Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.
paper
Cited
Public
Unavailable
- Authors
- Carlson, Christopher S; Eberle, Michael A; Rieder, Mark J; Yi, Qian; Kruglyak, Leonid; Nickerson, Deborah A
- Year
- 2004
- Journal
- American journal of human genetics
- PMID
- 14681826
- DOI
- 10.1086/381000
- PMCID
- PMC1181897
Common genetic polymorphisms may explain a portion of the heritable risk for common diseases. Within candidate genes, the number of common polymorphisms is finite, but direct assay of all existing common polymorphism is inefficient, because genotypes at many of these sites are strongly correlated. Thus, it is not necessary to assay all common variants if the patterns of allelic association between common variants can be described. We have developed an algorithm to select the maximally informative set of common single-nucleotide polymorphisms (tagSNPs) to assay in candidate-gene association studies, such that all known common polymorphisms either are directly assayed or exceed a threshold level of association with a tagSNP. The algorithm is based on the r(2) linkage disequilibrium (LD) statistic, because r(2) is directly related to statistical power to detect disease associations with unassayed sites. We show that, at a relatively stringent r(2) threshold (r2>0.8), the LD-selected tagSNPs resolve >80% of all haplotypes across a set of 100 candidate genes, regardless of recombination, and tag specific haplotypes and clades of related haplotypes in nonrecombinant regions. Thus, if the patterns of common variation are described for a candidate gene, analysis of the tagSNP set can comprehensively interrogate for main effects from common functional variation. We demonstrate that, although common variation tends to be shared between populations, tagSNPs should be selected separately for populations with different ancestries.
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| A whole-genome SNP array (RICE6K) for genomic breeding in rice. | Yu H et al. | β | 2014 | β |
| Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer. | Neslund-Dudas C et al. | β | 2014 | β |
| CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to BehΓ§et's disease in Koreans. | Park SR et al. | β | 2014 | β |
| COL1A1 polymorphism is associated with risks of osteosarcoma susceptibility and death. | He M et al. | β | 2014 | β |
| Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. | Lemaitre RN et al. | β | 2014 | β |
| Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways. | Hobbs CA et al. | β | 2014 | β |
| Development of a broad-based ADME panel for use in pharmacogenomic studies. | Brown AM et al. | β | 2014 | β |
| Dietary iron, iron homeostatic gene polymorphisms and the risk of advanced colorectal adenoma and cancer. | Ruder EH et al. | β | 2014 | β |
| DNA mismatch repair MSH2 gene-based SNP associated with different populations. | Abduljaleel Z et al. | β | 2014 | β |
| Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. | Cannon DS et al. | β | 2014 | β |
| Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. | Letra A et al. | β | 2014 | β |
| Gene-environment interactions and the risk of childhood acute lymphoblastic leukemia: exploring the role of maternal folate genes and folic Acid fortification. | Lupo PJ et al. | β | 2014 | β |
| Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination. | Kennedy RB et al. | β | 2014 | β |
| Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms. | MacArthur CJ et al. | β | 2014 | β |
| Gene variations in oestrogen pathways, CYP19A1, daily 17Ξ²-estradiol and mammographic density phenotypes in premenopausal women. | Flote VG et al. | β | 2014 | β |
| Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. | Ryan BM et al. | β | 2014 | β |
| Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. | Ide S et al. | β | 2014 | β |
| Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent. | Aminkeng F et al. | β | 2014 | β |
| Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease. | Costea I et al. | β | 2014 | β |
| LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population. | Xiao L et al. | β | 2014 | β |
| No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women. | Passarelli MN et al. | β | 2014 | β |
| Pharmacogenomic diversity in Singaporean populations and Europeans. | Brunham LR et al. | β | 2014 | β |
| Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers. | Li H et al. | β | 2014 | β |
| Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia. | Harmon QE et al. | β | 2014 | β |
| Population and genomic lessons from genetic analysis of two Indian populations. | Juyal G et al. | β | 2014 | β |
| Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer. | Geybels MS et al. | β | 2014 | β |
| Shared and independent colorectal cancer risk alleles in TGFΞ²-related genes in African and European Americans. | Kupfer SS et al. | β | 2014 | β |
| Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing: A Preliminary Investigation. | Sathyendra V et al. | β | 2014 | β |
| Single nucleotide polymorphisms in the metastasis-associated in colon cancer-1 gene predict the recurrence of hepatocellular carcinoma after transplantation. | Zheng Z et al. | β | 2014 | β |
| The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3. | Kim DS et al. | β | 2014 | β |
| The utility of low-density genotyping for imputation in the Thoroughbred horse. | Corbin LJ et al. | β | 2014 | β |
| Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal. | Tabak BA et al. | β | 2014 | β |
| 17q12-21 and asthma: interactions with early-life environmental exposures. | Blekic M et al. | β | 2013 | β |
| Age-dependent effect of the MAOA gene on childhood physical aggression. | Pingault JB et al. | β | 2013 | β |
| A genetic algorithm-support vector machine method with parameter optimization for selecting the tag SNPs. | Ilhan I et al. | β | 2013 | β |
| An integrative variant analysis pipeline for accurate genotype/haplotype inference in population NGS data. | Wang Y et al. | β | 2013 | β |
