Mechanisms of type-I- and type-II-interferon-mediated signalling.
paper
Cited
Public
Unavailable
- Authors
- Platanias, Leonidas C
- Year
- 2005
- Journal
- Nature reviews. Immunology
- PMID
- 15864272
- DOI
- 10.1038/nri1604
Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects. Because of these important properties, in the past two decades, major research efforts have been undertaken to understand the signalling mechanisms through which these cytokines induce their effects. Since the original discovery of the classical JAK (Janus activated kinase)-STAT (signal transducer and activator of transcription) pathway of signalling, it has become clear that the coordination and cooperation of multiple distinct signalling cascades - including the mitogen-activated protein kinase p38 cascade and the phosphatidylinositol 3-kinase cascade - are required for the generation of responses to interferons. It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance our current thinking about how interferons work.
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| Recombinant attenuated Salmonella vaccine promotes CD8<sup>+</sup> T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7. | Jeong JH et al. | — | 2025 | → |
| Reconfiguring the immune system to target cancer: Therapies based on T cells, cytokines, and vaccines. | Kar S et al. | — | 2025 | → |
| Regorafenib as a potential drug for severe COVID-19: inhibition of inflammasome activation in mice. | Jeong JH et al. | — | 2025 | → |
| Repeated exposures to PM<sub>2.5</sub> alter the mitochondria and the influenza-mediated interferon response in an air-liquid interface bronchial epithelium. | Chivé C et al. | — | 2025 | → |
| Research progress and development potential of oncolytic vaccinia virus. | Zhang X et al. | — | 2025 | → |
| Revolutionary Cancer Therapy for Personalization and Improved Efficacy: Strategies to Overcome Resistance to Immune Checkpoint Inhibitor Therapy. | Almawash S | — | 2025 | → |
| RNA N<sup>6</sup>-Methyladenosine-Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN-γ Signaling in Gastric Cancer. | Jang D et al. | — | 2025 | → |
| Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer. | Yao Q et al. | — | 2025 | → |
| RON Receptor Signaling and the Tumor Microenvironment. | Wachter E et al. | — | 2025 | → |
| Scalable, compressed phenotypic screening using pooled perturbations. | Liu N et al. | — | 2025 | → |
| Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease. | Mayer MG et al. | — | 2025 | → |
| Single cell analysis identified IFN signaling activation contributes to the pathogenesis of pediatric steroid-sensitive nephrotic syndrome. | Li QY et al. | — | 2025 | → |
| Single-cell multi-omics profiling uncovers the immune heterogeneity in HIV-infected immunological non-responders. | Liu X et al. | — | 2025 | → |
| Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics. | Lobato-Moreno S et al. | — | 2025 | → |
| SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity. | Tin E et al. | — | 2025 | → |
| STAT Signature Dish: Serving Immunity with a Side of Dietary Control. | Metwally H | — | 2025 | → |
| Sterile inflammation in laminopathies. | de Faria RC et al. | — | 2025 | → |
| Synergy of oncolytic adenovirus and immune checkpoint inhibitors: transforming cancer immunotherapy paradigms. | Cheng C et al. | — | 2025 | → |
| Targeting the interaction between long noncoding RNA XR_001779380 and Prdm1 to enhance IFN-γ immunity in murine neonatal intestinal epithelial cells. | Jin K et al. | — | 2025 | → |
| Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop. | Willemsen L et al. | — | 2025 | → |
| The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor. | Ren H et al. | — | 2025 | → |
| The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells. | Nakajima-Koyama M et al. | — | 2025 | → |
| The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis. | Gao J et al. | — | 2025 | → |
| The concerted actions of microRNA-29a and interferon-β modulate complete Freund's adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, interferon-stimulated gene 15, and p-extracellular signal-regulated kinase. | Liu CC et al. | — | 2025 | → |
| The Dual Role of Interferon Signaling in Myeloproliferative Neoplasms: Pathogenesis and Targeted Therapeutics. | Bonuomo V et al. | — | 2025 | → |
| The Effects of Fisetin on Gene Expression Profile and Cellular Metabolism in IFN-γ-Stimulated Macrophage Inflammation. | He Z et al. | — | 2025 | → |
| The function and mechanism of protein acylation in the regulation of viral infection. | Song L et al. | — | 2025 | → |
| The IFNγ-CIITA-MHC II axis modulates melanoma cell susceptibility to NK-cell-mediated cytotoxicity. | Krause LCM et al. | — | 2025 | → |
| The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment. | Yang RL et al. | — | 2025 | → |
| The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2. | Suryawanshi RK et al. | — | 2025 | → |
| The Multifactorial Pathogenesis of Endometriosis: A Narrative Review Integrating Hormonal, Immune, and Microbiome Aspects. | Datkhayeva Z et al. | — | 2025 | → |
| Therapeutic effect of baicalein as an antiparasitic agent against <i>Toxoplasma gondii</i> in vitro and in vivo. | Wu S et al. | — | 2025 | → |
| The Role of Posttranslational Modifications During Ebola Virus Infection. | Moreno-Contreras J et al. | — | 2025 | → |
| The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation. | Tolomeo M et al. | — | 2025 | → |
| The Type I Interferon Axis in Systemic Autoimmune Diseases: From Molecular Pathways to Targeted Therapy. | Ishihara R et al. | — | 2025 | → |
| The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade. | Bao Y et al. | — | 2025 | → |
| Three's company: The cooperative signals behind the differentiation of Th9 cells. | Rodriguez JA et al. | — | 2025 | → |
| Tilapia IFP35 is differently induced by three subgroups of type I IFNs via the JAK-STAT signaling. | Li L et al. | — | 2025 | → |
| Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy. | Lim KRQ et al. | — | 2025 | → |
| Transcriptional regulation and signaling of type IV interferon in Carassius gibelio. | Dai C et al. | — | 2025 | → |
| Transcriptomic Differences Between Immortalized Oral and Skin Keratinocytes. | Han C et al. | — | 2025 | → |
| Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics. | Xu X et al. | — | 2025 | → |
| Tumor-intrinsic interferon signaling drives pancreatic cancer resistance to tumor mucin1-targeted CAR T cell therapy. | Zhou R et al. | — | 2025 | → |
| Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8<sup>+</sup> T Cells to Promote an Antitumor Response. | Tu HF et al. | — | 2025 | → |
| Type I interferons in bacterial diseases: myeloid cells at the crossroads of protection and pathology. | Lyadova I | — | 2025 | → |
| Type I interferons in health and disease: molecular aspects and clinical implications. | Mavragani CP et al. | — | 2025 | → |
| Type I interferons regulate nitric oxide production in <i>Brucella abortus</i>-activated microglia contributing to neuronal death. | Rodríguez J et al. | — | 2025 | → |
| Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition. | Perez-Quintero LA et al. | — | 2025 | → |
| Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities. | Mendes-Monteiro L et al. | — | 2025 | → |
| USP18 is a key regulator of immune function in mouse midbrain microglia. | Lu L et al. | — | 2025 | → |
| VAPA suppresses BEFV and VSV-induced type I IFNs signaling response by targeting JAK1 for NEDD4-mediated ubiquitin-proteasome degradation. | Chen T et al. | — | 2025 | → |
| Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis. | Cui Q et al. | — | 2025 | → |
| Xiaoqinglong decoction combined with Yupingfeng powder alleviates combined allergic rhinitis and asthma syndrome by regulating the JAK2-STAT1-MHC II signaling pathway to suppress B lymphocyte activation. | Wang R et al. | — | 2025 | → |
| Zebrafish hif1β attenuates antiviral innate immunity by suppressing Irf7 transcriptional activity. | Yuan L et al. | — | 2025 | → |
| Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense. | Tong Z et al. | — | 2024 | → |
| A detailed insight into macrophages' role in shaping lung carcinogenesis. | Aktar T et al. | — | 2024 | → |
| Advances in Juvenile Dermatomyositis: Pathophysiology, Diagnosis, Treatment and Interstitial Lung Diseases-A Narrative Review. | Kobayashi I | — | 2024 | → |
| Age-related decline in CD8<sup>+</sup> tissue resident memory T cells compromises antitumor immunity. | Pei S et al. | — | 2024 | → |
| A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity. | Asemota S et al. | — | 2024 | → |
| An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification. | Kiran Kumar KD et al. | — | 2024 | → |
| An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity. | Chang-Rabley E et al. | — | 2024 | → |
| A pH-triggered self-releasing humic acid hydrogel loaded with porcine interferon α/γ achieves anti-pseudorabies virus effects by oral administration. | Sun M et al. | — | 2024 | → |
| Autologous T-Cell-Free Antigen Presentation System Unveils hCMV-Specific NK Cell Response. | Ustiuzhanina MO et al. | — | 2024 | → |
| Beneficial Effect of Olive Oil and Its Derivates: Focus on Hematological Neoplasm. | Campo C et al. | — | 2024 | → |
| Beta-cyfluthrin impairs implantation process by inducing mitochondrial defects and changes in reactive oxygen species-mediated signaling pathways in porcine trophectoderm and uterine luminal epithelial cells. | Park J et al. | — | 2024 | → |
| CAR T Cells Engineered to Secrete IFNκ Induce Tumor Ferroptosis via an IFNAR/STAT1/ACSL4 Axis. | Gao Y et al. | — | 2024 | → |
| CD8<sup>+</sup> T Cells Mediate Lethal Lung Pathology in the Absence of PD-L1 and Type I Interferon Signalling following LCMV Infection. | Spiteri AG et al. | — | 2024 | → |
| cGAS-STING, an important signaling pathway in diseases and their therapy. | Li Q et al. | — | 2024 | → |
| cGAS-STING-TBK1 Signaling Promotes Valproic Acid-Responsive Human Cytomegalovirus Immediate-Early Transcription during Infection of Incompletely Differentiated Myeloid Cells. | Albright ER et al. | — | 2024 | → |
| Characterization and expression profiling of buffalo IFN-lambda family. | Gautam D et al. | — | 2024 | → |
| Characterization of fish-specific IFNγ-related binding with a unique receptor complex and signaling through a novel pathway. | Shibasaki Y et al. | — | 2024 | → |
| Chronic Hepatitis C Infection Treated with Direct-Acting Antiviral Agents and Occurrence/Recurrence of Hepatocellular Carcinoma: Does It Still Matter? | Smirne C et al. | — | 2024 | → |
| Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies. | Wang B et al. | — | 2024 | → |
| Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood. | Yang M et al. | — | 2024 | → |
| Crosstalk Between Microbiota, Microbial Metabolites, and Interferons in the Inflammatory Bowel Disease Gut. | Vu VTD et al. | — | 2024 | → |
| Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion. | Mitra A et al. | — | 2024 | → |
| Current Status of Vaccines for Porcine Reproductive and Respiratory Syndrome: Interferon Response, Immunological Overview, and Future Prospects. | Li J et al. | — | 2024 | → |
| DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1. | Miao Y et al. | — | 2024 | → |
| Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity. | Yu S-S et al. | — | 2024 | → |
