Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG.
- Authors
- Pothecary, C A; Jane, D E; Salt, T E
- Year
- 2002
- Journal
- Neuropharmacology
- PMID
- 12213277
- DOI
- 10.1016/s0028-3908(02)00077-1
We have previously shown that activation of Group III metabotropic glutamate (mGlu) receptors modulates synaptic transmission in the superior colliculus. We thus investigated the effect of the selective mGlu8 receptor agonist (S)-3,4-dicarboxyphenylglycine (DCPG) on excitatory synaptic transmission in the superficial superior colliculus (SC) using an in vitro slice preparation of the rat SC. Field EPSPs evoked by optic tract stimulation under conditions of GABA receptor blockade were reduced by DCPG by up to 67.8+/-5.46% (EC(50) 1.25+/-0.56 microM), and this effect could be antagonised by LY341495 at a concentration (300 nM) known to be effective at mGlu8 receptors but not at mGlu4 or mGlu7 receptors. The broad-spectrum (mGlu4/mGlu7/mGlu8) agonist L-2-amino-4- phosphonobutyric acid (L-AP4) produced similar reductions of synaptic transmission (maximal reduction 68.6+/-2.33%; EC(50) 5.7+/-2.61 microM). These data are consistent with previous results which show that mGlu8 receptor activation can reduce synaptic transmission in the spinal cord, and indicate that similar mechanisms operate in other brain areas. Furthermore, this indicates that the mGlu8 receptor may have a role in the modulation of visual transmission in the superior colliculus.
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In this knowledge base
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|---|---|---|
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | 2009 | 18618593 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential. | Mercier MS et al. | — | 2014 | → |
| Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. | Broadstock M et al. | — | 2012 | → |
| Changes in the modulation of retinocollicular transmission through group III mGluRs long after an increase in intraocular pressure in a rat model of glaucoma. | Georgiou AL et al. | — | 2012 | → |
| Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma. | Georgiou AL et al. | — | 2010 | → |
| Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses. | Quraishi S et al. | — | 2010 | → |
| Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease. | Austin PJ et al. | — | 2010 | → |
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | Chen AC et al. | — | 2009 | → |
| Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. | Young RL et al. | — | 2008 | → |
| Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor. | Neale SA et al. | — | 2006 | → |
| Changes in glutamate receptor function in synaptic input to the superficial superior colliculus (SSC) with aging and in retinal degeneration in the Royal College of Surgeons (RCS) rat. | Pothecary CA et al. | — | 2005 | → |
| Immunoreactivity for the group III receptor subtype mGluR4a in the visual layers of the rat superior colliculus. | Puente N et al. | — | 2005 | → |
| Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands. | Frisby CL et al. | — | 2005 | → |
| Melatonin decreases calcium levels in retinotectal axons of Xenopus laevis by indirect activation of group III metabotropic glutamate receptors. | Prada C et al. | — | 2005 | → |
| Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development. | Lacey CJ et al. | — | 2005 | → |
| Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG. | Bäckström P et al. | — | 2005 | → |
| Activation of Group II and Group III metabotropic glutamate receptors by endogenous ligand(s) and the modulation of synaptic transmission in the superficial superior colliculus. | Thompson H et al. | — | 2004 | → |
| Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels. | White AM et al. | — | 2003 | → |