| A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. | Sheridan J et al. | β | 2013 | β |
| A small number of candidate gene SNPs reveal continental ancestry in African Americans. | Kodaman N et al. | β | 2013 | β |
| Association between genetic polymorphisms in Ca(v)2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. | Ide S et al. | β | 2013 | β |
| [Association between the myeloperoxidase gene polymorphisms and the susceptibility to prostate cancer: a case-control study in a Chinese population]. | Ding G et al. | β | 2013 | β |
| Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants. | Marcil V et al. | β | 2013 | β |
| Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. | Hawthorne F et al. | β | 2013 | β |
| Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates. | Cho P et al. | β | 2013 | β |
| Association of polymorphisms in natural killer cell-related genes with preterm birth. | Harmon QE et al. | β | 2013 | β |
| Association of serotonin transporter gene (SLC6A4) polymorphisms with schizophrenia susceptibility and symptoms in a Chinese-Han population. | Li W et al. | β | 2013 | β |
| Association of variants in estrogen-related pathway genes with prostate cancer risk. | Holt SK et al. | β | 2013 | β |
| Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case-control study. | He F et al. | β | 2013 | β |
| Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population. | Moon CM et al. | β | 2013 | β |
| Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity. | Ovsyannikova IG et al. | β | 2013 | β |
| Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure. | Bukvic BK et al. | β | 2013 | β |
| Automatic diagnosis of pathological myopia from heterogeneous biomedical data. | Zhang Z et al. | β | 2013 | β |
| Candidate gene studies in hypodontia suggest role for FGF3. | Vieira AR et al. | β | 2013 | β |
| Chiari malformation type I: a case-control association study of 58 developmental genes. | Urbizu A et al. | β | 2013 | β |
| Clinical significance of MYT1L gene polymorphisms in Chinese patients with gastric cancer. | Zhang Y et al. | β | 2013 | β |
| Common genetic variants in the 9p21 region and their associations with multiple tumours. | Gu F et al. | β | 2013 | β |
| Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer. | Brenner AV et al. | β | 2013 | β |
| Common single-nucleotide polymorphisms in the estrogen receptor Ξ² promoter are associated with colorectal cancer survival in postmenopausal women. | Passarelli MN et al. | β | 2013 | β |
| COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. | Makar KW et al. | β | 2013 | β |
| DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial. | Doherty JA et al. | β | 2013 | β |
| Efficiently identifying significant associations in genome-wide association studies. | Kostem E et al. | β | 2013 | β |
| ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: a model for erbB-2 negative human breast cancer. | Santos S et al. | β | 2013 | β |
| Evaluating coverage of exons by HapMap SNPs. | Dong X et al. | β | 2013 | β |
| Gene-based multiple regression association testing for combined examination of common and low frequency variants in quantitative trait analysis. | Yoo YJ et al. | β | 2013 | β |
| Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. | Carlson CS et al. | β | 2013 | β |
| Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. | Lin JY et al. | β | 2013 | β |
| Genetic variants in the vitamin D pathway and breast cancer disease-free survival. | Pande M et al. | β | 2013 | β |
| Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. | Kleinstein SE et al. | β | 2013 | β |
| Genome-wide and local pattern of linkage disequilibrium and persistence of phase for 3 Danish pig breeds. | Wang L et al. | β | 2013 | β |
| Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. | Zhang M et al. | β | 2013 | β |
| Genome-wide association study signal at the 12q12 locus for Crohn's disease may represent associations with the MUC19 gene. | Kumar V et al. | β | 2013 | β |
| Genotype imputation accuracy in a F2 pig population using high density and low density SNP panels. | GualdrΓ³n Duarte JL et al. | β | 2013 | β |
| Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. | Popanda O et al. | β | 2013 | β |
| GStream: improving SNP and CNV coverage on genome-wide association studies. | Alonso A et al. | β | 2013 | β |
| GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. | Bottolo L et al. | β | 2013 | β |
| How to select tag SNPs in genetic association studies? The CLONTagger method with parameter optimization. | Ilhan I et al. | β | 2013 | β |
| Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study. | Kraus S et al. | β | 2013 | β |
| Impact of marker ascertainment bias on genomic selection accuracy and estimates of genetic diversity. | Heslot N et al. | β | 2013 | β |
| Imputation-based genomic coverage assessments of current human genotyping arrays. | Nelson SC et al. | β | 2013 | β |
| Inferring polymorphism-induced regulatory gene networks active in human lymphocyte cell lines by weighted linear mixed model analysis of multiple RNA-Seq datasets. | Zhang W et al. | β | 2013 | β |
| Innate immunity gene polymorphisms and the risk of colorectal neoplasia. | Chang CM et al. | β | 2013 | β |
| Interleukin-13 genetic variants, household carpet use and childhood asthma. | Tsai CH et al. | β | 2013 | β |
| Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. | Swartz MD et al. | β | 2013 | β |
| Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes. | Slager SL et al. | β | 2013 | β |
| Neurotransmitter systems and neurotrophic factors in autism: association study of 37 genes suggests involvement of DDC. | Toma C et al. | β | 2013 | β |
| Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer. | Karami S et al. | β | 2013 | β |
| Polymorphisms in thymic stromal lymphopoietin gene demonstrate a gender and nasal polyposis-dependent association with chronic rhinosinusitis. | Zhang Y et al. | β | 2013 | β |