| Different activation of STAT1 and STAT2 phosphorylation by IFNc, IFNd, and IFNh in tilapia. | Wen Q et al. | — | 2024 | → |
| Discovery of the First-in-Class Inhibitors of Hypoxia Up-Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation. | Papadopoulou D et al. | — | 2024 | → |
| Disease tolerance as immune defense strategy in bats: One size fits all? | Pei G et al. | — | 2024 | → |
| Distinct antiviral activities of IFNφ1 and IFNφ4 in zebrafish. | Chen K et al. | — | 2024 | → |
| Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis. | Kenny G et al. | — | 2024 | → |
| Early transcriptomic changes in peripheral blood 7 days after embryo transfer in dairy cattle. | Strangstalien A et al. | — | 2024 | → |
| Echinacoside inhibits tumor immune evasion by downregulating inducible PD-L1 and reshaping tumor immune landscape in breast and colorectal cancer. | Wang X et al. | — | 2024 | → |
| Effector T Cells Promote Fibrosis in Corneal Transplantation Failure. | Wang S et al. | — | 2024 | → |
| Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets. | Ritter J et al. | — | 2024 | → |
| Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review). | Xu M et al. | — | 2024 | → |
| Enhanced feature matching in single-cell proteomics characterizes IFN-γ response and co-existence of cell states. | Krull KK et al. | — | 2024 | → |
| Enhancement of Macrophage Immunity against Chlamydial Infection by Natural Killer T Cells. | Peng Y et al. | — | 2024 | → |
| Enhancing antitumor immunity in Lewis lung cancer through plasma-treated medium-induced activation of dendritic cells. | Lee CB et al. | — | 2024 | → |
| Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19. | Covill LE et al. | — | 2024 | → |
| Evasion of the Antiviral Innate Immunity by PRV. | Wang C et al. | — | 2024 | → |
| Evidence for a sex-dependent effect modification in the association between IFN-λ DNA polymorphisms and expression of IFN-λ and interferon-stimulated genes in human PBMCs. | Roy DG et al. | — | 2024 | → |
| Exploring emerging JAK inhibitors in the treatment of Aicardi-Goutières syndrome. | Politano D et al. | — | 2024 | → |
| Expression of interferon-stimulated genes, but not polymorphisms in the interferon α/β receptor 2 gene, is associated with coronavirus disease 2019 mortality. | Hamidah B et al. | — | 2024 | → |
| Feasibility of Using a Type I IFN-Based Non-Animal Approach to Predict Vaccine Efficacy and Safety Profiles. | Abdel-Haq H | — | 2024 | → |
| Firing up "cold" tumors: Ferroptosis causes immune activation by improving T cell infiltration. | Li X et al. | — | 2024 | → |
| FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors. | Tu HF et al. | — | 2024 | → |
| FOXP3<sup>+</sup> regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity. | Liu X et al. | — | 2024 | → |
| GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors. | Chang H et al. | — | 2024 | → |
| Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors. | Malhotra J et al. | — | 2024 | → |
| HDAC Inhibitors Induce HLA Class I Molecules through the SOX10-IRF1 Axis in Clear Cell Sarcoma Cells. | Nguyen MT et al. | — | 2024 | → |
| Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms. | Wu Y et al. | — | 2024 | → |
| High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma. | Daneels W et al. | — | 2024 | → |
| How to drug a cloud? Targeting intrinsically disordered proteins. | Uversky VN | — | 2024 | → |
| HSV-2 Manipulates Autophagy through Interferon Pathway: A Strategy for Viral Survival. | Dass D et al. | — | 2024 | → |
| IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling. | Li TH et al. | — | 2024 | → |
| IFNh and IRF9 influence the transcription of MHCII mediated by IFNγ to maintain immune balance in sea perch lateolabrax japonicus. | Lu X et al. | — | 2024 | → |
| IFNα Subtypes in HIV Infection and Immunity. | Karakoese Z et al. | — | 2024 | → |
| <i>In silico</i> assessment of CAR macrophages activity against SARS-CoV-2 infection. | Amoddeo A | — | 2024 | → |
| Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective. | Nguyen TTT et al. | — | 2024 | → |
| Increased Susceptibility of <i>Rousettus aegyptiacus</i> Bats to Respiratory SARS-CoV-2 Challenge Despite Its Distinct Tropism for Gut Epithelia in Bats. | Mohl BP et al. | — | 2024 | → |
| Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis. | Salzmann RJS et al. | — | 2024 | → |
| In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity. | Rooda I et al. | — | 2024 | → |
| Inhibiting the P2Y<sub>12</sub> Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses. | Sowa MA et al. | — | 2024 | → |
| Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion. | Li S et al. | — | 2024 | → |
| Integrative Multi-PTM Proteomics Reveals Dynamic Global, Redox, Phosphorylation, and Acetylation Regulation in Cytokine-Treated Pancreatic Beta Cells. | Gluth A et al. | — | 2024 | → |
| Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity. | Swaraj S et al. | — | 2024 | → |
| Interferon-Induced Transmembrane Protein 1 (IFITM1) Is Downregulated in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors. | Park GH et al. | — | 2024 | → |
| Interferon Inhibition in SLE: From Bench to Bedside. | Deligeorgakis D et al. | — | 2024 | → |
| Interferons and interferon-related pathways in heart disease. | Tran DT et al. | — | 2024 | → |
| Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance. | Otter CJ et al. | — | 2024 | → |
| Interferons in the treatment of myeloproliferative neoplasms. | Vachhani P et al. | — | 2024 | → |
| Interferons in vitreoretinal diseases; a review on their clinical application, and mechanism of action. | Afarid M et al. | — | 2024 | → |
| Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy. | Viengkhou B et al. | — | 2024 | → |
| Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages. | Valdés-López JF et al. | — | 2024 | → |
| Intricate Role of the Cyclic Guanosine Monophosphate Adenosine Monophosphate Synthase-Stimulator of Interferon Genes (cGAS-STING) Pathway in Traumatic Brain Injury-Generated Neuroinflammation and Neuronal Death. | Kumari D et al. | — | 2024 | → |
| IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease. | Joshi R et al. | — | 2024 | → |
| ISG15-LFA1 interactions in latent HIV clearance: mechanistic implications in designing antiviral therapies. | Koka PS et al. | — | 2024 | → |
| ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo. | Lee EJ et al. | — | 2024 | → |
| JAK inhibitors for the treatment of vitiligo. | Inoue S et al. | — | 2024 | → |
| Knockout of IRF3 and IRF7 genes by CRISPR/Cas9 technology enhances porcine virus replication in the swine testicular (ST) cell line. | Sun X et al. | — | 2024 | → |
| Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions. | Liang Y et al. | — | 2024 | → |
| LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-<i>Cryptosporidium</i> defense. | Sharmin Z et al. | — | 2024 | → |
| Loss of the DNA repair protein, polynucleotide kinase/phosphatase, activates the type 1 interferon response independent of ionizing radiation. | Kate WD et al. | — | 2024 | → |
| LPS and type I and II interferons have opposing effects on epigenetic regulation of LAIR1 expression in mouse and human macrophages. | Dorando HK et al. | — | 2024 | → |
| <i>Salmonella</i> Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner. | Shuster M et al. | — | 2024 | → |
| Macrophage fate: to kill or not to kill? | Marrufo AM et al. | — | 2024 | → |
| Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin. | Patel H et al. | — | 2024 | → |
| Mechanisms underlying the compromised clinical efficacy of interferon in clearing HBV. | Lei Z et al. | — | 2024 | → |
| MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation. | Zhang Y et al. | — | 2024 | → |
| Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment. | Moinuddin A et al. | — | 2024 | → |
| Metabolic regulation of type I interferon production. | O'Carroll SM et al. | — | 2024 | → |
| Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1. | Chang T et al. | — | 2024 | → |
| Metformin suppresses gastric cancer progression by disrupting the STAT1-PRMT1 axis. | Wang K et al. | — | 2024 | → |
| Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage. | Arvanitaki ES et al. | — | 2024 | → |
| Microglia signaling in health and disease - Implications in sex-specific brain development and plasticity. | Pramanik S et al. | — | 2024 | → |
| Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches. | Yıldırım B et al. | — | 2024 | → |
| Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14. | Graves D et al. | — | 2024 | → |
| Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities. | Qin Y et al. | — | 2024 | → |
| Morphologic characterization and cytokine response of chicken bone-marrow derived dendritic cells to infection with high and low pathogenic avian influenza virus. | Mo J et al. | — | 2024 | → |
| Mucosal Immunity against SARS-CoV-2 in the Respiratory Tract. | Noh HE et al. | — | 2024 | → |
| Multiple functions of the nonstructural protein 3D in picornavirus infection. | Xu C et al. | — | 2024 | → |
| Non-apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages. | Sun C et al. | — | 2024 | → |
| Novel Insights into Parkin-Mediated Mitochondrial Dysfunction and "Mito-Inflammation" in α-Synuclein Toxicity. The Role of the cGAS-STING Signalling Pathway. | Gąssowska-Dobrowolska M et al. | — | 2024 | → |
| Oncolytic virotherapy against lung cancer: key receptors and signaling pathways of viral entry. | Dong W et al. | — | 2024 | → |
| Optimizing Pancreatic Cancer Therapy: The Promise of Immune Stimulatory Oncolytic Viruses. | Thoidingjam S et al. | — | 2024 | → |
| Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death. | Martin AT et al. | — | 2024 | → |
| Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives. | Bchetnia M et al. | — | 2024 | → |
| Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review. | Serrano García L et al. | — | 2024 | → |
| Physiological functions of ULK1/2. | Pareek G et al. | — | 2024 | → |
| Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management. | Woodfin S et al. | — | 2024 | → |
| Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus. | Fan W et al. | — | 2024 | → |
| Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human. | Prakash P et al. | — | 2024 | → |
| Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia. | Bowen CA et al. | — | 2024 | → |
| Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity. | Bouwman W et al. | — | 2024 | → |
| Recombinant soluble type I interferon receptor exerts antiviral activity by inducing proteins related to autophagy. | Aliaga-Gaspar P et al. | — | 2024 | → |
| Role of IFN-α in Rheumatoid Arthritis. | Lin CMA et al. | — | 2024 | → |
| Role of microglia in stroke. | Planas AM | — | 2024 | → |
| Ruxolitinib Improves Immune-Dysregulation Features but not Epigenetic Abnormality in a Patient with STAT1 GOF. | Koh JY et al. | — | 2024 | → |
| SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling. | Otter CJ et al. | — | 2024 | → |
| Scalable genetic screening for regulatory circuits using compressed Perturb-seq. | Yao D et al. | — | 2024 | → |
| Secretion of functional interferon by the type 3 secretion system of enteropathogenic Escherichia coli. | Rostovsky I et al. | — | 2024 | → |
| Siglec-H<sup>-/-</sup> Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21<sup>+</sup> CD4 T Cells. | Ahodantin J et al. | — | 2024 | → |
