Serotonin transporter gene polymorphisms in alcohol dependence.
paper
Cited
Public
Unavailable
- Authors
- Thompson, M D; Gonzalez, N; Nguyen, T; Comings, D E; George, S R; O'Dowd, B F
- Year
- 2000
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 11113619
- DOI
- 10.1016/s0741-8329(00)00105-1
The serotonin transporter (5-HTT) gene is a candidate gene in alcohol dependence because serotonin reuptake inhibitors (SRIs) can alleviate alcohol withdrawal. Studies of the 5-HTT gene in alcohol dependence have not resulted in a consensus. Recent studies have examined the transcriptionally active promoter polymorphism, a 44-bp deletion resulting in short (S) or long (L) alleles. In this study, 131 alcohol-dependent patients of Northern and Western European descent were genotyped. Seventy of these patients were diagnosed with alcohol dependence without comorbid disorders. Sixty-one patients were diagnosed with alcohol dependence comorbid with Tourette syndrome (alcoholic-TS). We found an excess of the S allele in alcohol-dependent patients (47%) compared with 125 ethnically matched controls (39%). A similar trend was found in 150 ethnically matched TS patients without alcohol dependence comorbidity (51%). However, the statistical significance of this trend in the data was not present after Bonferroni correction. The data presented suggests a trend toward increased frequency of the S promoter allele in alcohol-dependent, alcoholic-TS and TS patients.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors. | Rubens M et al. | — | 2016 | → |
| Associations of 5HTTLPR polymorphism with major depressive disorder and alcohol dependence: A systematic review and meta-analysis. | Oo KZ et al. | — | 2016 | → |
| Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy. | Thompson MD et al. | — | 2016 | → |
| A meta-analysis of the associations between the SLC6A4 promoter polymorphism (5HTTLPR) and the risk for alcohol dependence. | Villalba K et al. | — | 2015 | → |
| Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache. | Schürks M et al. | — | 2014 | → |
| Pharmacogenetics of the G protein-coupled receptors. | Thompson MD et al. | — | 2014 | → |
| Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder. | Cao J et al. | — | 2013 | → |
| [Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population]. | Wang XJ et al. | — | 2011 | → |
| Role of the serotonergic system in alcohol dependence: from animal models to clinics. | Sari Y et al. | — | 2011 | → |
| An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men. | Shin S et al. | — | 2010 | → |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | — | 2010 | → |
| The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. | McHugh RK et al. | — | 2010 | → |
| Differential role of serotonergic polymorphisms in alcohol and heroin dependence. | Saiz PA et al. | — | 2009 | → |
| Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. | Saraceno L et al. | — | 2009 | → |
| Psychological vulnerability differences in students--carriers or not of the serotonin transporter promoter allele S: effect of adverse experiences. | Veletza S et al. | — | 2009 | → |
| G protein-coupled receptor pharmacogenetics. | Thompson MD et al. | — | 2008 | → |
| Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case-control study. | Sieminska A et al. | — | 2008 | → |
| Mozart's movements and behaviour: a case of Tourette's syndrome? | Ashoori A et al. | — | 2008 | → |
| Serotonin transporter gene polymorphisms and sertraline response in major depression patients. | Dogan O et al. | — | 2008 | → |
| The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan. | Wu CY et al. | — | 2008 | → |
| A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. | Thompson MD et al. | — | 2007 | → |
| Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Dick DM et al. | — | 2007 | → |
| Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. | Covault J et al. | — | 2007 | → |
| Mozart's movements and behaviour: a case of Tourette's syndrome? | Ashoori A et al. | — | 2007 | → |
| Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. | Daws LC et al. | — | 2006 | → |
| Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). | Lorenz JG et al. | — | 2006 | → |
| Influence of the serotonin transporter gene on comorbid disorders among alcohol-dependent individuals. | Marques FZ et al. | — | 2006 | → |
| Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link? | Lesch KP | — | 2005 | → |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | — | 2005 | → |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | — | 2005 | → |
| Association between the serotonin transporter gene and alcohol consumption in social drinkers. | Munafò MR et al. | — | 2005 | → |
| Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. | Feinn R et al. | — | 2005 | → |
| The G protein-coupled receptors: pharmacogenetics and disease. | Thompson MD et al. | — | 2005 | → |
| [Alcohol dependence and polymorphisms of serotonin-related genes]. | Gorwood P et al. | — | 2004 | → |
| Alcoholism and seasonal affective disorder. | Sher L | — | 2004 | → |
| Association between low-activity serotonin transporter genotype and heroin dependence: behavioral and personality correlates. | Gerra G et al. | — | 2004 | → |
| Biological and behavioral markers of alcohol sensitivity. | Fromme K et al. | — | 2004 | → |
| Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. | Konishi T et al. | — | 2004 | → |
| Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. | Thompson MD et al. | — | 2004 | → |
| A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | Thompson MD et al. | — | 2003 | → |
| Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5-hydroxytryptamine-2c receptor). | Johann M et al. | — | 2003 | → |
| Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. | Hahn MK et al. | — | 2002 | → |
| Relationships between seasonality and alcohol use: a genetic hypothesis. | Sher L | — | 2002 | → |