| Population parameters incorporated into genome-wide tagSNP selection. | Silesian AP et al. | β | 2013 | β |
| Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies. | Balan S et al. | β | 2013 | β |
| SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome. | Sun S et al. | β | 2013 | β |
| Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk. | Hussain SK et al. | β | 2013 | β |
| Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans. | Namkung JH et al. | β | 2013 | β |
| Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants. | Winters AH et al. | β | 2013 | β |
| Some polymorphisms in Epstein-Barr virus-induced gene 3 modify the risk for chronic rhinosinusitis. | Zhang Y et al. | β | 2013 | β |
| Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer. | Reid-Lombardo KM et al. | β | 2013 | β |
| Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. | Burke LS et al. | β | 2013 | β |
| Using a Bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. | Cao Y et al. | β | 2013 | β |
| VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy. | Peng J et al. | β | 2013 | β |
| Windfalls and pitfalls: Applications of population genetics to the search for disease genes. | Edge MD et al. | β | 2013 | β |
| 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. | Huang J et al. | β | 2012 | β |
| A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia. | Lupo PJ et al. | β | 2012 | β |
| A Collective Ranking Method for Genome-wide Association Studies. | Liu J et al. | β | 2012 | β |
| A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer. | Campa D et al. | β | 2012 | β |
| Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease. | Kim DS et al. | β | 2012 | β |
| AGTR1 gene variation: association with depression and frontotemporal morphology. | Taylor WD et al. | β | 2012 | β |
| An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples. | RibasΓ©s M et al. | β | 2012 | β |
| An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. | Lupo PJ et al. | β | 2012 | β |
| An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. | Abbott D et al. | β | 2012 | β |
| Antipsychotic-induced movement disorders in long-stay psychiatric patients and 45 tag SNPs in 7 candidate genes: a prospective study. | Bakker PR et al. | β | 2012 | β |
| Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects. | Zhang Y et al. | β | 2012 | β |
| Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population. | Lu R et al. | β | 2012 | β |
| Association of CLCNKB haplotypes and hypertension in Mongolian and Han populations. | Su X et al. | β | 2012 | β |
| Association of germline variation in CCNE1 and CDK2 with breast cancer risk, progression and survival among Chinese Han women. | Han JY et al. | β | 2012 | β |
| Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. | Daley D et al. | β | 2012 | β |
| Associations between maternal genotypes and metabolites implicated in congenital heart defects. | Chowdhury S et al. | β | 2012 | β |
| Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. | Li W et al. | β | 2012 | β |
| Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population. | Yamada K et al. | β | 2012 | β |
| A unified framework for haplotype inference in nuclear families. | Iliadis A et al. | β | 2012 | β |
| Bitter taste receptor polymorphisms and human aging. | Campa D et al. | β | 2012 | β |
| California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study. | Kharrazi M et al. | β | 2012 | β |
| Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. | RibasΓ©s M et al. | β | 2012 | β |
| Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. | Ji Y et al. | β | 2012 | β |
| Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. | Delaney JT et al. | β | 2012 | β |
| Combined polymorphisms in oxidative stress genes predict coronary artery disease and oxidative stress in coronary angiography patients. | Heslop CL et al. | β | 2012 | β |
| Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer. | Aschebrook-Kilfoy B et al. | β | 2012 | β |
| Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk. | Schonfeld SJ et al. | β | 2012 | β |
| Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia. | Karns R et al. | β | 2012 | β |
| Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. | Johnson CO et al. | β | 2012 | β |
| Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. | Wu JM et al. | β | 2012 | β |
| CUBN as a novel locus for end-stage renal disease: insights from renal transplantation. | Reznichenko A et al. | β | 2012 | β |
| DNA-repair gene variants are associated with glioblastoma survival. | Wibom C et al. | β | 2012 | β |
| Effects of vitamin A and D receptor gene polymorphisms/haplotypes on immune responses to measles vaccine. | Ovsyannikova IG et al. | β | 2012 | β |
| Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. | Montesanto A et al. | β | 2012 | β |
| Fine-mapping CASP8 risk variants in breast cancer. | Camp NJ et al. | β | 2012 | β |
| Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. | Lemas DJ et al. | β | 2012 | β |
| Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population. | Wang H et al. | β | 2012 | β |
| Genetic variability in IL23R and risk of colorectal adenoma and colorectal cancer. | Poole EM et al. | β | 2012 | β |
| Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans. | Takata Y et al. | β | 2012 | β |
| Genetic variation in myosin 1H contributes to mandibular prognathism. | Tassopoulou-Fishell M et al. | β | 2012 | β |
| Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk. | Barry KH et al. | β | 2012 | β |
| Genotyping of single nucleotide polymorphisms by 5' nuclease allelic discrimination. | Malkki M et al. | β | 2012 | β |
| Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers. | Sakoda LC et al. | β | 2012 | β |
| Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation. | Ji Y et al. | β | 2012 | β |