| Signaling by Type I Interferons in Immune Cells: Disease Consequences. | Zannikou M et al. | — | 2024 | → |
| Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease. | Ferguson CM et al. | — | 2024 | → |
| Single-Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease. | Shen Y et al. | — | 2024 | → |
| SOXC are critical regulators of adult bone mass. | Angelozzi M et al. | — | 2024 | → |
| SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus. | Chen M et al. | — | 2024 | → |
| STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection. | Gonzalez-Ferrer S et al. | — | 2024 | → |
| Sterile activation of RNA-sensing pathways in autoimmunity. | Li J et al. | — | 2024 | → |
| STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. | Woo MS et al. | — | 2024 | → |
| Structural and Functional Characterization of a Fish Type I Subgroup d IFN Reveals Its Binding to Receptors. | Guan Y et al. | — | 2024 | → |
| Successful treatment of invasive mycobacterium infection with interferon beta in a patient with Interferon-Gamma Receptor 1 deficiency. | Alroqi F et al. | — | 2024 | → |
| Supersulphides suppress type-I and type-II interferon responses by blocking JAK/STAT signalling in macrophages. | Li X et al. | — | 2024 | → |
| Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids. | Boreland AJ et al. | — | 2024 | → |
| TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. | Damhofer H et al. | — | 2024 | → |
| Targeted Transcriptome Analysis of Beef Cattle Persistently Infected with Bovine Viral Diarrhea Virus. | Adkins M et al. | — | 2024 | → |
| Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy. | Li J et al. | — | 2024 | → |
| Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential. | Zhang Y et al. | — | 2024 | → |
| Temporal Dynamics of Purinergic Receptor Expression in the Lungs of Marek's Disease (MD) Virus-Infected Chickens Resistant or Susceptible to MD. | Akbar H et al. | — | 2024 | → |
| The battle between host antiviral innate immunity and immune evasion by cytomegalovirus. | Li S et al. | — | 2024 | → |
| The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination. | Hazra B et al. | — | 2024 | → |
| The Dynamic Relationship between Dengue Virus and the Human Cutaneous Innate Immune Response. | Martí MM et al. | — | 2024 | → |
| The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression. | Ivanov KI et al. | — | 2024 | → |
| The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs. | Johnson GA et al. | — | 2024 | → |
| The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment. | Liu H et al. | — | 2024 | → |
| The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis. | Antony F et al. | — | 2024 | → |
| The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production. | Kang Z et al. | — | 2024 | → |
| The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting. | Roesmann F et al. | — | 2024 | → |
| The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response. | van Huizen M et al. | — | 2024 | → |
| Therapeutic advances of targeting receptor tyrosine kinases in cancer. | Tomuleasa C et al. | — | 2024 | → |
| The role of intestinal flora on tumor immunotherapy: recent progress and treatment implications. | Zhou Y et al. | — | 2024 | → |
| The Role of IRF9 Upregulation in Modulating Sensitivity to Olaparib and Platinum-Based Chemotherapies in Breast Cancer. | Choi S et al. | — | 2024 | → |
| Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both? | Hardtke-Wolenski M et al. | — | 2024 | → |
| Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns. | Dagostino R et al. | — | 2024 | → |
| Toll-like Receptor Homologue CD180 Ligation of B Cells Upregulates Type I IFN Signature in Diffuse Cutaneous Systemic Sclerosis. | Erdő-Bonyár S et al. | — | 2024 | → |
| Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells. | Li Y et al. | — | 2024 | → |
| Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling. | Jacobs MME et al. | — | 2024 | → |
| Transcriptional control of interferon-stimulated genes. | Babadei O et al. | — | 2024 | → |
| Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns. | Cho HM et al. | — | 2024 | → |
| Transcriptome Analysis Reveals Anti-Cancer Effects of Isorhapontigenin (ISO) on Highly Invasive Human T24 Bladder Cancer Cells. | Li AH et al. | — | 2024 | → |
| Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future. | Wei H et al. | — | 2024 | → |
| Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon. | Ghosh C et al. | — | 2024 | → |
| Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes. | Fischer MA et al. | — | 2024 | → |
| Type-II IFN inhibits SARS-CoV-2 replication in human lung epithelial cells and ex vivo human lung tissues through indoleamine 2,3-dioxygenase-mediated pathways. | Yang D et al. | — | 2024 | → |
| Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade. | Holzgruber J et al. | — | 2024 | → |
| Type I interferon signaling regulates myeloid and T cell crosstalk in the glioblastoma tumor microenvironment. | Lim J et al. | — | 2024 | → |
| Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling. | Bodega-Mayor I et al. | — | 2024 | → |
| Unraveling the Complexity of Chikungunya Virus Infection Immunological and Genetic Insights in Acute and Chronic Patients. | Fritsch H et al. | — | 2024 | → |
| Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling. | Rahman M et al. | — | 2024 | → |
| Unraveling the Role of the NLRP3 Inflammasome in Lymphoma: Implications in Pathogenesis and Therapeutic Strategies. | Stergiou IE et al. | — | 2024 | → |
| Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development. | El-Maradny YA et al. | — | 2024 | → |
| Unveiling the therapeutic prospects of IFNW1 and IFNA21: insights into glioma pathogenesis and clinical significance. | Cheng H et al. | — | 2024 | → |
| Up-and-Coming Drugs for the Treatment of Vitiligo. | Seong SH et al. | — | 2024 | → |
| 3C<sup>pro</sup> of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation. | Wu X et al. | — | 2023 | → |
| A co-formulation of interferons alpha2b and gamma distinctively targets cell cycle in the glioblastoma-derived cell line U-87MG. | Miranda J et al. | — | 2023 | → |
| [Advances of Immunotherapy Resistance and Coping Strategies in Non-small Cell Lung Cancer]. | Jing Y et al. | — | 2023 | → |
| African swine fever virus pA104R protein acts as a suppressor of type I interferon signaling. | Chen Q et al. | — | 2023 | → |
| African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation. | Chen Q et al. | — | 2023 | → |
| A new approach to overcoming resistance to immunotherapy: nanotechnology. | Shao J et al. | — | 2023 | → |
| Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response. | Bergeron HC et al. | — | 2023 | → |
| Antiviral response and immunopathogenesis of interleukin 27 in COVID-19. | Valdés-López JF et al. | — | 2023 | → |
| Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response. | Liu J et al. | — | 2023 | → |
| Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications. | Blicharz L et al. | — | 2023 | → |
| Avian Leukosis: Will We Be Able to Get Rid of It? | Fandiño S et al. | — | 2023 | → |
| Based on network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in the treatment of vitiligo and COVID-19. | Wang Y et al. | — | 2023 | → |
| Breaking down the cellular responses to type I interferon neurotoxicity in the brain. | Viengkhou B et al. | — | 2023 | → |
| Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2. | Sun H et al. | — | 2023 | → |
| Chemical Biology Perspectives on STING Agonists as Tumor Immunotherapy. | Xuan C et al. | — | 2023 | → |
| Chimeric Antigen Receptor-T Cell and Oncolytic Viral Therapies for Gastric Cancer and Peritoneal Carcinomatosis of Gastric Origin: Path to Improving Combination Strategies. | Chen C et al. | — | 2023 | → |
| Chromosomal instability and inflammation: a catch-22 for cancer cells. | van den Brink A et al. | — | 2023 | → |
| CMPK2 restricts Zika virus replication by inhibiting viral translation. | Pawlak JB et al. | — | 2023 | → |
| Co-infection of mice with SARS-CoV-2 and <i>Mycobacterium tuberculosis</i> limits early viral replication but does not affect mycobacterial loads. | Baker PJ et al. | — | 2023 | → |
| Combining network pharmacology, molecular docking, molecular dynamics simulation, and experimental verification to examine the efficacy and immunoregulation mechanism of FHB granules on vitiligo. | Li X et al. | — | 2023 | → |
| Comprehensive overview of 2022 human monkeypox outbreak and its pathology, prevention, and treatment: A strategy for disease control. | Yashavarddhan MH et al. | — | 2023 | → |
| Corticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19. | Jeong HW et al. | — | 2023 | → |
| COVID-19: A novel holistic systems biology approach to predict its molecular mechanisms (in vitro) and repurpose drugs. | Sameni M et al. | — | 2023 | → |
| Diagnostic Predictors of Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. | Meliante PG et al. | — | 2023 | → |
| Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions. | Harney DJ et al. | — | 2023 | → |
| Differential expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Alzheimer's disease and HIV-1 associated neurocognitive disorders. | Garces A et al. | — | 2023 | → |
| Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models. | Blomberg E et al. | — | 2023 | → |
| DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation. | Kasumba DM et al. | — | 2023 | → |
| Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy. | Han J et al. | — | 2023 | → |
| Effects of Dietary <i>Limosilactobacillus fermentum</i> and <i>Lacticaseibacillus paracasei</i> Supplementation on the Intestinal Stem Cell Proliferation, Immunity, and Ileal Microbiota of Broiler Chickens Challenged by Coccidia and <i>Clostridium perfringens</i>. | Guo S et al. | — | 2023 | → |
| Efficiency of Interferon-γ in Activating Dendritic Cells and Its Potential Synergy with Toll-like Receptor Agonists. | Bian Y et al. | — | 2023 | → |
| EMT and Inflammation: Crossroads in HCC. | Sengez B et al. | — | 2023 | → |
| Epigenomic landscape exhibits interferon signaling suppression in the patient of myocarditis after BNT162b2 vaccination. | Kim H et al. | — | 2023 | → |
| Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity. | Malik A et al. | — | 2023 | → |
| Evaluating ropeginterferon alfa-2b for the treatment of adults with polycythemia vera. | Krecak I et al. | — | 2023 | → |
| Evidence for increased interferon type I activity in CD8+ T cells in giant cell arteritis patients. | van Nieuwland M et al. | — | 2023 | → |
| Exercise-induced modulation of Interferon-signature: a therapeutic route toward management of Systemic Lupus Erythematosus. | Spinelli FR et al. | — | 2023 | → |
| Exploring the shared molecular mechanisms between systemic lupus erythematosus and primary Sjögren's syndrome based on integrated bioinformatics and single-cell RNA-seq analysis. | Cui Y et al. | — | 2023 | → |
| Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response. | Russ E et al. | — | 2023 | → |
| FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer. | Canel M et al. | — | 2023 | → |
| From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery-An Australian Example. | Kumar P et al. | — | 2023 | → |
| Functional Landscape of African Swine Fever Virus-Host and Virus-Virus Protein Interactions. | Dolata KM et al. | — | 2023 | → |
| Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes. | Wang H et al. | — | 2023 | → |
| Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma. | Fang Y et al. | — | 2023 | → |
| Hyperlipidaemia elicits an atypical, T helper 1-like CD4<sup>+</sup> T-cell response: a key role for very low-density lipoprotein. | van Os BW et al. | — | 2023 | → |
| Identification, expression pattern and functional characterization of IFN-γ involved in activating JAK-STAT pathway in Sebastes schlegeli. | Zhang M et al. | — | 2023 | → |
| Identification of a targetable JAK-STAT enriched androgen receptor and androgen receptor splice variant positive triple-negative breast cancer subtype. | Asemota S et al. | — | 2023 | → |
| IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity. | Gómez-Herranz M et al. | — | 2023 | → |
| IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. | Hsieh YT et al. | — | 2023 | → |
| IFNT stimulates lysosomal function via type I IFN signaling pathway in pregnant bovine leukocytes. | Talukder MAS et al. | — | 2023 | → |
| IFN-γ: An overlooked cytokine in dermatomyositis with anti-MDA5 antibodies. | Thuner J et al. | — | 2023 | → |
| IL-6/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization. | Yang L et al. | — | 2023 | → |
| Immune Checkpoint Inhibitor Rechallenge in Renal Cell Carcinoma: Current Evidence and Future Directions. | Sammarco E et al. | — | 2023 | → |
| Immune checkpoint inhibitors in breast cancer: development, mechanisms of resistance and potential management strategies. | Wong RS et al. | — | 2023 | → |
| Immune Functions of Astrocytes in Viral Neuroinfections. | Jorgačevski J et al. | — | 2023 | → |
| Immune responses elicited by ssRNA(-) oncolytic viruses in the host and in the tumor microenvironment. | Bykov Y et al. | — | 2023 | → |
| Immunogenic cell death in cancer immunotherapy. | Choi M et al. | — | 2023 | → |
| Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics. | Lee Y et al. | — | 2023 | → |
| Immunomodulatory Role of Interferons in Viral and Bacterial Infections. | Mertowska P et al. | — | 2023 | → |
| Inflammatory Control of Viral Infection. | Chakravarty S et al. | — | 2023 | → |
| Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING. | Pinjusic K et al. | — | 2023 | → |
| Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma. | Angeles AK et al. | — | 2023 | → |
| Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin. | Liang WW et al. | — | 2023 | → |
| Interference of B lymphocyte tolerance by prolactin in rheumatic autoimmune diseases. | Mousavi MJ et al. | — | 2023 | → |
| Interferon antagonists encoded by SARS-CoV-2 at a glance. | Lee JH et al. | — | 2023 | → |
| Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity. | Unali G et al. | — | 2023 | → |
| Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons. | Danastas K et al. | — | 2023 | → |
| Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle. | Carvajal Ibañez D et al. | — | 2023 | → |
| Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells. | Alfarano G et al. | — | 2023 | → |
| Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection. | Duncan JKS et al. | — | 2023 | → |
| Interferons and Resistance Mechanisms in Tumors and Pathogen-Driven Diseases-Focus on the Major Histocompatibility Complex (MHC) Antigen Processing Pathway. | Massa C et al. | — | 2023 | → |
| Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections. | Wang C et al. | — | 2023 | → |
| Interferons-Implications in the Immune Response to Respiratory Viruses. | Bergeron HC et al. | — | 2023 | → |
| Interferon-β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke. | Kuo PC et al. | — | 2023 | → |
| Interleukin-22 facilitates the interferon-λ-mediated production of tripartite motif protein 25 to inhibit replication of duck viral hepatitis A virus type 1. | An H et al. | — | 2023 | → |
| Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury. | Asano S et al. | — | 2023 | → |
| JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction. | Khatri A et al. | — | 2023 | → |
| Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care. | Papadopoulou C et al. | — | 2023 | → |
| Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction. | Nguyen HC et al. | — | 2023 | → |
| Machine learning reveals STAT motifs as predictors for GR-mediated gene repression. | Höllbacher B et al. | — | 2023 | → |
| Management of the refractory vitiligo patient: current therapeutic strategies and future options. | Wang X et al. | — | 2023 | → |
| Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis? | Yang Y et al. | — | 2023 | → |
| Mechanisms and clinical implications in renal carcinoma resistance: narrative review of immune checkpoint inhibitors. | Samnani S et al. | — | 2023 | → |
| METTL3 suppresses pancreatic ductal adenocarcinoma progression through activating endogenous dsRNA-induced anti-tumor immunity. | Zhu L et al. | — | 2023 | → |
| MICa/b-dependent activation of natural killer cells by CD64<sup>+</sup> inflammatory type 2 dendritic cells contributes to autoimmunity. | Sánchez-Cerrillo I et al. | — | 2023 | → |
| Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation. | Biswas K | — | 2023 | → |
| MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state. | Cui J et al. | — | 2023 | → |
| Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish. | Leiba J et al. | — | 2023 | → |
| Molecular and cellular factors determining the functional pleiotropy of cytokines. | McFarlane A et al. | — | 2023 | → |
| Molecular mechanisms of immunotherapy resistance in triple-negative breast cancer. | Zheng Y et al. | — | 2023 | → |
| Mouse B2 SINE elements function as IFN-inducible enhancers. | Horton I et al. | — | 2023 | → |
| Multi-target regulatory mechanism of Yang Xin Tang - a traditional Chinese medicine against dementia. | Lo TY et al. | — | 2023 | → |
| Nile tilapia TBK1 interacts with STING and TRAF3 and is involved in the IFN-β pathway in the immune response. | Zheng Q et al. | — | 2023 | → |
| N-MYC-interacting protein enhances type II interferon signaling by inhibiting STAT1 sumoylation. | Feng L et al. | — | 2023 | → |
| Non-selective dampening of the host immune response after hepatitis C clearance and its association with circulating chemokine and endotoxin levels. | Quinn G et al. | — | 2023 | → |
| Novel Mechanisms and Future Opportunities for the Management of Radiation Necrosis in Patients Treated for Brain Metastases in the Era of Immunotherapy. | Vaios EJ et al. | — | 2023 | → |
| Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms. | Wang B et al. | — | 2023 | → |
| Pan-cancer analysis reveals signal transducer and activator of transcription (STAT) gene family as biomarkers for prognostic prediction and therapeutic guidance. | Cheng M et al. | — | 2023 | → |
| Participation of Single-Nucleotide Variants in <i>IFNAR1</i> and <i>IFNAR2</i> in the Immune Response against SARS-CoV-2 Infection: A Systematic Review. | López-Bielma MF et al. | — | 2023 | → |
| PAUSE: principled feature attribution for unsupervised gene expression analysis. | Janizek JD et al. | — | 2023 | → |
| PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells. | Larsen TV et al. | — | 2023 | → |
| PD-L1: expression regulation. | Zhou YJ et al. | — | 2023 | → |
| PEOPLE (NTC03447678), a phase II trial to test pembrolizumab as first-line treatment in patients with advanced NSCLC with PD-L1 <50%: a multiomics analysis. | Lo Russo G et al. | — | 2023 | → |
| Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo. | Nilsen KE et al. | — | 2023 | → |
| Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy. | Wong B et al. | — | 2023 | → |
| Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance. | Hossain SM et al. | — | 2023 | → |
| Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors. | Toney NJ et al. | — | 2023 | → |
| Potential roles of IFI44 genes in high resistance to Vibrio in hybrids of Argopecten scallops. | Qu X et al. | — | 2023 | → |
| Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8<sup>+</sup> T cells in HIV infection. | Cabral-Piccin MP et al. | — | 2023 | → |
| Protective versus Pathogenic Type I Interferon Responses during Virus Infections. | Jung KI et al. | — | 2023 | → |
| Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice. | Huang H et al. | — | 2023 | → |
| Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus. | Storozynsky QT et al. | — | 2023 | → |
| Rapid recruitment and IFN-I-mediated activation of monocytes dictate focal radiotherapy efficacy. | Tadepalli S et al. | — | 2023 | → |
| Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1. | Nchioua R et al. | — | 2023 | → |
| Remodeled tumor immune microenvironment (TIME) parade via natural killer cells reprogramming in breast cancer. | Elanany MM et al. | — | 2023 | → |
| RETRACTED: Network Pharmacology and Molecular Modeling to Elucidate the Potential Mechanism of Neem Oil against <i>Acne vulgaris</i>. | Kola-Mustapha AT et al. | — | 2023 | → |
| Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses. | Zhu X et al. | — | 2023 | → |
| Role of Innate Interferon Responses at the Ocular Surface in Herpes Simplex Virus-1-Induced Herpetic Stromal Keratitis. | Ren J et al. | — | 2023 | → |
| Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection. | Mihaescu G et al. | — | 2023 | → |
| Role of Serum Inflammatory Cytokines in Sepsis Rats Following BMSCs Transplantation: Protein Microarray Analysis. | Xiu G et al. | — | 2023 | → |
| Salmonella Typhimurium induces genome-wide expression and phosphorylation changes that modulate immune response, intracellular survival and vesicle transport in infected neutrophils. | Zaldívar-López S et al. | — | 2023 | → |
| SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB. | Lacasse É et al. | — | 2023 | → |
| SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction. | Khatun O et al. | — | 2023 | → |
| Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity. | Chen HA et al. | — | 2023 | → |
| SERPINB1 promotes Senecavirus A replication by degrading IKBKE and regulating the IFN pathway via autophagy. | Yan J et al. | — | 2023 | → |
| Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine. | Cheung F et al. | — | 2023 | → |
| Shedding Lights on the Extracellular Vesicles as Functional Mediator and Therapeutic Decoy for COVID-19. | Thakur A | — | 2023 | → |
| Signaling pathways in macrophages: molecular mechanisms and therapeutic targets. | Li M et al. | — | 2023 | → |
| Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection. | Wu Z et al. | — | 2023 | → |
| Single cell transcriptome analyses reveal the roles of B cells in fructose-induced hypertension. | Kim CW et al. | — | 2023 | → |
| Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years. | Read JF et al. | — | 2023 | → |
| STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. | Zanin N et al. | — | 2023 | → |
| STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD<sup>+</sup>-biosynthetic and consuming enzymes. | Murata H et al. | — | 2023 | → |
| Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma. | Horowitch B et al. | — | 2023 | → |
| Synergistic Effects of Azithromycin and STING Agonist Promote IFN-I Production by Enhancing the Activation of STING-TBK1 Signaling. | Petcharat K et al. | — | 2023 | → |
| Targeted mutations in IFNα2 improve its antiviral activity against various viruses. | Karakoese Z et al. | — | 2023 | → |
| Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca<sup>2+</sup> signalling. | Sun Y et al. | — | 2023 | → |
| Targeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells. | Saleiro D et al. | — | 2023 | → |
| The crucial regulatory role of type I interferon in inflammatory diseases. | Ji L et al. | — | 2023 | → |
| The host transcriptome change involved in the inhibitory effect of exogenous interferon-γ on Getah virus replication. | Li J et al. | — | 2023 | → |
| The induction and suppression of type I and type III interferons by human group H rotavirus. | Liu XY et al. | — | 2023 | → |
| The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling. | Latha K et al. | — | 2023 | → |
| The Interplay between T Cells and Cancer: The Basis of Immunotherapy. | Chen C et al. | — | 2023 | → |
| The Intersection of COVID-19 and Rheumatoid Arthritis: Shared Mechanisms, Treatment Challenges, and Potential Therapeutic Approaches. | Xiao J et al. | — | 2023 | → |
| The Role of Interferon Receptors α/β/γ Ablation During Western Diet-Induced Obesity and Insulin Resistance in the Inflectional Model AG129 Mice Strain. | Costa-Bartuli E et al. | — | 2023 | → |
| The Role of Interferons in Long Covid Infection. | Karbalaeimahdi M et al. | — | 2023 | → |
| The role of mitochondria in the resistance of melanoma to PD-1 inhibitors. | Du F et al. | — | 2023 | → |
| The Role of Myositis-Specific and Myositis-Associated Autoantibodies and the Activation of Type I Interferon Pathway in the Generation of Clinical Phenotypes of Inflammatory Myopathies. | Skarlis C et al. | — | 2023 | → |
| The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes. | Russell MA et al. | — | 2023 | → |
| Tocilizumab for the fifth progression of cystic childhood craniopharyngioma-a case report. | de Vos-Kerkhof E et al. | — | 2023 | → |
| Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics. | Subedi P et al. | — | 2023 | → |
| Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors. | Xu Q et al. | — | 2023 | → |
| Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection. | Bragazzi Cunha J et al. | — | 2023 | → |
| UNC93B1 facilitates TLR18-mediated NF-κB signal activation in Schizothorax prenanti. | Yang S et al. | — | 2023 | → |
| Understanding immune checkpoints and PD-1/PD-L1-mediated immune resistance towards tumour immunotherapy. | Singh S et al. | — | 2023 | → |
| Understanding the regulation of "Don't Eat-Me" signals by inflammatory signaling pathways in the tumor microenvironment for more effective therapy. | Karizak AZ et al. | — | 2023 | → |
| Viral miRNA regulation of host gene expression. | Diggins NL et al. | — | 2023 | → |
| Viral recognition and the antiviral interferon response. | Dalskov L et al. | — | 2023 | → |
| Whole blood transcriptome identifies interferon-regulated genes as key drivers in thrombotic primary antiphospholipid syndrome. | Verrou KM et al. | — | 2023 | → |
| Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. | Xiong ST et al. | — | 2023 | → |
| γ-Secretase fanning the fire of innate immunity. | Liu C et al. | — | 2023 | → |
| A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer. | Chou PH et al. | — | 2022 | → |
| A child with bronchiectasis, chronic mucocutaneous candidiasis, and hypothyroidism secondary to STAT1 gain-of-function mutation: A case report and review of the literature. | Alidrisi D et al. | — | 2022 | → |
| Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer. | Demel UM et al. | — | 2022 | → |
| Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses. | Wang H et al. | — | 2022 | → |
| African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation. | Li L et al. | — | 2022 | → |
| African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation. | Riera E et al. | — | 2022 | → |
| Altered increase in STAT1 expression and phosphorylation in severe COVID-19. | Rincon-Arevalo H et al. | — | 2022 | → |
| A novel defined m7G regulator signature to investigate the association between molecular characterization and clinical significance in lung adenocarcinoma. | Dong Y et al. | — | 2022 | → |
| Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment. | Souri M et al. | — | 2022 | → |
| Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques. | Trease AJ et al. | — | 2022 | → |
| Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses. | Oh SJ et al. | — | 2022 | → |
| Antiviral response within different cell types of the CNS. | Telikani Z et al. | — | 2022 | → |
| A randomized, double-blind, placebo-controlled phase I trial of inhalation treatment of recombinant TFF2-IFN protein: A multifunctional candidate for the treatment of COVID-19. | Liu Y et al. | — | 2022 | → |
| Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases. | Dubey AR et al. | — | 2022 | → |
| Biting the hand that feeds: Metabolic determinants of cell fate during infection. | Fraschilla I et al. | — | 2022 | → |
| Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling. | Gajjela BK et al. | — | 2022 | → |
| Cancer Resistance to Immunotherapy: Molecular Mechanisms and Tackling Strategies. | Vu SH et al. | — | 2022 | → |
| Challenges of the Immunotherapy: Perspectives and Limitations of the Immune Checkpoint Inhibitor Treatment. | Dobosz P et al. | — | 2022 | → |
| Characterization of Immunoactive and Immunotolerant CD4+ T Cells in Breast Cancer by Measuring Activity of Signaling Pathways That Determine Immune Cell Function. | Wesseling-Rozendaal Y et al. | — | 2022 | → |
| Chemerin Affects P<sub>4</sub> and E<sub>2</sub> Synthesis in the Porcine Endometrium during Early Pregnancy. | Gudelska M et al. | — | 2022 | → |
| Chrysin inhibits hepatocellular carcinoma progression through suppressing programmed death ligand 1 expression. | Rong W et al. | — | 2022 | → |
| CILP, a Putative Gene Associated With Immune Infiltration in Breast Cancer Brain Metastases. | Sun X et al. | — | 2022 | → |
| Clinical Management of Herpes Simplex Virus Keratitis. | Labib BA et al. | — | 2022 | → |
| Cloning and codon optimization of a novel feline interferon omega gene for production by <i>Pichia pastoris</i> and its antiviral efficacy in polyethylene glycol-modified form. | Wang Y et al. | — | 2022 | → |
| CMTM6 as a master regulator of PD-L1. | Yaseen MM et al. | — | 2022 | → |
| Combined treatment with anti-PSMA CAR NK-92 cell and anti-PD-L1 monoclonal antibody enhances the antitumour efficacy against castration-resistant prostate cancer. | Wang F et al. | — | 2022 | → |
| Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in an <i>in vitro</i> interstitial cystitis/bladder pain syndrome model. | Kuret T et al. | — | 2022 | → |
| Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity. | Pujantell M et al. | — | 2022 | → |
| COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity. | David S et al. | — | 2022 | → |
| Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury. | Córdoba-David G et al. | — | 2022 | → |
| Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases-RA as a role model. | Takeuchi T | — | 2022 | → |
| Cytokines and microRNAs in SARS-CoV-2: What do we know? | Rarani FZ et al. | — | 2022 | → |
| Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium. | Guo-Parke H et al. | — | 2022 | → |
| Deciphering signal transduction networks in the liver by mechanistic mathematical modelling. | D'Alessandro LA et al. | — | 2022 | → |
| Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer. | Das A et al. | — | 2022 | → |
| Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. | Chen Q et al. | — | 2022 | → |
| Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy. | Wong B et al. | — | 2022 | → |
| Detrimental Effects of IFN-γ on an Epidermolysis Bullosa Simplex Cell Model and Protection by a Humanized Anti-IFN-γ Monoclonal Antibody. | Badowski C et al. | — | 2022 | → |
| Development and Evaluation of a Bicistronic DNA Vaccine against Nervous Necrosis Virus in Pearl Gentian Grouper (<i>Epinephelus lanceolatus</i> × <i>Epinephelus fuscoguttatus</i>). | Lin T et al. | — | 2022 | → |
| Dietary supplementation of exopolysaccharides from <i>Lactobacillus rhamnosus</i> GCC-3 improved the resistance of zebrafish against spring viremia of carp virus infection. | Xie M et al. | — | 2022 | → |
| Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome. | David Q et al. | — | 2022 | → |
| Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. | Schuhenn J et al. | — | 2022 | → |
| Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. | Shemesh A et al. | — | 2022 | → |
| Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms. | Saleiro D et al. | — | 2022 | → |
| Distinct Molecular Signatures of Aging in Healthy and HIV-Infected Individuals. | Rinaldi S et al. | — | 2022 | → |
| Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals. | Karakoese Z et al. | — | 2022 | → |
| DnaJ-induced TLR7 mediates an increase in interferons through the TLR4-engaged AKT/NF-κB and JNK signaling pathways in macrophages. | Yu H et al. | — | 2022 | → |
| Drug Resistance in Colorectal Cancer: From Mechanism to Clinic. | Wang Q et al. | — | 2022 | → |
| Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis. | Iwasaki T et al. | — | 2022 | → |
| Effectiveness and safety of tofacitinib combined with narrowband ultraviolet B phototherapy for patients with refractory vitiligo in real-world clinical practice. | Song H et al. | — | 2022 | → |
| Effect of the m6ARNA gene on the prognosis of thyroid cancer, immune infiltration, and promising immunotherapy. | Xia M et al. | — | 2022 | → |
| Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer. | Gómez-Herranz M et al. | — | 2022 | → |
| Emerging role of natural products in cancer immunotherapy. | Dong S et al. | — | 2022 | → |
| Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis. | Hu X et al. | — | 2022 | → |
| Emerging roles of innate and adaptive immunity in Alzheimer's disease. | Chen X et al. | — | 2022 | → |
| Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID. | Tan PH et al. | — | 2022 | → |
| Endogenous Retrovirus Elements Are Co-Expressed with IFN Stimulation Genes in the JAK-STAT Pathway. | Wang Y et al. | — | 2022 | → |
| Epigallocatechin-3-gallate exhibits anti-inflammatory effects in a human interface dermatitis model-implications for therapy. | Braegelmann C et al. | — | 2022 | → |
| Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. | Luo S et al. | — | 2022 | → |
| Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin. | Mattoo SU et al. | — | 2022 | → |
| Extracellular vesicle PD-L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies. | Liu J et al. | — | 2022 | → |
| Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines. | Lu J et al. | — | 2022 | → |
| Functional analysis and regulation mechanism of interferon gamma in macrophages of large yellow croaker (Larimichthys crocea). | Xu D et al. | — | 2022 | → |
| Functional inference of gene regulation using single-cell multi-omics. | Kartha VK et al. | — | 2022 | → |
| Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of <i>PTPRM</i> Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling. | Rioux G et al. | — | 2022 | → |
| Generation, secretion and degradation of cancer immunotherapy target PD-L1. | Shen DD et al. | — | 2022 | → |
| Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. | Wang Y et al. | — | 2022 | → |
| Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden. | Georgoulias G et al. | — | 2022 | → |
| High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry. | Yiu G et al. | — | 2022 | → |
| Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. | Guo P et al. | — | 2022 | → |
| HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages. | Martins LJ et al. | — | 2022 | → |
| How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids. | Strickland BA et al. | — | 2022 | → |
| Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation. | Zhang L et al. | — | 2022 | → |
| <i>Anaplasma phagocytophilum</i> Transmission Activates Immune Pathways While Repressing Wound Healing in the Skin. | Underwood J et al. | — | 2022 | → |
| Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape. | Chen G et al. | — | 2022 | → |
| Identification of an immune-related gene prognostic index for predicting survival and immunotherapy efficacy in papillary renal cell carcinoma. | Chen D et al. | — | 2022 | → |
| Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach. | Singh A et al. | — | 2022 | → |
| IFI44 is an immune evasion biomarker for SARS-CoV-2 and <i>Staphylococcus aureus</i> infection in patients with RA. | Zheng Q et al. | — | 2022 | → |
| IFN-γ Induces PD-L1 Expression in Primed Human Basophils. | Bonam SR et al. | — | 2022 | → |
| IFN-γ, should not be ignored in SLE. | Liu W et al. | — | 2022 | → |
| Immunoregulation by type I interferons in the peritoneal cavity. | Chuah JJM et al. | — | 2022 | → |
| Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathway activity. | Bouwman W et al. | — | 2022 | → |
| Increased IRF9-STAT2 Signaling Leads to Adaptive Resistance toward Targeted Therapy in Melanoma by Restraining GSDME-Dependent Pyroptosis. | Wang D et al. | — | 2022 | → |
| Inducible miR-150 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Genome and Suppressor of Cytokine Signaling 1. | Li S et al. | — | 2022 | → |
| Inflammation Regulates Haematopoietic Stem Cells and Their Niche. | Ho NP et al. | — | 2022 | → |
| Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. | Hossain SM et al. | — | 2022 | → |
| Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection. | Salzmann M et al. | — | 2022 | → |
| Insights into functional connectivity in mammalian signal transduction pathways by pairwise comparison of protein interaction partners of critical signaling hubs. | Ramana CV | — | 2022 | → |
| Insights into the modulation of the interferon response and NAD<sup>+</sup> in the context of COVID-19. | Habeichi NJ et al. | — | 2022 | → |
| Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway. | Naik NG et al. | — | 2022 | → |
| Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA). | Verweyen EL et al. | — | 2022 | → |
| Interferon Alpha, but Not Interferon Beta, Acts Early To Control Chronic Chikungunya Virus Pathogenesis. | Locke MC et al. | — | 2022 | → |
| Interferon Beta-1a versus Combined Interferon Beta-1a and Oligodendrocyte-Specific FGFR1 Deletion in Experimental Autoimmune Encephalomyelitis. | Rajendran R et al. | — | 2022 | → |
| Interferon beta attenuates recognition memory impairment and improves brain glucose uptake in a rat model of Alzheimer's disease: Involvement of mitochondrial biogenesis and PI3K pathway. | Azarafrouz F et al. | — | 2022 | → |
| Interferon-beta inhibits human glioma stem cell growth by modulating immune response and cell cycle related signaling pathways. | Han XX et al. | — | 2022 | → |
| Interferon Signaling in Estrogen Receptor-positive Breast Cancer: A Revitalized Topic. | Fu X et al. | — | 2022 | → |
| Interferon Signaling in the Endometrium and in Endometriosis. | Park Y et al. | — | 2022 | → |
| Interferon-α promotes MHC I antigen presentation of islet β cells through STAT1-IRF7 pathway in type 1 diabetes. | Jiang H et al. | — | 2022 | → |
| Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence. | Cambuli F et al. | — | 2022 | → |
| Intranasal Delivery of RIG-I Agonist Drives Pulmonary Myeloid Cell Activation in Mice. | Nair S et al. | — | 2022 | → |
| Involvement of Type I Interferon Signaling in Muscle Stem Cell Proliferation During Dermatomyositis. | Gallay L et al. | — | 2022 | → |
| ISG15 deficiency restricts HIV-1 infection. | Jurczyszak D et al. | — | 2022 | → |
| JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction. | Vogel A et al. | — | 2022 | → |
| Knockdown of IFNAR2 reduces the inflammatory response in mouse model of type 1 diabetes. | Sun W et al. | — | 2022 | → |
| LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells. | Li L et al. | — | 2022 | → |
| LATS1 is a central signal transmitter for achieving full type-I interferon activity. | Zuo Y et al. | — | 2022 | → |
| Lessons in self-defence: inhibition of virus entry by intrinsic immunity. | Majdoul S et al. | — | 2022 | → |
| Mechanisms of TNF-independent RIPK3-mediated cell death. | Tummers B et al. | — | 2022 | → |
| Mechanisms of vascular inflammation in deficiency of adenosine deaminase 2 (DADA2). | Lee PY et al. | — | 2022 | → |
| Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs-MDSCs in newborns. | Perego M et al. | — | 2022 | → |
| Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors. | Tian X et al. | — | 2022 | → |
| Melanoma: An immunotherapy journey from bench to bedside. | Navani V et al. | — | 2022 | → |
| MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS. | Xu S et al. | — | 2022 | → |
| Mitochondrial RNA, a new trigger of the innate immune system. | Grochowska J et al. | — | 2022 | → |
| Modeling Innate Antiviral Immunity in Physiological Context. | Goldstein ME et al. | — | 2022 | → |
| Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review. | He WR et al. | — | 2022 | → |
| mRNA delivery technologies: Toward clinical translation. | Gómez-Aguado I et al. | — | 2022 | → |
| Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation. | Iorio R et al. | — | 2022 | → |
| New Insights into the Crosstalk among the Interferon and Inflammatory Signaling Pathways in Response to Viral Infections: Defense or Homeostasis. | Dai J et al. | — | 2022 | → |
| Novel Dimeric Architecture of an IFN-γ-Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish. | Zhu X et al. | — | 2022 | → |
| Oncolytic virus treatment differentially affects the CD56<sup>dim</sup> and CD56<sup>bright</sup> NK cell subsets in vivo and regulates a spectrum of human NK cell activity. | Wantoch M et al. | — | 2022 | → |
| Participation of interferons in psoriatic inflammation. | Gu H et al. | — | 2022 | → |
| Pathogenesis and Manifestations of Zika Virus-Associated Ocular Diseases. | Labib BA et al. | — | 2022 | → |
| Pathogenic role of cytokines in COVID-19, its association with contributing co-morbidities and possible therapeutic regimens. | Tanveer A et al. | — | 2022 | → |
| Pharmacological Treatments Available for Immune-Checkpoint-Inhibitor-Induced Colitis. | Ohwada S et al. | — | 2022 | → |
| Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR. | Wang Z et al. | — | 2022 | → |
| Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation. | Kalliara E et al. | — | 2022 | → |
| Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation. | Yu Y et al. | — | 2022 | → |
| Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways. | Deng Y et al. | — | 2022 | → |
| Potential therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition. | Henderson Berg MH et al. | — | 2022 | → |
| Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy. | Sutcliffe M et al. | — | 2022 | → |
| Preliminary Analysis of Cervical Cancer Immunotherapy. | Ma Z et al. | — | 2022 | → |
| Programmed Cell Death-Ligand 1 in Head and Neck Squamous Cell Carcinoma: Molecular Insights, Preclinical and Clinical Data, and Therapies. | Meliante PG et al. | — | 2022 | → |
| Proteomics and Phospho-Proteomics Profiling of the Co-Formulation of Type I and II Interferons, HeberFERON, in the Glioblastoma-Derived Cell Line U-87 MG. | Vázquez-Blomquist D et al. | — | 2022 | → |
| pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells. | Mohnke J et al. | — | 2022 | → |
| Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives. | Hasselbalch H et al. | — | 2022 | → |
| Refractory alopecia universalis associated with dermatomyositis successfully treated with tofacitinib. | Castillo R et al. | — | 2022 | → |
| Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1. | Perez RE et al. | — | 2022 | → |
| Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation. | Mathé J et al. | — | 2022 | → |
| Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium. | Sáenz JB et al. | — | 2022 | → |
| Regulatory T-Cell Enhancement, Expression of Adhesion Molecules, and Production of Anti-Inflammatory Factors Are Differentially Modulated by Spheroid-Cultured Mesenchymal Stem Cells. | Silva-Carvalho AÉ et al. | — | 2022 | → |
| RelB upregulates PD-L1 and exacerbates prostate cancer immune evasion. | Zhang Y et al. | — | 2022 | → |
| Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins. | Lee MS et al. | — | 2022 | → |
| Resistance to immunotherapy in human malignancies: Mechanisms, research progresses, challenges, and opportunities. | Bashash D et al. | — | 2022 | → |
| RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes. | Sun J et al. | — | 2022 | → |
| Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis. | Chen CL et al. | — | 2022 | → |
| Role of Hypoxia in the Interferon Response. | Arnaiz E et al. | — | 2022 | → |
| Role of Interferons in <i>Mycobacterium tuberculosis</i> Infection. | Shanmuganathan G et al. | — | 2022 | → |
| SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1. | Fung SY et al. | — | 2022 | → |
| SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication. | Miyamoto Y et al. | — | 2022 | → |
| Self-Blockade of PD-L1 with Bacteria-Derived Outer-Membrane Vesicle for Enhanced Cancer Immunotherapy. | Pan J et al. | — | 2022 | → |
| Serum and Urine Interferon Gamma-Induced Protein 10 (IP-10) Levels in Lupus Nephritis. | Brady MP et al. | — | 2022 | → |
| Silencing of <i>ApoE</i> with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer’s Disease | Ferguson CM et al. | — | 2022 | — |
| Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD. | Piper C et al. | — | 2022 | → |
| Single-Cell Transcriptome Analysis Reveals the M2 Macrophages and Exhausted T Cells and Intratumoral Heterogeneity in Triple-Negative Breast Cancer. | Xu L et al. | — | 2022 | → |
| Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis. | Xiong W et al. | — | 2022 | → |
| SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps. | Sertznig H et al. | — | 2022 | → |
| STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion. | Li J et al. | — | 2022 | → |
| Strategies for the induction of anti-inflammatory mesenchymal stem cells and their application in the treatment of immune-related nephropathy. | Zhou C et al. | — | 2022 | → |
| Stress induced microglial activation contributes to depression. | Li B et al. | — | 2022 | → |
| Structural and Functional Analyses of Type I IFNa Shed Light Into Its Interaction With Multiple Receptors in Fish. | Wang Z et al. | — | 2022 | → |
| Suppressors of Cytokine Signaling and Hepatocellular Carcinoma. | Masuzaki R et al. | — | 2022 | → |
| Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism. | Chin CV et al. | — | 2022 | → |
| Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling. | Zoellner N et al. | — | 2022 | → |
| Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC. | Swartzel JC et al. | — | 2022 | → |
| Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance. | Deng J et al. | — | 2022 | → |
| Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation. | Lopez-Pelaez M et al. | — | 2022 | → |
| Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins. | Zheng L et al. | — | 2022 | → |
| Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy. | Zhou Z et al. | — | 2022 | → |
| Temporal regulation of interferon signalling in human EndoC-βH1 cells. | Dhayal S et al. | — | 2022 | → |
| The Analyses of Cetacean Virus-Responsive Genes Reveal Evolutionary Marks in Mucosal Immunity-Associated Genes. | Chung O et al. | — | 2022 | → |
| The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes. | West PK et al. | — | 2022 | → |
| The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted. | Lebeau G et al. | — | 2022 | → |
| The gamble between oncolytic virus therapy and IFN. | Li Q et al. | — | 2022 | → |
| The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation. | Fan Z et al. | — | 2022 | → |
| The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity. | Rasmi Y et al. | — | 2022 | → |
| The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression. | Choi KM et al. | — | 2022 | → |
| The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology. | Swati et al. | — | 2022 | → |
| The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes. | Joyo Y et al. | — | 2022 | → |
| Therapeutic potential of interferon-gamma in tuberculosis. | Berns SA et al. | — | 2022 | → |
| The Role of the Immune System in the Development of Endometriosis. | Abramiuk M et al. | — | 2022 | → |
| The role of type I IFN in autoimmune and autoinflammatory diseases with CNS involvement. | Raftopoulou S et al. | — | 2022 | → |
| The Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection. | Park ES et al. | — | 2022 | → |
| Tilsotolimod: an investigational synthetic toll-like receptor 9 (TLR9) agonist for the treatment of refractory solid tumors and melanoma. | Karime C et al. | — | 2022 | → |
| TLR3-driven IFN-β antagonizes STAT5-activating cytokines and suppresses innate type 2 response in the lung. | Tei R et al. | — | 2022 | → |
| Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines. | Doratt BM et al. | — | 2022 | → |
| Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus. | Bertrams W et al. | — | 2022 | → |
| Type I interferon-mediated tumor immunity and its role in immunotherapy. | Yu R et al. | — | 2022 | → |
| Type-I Interferon Signaling in Fanconi Anemia. | Landelouci K et al. | — | 2022 | → |
| Type I Interferon Signaling is Required for Oncostatin-M Driven Inflammatory Responses in Mouse Lung. | MacDonald K et al. | — | 2022 | → |
| Type I Interferons in Autoimmunity. | Fernandez-Ruiz R et al. | — | 2022 | → |
| Type-I interferons in the immunopathogenesis and treatment of Coronavirus disease 2019. | Khorramdelazad H et al. | — | 2022 | → |
| Types of Interferons and Their Expression in Plant Systems. | Cao L et al. | — | 2022 | → |
| Understanding the functional inflammatory factors involved in therapeutic response to immune checkpoint inhibitors for pan-cancer. | Wu Y et al. | — | 2022 | → |
| When does hepatitis B virus meet long-stranded noncoding RNAs? | Lei B et al. | — | 2022 | → |
| Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets. | Sintov E et al. | — | 2022 | → |
| Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis. | Slonchak A et al. | — | 2022 | → |
| 5-Hydroxymethylfurfural Enhances the Antiviral Immune Response in Macrophages through the Modulation of RIG-I-Mediated Interferon Production and the JAK/STAT Signaling Pathway. | Zou H et al. | — | 2021 | → |
| Activation of plasmacytoid dendritic cells promotes AML-cell fratricide. | Fatehchand K et al. | — | 2021 | → |
| Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer. | De Angelis C et al. | — | 2021 | → |
| Adaptive homeostasis and the p53 isoform network. | Mehta S et al. | — | 2021 | → |
| Advances in mRNA non-viral delivery approaches. | Ibba ML et al. | — | 2021 | → |
| Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes. | Feng E et al. | — | 2021 | → |
| A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense. | Li J et al. | — | 2021 | → |
| A new insight into mechanisms of interferon alpha neurotoxicity: Expression of GRIN3A subunit of NMDA receptors and NMDA-evoked exocytosis. | Obolenskaya M et al. | — | 2021 | → |
| A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder. | Sarohan AR et al. | — | 2021 | → |
| A novel phosphoproteomic landscape evoked in response to type I interferon in the brain and in glial cells. | Viengkhou B et al. | — | 2021 | → |
| An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity. | Zhang Y et al. | — | 2021 | → |
| Antiviral effects of human placenta hydrolysate (Laennec<sup>®</sup>) against SARS-CoV-2 in vitro and in the ferret model. | Kim EH et al. | — | 2021 | → |
| A primer on cytokines. | Chauhan P et al. | — | 2021 | → |
| Breast cancer resistance mechanisms: challenges to immunotherapy. | Hanna A et al. | — | 2021 | → |
| Bridging Radiotherapy to Immunotherapy: The IFN-JAK-STAT Axis. | Shi LZ et al. | — | 2021 | → |
| Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional studies. | Siddiqi KZ et al. | — | 2021 | → |
| Concentration-Dependent Type 1 Interferon-Induced Regulation of MX1 and FABP3 in Bovine Endometrial Explants. | Schabmeyer ST et al. | — | 2021 | → |
| Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†. | Chaney HL et al. | — | 2021 | → |
| Control of Innate Immune Activation by Severe Acute Respiratory Syndrome Coronavirus 2 and Other Coronaviruses. | Kehrer T et al. | — | 2021 | → |
| Could Antigen Presenting Cells Represent a Protective Element during SARS-CoV-2 Infection in Children? | Lauro R et al. | — | 2021 | → |
| Crosstalk Between Autophagy and the cGAS-STING Signaling Pathway in Type I Interferon Production. | Zhang K et al. | — | 2021 | → |
| DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection. | Zhang R et al. | — | 2021 | → |
| Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes. | Tauzin A et al. | — | 2021 | → |
| Differential roles of interferons in innate responses to mucosal viral infections. | Walker FC et al. | — | 2021 | → |
| DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes. | Hatanaka Y et al. | — | 2021 | → |
| Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? | Wu M et al. | — | 2021 | → |
| Editorial: Sensing DNA in Antiviral Innate Immunity. | Lin R et al. | — | 2021 | → |
| Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant. | Bang YJ et al. | — | 2021 | → |
| Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34<sup>-</sup> and immature CD34<sup>+</sup> cells. | Berger MG et al. | — | 2021 | → |
| [ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling]. | Wei G et al. | — | 2021 | → |
| Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival. | Kalinin RS et al. | — | 2021 | → |
| Enterovirus A71 2B Inhibits Interferon-Activated JAK/STAT Signaling by Inducing Caspase-3-Dependent Karyopherin-α1 Degradation. | Sun M et al. | — | 2021 | → |
| Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis. | Verstappen GM et al. | — | 2021 | → |
| Epromoters function as a hub to recruit key transcription factors required for the inflammatory response. | Santiago-Algarra D et al. | — | 2021 | → |
| Estrogen Aggravates Tumor Growth in a Diffuse Gastric Cancer Xenograft Model. | Lee S et al. | — | 2021 | → |
| Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | Negi CK et al. | — | 2021 | → |
| Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes. | Padariya M et al. | — | 2021 | → |
| Gene editing to investigate the role of conceptus factors in the establishment of pregnancy in the pig. | Geisert RD et al. | — | 2021 | → |
| Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study. | Fernández M et al. | — | 2021 | → |
| Germline SAMD9L truncation variants trigger global translational repression. | Allenspach EJ et al. | — | 2021 | → |
| Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation. | Dilucca M et al. | — | 2021 | → |
| Herpes simplex virus interference with immunity: Focus on dendritic cells. | Ma F et al. | — | 2021 | → |
| High-Throughput RNA Sequencing Reveals the Effect of NB-UVB Phototherapy on Major Inflammatory Molecules of Lesional Psoriasis. | Vacharanukrauh P et al. | — | 2021 | → |
| Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection. | Lum KK et al. | — | 2021 | → |
| Human Cytomegalovirus UL23 Attenuates Signal Transducer and Activator of Transcription 1 Phosphorylation and Type I Interferon Response. | Feng L et al. | — | 2021 | → |
| Human rhinovirus serotypes induces different immune responses. | Kim JH et al. | — | 2021 | → |
| Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses. | Zheng W et al. | — | 2021 | → |
| IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling. | Li TH et al. | — | 2021 | → |
| IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. | Shemesh M et al. | — | 2021 | → |
| IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. | Maia A et al. | — | 2021 | → |
| Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway. | Alicea-Torres K et al. | — | 2021 | → |
| Immunity and Viral Infections: Modulating Antiviral Response via CRISPR-Cas Systems. | Brezgin S et al. | — | 2021 | → |
| Immunoregulatory Functions of Interferons During Genital HSV-2 Infection. | Feng E et al. | — | 2021 | → |
| Immunotherapy of Ovarian Cancer with Particular Emphasis on the PD-1/PDL-1 as Target Points. | Świderska J et al. | — | 2021 | → |
| Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection. | Schwerdtfeger M et al. | — | 2021 | → |
| Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection. | Muñoz-Moreno R et al. | — | 2021 | → |
| Infecting mosquitoes alters DENV-2 characteristics and enhances hemorrhage-induction potential in Stat1-/- mice. | Cheang KW et al. | — | 2021 | → |
| Infection-induced inflammation from specific inborn errors of immunity to COVID-19. | Ku CL et al. | — | 2021 | → |
| Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer's disease reveals key pathways and hub genes with potential diagnostic utility: a preliminary study. | Cardona K et al. | — | 2021 | → |
| Inhibiting interferon pathways in dermatomyositis: rationale and preliminary evidence. | Casal-Dominguez M et al. | — | 2021 | → |
| Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis. | Wang VE et al. | — | 2021 | → |
| Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes. | Elrefaey AME et al. | — | 2021 | → |
| Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies. | Small S et al. | — | 2021 | → |
| Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract. | Mifsud EJ et al. | — | 2021 | → |
| Integrated Network Analysis to Identify Key Modules and Potential Hub Genes Involved in Bovine Respiratory Disease: A Systems Biology Approach. | Hasankhani A et al. | — | 2021 | → |
| Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19. | Ma Y et al. | — | 2021 | → |
| Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-<i>Versus</i>-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease. | Haring E et al. | — | 2021 | → |
| Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production. | Mu M et al. | — | 2021 | → |
| Interferon Gamma Inhibits Equine Herpesvirus 1 Replication in a Cell Line-Dependent Manner. | Kim SK et al. | — | 2021 | → |
| Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens. | Rafeld HL et al. | — | 2021 | → |
| Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions. | Tan PH et al. | — | 2021 | → |
| Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family. | Haque M et al. | — | 2021 | → |
