Subjective, physiological, and cognitive responses to intravenous nicotine: effects of sex and menstrual cycle phase.
paper
Cited
Public
Unavailable
- Authors
- DeVito, Elise E; Herman, Aryeh I; Waters, Andrew J; Valentine, Gerald W; Sofuoglu, Mehmet
- Year
- 2014
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 24345818
- DOI
- 10.1038/npp.2013.339
- PMCID
- PMC3988546
Nicotine dependence is a serious public health concern. Optimal treatment of nicotine dependence will require greater understanding of the mechanisms that contribute to the maintenance of smoking behaviors. A growing literature indicates sex and menstrual phase differences in responses to nicotine. The aim of this study was to assess sex and menstrual phase influences on a broad range of measures of nicotine response including subjective drug effects, cognition, physiological responses, and symptoms of withdrawal, craving, and affect. Using a well-established intravenous nicotine paradigm and biochemical confirmation of overnight abstinence and menstrual cycle phase, analyses were performed to compare sex (age 18-50 years; 115 male and 45 female) and menstrual cycle phase (29 follicular and 16 luteal) effects. Females had diminished subjective drug effects of, but greater physiological responses to, nicotine administration. Luteal-phase females showed diminished subjective drug effects and better cognition relative to follicular-phase women. These findings offer candidate mechanisms through which the luteal phase, wherein progesterone is dominant relative to estradiol, may be protective against vulnerability to smoking.
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| Title | Year | PMID |
|---|---|---|
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | 2017 | 27067016 |
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