High intensity dependence of auditory evoked dipole source activity indicates decreased serotonergic activity in abstinent ecstasy (MDMA) users.
paper
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- Authors
- Tuchtenhagen, F; Daumann, J; Norra, C; Gobbelé, R; Becker, S; Pelz, S; Sass, H; Buchner, H; Gouzoulis-Mayfrank, E
- Year
- 2000
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 10788760
- DOI
- 10.1016/S0893-133X(99)00140-2
Neurotoxic damage of central serotonergic systems has been demonstrated in numerous animal studies after exposure to methylenedioxyamphetamines (ecstasy). A high intensity dependence of auditory evoked potentials and, particularly, of the tangential N1/P2 source activity has been associated with low levels of serotonergic neurotransmission in humans. We performed an auditory evoked potentials study in 28 abstinent recreational ecstasy users and two equally sized groups of cannabis users and nonusers. The ecstasy users exhibited an increase of the amplitude of the tangential N1/P2 source activity with higher stimulus intensities; whereas, both control groups failed to exhibit this feature. These data are in line with the hypothesis that abstinent ecstasy users present with diminished central serotonergic activity. This feature of information processing is probably related to the well-recognized neurotoxic potential of ecstasy. Our data indicate that recreational ecstasy use may cause long-term alterations in the function (and possibly structure) of the human brain.
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| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mephedrone and MDMA: A comparative review. | Mead J et al. | — | 2020 | → |
| Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder. | Lijffijt M et al. | — | 2017 | → |
| The Loudness Dependence of Auditory Evoked Potentials (LDAEP) in individuals at risk for developing bipolar disorders and schizophrenia. | Hagenmuller F et al. | — | 2016 | → |
| Tobacco use is associated with reduced amplitude and intensity dependence of the cortical auditory evoked N1-P2 component. | Jawinski P et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Serotonin: from sensory processing to schizophrenia using an electrophysiological method. | Juckel G | — | 2015 | → |
| Trait impulsivity and increased pre-attentional sensitivity to intense stimuli in bipolar disorder and controls. | Lijffijt M et al. | — | 2015 | → |
| Brainstem raphe alterations depicted by transcranial sonography do not result in serotonergic functional impairment. | Krogias C et al. | — | 2013 | → |
| MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users. | Parrott AC | — | 2013 | → |
| Verbal memory deficits are correlated with prefrontal hypometabolism in (18)FDG PET of recreational MDMA users. | Bosch OG et al. | — | 2013 | → |
| Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology. | Schaaff N et al. | — | 2012 | → |
| The loudness dependence of auditory evoked potentials and effects of psychopathology and psychopharmacotherapy in psychiatric inpatients. | Ostermann J et al. | — | 2012 | → |
| Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participants. | Simmons JG et al. | — | 2011 | → |
| Determination of the loudness dependence of auditory evoked potentials: single-electrode estimation versus dipole source analysis. | Hagenmuller F et al. | — | 2011 | → |
| Evidence of neurotoxicity of ecstasy: sustained effects on electroencephalographic activity in polydrug users. | Adamaszek M et al. | — | 2010 | → |
| Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene. | Juckel G et al. | — | 2010 | → |
| Clinical symptoms of major depression are associated with the intensity dependence of auditory event-related potential components. | Linka T et al. | — | 2009 | → |
| Enhanced intensity dependence and aggression history indicate previous regular ecstasy use in abstinent polydrug users. | Wan L et al. | — | 2009 | → |
| Neuroendocrine and subjective responses to pharmacological challenge with citalopram: a controlled study in male and female ecstasy/MDMA users. | Allott K et al. | — | 2009 | → |
| No association between chronic cannabis use and loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission. | Roser P et al. | — | 2009 | → |
| Recent EEG and ERP findings in substance abusers. | Ceballos NA et al. | — | 2009 | → |
| [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials. | Pogarell O et al. | — | 2008 | → |
| An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertraline. | Guille V et al. | — | 2008 | → |
| Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers. | Juckel G et al. | — | 2008 | → |
| Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study. | de Sola S et al. | — | 2008 | → |
| Ecstasy (3,4-methylenedioxymethamphetamine)-induced inappropriate antidiuretic hormone secretion. | Farah R et al. | — | 2008 | → |
| Effects of selective and combined serotonin and dopamine depletion on the loudness dependence of the auditory evoked potential (LDAEP) in humans. | O'Neill BV et al. | — | 2008 | → |
| Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: associations with posttraumatic stress disorder. | Metzger LJ et al. | — | 2008 | → |
| Loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission: simultaneous electrophysiological recordings and in vivo microdialysis in the rat primary auditory cortex. | Wutzler A et al. | — | 2008 | → |
| Loudness dependence of evoked dipole source activity during acute serotonin challenge in females. | Norra C et al. | — | 2008 | → |
| Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users. | Hanson KL et al. | — | 2008 | → |
| The loudness dependence of the auditory evoked potential (LDAEP) as an in vivo biomarker of central serotonergic function in humans: rationale, evaluation and review of findings. | O'Neill BV et al. | — | 2008 | → |
| A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users. | de Win MM et al. | — | 2007 | → |
| Challenge tests of monoaminergic systems: neurophysiological aspects. | Norra C | — | 2007 | → |
| Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy"). | Quednow BB et al. | — | 2007 | → |
| Event-related potentials in psychiatry. | Pogarell O et al. | — | 2007 | → |
| High-dose glycine inhibits the loudness dependence of the auditory evoked potential (LDAEP) in healthy humans. | O'Neill BV et al. | — | 2007 | → |
| Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers. | Juckel G et al. | — | 2007 | → |
| Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice. | Pogarell O et al. | — | 2007 | → |
| The intensity dependence of auditory ERP components in unmedicated patients with major depression and healthy controls. An analysis of group differences. | Linka T et al. | — | 2007 | → |
| Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function. | Nathan PJ et al. | — | 2006 | → |
| Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humans. | O'Neill BV et al. | — | 2006 | → |
| Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study. | de Win MM et al. | — | 2006 | → |
| Event related potentials and fMRI in neuropsychopharmacology. | Pogarell O et al. | — | 2006 | → |
| Further evidence for an association of 5-HTTLPR with intensity dependence of auditory-evoked potentials. | Hensch T et al. | — | 2006 | → |
| Intensity dependence of auditory evoked dipole source activity in polydrug ecstasy users: evidence from an 18 months longitudinal study. | Daumann J et al. | — | 2006 | → |
| Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects? | Uhl I et al. | — | 2006 | → |
| MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress. | Parrott AC | — | 2006 | → |
| Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction. | Quednow BB et al. | — | 2006 | → |
| Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. | Thomasius R et al. | — | 2006 | → |
| Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage? | Gouzoulis-Mayfrank E et al. | — | 2006 | → |
| Association of BDNF serum concentrations with central serotonergic activity: evidence from auditory signal processing. | Lang UE et al. | — | 2005 | → |
| Pathways into ecstasy use: the role of prior cannabis use and ecstasy availability. | Zimmermann P et al. | — | 2005 | → |
| Serotonergic modulation of mismatch negativity. | Kähkönen S et al. | — | 2005 | → |
| Sound level dependence of the primary auditory cortex: Simultaneous measurement with 61-channel EEG and fMRI. | Mulert C et al. | — | 2005 | → |
| The P3 in 'ecstasy' polydrug users during response inhibition and execution. | Gamma A et al. | — | 2005 | → |
| Angry cognitive bias, trait aggression and impulsivity in substance users. | Bond AJ et al. | — | 2004 | → |
| Plasticity of the acoustic startle reflex in currently abstinent ecstasy (MDMA) users. | Heekeren K et al. | — | 2004 | → |
| Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. | Pogarell O et al. | — | 2004 | → |
| The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression. | Linka T et al. | — | 2004 | → |
| Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing. | Gallinat J et al. | — | 2003 | → |
| Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential. | Strobel A et al. | — | 2003 | → |
| Altered states: the clinical effects of Ecstasy. | Cole JC et al. | — | 2003 | → |
| Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia. | Umbricht D et al. | — | 2003 | → |
| Enhanced intensity dependence as a marker of low serotonergic neurotransmission in borderline personality disorder. | Norra C et al. | — | 2003 | → |
| Evidence for disturbed cortical signal processing and altered serotonergic neurotransmission in generalized anxiety disorder. | Senkowski D et al. | — | 2003 | → |
| Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users. | Thomasius R et al. | — | 2003 | → |
| Neurophysiologic correlates of psychiatric disorders and potential applications in epilepsy. | Halford JJ | — | 2003 | → |
| Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity. | Juckel G et al. | — | 2003 | → |
| Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion? | Debener S et al. | — | 2002 | → |
| Preventing problems in Ecstasy users: reduce use to reduce harm. | Baggott MJ | — | 2002 | → |
| Experimentally induced aggressive behavior in subjects with 3,4-methylenedioxy-methamphetamine ("Ecstasy") use history: psychobiological correlates. | Gerra G et al. | — | 2001 | → |
| The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs. | Kalant H | — | 2001 | → |