Pluripotent stem cells in neuropsychiatric disorders.
paper
Cited
Public
- Authors
- Soliman, M A; Aboharb, F; Zeltner, N; Studer, L
- Year
- 2017
- Journal
- Molecular psychiatry
- PMID
- 28322279
- DOI
- 10.1038/mp.2017.40
- PMCID
- PMC5582162
Neuropsychiatric disorders place an enormous medical burden on patients across all social and economic ranks. The current understanding of the molecular and cellular causes of neuropsychiatric disease remains limited, which leads to a lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology offers a novel platform for modeling the genetic contribution to mental disorders and yields access to patient-specific cells for drug discovery and personalized medicine. Here, we review recent progress in using iPSC technology to model and potentially treat neuropsychiatric disorders by focusing on the most prevalent conditions in psychiatry, including depression, anxiety disorders, bipolar disorder and schizophrenia.
(a) Graphic representation of disability-adjusted life years (DALYs), years lived with disability (YLDs) and years of life lost (YLLs). (b) Graph representing the DALY burden of leading neuropsychiatric disorders, as well as comparable non-neuropsychiatric diseases.
Schematic representation of induced pluripotent stem cell generation and application. A biopsy is taken from a patient (skin, blood or other tissues). Patient cells are reprogrammed into pluripotent stem cells and differentiated into the neuronal cell types of interest. Patient-derived neurons could be used for elucidating disease mechanism, high-throughput drug screening, drug testing and toxicity studies, biomarker identification and patient stratification. iPSC, human-induced pluripotent stem cell.
Timeline of iPSC technology development. Developments of neuropsychiatric disease models are represented on the lower side of the timeline panel, whereas developments in generating specific neuronal cell populations are represented in the upper part of the panel. BPD, bipolar disorder; iPSC, human-induced pluripotent stem cell; SCZ, schizophrenia.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Differentiation of human iPSCs into dopaminergic neurons: comparative analysis of 2D and 3D protocols for disease modeling and pharmacology. | Marcotto GS et al. | β | 2026 | β |
| A new dawn: Vitalising translational oncology research in Africa with the help of advanced cell culture models. | Klima S et al. | β | 2025 | β |
| Dysregulation of glutamatergic and GABAergic neurons in Treatment-Resistant Depression: Insights from patient-derived neurons. | Tomasoni Z et al. | β | 2025 | β |
| From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care. | Tanaka M | β | 2025 | β |
| LXR agonist rescues synaptic dysfunction and degeneration in SPG3A patient-specific iPSC-derived neurons. | Thakur G et al. | β | 2025 | β |
| Small peptide P110 mitigates axonal degeneration of SPG15 patient iPSC-derived neurons by targeting mitochondrial dysfunction. | Tamilselvam B et al. | β | 2025 | β |
| The Therapeutic Potential of Stem Cells in Depression. | Jurczenko L et al. | β | 2025 | β |
| Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells. | Mattingly Z et al. | β | 2025 | β |
| Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. | Wang L et al. | β | 2024 | β |
| Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview. | Choudhary A et al. | β | 2024 | β |
| Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. | Niemsiri V et al. | β | 2024 | β |
| From Cell to Circuit: Investigating Functional Topological Changes in iPSC-derived Neuronal Networks in Major Depressive Disorder | Wetzel C et al. | β | 2024 | β |
| Geraniol mitigates anxiety-like behaviors in rats by reducing oxidative stress, repairing impaired hippocampal neurotransmission, and normalizing brain cortical-EEG wave patterns after a single electric foot-shock exposure. | Nisar R et al. | β | 2024 | β |
| Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. | Triebelhorn J et al. | β | 2024 | β |
| Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia. | Spathopoulou A et al. | β | 2024 | β |
| Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells. | Muhtaseb AW et al. | β | 2024 | β |
| Patient-derived induced pluripotent stem cells: Tools to advance the understanding and drug discovery in Major Depressive Disorder. | Vaz A et al. | β | 2024 | β |
| RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1. | Choi W et al. | β | 2024 | β |
| Systematic Approach in the Development of Chitosan Functionalized Iloperidone Nanoemulsions for Transnasal Delivery, In Vitro and In Vivo Studies. | Sawant ND et al. | β | 2024 | β |
| Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons. | Γlvarez Z et al. | β | 2023 | β |
| Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes. | Stogsdill JA et al. | β | 2023 | β |
| iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function. | Eade KT et al. | β | 2023 | β |
| On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. | Niemis W et al. | β | 2023 | β |
| Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders. | Pandamooz S et al. | β | 2023 | β |
| Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression. | Sachdeva P et al. | β | 2023 | β |
| Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders. | Dutan Polit L et al. | β | 2023 | β |
| The multimodal Munich Clinical Deep Phenotyping study to bridge the translational gap in severe mental illness treatment research. | KrΔmΓ‘Ε L et al. | β | 2023 | β |
| A bioinformatic inquiry of the EAAT2 interactome in postmortem and neuropsychiatric datasets. | Asah S et al. | β | 2022 | β |