| Identification of haplotype tag single nucleotide polymorphisms within the receptor for advanced glycation end products gene and their clinical relevance in patients with major trauma. | Zeng L et al. | β | 2012 | β |
| Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. | Mikuls TR et al. | β | 2012 | β |
| LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era. | Cerhan JR et al. | β | 2012 | β |
| Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse. | Wu JM et al. | β | 2012 | β |
| Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. | Gilsing AM et al. | β | 2012 | β |
| miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines. | Zhang W et al. | β | 2012 | β |
| Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. | Yu H et al. | β | 2012 | β |
| Mouse models of cancer: does the strain matter? | Hunter KW | β | 2012 | β |
| Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. | Kennedy RB et al. | β | 2012 | β |
| Multiple ant colony algorithm method for selecting tag SNPs. | Liao B et al. | β | 2012 | β |
| NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. | Amre DK et al. | β | 2012 | β |
| NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. | Sandford AJ et al. | β | 2012 | β |
| No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density. | Vachon CM et al. | β | 2012 | β |
| Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes. | Slattery ML et al. | β | 2012 | β |
| Polymorphism of THBS1 rs1478604 A>G in 5-untranslated region is associated with lymph node metastasis of gastric cancer in a Southeast Chinese population. | Lin XD et al. | β | 2012 | β |
| Polymorphisms in immune function genes and non-Hodgkin lymphoma survival. | Aschebrook-Kilfoy B et al. | β | 2012 | β |
| Population model-based inter-diplotype similarity measure for accurate diplotype clustering. | Onuki R et al. | β | 2012 | β |
| Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey. | Jeff JM et al. | β | 2012 | β |
| Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. | Takata Y et al. | β | 2012 | β |
| Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. | Hebbring SJ et al. | β | 2012 | β |
| Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer. | Safaeian M et al. | β | 2012 | β |
| Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects. | Zhang Y et al. | β | 2012 | β |
| Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. | Chen LS et al. | β | 2012 | β |
| SNP discovery, expression and cis-regulatory variation in the UGT2B genes. | Sun C et al. | β | 2012 | β |
| SNP mining in C. clementina BAC end sequences; transferability in the Citrus genus (Rutaceae), phylogenetic inferences and perspectives for genetic mapping. | Ollitrault P et al. | β | 2012 | β |
| The bovine CXCR1 gene is highly polymorphic. | Pighetti GM et al. | β | 2012 | β |
| The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk. | Andreotti G et al. | β | 2012 | β |
| Transferability and fine mapping of genome-wide associated loci for lipids in African Americans. | Adeyemo A et al. | β | 2012 | β |
| Variant on chromosome 9p is associated with left ventricular mass: results from two cohorts of essential hypertensive individuals. | Menni C et al. | β | 2012 | β |
| A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals. | Ling Y et al. | β | 2011 | β |
| A comparison of approaches to account for uncertainty in analysis of imputed genotypes. | Zheng J et al. | β | 2011 | β |
| ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. | Cohen SS et al. | β | 2011 | β |
| A hidden two-locus disease association pattern in genome-wide association studies. | Yang C et al. | β | 2011 | β |
| A multistage association study identifies a breast cancer genetic locus at NCOA7. | Higginbotham KS et al. | β | 2011 | β |
| Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas. | Berntsson SG et al. | β | 2011 | β |
| A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk. | Hosgood HD et al. | β | 2011 | β |
| A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk. | Sun C et al. | β | 2011 | β |
| A single nucleotide polymorphism in NF-ΞΊB inducing kinase is associated with mortality in septic shock. | Thair SA et al. | β | 2011 | β |
| Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin. | Carrai M et al. | β | 2011 | β |
| Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock. | Nakada TA et al. | β | 2011 | β |
| Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study. | Zakai NA et al. | β | 2011 | β |
| Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph). | Butterbach K et al. | β | 2011 | β |
| Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population. | Namkung JH et al. | β | 2011 | β |
| Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation. | Ro H et al. | β | 2011 | β |
| Association of TNFSF8 polymorphisms with peripheral neutrophil count. | Arruda-Olson AM et al. | β | 2011 | β |
| Association of TSC gene variants and hypertension in Mongolian and Han populations. | Chang PY et al. | β | 2011 | β |
| Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination. | Haralambieva IH et al. | β | 2011 | β |
| Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease. | Krupoves A et al. | β | 2011 | β |
| Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study. | Ling Y et al. | β | 2011 | β |
| Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample. | Jitoku D et al. | β | 2011 | β |
| Association study of RELN polymorphisms with schizophrenia in Han Chinese population. | Li W et al. | β | 2011 | β |
| A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population. | Sun H et al. | β | 2011 | β |
| Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation. | Feng Q et al. | β | 2011 | β |
| Centrosome-related genes, genetic variation, and risk of breast cancer. | Olson JE et al. | β | 2011 | β |
| Cerivastatin, genetic variants, and the risk of rhabdomyolysis. | Marciante KD et al. | β | 2011 | β |
