Diagnostic criteria for monoclonal B-cell lymphocytosis.
paper
Cited
Public
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- Authors
- Marti, Gerald E; Rawstron, Andy C; Ghia, Paolo; Hillmen, Peter; Houlston, Richard S; Kay, Neil; Schleinitz, Thérèse A; Caporaso, Neil; International Familial CLL Consortium
- Year
- 2005
- Journal
- British journal of haematology
- PMID
- 16042682
- DOI
- 10.1111/j.1365-2141.2005.05550.x
Very low levels of circulating monoclonal B-cell subpopulations can now be detected in apparently healthy individuals using flow cytometry. We propose the term 'monoclonal B-cell lymphocytosis' (MBL) to describe this finding. The aim of this document is to provide a working definition of MBL for future clinical, epidemiological and laboratory studies. We propose that the detection of a monoclonal B-cell population by light chain restriction is sufficient to define this condition in individuals not meeting the diagnostic criteria for other B-lymphoproliferative disorders. The majority of individuals with MBL will have cells that are indistinguishable from chronic lymphocytic leukaemia (CLL). However, this blood cell clonal expansion of CD5+ or CD5- B-lymphocytes is age-dependent and immunophenotypic heterogeneity is common. Longitudinal studies are required to determine whether MBL is a precursor state to CLL or other B-lymphoproliferative disease in a situation analogous to a monoclonal gammopathy of undetermined significance and myeloma. Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL.
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| Low levels of monoclonal small B cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type. | Tierens AM et al. | β | 2010 | β |
| Monoclonal B cell lymphocytosis: clinical and population perspectives. | Caporaso NE et al. | β | 2010 | β |
| Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. | Shanafelt TD et al. | β | 2010 | β |
| NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation. | Porter DL et al. | β | 2010 | β |
| Non-CLL-like monoclonal B-cell lymphocytosis in the general population: prevalence and phenotypic/genetic characteristics. | Nieto WG et al. | β | 2010 | β |
| Prevalence, clinical aspects, and natural history of IgM MGUS. | McMaster ML et al. | β | 2010 | β |
| Prevalence of monoclonal B-cell lymphocytosis: a systematic review. | Shim YK et al. | β | 2010 | β |
| Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. | Lanasa MC et al. | β | 2010 | β |
| T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. | Howard MT et al. | β | 2010 | β |
| Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia. | Zhang J et al. | β | 2010 | β |
| B-cell clones as early markers for chronic lymphocytic leukemia. | Landgren O et al. | β | 2009 | β |
| B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. | Shanafelt TD et al. | β | 2009 | β |
| Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. | Shanafelt TD et al. | β | 2009 | β |
| Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders. | Nakahashi H et al. | β | 2009 | β |
| Clinical features and outcome of Chinese patients with monoclonal B-cell lymphocytosis. | Xu W et al. | β | 2009 | β |
| Epigenetic alterations in a murine model for chronic lymphocytic leukemia. | Chen SS et al. | β | 2009 | β |
| Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages. | Veneri D et al. | β | 2009 | β |
| Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients. | Del Giudice I et al. | β | 2009 | β |
| Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. | Nieto WG et al. | β | 2009 | β |
| Lymphocytes, B lymphocytes, and clonal CLL cells: observations on the impact of the new diagnostic criteria in the 2008 Guidelines for Chronic Lymphocytic Leukemia (CLL). | Mulligan CS et al. | β | 2009 | β |
| Monoclonal B-cell lymphocytosis. | Rawstron AC | β | 2009 | β |
| Monoclonal B-cell lymphocytosis: definitions and natural history. | Shanafelt T et al. | β | 2009 | β |
| Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. | Matos DM et al. | β | 2009 | β |
| Monoclonal B lymphocytosis in the general population. | Dagklis A et al. | β | 2009 | β |
| Predicting clinical outcome in CLL: how and why. | Shanafelt TD | β | 2009 | β |
| Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia. | Toro JR et al. | β | 2009 | β |
| The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. | Dagklis A et al. | β | 2009 | β |
| The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. | Rossi D et al. | β | 2009 | β |
| The secret lives of monoclonal B cells. | Vogt RF et al. | β | 2009 | β |
| Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia. | Fuller SJ et al. | β | 2008 | β |
| Chronic lymphocytic leukaemia. | Dighiero G et al. | β | 2008 | β |
| [Chronic lymphocytic leukaemia: current management]. | Aurran-Schleinitz T et al. | β | 2008 | β |
| Classification of lymphoid neoplasms: the microscope as a tool for disease discovery. | Jaffe ES et al. | β | 2008 | β |
| Clinical role of flow cytometry in redefining bone marrow involvement in diffuse large B-cell lymphoma (DLBCL) - a new perspective. | Talaulikar D et al. | β | 2008 | β |
| Epidemiology, pathology and treatment of non-follicular indolent lymphomas. | Landgren O et al. | β | 2008 | β |
| Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. | Hallek M et al. | β | 2008 | β |
| Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. | Ahmad E et al. | β | 2008 | β |
| Indolent lymphomas other than follicular and marginal zone lymphomas. | Peinert S et al. | β | 2008 | β |
| Inherited predisposition to chronic lymphocytic leukemia. | Brown JR | β | 2008 | β |
| MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)? | Shanafelt TD et al. | β | 2008 | β |
| Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. | Rawstron AC et al. | β | 2008 | β |
| Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? | Caligaris-Cappio F et al. | β | 2008 | β |
| Peripheral blood lymphocytosis--what is the threshold for further investigation? | Carney D | β | 2008 | β |
| TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. | Bekeredjian-Ding I et al. | β | 2008 | β |
| Unusual direct phycoerythrin labeling of B-cells from a splenic marginal zone lymphoma. | Tabary T et al. | β | 2008 | β |
| Using peripheral smear review, age and absolute lymphocyte count as predictors of abnormal peripheral blood lymphocytoses diagnosed by flow cytometry. | Andrews JM et al. | β | 2008 | β |
| 2006 Bethesda International Consensus recommendations on the flow cytometric immunophenotypic analysis of hematolymphoid neoplasia: medical indications. | Davis BH et al. | β | 2007 | β |
| Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly. | Ghia P et al. | β | 2007 | β |
| Antibody response to 7-valent conjugated pneumococcal vaccine in patients with chronic lymphocytic leukaemia. | Sinisalo M et al. | β | 2007 | β |
| B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred. | Abbasi F et al. | β | 2007 | β |
| B cells behaving badly. | Shim YK et al. | β | 2007 | β |
| Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation. | Hardy NM et al. | β | 2007 | β |
| [Chronic lymphocytic leukaemia: an autoimmune disorder? Prognostic factors and the current view of pathogenesis]. | Pajor L | β | 2007 | β |
| Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesis. | Linet MS et al. | β | 2007 | β |
| Chronic lymphocytic leukaemia genetics overview. | Caporaso N et al. | β | 2007 | β |
| Chronic lymphocytic leukemia. | Ghia P et al. | β | 2007 | β |
| Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis. | Fung SS et al. | β | 2007 | β |
| Cytometry in monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia--the Hunting of the Snark? | Shapiro HM | β | 2007 | β |
| Differential diagnosis in chronic lymphocytic leukaemia. | Matutes E et al. | β | 2007 | β |
| Familial CLL: genes and environment. | Goldin LR et al. | β | 2007 | β |
| High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia. | Hensel M et al. | β | 2007 | β |
| Is "leukemia" an appropriate label for all patients who meet the diagnostic criteria of chronic lymphocytic leukemia? | Victor Hoffbrand A et al. | β | 2007 | β |
| Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies. | Vogt RF et al. | β | 2007 | β |
| Monoclonal B-cell lymphocytosis: good news for patients and CLL investigators. | Rawstron AC | β | 2007 | β |
| Monoclonal B-cell lymphocytosis in blood donors. | Rachel JM et al. | β | 2007 | β |
| Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases. | Landgren O et al. | β | 2007 | β |
| Occult bone marrow involvement in patients with diffuse large B-cell lymphoma: results of a pilot study. | Talaulikar D et al. | β | 2007 | β |
| Outreach monitoring service for patients with indolent B-cell and plasma cell disorders: a UK experience. | Rawstron AC et al. | β | 2007 | β |
| Overview of monoclonal B-cell lymphocytosis. | Marti G et al. | β | 2007 | β |
| Pathology of chronic lymphocytic leukemia: an update. | Inamdar KV et al. | β | 2007 | β |
| Prevalence and natural history of monoclonal and polyclonal B-cell lymphocytosis in a residential adult population. | Shim YK et al. | β | 2007 | β |
| Prognostic markers in chronic lymphocytic leukaemia. | Hamblin TJ | β | 2007 | β |
| Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. | Landgren O et al. | β | 2007 | β |
| Revision of the guidelines for diagnosis and therapy of chronic lymphocytic leukemia (CLL). | Eichhorst B et al. | β | 2007 | β |
| The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia. | Rawstron AC et al. | β | 2007 | β |
| The normal counterpart to the chronic lymphocytic leukemia B cell. | Caligaris-Cappio F et al. | β | 2007 | β |
| WaldenstrΓΆm macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition. | McMaster ML et al. | β | 2007 | β |
| A new automated flow cytometry data analysis approach for the diagnostic screening of neoplastic B-cell disorders in peripheral blood samples with absolute lymphocytosis. | Costa ES et al. | β | 2006 | β |
| Chronic lymphocytic leukemia: diagnosis and treatment. | Yee KW et al. | β | 2006 | β |
| Clonal lymphocytic populations in Philadelphia-negative chronic myeloproliferative disorders: is the T-cell clonality of 'undetermined' significance (TCUS) linked to a worse clinical outcome? | StΓ³j A et al. | β | 2006 | β |
| Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia. | Shanafelt TD et al. | β | 2006 | β |
| Predicting chronic leukaemias from assessment of complete peripheral blood counts. | Hayran M et al. | β | 2006 | β |
| Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia. | Hamblin AD et al. | β | 2005 | β |