Deep brain stimulation in addiction due to psychoactive substance use.
- Authors
- Kuhn, Jens; Bührle, Christian P; Lenartz, Doris; Sturm, Volker
- Year
- 2013
- Journal
- Handbook of clinical neurology
- PMID
- 24112900
- DOI
- 10.1016/B978-0-444-53497-2.00021-8
Addiction is one of the most challenging health problems. It is associated with enormous individual distress and tremendous socioeconomic consequences. Unfortunately, its underlying mechanisms are not fully understood, and pharmacological, psychological, or social interventions often fail to achieve long-lasting remission. Next to genetic, social, and contextual factors, a substance-induced dysfunction of the brain's reward system is considered a decisive factor for the establishment and maintenance of addiction. Due to its successful application and approval for several neurological disorders, deep brain stimulation (DBS) is known as a powerful tool for modulating dysregulated networks and has also been considered for substance addiction. Initial promising case reports of DBS in alcohol and heroin addiction in humans have recently been published. Likewise, results from animal studies mimicking different kinds of substance addiction point in a similar direction. The objective of this review is to provide an overview of the published results on DBS in addiction, and to discuss whether these preliminary results justify further research, given the novelty of this treatment approach.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Physical Therapy for Addiction. | Xiao LJ et al. | — | 2025 | → |
| Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction. | Giménez S et al. | — | 2024 | → |
| A randomized controlled trial on the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male patients undergoing methadone maintenance treatment. | Ravari HB et al. | — | 2024 | → |
| Role of deep brain stimulation (DBS) in addiction disorders. | Iqbal J et al. | — | 2023 | → |
| Deep Brain Stimulation in Drug Addiction Treatment: Research Progress and Perspective. | Chang R et al. | — | 2022 | → |
| Recent advances in deep brain stimulation in psychiatric disorders | Clair A et al. | — | 2018 | — |
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| "Killing Two Birds with One Stone": Alcohol Use Reduction Interventions with Potential Efficacy in Enhancing Self-Control. | Leeman RF et al. | — | 2014 | → |
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