| Interferon-β suppresses inflammatory pain through activating µ-opioid receptor. | Liu CC et al. | — | 2021 | → |
| Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B. | Goh ZY et al. | — | 2021 | → |
| Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells. | Khan S et al. | — | 2021 | → |
| Irradiation Suppresses IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8<sup>+</sup> T Cells Cytotoxicity. | Wang CI et al. | — | 2021 | → |
| <i>Toxoplasma gondii</i> Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape. | Yao L et al. | — | 2021 | → |
| JAK3 and PI3K mediates the suppressive effects of interferon tau on neutrophil extracellular traps formation during peri-implantation period. | Alhussien MN et al. | — | 2021 | → |
| Janus Kinase Inhibitors in the Treatment of Vitiligo: A Review. | Qi F et al. | — | 2021 | → |
| Lack of Cell Cycle Inhibitor p21 and Low CD4<sup>+</sup> T Cell Suppression in Newborns After Exposure to IFN-β. | Jans J et al. | — | 2021 | → |
| Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons. | Demiroz D et al. | — | 2021 | → |
| Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins. | Hirschenberger M et al. | — | 2021 | → |
| Lysosomal amino acid transporters as key players in inflammatory diseases. | Toyama-Sorimachi N et al. | — | 2021 | → |
| Management of Sjögren's Syndrome: Present Issues and Future Perspectives. | Vitali C et al. | — | 2021 | → |
| Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. | Bordt EA et al. | — | 2021 | → |
| Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome. | Zou R et al. | — | 2021 | → |
| MiR-139 Induces an Interferon-β Response in Prostate Cancer Cells by Binding to RIG-1. | Nam RK et al. | — | 2021 | → |
| miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. | Sewastianik T et al. | — | 2021 | → |
| Molecular and functional characterization of interferon regulatory factor 1 (IRF1) in amphibian Xenopus tropicalis. | Gan Z et al. | — | 2021 | → |
| Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma. | Ballesteros PÁ et al. | — | 2021 | → |
| Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment. | Nguyen TT et al. | — | 2021 | → |
| Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. | Yang KC et al. | — | 2021 | → |
| Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction. | Mancini A et al. | — | 2021 | → |
| Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells. | Todoerti K et al. | — | 2021 | → |
| Oncolytic Adenoviruses for Cancer Therapy. | Tripodi L et al. | — | 2021 | → |
| Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-γ dependent apoptosis of cervical cancer cells. | Wang Y et al. | — | 2021 | → |
| Pathogenesis of Anti-melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis: A Concise Review With an Emphasis on Type I Interferon System. | Hu H et al. | — | 2021 | → |
| PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma. | Tobin JWD et al. | — | 2021 | → |
| Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection. | Bahari Z et al. | — | 2021 | → |
| Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection. | Ding J et al. | — | 2021 | → |
| Plasmacytoid Dendritic Cells Mediate Myocardial Ischemia/Reperfusion Injury by Secreting Type I Interferons. | Lai L et al. | — | 2021 | → |
| Polycythemia Vera (PV): Update on Emerging Treatment Options. | Benevolo G et al. | — | 2021 | → |
| Potent and Selective Knockdown of Tyrosine Kinase 2 by Antisense Oligonucleotides. | Tran NV et al. | — | 2021 | → |
| Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus. | Wang G et al. | — | 2021 | → |
| Protein cysteine palmitoylation in immunity and inflammation. | Lin H | — | 2021 | → |
| Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon. | Zhu C et al. | — | 2021 | → |
| Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations. | Akkurt Arslan M et al. | — | 2021 | → |
| Recent advances in prognostication and treatment of polycythemia vera. | Marcellino BK et al. | — | 2021 | → |
| Recent Progress in Interferon Therapy for Myeloid Malignancies. | Healy FM et al. | — | 2021 | → |
| Regulation of Monocyte Adhesion and Type I Interferon Signaling by CD52 in Patients With Systemic Sclerosis. | Rudnik M et al. | — | 2021 | → |
| Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer. | Zhang H et al. | — | 2021 | → |
| Resistance to immune checkpoint inhibitors in advanced gastro-oesophageal cancers. | Baxter MA et al. | — | 2021 | → |
| RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection. | Brisse M et al. | — | 2021 | → |
| Robust innate immune responses at the placenta during early gestation may limit in utero HIV transmission. | Johnson EL et al. | — | 2021 | → |
| SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. | Li Y et al. | — | 2021 | → |
| Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway. | Murai Y et al. | — | 2021 | → |
| Seizing control: How dense granule effector proteins enable Toxoplasma to take charge. | Panas MW et al. | — | 2021 | → |
| Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. | Ghita L et al. | — | 2021 | → |
| Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa. | Mariottoni P et al. | — | 2021 | → |
| STAT1 maintains naïve CD8<sup>+</sup> T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis. | Kye YC et al. | — | 2021 | → |
| Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across. | Minnaert AK et al. | — | 2021 | → |
| Super-Enhancer Induced IL-20RA Promotes Proliferation/Metastasis and Immune Evasion in Colorectal Cancer. | Yu D et al. | — | 2021 | → |
| Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers <i>via</i> Dormancy Regulation. | Yang C et al. | — | 2021 | → |
| The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ. | Nelli RK et al. | — | 2021 | → |
| The Complexity of the cGAS-STING Pathway in CNS Pathologies. | Fryer AL et al. | — | 2021 | → |
| The effect of air pollution on the transcriptomics of the immune response to respiratory infection. | Croft DP et al. | — | 2021 | → |
| The Importance of Interferon-Tau in the Diagnosis of Pregnancy. | Kowalczyk A et al. | — | 2021 | → |
| The Mechanism behind Influenza Virus Cytokine Storm. | Gu Y et al. | — | 2021 | → |
| The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis. | Lin H et al. | — | 2021 | → |
| The Pathogenic Role of Interferons in the Hyperinflammatory Response on Adult-Onset Still's Disease and Macrophage Activation Syndrome: Paving the Way towards New Therapeutic Targets. | Di Cola I et al. | — | 2021 | → |
| The perplexing role of immuno-oncology drugs in osteosarcoma. | Smrke A et al. | — | 2021 | → |
| Therapeutic Development Based on the Immunopathogenic Mechanisms of Psoriasis. | Tseng JC et al. | — | 2021 | → |
| The role of cGAS/STING in intestinal immunity. | Wottawa F et al. | — | 2021 | → |
| The Role of Interferons in the Pathogenesis of Sjögren's Syndrome and Future Therapeutic Perspectives. | Del Papa N et al. | — | 2021 | → |
| The role of interferons type I, II and III in myositis: A review. | Bolko L et al. | — | 2021 | → |
| The Role of microRNAs in the Infection by <i>T. gondii</i> in Humans. | de Faria Junior GM et al. | — | 2021 | → |
| The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation. | Liu H et al. | — | 2021 | → |
| Tilapia dsRNA-activated protein kinase R (PKR): An interferon-induced antiviral effector with translation inhibition activity. | Gan Z et al. | — | 2021 | → |
| Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma. | Haymaker C et al. | — | 2021 | → |
| TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma. | Krug J et al. | — | 2021 | → |
| Topical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment. | Ni G et al. | — | 2021 | → |
| Toxoplasma gondii infection and its implications within the central nervous system. | Matta SK et al. | — | 2021 | → |
| Toxoplasma gondii manipulates host cell signaling pathways via its secreted effector molecules. | Ihara F et al. | — | 2021 | → |
| Transcriptomic Analysis of Interferon Response in Toll-Like Receptor 2 Ligand-Treated and Herpes Simplex Virus 1-Infected Neurons and Astrocytes. | Bansode YD et al. | — | 2021 | → |
| TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease. | Jones EL et al. | — | 2021 | → |
| Type I and II Interferons in the Anti-Tumor Immune Response. | Fenton SE et al. | — | 2021 | → |
| Type I Interferons Are Involved in the Intracellular Growth Control of <i>Mycobacterium abscessus</i> by Mediating NOD2-Induced Production of Nitric Oxide in Macrophages. | Ahn JH et al. | — | 2021 | → |
| Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes. | Marroqui L et al. | — | 2021 | → |
| Type I Interferon Signaling Accelerates Liver Regeneration by Metabolic Modulation in Noninfectious Conditions. | Wu MS et al. | — | 2021 | → |
| Type I Interferon signaling controls the accumulation and transcriptomes of monocytes in the aged lung. | D'Souza SS et al. | — | 2021 | → |
| Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis. | Tang Y et al. | — | 2021 | → |
| VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems. | Ravi B et al. | — | 2021 | → |
| Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific differences in intestinal differentiation markers and Schlafen family members expression levels. | Vomhof-DeKrey EE et al. | — | 2021 | → |
| Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway. | Meyts I et al. | — | 2021 | → |
| Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains. | Castaño-Rodriguez C et al. | — | 2021 | → |
| Virus-Induced Tumorigenesis and IFN System. | Iuliano M et al. | — | 2021 | → |
| Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID‑19 (Review). | Name JJ et al. | — | 2021 | → |
| Why Does SARS-CoV-2 Infection Induce Autoantibody Production? | Macela A et al. | — | 2021 | → |
| Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2. | Fanunza E et al. | — | 2021 | → |
| All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes. | Yang E et al. | — | 2020 | → |
| Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease. | Fox LE et al. | — | 2020 | → |
| Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3. | Wang P et al. | — | 2020 | → |
| Genetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis. | Ciccarese F et al. | — | 2020 | → |
| IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration. | Behnke V et al. | — | 2020 | → |
| Immunostimulatory Endogenous Nucleic Acids Perpetuate Interface Dermatitis-Translation of Pathogenic Fundamentals Into an <i>In Vitro</i> Model. | Braegelmann C et al. | — | 2020 | → |
| Innate Immunity and Biological Therapies for the Treatment of Sjögren's Syndrome. | Srivastava A et al. | — | 2020 | → |
| Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. | Zanin N et al. | — | 2020 | → |
| Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19. | Zheng HY et al. | — | 2020 | → |
| MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. | Kapoor T et al. | — | 2020 | → |
| Relationship Between T-Cell Exosomes and Cellular Subsets in SLE According to Type I IFN-Signaling. | López P et al. | — | 2020 | → |
| RNA Based Approaches to Profile Oncogenic Pathways From Low Quantity Samples to Drive Precision Oncology Strategies. | van de Stolpe A et al. | — | 2020 | → |
| The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor? | Ballotti R et al. | — | 2020 | → |
| Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway. | Yang Q et al. | — | 2020 | → |