Inhibition of neurogenesis interferes with hippocampus-dependent memory function.
paper
Cited
Public
Unavailable
- Authors
- Winocur, Gordon; Wojtowicz, J Martin; Sekeres, Melanie; Snyder, Jason S; Wang, Sabrina
- Year
- 2006
- Journal
- Hippocampus
- PMID
- 16411241
- DOI
- 10.1002/hipo.20163
Rats treated with low dose irradiation, to inhibit adult hippocampal neurogenesis, and control rats were administered a non-matching-to-sample (NMTS) task, which measured conditional rule learning and memory for specific events, and a test of fear conditioning in which a discrete CS was paired with an aversive US in a complex environment. Irradiated rats were impaired on the NMTS task when the intervals between sample and test trials were relatively long, and in associating the shock-induced fear with contextual cues in the fear conditioning task. Irradiated rats were not impaired in learning the basic NMTS rule or in performing that task when the intervals between the sample and test trials were short. Nor were there group differences in conditioning the fear response to the CS in the fear conditioning task. The results, which extend the range of hippocampus-dependent tasks that can be said to be vulnerable to the effects of neurogenesis suppression, support the hypothesis that new hippocampal cells generated in adulthood participate in a broad range of hippocampal functions.
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| Title | Year | PMID |
|---|---|---|
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | 2013 | 23981442 |
| Stress, stress hormones, and adult neurogenesis. | 2012 | 21281629 |
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| Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain. | Ford EC et al. | β | 2011 | β |
| Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. | Conboy L et al. | β | 2011 | β |
| Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone. | Hamani C et al. | β | 2011 | β |
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| (-)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice. | Yoo KY et al. | β | 2010 | β |
| Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. | Luo Y et al. | β | 2010 | β |
| Hippocampal adult neurogenesis is enhanced by chronic eszopiclone treatment in rats. | Methippara M et al. | β | 2010 | β |
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| Moderate exercise delays the motor performance decline in a transgenic model of ALS. | Carreras I et al. | β | 2010 | β |
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| Noise trauma impairs neurogenesis in the rat hippocampus. | Kraus KS et al. | β | 2010 | β |
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| Prolactin-induced mitogenesis in the subventricular zone of the maternal brain during early pregnancy is essential for normal postpartum behavioral responses in the mother. | Larsen CM et al. | β | 2010 | β |
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| Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. | Noonan MA et al. | β | 2010 | β |
| Selective impairments to memory consolidation in chicks produced by 5'-iodo-2'-deoxyuridine. | Komissarova NV et al. | β | 2010 | β |
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| Treatment with progesterone after focal cerebral ischemia suppresses proliferation of progenitor cells but enhances survival of newborn neurons in adult male mice. | Zhang Z et al. | β | 2010 | β |
| Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. | Wong-Goodrich SJ et al. | β | 2010 | β |
| Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus. | Barr JL et al. | β | 2010 | β |
| Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. | Deng W et al. | β | 2009 | β |
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| Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging. | Pawluski JL et al. | β | 2009 | β |
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| Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. | HernΓ‘ndez-Rabaza V et al. | β | 2009 | β |
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| New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning. | Jaholkowski P et al. | β | 2009 | β |
| NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus. | Maekawa M et al. | β | 2009 | β |
| Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. | Correa DD et al. | β | 2009 | β |
| Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD. | Fishman K et al. | β | 2009 | β |
| Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. | Trouche S et al. | β | 2009 | β |
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| Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. | Shapiro LA et al. | β | 2009 | β |
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| The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors. | Zaben M et al. | β | 2009 | β |
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