| An in vitro model of neuronal ensembles. | Rabadan MA et al. | β | 2022 | β |
| Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease. | Pinals RL et al. | β | 2022 | β |
| Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention. | Wang Y et al. | β | 2022 | β |
| Deepening the understanding of CNVs on chromosome 15q11-13 by using hiPSCs: An overview. | Giovenale AMG et al. | β | 2022 | β |
| iPSCs and DRGs: stepping stones to new pain therapies. | Alsaloum M et al. | β | 2022 | β |
| Monitoring Axonal Degeneration in Human Pluripotent Stem Cell Models of Hereditary Spastic Paraplegias. | Li XJ et al. | β | 2022 | β |
| Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications. | Lucido MJ et al. | β | 2021 | β |
| Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. | Vadodaria KC et al. | β | 2021 | β |
| Induced Pluripotent Stem Cells (iPSCs) Technology: Potential Targets for Depression. | Colpo GD et al. | β | 2021 | β |
| Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders. | Unterholzner J et al. | β | 2021 | β |
| Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids. | Willner MJ et al. | β | 2021 | β |
| N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. | Yu JZ et al. | β | 2021 | β |
| Neural Differentiation of Mouse Embryonic Stem Cells-An <i>in vitro</i> Approach to Profile DNA Methylation of Reprogramming Factor Sox2-SRR2. | Batool S et al. | β | 2021 | β |
| Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics. | Akhtar A et al. | β | 2021 | β |
| Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. | Kim NS et al. | β | 2021 | β |
| Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. | Nakatsuka N et al. | β | 2021 | β |
| Stem cell-based models and therapies: a key approach into schizophrenia treatment. | Larijani B et al. | β | 2021 | β |
| Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. | Wang X et al. | β | 2021 | β |
| Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy. | Matt SM | β | 2021 | β |
| The promise of precision medicine in autism. | Kostic A et al. | β | 2021 | β |
| Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched. | Reed X et al. | β | 2021 | β |
| Translational genomics and beyond in bipolar disorder. | Zhang C et al. | β | 2021 | β |
| Human induced pluripotent stem cells technology in treatment resistant depression: novel strategies and opportunities to unravel ketamine's fast-acting antidepressant mechanisms. | Marcatili M et al. | β | 2020 | β |
| Human pluripotent stem cell-derived models and drug screening in CNS precision medicine. | Silva MC et al. | β | 2020 | β |
| Mental health dished up-the use of iPSC models in neuropsychiatric research. | McNeill RV et al. | β | 2020 | β |
| Modeling genetic epilepsies in a dish. | Niu W et al. | β | 2020 | β |
| Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques. | Collo G et al. | β | 2020 | β |
| Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. | Griffin SM et al. | β | 2020 | β |
| Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia. | GouvΓͺa-Junqueira D et al. | β | 2020 | β |
| Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy. | Sterlini B et al. | β | 2020 | β |
| Stem Cells for Improving the Treatment of Neurodevelopmental Disorders. | Donegan JJ et al. | β | 2020 | β |
| Stress-Induced Morphological, Cellular and Molecular Changes in the Brain-Lessons Learned from the Chronic Mild Stress Model of Depression. | Khan AR et al. | β | 2020 | β |
| The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders. | Lee KM et al. | β | 2020 | β |
| Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders. | Christian KM et al. | β | 2020 | β |
| Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. | Vadodaria KC et al. | β | 2019 | β |
| Applications of Human Brain Organoids to Clinical Problems. | Chen HI et al. | β | 2019 | β |
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| Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. | Fantuzzo JA et al. | β | 2019 | β |
| Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2. | Dalla Vecchia E et al. | β | 2019 | β |
| Drug discovery in psychopharmacology: from 2D models to cerebral organoidsβ©. | Rossetti AC et al. | β | 2019 | β |
| Induced pluripotent stem cells for neural drug discovery. | Farkhondeh A et al. | β | 2019 | β |
| Modeling Psychiatric Diseases with Induced Pluripotent Stem Cells. | van Hugte E et al. | β | 2019 | β |
| Oligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interaction. | Raabe FJ et al. | β | 2019 | β |
| Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp. | Mis MA et al. | β | 2019 | β |
| Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. | Vadodaria KC et al. | β | 2019 | β |
| Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics. | Dib-Hajj SD et al. | β | 2019 | β |
| Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models. | Logan S et al. | β | 2019 | β |
| Transcriptome Changes in Relation to Manic Episode. | Lee YC et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
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| Potential Use of Stem Cells in Mood Disorders. | Colpo GD et al. | β | 2018 | β |
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| Mouse models and induced pluripotent stem cells in researching psychiatric disorders. | Deng B | β | 2017 | β |
| Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells. | Brennand KJ | β | 2017 | β |
| Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains. | Hoffman GE et al. | β | 2017 | β |
| Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease. | Wolf EJ et al. | β | 2017 | β |