2 metabotropic glutamate receptors play differential roles in hippocampal long-term depression and long-term potentiation in freely moving rats. | Manahan-Vaughan D | β | 1997 | β |
| Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro. | O'Leary DM et al. | β | 1997 | β |
| Group I metabotropic glutamate receptors mGluR1alpha and mGluR5a: localization in both synaptic layers of the rat retina. | Koulen P et al. | β | 1997 | β |
| Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb. | Kinzie JM et al. | β | 1997 | β |
| Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. | Iwakabe H et al. | β | 1997 | β |
| Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells. | Toms NJ et al. | β | 1997 | β |
| Localization of mGluR4 protein in the rat cerebral cortex and hippocampus. | Phillips T et al. | β | 1997 | β |
| Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons. | Netzeband JG et al. | β | 1997 | β |
| Metabotropic glutamate receptor agonists evoke calcium waves in isolated MΓΌller cells. | Keirstead SA et al. | β | 1997 | β |
| Metabotropic glutamate receptor mRNA expression in rat spinal cord. | Valerio A et al. | β | 1997 | β |
| Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors. | Dietrich D et al. | β | 1997 | β |
| Metabotropic glutamate receptors regulate N-methyl-D-aspartate-mediated synaptic transmission in nucleus accumbens. | Martin G et al. | β | 1997 | β |
| Modulation of mEPSCs in olfactory bulb mitral cells by metabotropic glutamate receptors. | Schoppa NE et al. | β | 1997 | β |
| Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices. | Schaffhauser H et al. | β | 1997 | β |
| Pharmacology and functions of metabotropic glutamate receptors. | Conn PJ et al. | β | 1997 | β |
| Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes. | Sharon D et al. | β | 1997 | β |
| Selective metabotropic receptor agonists distinguish non-ionotropic glutamate binding sites. | Testa CM et al. | β | 1997 | β |
| Subdivisions of the guinea-pig accessory olfactory bulb revealed by the combined method with immunohistochemistry, electrophysiological, and optical recordings. | Sugai T et al. | β | 1997 | β |
| The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. | Scherer SW et al. | β | 1997 | β |
| The L-AP4 receptor. | Thomsen C | β | 1997 | β |
| The mGluR6 5' upstream transgene sequence directs a cell-specific and developmentally regulated expression in retinal rod and ON-type cone bipolar cells. | Ueda Y et al. | β | 1997 | β |
| The pharmacology of amino-acid responses in septal neurons. | Kumamoto E | β | 1997 | β |
| The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. | Hashimoto T et al. | β | 1997 | β |
| Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. | Kamiya H et al. | β | 1996 | β |
| Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices. | Pizzi M et al. | β | 1996 | β |
| Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. | Kemp MC et al. | β | 1996 | β |
| alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. | Thomas NK et al. | β | 1996 | β |
| A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus. | Yoshino M et al. | β | 1996 | β |
| A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. | BrΓ€uner-Osborne H et al. | β | 1996 | β |
| Bioenergetics and glutamate excitotoxicity. | Greene JG et al. | β | 1996 | β |
| Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate. | Kubokawa K et al. | β | 1996 | β |
| Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. | BrandstΓ€tter JH et al. | β | 1996 | β |
| Decrease in [Ca2+]c but not in cAMP Mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway. | Herrero I et al. | β | 1996 | β |
| Glutamate receptors and development of the visual cortex: effect of metabotropic agonists on cAMP. | Flavin HJ et al. | β | 1996 | β |
| Group II and group III metabotropic glutamate receptors in the rat retina: distributions and developmental expression patterns. | Koulen P et al. | β | 1996 | β |
| Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. | Makoff A et al. | β | 1996 | β |
| Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. | Li JL et al. | β | 1996 | β |
| L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid). | HΓΆlscher C et al. | β | 1996 | β |
| Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells. | Thomsen C | β | 1996 | β |
| Molecular characterization and localization of human metabotropic glutamate receptor type 3. | Makoff A et al. | β | 1996 | β |
| Molecular characterization and localization of human metabotropic glutamate receptor type 4. | Makoff A et al. | β | 1996 | β |
| Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3. | Emile L et al. | β | 1996 | β |
| Multiple actions of 1S,3R-ACPD in modulating endogenous synaptic transmission to spinal respiratory motoneurons. | Dong XW et al. | β | 1996 | β |
| Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. | Bedingfield JS et al. | β | 1996 | β |
| Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. | Lujan R et al. | β | 1996 | β |
| Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. | Bushell TJ et al. | β | 1996 | β |
| Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. | Jane DE et al. | β | 1996 | β |
| Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar cortex: a light and electron microscope study in the rat. | Kinoshita A et al. | β | 1996 | β |
| Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinencephalic areas: a light and electron microscope study in the rat. | Kinoshita A et al. | β | 1996 | β |
| Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. | Sekiyama N et al. | β | 1996 | β |
| The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. | Toms NJ et al. | β | 1996 | β |
| The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. | Petralia RS et al. | β | 1996 | β |
| The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. | Gomeza J et al. | β | 1996 | β |
| Two components of metabotropic glutamate responses in acutely dissociated CA3 pyramidal neurons of the rat. | Harata N et al. | β | 1996 | β |
| [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. | Eriksen L et al. | β | 1995 | β |
| Get receptive to metabotropic glutamate receptors. | Pin JP et al. | β | 1995 | β |
| The metabotropic glutamate receptors: structure and functions. | Pin JP et al. | β | 1995 | β |