| Characterization of novel and uncharacterized p53 SNPs in the Chinese population--intron 2 SNP co-segregates with the common codon 72 polymorphism. | Phang BH et al. | β | 2011 | β |
| Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. | Sakoda LC et al. | β | 2011 | β |
| Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma. | Zhang AQ et al. | β | 2011 | β |
| Common genetic variants related to genomic integrity and risk of papillary thyroid cancer. | Neta G et al. | β | 2011 | β |
| Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes. | Nyante SJ et al. | β | 2011 | β |
| Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans. | Haralambieva IH et al. | β | 2011 | β |
| Common variants in the periostin gene influence development of atherosclerosis in young persons. | Hixson JE et al. | β | 2011 | β |
| Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. | Signorello LB et al. | β | 2011 | β |
| Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead. | van Bemmel DM et al. | β | 2011 | β |
| Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk. | Gibson TM et al. | β | 2011 | β |
| Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. | RibasΓ©s M et al. | β | 2011 | β |
| Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection. | Park JE et al. | β | 2011 | β |
| Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. | Hoffmann TJ et al. | β | 2011 | β |
| DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. | Gao Y et al. | β | 2011 | β |
| Effect of heme oxygenase-1 polymorphisms on lung function and gene expression. | Tanaka G et al. | β | 2011 | β |
| Efficient genomewide selection of PCA-correlated tSNPs for genotype imputation. | Javed A et al. | β | 2011 | β |
| Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma. | Li R et al. | β | 2011 | β |
| Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine. | Haralambieva IH et al. | β | 2011 | β |
| Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. | Juran BD et al. | β | 2011 | β |
| Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer. | Poole EM et al. | β | 2011 | β |
| Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case-control study of Chinese Han population. | Du W et al. | β | 2011 | β |
| Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer risk. | Barry KH et al. | β | 2011 | β |
| Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival. | Slattery ML et al. | β | 2011 | β |
| Genetic variation in DNA repair pathway genes and melanoma risk. | Zhang M et al. | β | 2011 | β |
| Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers. | Neuhausen SL et al. | β | 2011 | β |
| Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. | Ronald J et al. | β | 2011 | β |
| Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer. | Madeleine MM et al. | β | 2011 | β |
| Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. | Gong J et al. | β | 2011 | β |
| Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies. | Lan Q et al. | β | 2011 | β |
| Genetic variation in the FAS gene and associations with acute lung injury. | Glavan BJ et al. | β | 2011 | β |
| Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes. | Trabert B et al. | β | 2011 | β |
| Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer. | Li Y et al. | β | 2011 | β |
| Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy. | Li Y et al. | β | 2011 | β |
| Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism. | Heit JA et al. | β | 2011 | β |
| Genomics of the NF-ΞΊB signaling pathway: hypothesized role in ovarian cancer. | White KL et al. | β | 2011 | β |
| Haplotypes and haplotype-pairs of IL-1 beta and IL-6 genes and risk of non fatal myocardial infarction in the Western New York Acute MI Study. | de Gaetano M et al. | β | 2011 | β |
| Identification of a combination of SNPs associated with Graves' disease using swarm intelligence. | Wei B et al. | β | 2011 | β |
| Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. | Kovacic MB et al. | β | 2011 | β |
| Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease. | Lingappa JR et al. | β | 2011 | β |
| Implication of next-generation sequencing on association studies. | Siu H et al. | β | 2011 | β |
| Including non-additive genetic effects in Bayesian methods for the prediction of genetic values based on genome-wide markers. | Wittenburg D et al. | β | 2011 | β |
| Increasing power of genome-wide association studies by collecting additional single-nucleotide polymorphisms. | Kostem E et al. | β | 2011 | β |
| Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population. | Chen Q et al. | β | 2011 | β |
| Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer. | Yang XR et al. | β | 2011 | β |
| Leucyl/cystinyl aminopeptidase gene variants in septic shock. | Nakada TA et al. | β | 2011 | β |
| Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers. | Swamy GK et al. | β | 2011 | β |
| Modeling of environmental and genetic interactions with AMBROSIA, an information-theoretic model synthesis method. | Chanda P et al. | β | 2011 | β |
| MYH9 and APOL1 are both associated with sickle cell disease nephropathy. | Ashley-Koch AE et al. | β | 2011 | β |
| New contributions to the study of common double mutants in the human LDL receptor gene. | Tejedor MT et al. | β | 2011 | β |
| Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. | Hoffmann TJ et al. | β | 2011 | β |
| Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer. | Glubb DM et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial. | Cresci S et al. | β | 2011 | β |
| Phred-Phrap package to analyses tools: a pipeline to facilitate population genetics re-sequencing studies. | Machado M et al. | β | 2011 | β |
| Pituitary tumor transforming gene-1 haplotypes and risk of pituitary adenoma: a case-control study. | Chen S et al. | β | 2011 | β |
| Polymorphisms in ABCB1 and ERCC2 associated with ovarian cancer outcome. | Peethambaram P et al. | β | 2011 | β |
| Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. | Adams LA et al. | β | 2011 | β |
| Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk. | Seibold P et al. | β | 2011 | β |
| Polymorphisms in the MUC16 gene: potential implication in epithelial ovarian cancer. | Bouanene H et al. | β | 2011 | β |
| Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck. | Yu H et al. | β | 2011 | β |
| POMC and TP53 genetic variability and risk of basal cell carcinoma of skin: Interaction between host and genetic factors. | Rizzato C et al. | β | 2011 | β |
| Robust linear regression methods in association studies. | LourenΓ§o VM et al. | β | 2011 | β |
| Sequential Support Vector Regression with Embedded Entropy for SNP Selection and Disease Classification. | Liang Y et al. | β | 2011 | β |
| Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. | Morey RA et al. | β | 2011 | β |
| Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis. | Takata Y et al. | β | 2011 | β |
| Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population. | Liao LH et al. | β | 2011 | β |
| SNPPicker: high quality tag SNP selection across multiple populations. | Sicotte H et al. | β | 2011 | β |
| Soluble CD14 and CD14 polymorphisms in rheumatoid arthritis. | Mikuls TR et al. | β | 2011 | β |
| Strategies for genotyping. | Crawford DC et al. | β | 2011 | β |
| Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer. | Pankratz VS et al. | β | 2011 | β |
| Technological issues and experimental design of gene association studies. | Distefano JK et al. | β | 2011 | β |
| The association between variants on chromosome 9p21 and inflammatory biomarkers in ethnically diverse women with coronary heart disease: a pilot study. | Beckie TM et al. | β | 2011 | β |
| The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms. | Ovsyannikova IG et al. | β | 2011 | β |
| The influence of genetic variation in surfactant protein B on severe lung injury in African American children. | Dahmer MK et al. | β | 2011 | β |
| The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans. | Perera MA et al. | β | 2011 | β |
| The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. | Leduc MS et al. | β | 2011 | β |
| The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity. | Ovsyannikova IG et al. | β | 2011 | β |
| Tight junction defects in patients with atopic dermatitis. | De Benedetto A et al. | β | 2011 | β |
| Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour. | Kratz CP et al. | β | 2011 | β |
| Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC). | Campa D et al. | β | 2011 | β |
| Variation in innate immunity genes and risk of multiple myeloma. | Purdue MP et al. | β | 2011 | β |
| Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey. | Dumitrescu L et al. | β | 2011 | β |
| Variations in chromosomes 9 and 6p21.3 with risk of non-Hodgkin lymphoma. | Wang SS et al. | β | 2011 | β |
| Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer. | Koutros S et al. | β | 2011 | β |
| 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine. | Haralambieva IH et al. | β | 2010 | β |
| A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. | Jia Y et al. | β | 2010 | β |
| A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. | Campa D et al. | β | 2010 | β |
| Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. | Zhang L et al. | β | 2010 | β |
| A haplotype of glycogen synthase kinase 3Ξ² is associated with early onset of unipolar major depression. | Saus E et al. | β | 2010 | β |
| A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. | Cree BA et al. | β | 2010 | β |
| Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia. | Maekawa M et al. | β | 2010 | β |
| APC Yin-Yang haplotype associated with colorectal cancer risk. | Garre P et al. | β | 2010 | β |
| Application of single nucleotide polymorphisms to non-model species: a technical review. | Garvin MR et al. | β | 2010 | β |
| Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. | Iwayama Y et al. | β | 2010 | β |
| Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. | Schildkraut JM et al. | β | 2010 | β |
| Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population. | Suazo J et al. | β | 2010 | β |
| Association of hepsin gene variants with prostate cancer risk and prognosis. | Holt SK et al. | β | 2010 | β |
| Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. | Namkung JH et al. | β | 2010 | β |
| Association of transforming growth factor-Ξ²1 gene variants with risk of coal workers' pneumoconiosis. | Qian H et al. | β | 2010 | β |
| Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers. | Park SL et al. | β | 2010 | β |
| Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment. | Pankratz VS et al. | β | 2010 | β |
| Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. | Yang XR et al. | β | 2010 | β |
| Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies. | Fridley BL et al. | β | 2010 | β |
| Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. | Friedlander Y et al. | β | 2010 | β |
| Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans. | Bordicchia M et al. | β | 2010 | β |
| Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. | Yang Z et al. | β | 2010 | β |
| Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. | Mangravite LM et al. | β | 2010 | β |
| Common genetic variants and risk for HPV persistence and progression to cervical cancer. | Wang SS et al. | β | 2010 | β |
| Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. | Peloso GM et al. | β | 2010 | β |
| Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes. | Yang HP et al. | β | 2010 | β |
| Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis. | Van Hee VC et al. | β | 2010 | β |
| Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. | Fornage M et al. | β | 2010 | β |
| Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. | Wang Y et al. | β | 2010 | β |
| Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. | Zhang G et al. | β | 2010 | β |
| Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2 deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age. | Turkovic L et al. | β | 2010 | β |
| Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity. | Sucheston L et al. | β | 2010 | β |
| Contrasting methods of quantifying fine structure of human recombination. | Clark AG et al. | β | 2010 | β |
| C-reactive protein and risk of lung cancer. | Chaturvedi AK et al. | β | 2010 | β |
| Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome. | Zheng J et al. | β | 2010 | β |
| Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. | Soria V et al. | β | 2010 | β |
| Diversity in the glucose transporter-4 gene (SLC2A4) in humans reflects the action of natural selection along the old-world primates evolution. | Tarazona-Santos E et al. | β | 2010 | β |
| Efficient genome-wide TagSNP selection across populations via the linkage disequilibrium criterion. | Liu L et al. | β | 2010 | β |
| Estimating effect sizes in genome-wide association studies. | BukszΓ‘r J et al. | β | 2010 | β |
| Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". | Johnatty SE et al. | β | 2010 | β |
| Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study. | Palmer ND et al. | β | 2010 | β |
| Extent and distribution of linkage disequilibrium in the Old Order Amish. | Van Hout CV et al. | β | 2010 | β |
| FastTagger: an efficient algorithm for genome-wide tag SNP selection using multi-marker linkage disequilibrium. | Liu G et al. | β | 2010 | β |
| Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. | Theodoraki EV et al. | β | 2010 | β |
| Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. | Letra A et al. | β | 2010 | β |
| General lessons from large-scale studies to identify human cancer predisposition genes. | Cazier JB et al. | β | 2010 | β |
| Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults. | Costea I et al. | β | 2010 | β |
| Genetic evaluation of Angus cattle for carcass marbling using ultrasound and genomic indicators. | MacNeil MD et al. | β | 2010 | β |
| Genetic polymorphisms and human sensitivity to opioid analgesics. | Nishizawa D et al. | β | 2010 | β |
| Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival. | Han X et al. | β | 2010 | β |
| Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. | Markunas CA et al. | β | 2010 | β |
| Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. | Slattery ML et al. | β | 2010 | β |
| Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. | Laje G et al. | β | 2010 | β |
| Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. | Poole EM et al. | β | 2010 | β |
| Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma. | Clifford RJ et al. | β | 2010 | β |
| Genome-wide association studies in cancer--current and future directions. | Chung CC et al. | β | 2010 | β |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | β | 2010 | β |
| Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14. | Fitzgerald LM et al. | β | 2010 | β |
| Genotype imputation for genome-wide association studies. | Marchini J et al. | β | 2010 | β |
| Haplotype analyses, mechanism and evolution of common double mutants in the human LDL receptor gene. | Tejedor MT et al. | β | 2010 | β |
| Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans. | Namkung JH et al. | β | 2010 | β |
| IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. | Cardoso CC et al. | β | 2010 | β |
| Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. | Grucza RA et al. | β | 2010 | β |
| Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. | Carty CL et al. | β | 2010 | β |
| Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. | Becker ML et al. | β | 2010 | β |
| Introduction to linkage disequilibrium, the HapMap, and imputation. | Neale BM | β | 2010 | β |
| Linkage and association studies of joint morbidity from rheumatoid arthritis. | Min JY et al. | β | 2010 | β |
| Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models. | Fridley BL et al. | β | 2010 | β |
| Low linkage disequilibrium in wild Anopheles gambiae s.l. populations. | Harris C et al. | β | 2010 | β |
| MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. | Li Y et al. | β | 2010 | β |
| Methods: genetic epidemiology. | Benke KS et al. | β | 2010 | β |
| MISS: a non-linear methodology based on mutual information for genetic association studies in both population and sib-pairs analysis. | Brunel H et al. | β | 2010 | β |
| MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. | JagomΓ€gi T et al. | β | 2010 | β |
| Multi-objective tag SNPs selection using evolutionary algorithms. | Ting CK et al. | β | 2010 | β |
| Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricaemia in Han Chinese. | Li C et al. | β | 2010 | β |
| Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. | Hersh CP et al. | β | 2010 | β |
| Novel cleft susceptibility genes in chromosome 6q. | Letra A et al. | β | 2010 | β |
| Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. | Moore LE et al. | β | 2010 | β |
| Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer. | Koutros S et al. | β | 2010 | β |
| Pharmacogenomics of suicidal events. | Brent D et al. | β | 2010 | β |
| Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum. | Harris C et al. | β | 2010 | β |
| Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. | Hoeft B et al. | β | 2010 | β |
| Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya. | Zhang L et al. | β | 2010 | β |
| Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. | Ovsyannikova IG et al. | β | 2010 | β |
| Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study. | Campa D et al. | β | 2010 | β |
| Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. | Koutros S et al. | β | 2010 | β |
| Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. | Dupont WD et al. | β | 2010 | β |
| PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). | Dossus L et al. | β | 2010 | β |
| Risk of ovarian cancer and inherited variants in relapse-associated genes. | Peedicayil A et al. | β | 2010 | β |
| Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. | Ovsyannikova IG et al. | β | 2010 | β |
| Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels. | Zhang Y et al. | β | 2010 | β |
| Sex-specific association of the Reelin gene with bipolar disorder. | Goes FS et al. | β | 2010 | β |
| Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome. | Heike CL et al. | β | 2010 | β |
| SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine. | Dhiman N et al. | β | 2010 | β |
| Tag SNP selection using particle swarm optimization. | Chuang LY et al. | β | 2010 | β |
| The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women. | Tong SY et al. | β | 2010 | β |
| The missing linkage: what pharmacogenetic associations are left to find in CYP3A? | Perera MA | β | 2010 | β |
| The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data. | Kumasaka N et al. | β | 2010 | β |
| Variants in blood pressure genes and the risk of renal cell carcinoma. | Andreotti G et al. | β | 2010 | β |
| Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study. | Wassel CL et al. | β | 2010 | β |
| Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome. | Locke AE et al. | β | 2010 | β |
| Variation in genes required for normal mitosis and risk of breast cancer. | Olson JE et al. | β | 2010 | β |
| VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. | Crawford DC et al. | β | 2010 | β |
| Whole genome single nucleotide polymorphism associations with feed intake and feed efficiency in beef cattle. | Sherman EL et al. | β | 2010 | β |
| A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder. | Real E et al. | β | 2009 | β |
| A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies. | Sun YV et al. | β | 2009 | β |
| Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. | MΓ©nard V et al. | β | 2009 | β |
| An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. | Dong LM et al. | β | 2009 | β |
| A neurologist's guide to genome-wide association studies. | Mullen SA et al. | β | 2009 | β |
| A novel study design to investigate the early-life origins of asthma in children (SAGE study). | Kozyrskyj AL et al. | β | 2009 | β |
| A pilot genome-wide association study of early-onset breast cancer. | Kibriya MG et al. | β | 2009 | β |
| Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. | Moore LE et al. | β | 2009 | β |
| A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. | Purdue MP et al. | β | 2009 | β |
| Application of genome-wide SNP data for uncovering pairwise relationships and quantitative trait loci. | Sham PC et al. | β | 2009 | β |
| Application of principal component analysis to pharmacogenomic studies in Canada. | Visscher H et al. | β | 2009 | β |
| Approaches to the identification of susceptibility genes. | Collins A | β | 2009 | β |
| A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation. | Wu LM et al. | β | 2009 | β |
| Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. | Hosgood HD et al. | β | 2009 | β |
| Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery. | Nishizawa D et al. | β | 2009 | β |
| Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis. | Ragland M et al. | β | 2009 | β |
| Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study. | Carty CL et al. | β | 2009 | β |
| Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. | Sperati CJ et al. | β | 2009 | β |
| Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. | Pal P et al. | β | 2009 | β |
| Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. | Sherva R et al. | β | 2009 | β |
| Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population. | Krupoves A et al. | β | 2009 | β |
| Asthma and genes encoding components of the vitamin D pathway. | BossΓ© Y et al. | β | 2009 | β |
| A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans. | Deka R et al. | β | 2009 | β |
| A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. | He JQ et al. | β | 2009 | β |
| AXIS inhibition protein 2, orofacial clefts and a family history of cancer. | Menezes R et al. | β | 2009 | β |
| Bayesian variable and model selection methods for genetic association studies. | Fridley BL | β | 2009 | β |
| Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. | Goode EL et al. | β | 2009 | β |
| Candidate gene association mapping of Arabidopsis flowering time. | Ehrenreich IM et al. | β | 2009 | β |
| Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies. | Zhang J et al. | β | 2009 | β |
| Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. | Cunningham JM et al. | β | 2009 | β |
| CGTS: a site-clustering graph based tagSNP selection algorithm in genotype data. | Wang J et al. | β | 2009 | β |
| Coevolution of interacting fertilization proteins. | Clark NL et al. | β | 2009 | β |
| Common genetic variation and haplotypes of the anion exchanger SLC4A2 in primary biliary cirrhosis. | Juran BD et al. | β | 2009 | β |
| Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population. | Li R et al. | β | 2009 | β |
| Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk. | Wang SS et al. | β | 2009 | β |
| Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study. | Reiner AP et al. | β | 2009 | β |
| Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. | Abraham JE et al. | β | 2009 | β |
| Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry. | Pal P et al. | β | 2009 | β |
| Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. | Park KH et al. | β | 2009 | β |
| C-reactive protein genotypes and haplotypes, polymorphisms in NSAID-metabolizing enzymes, and risk of colorectal polyps. | Poole EM et al. | β | 2009 | β |
| Database mining for selection of SNP markers useful in admixture mapping. | Baye TM et al. | β | 2009 | β |
| Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. | Stanford JL et al. | β | 2009 | β |
| Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group. | Bromley CM et al. | β | 2009 | β |
| Developments in statistical analysis in quantitative genetics. | Sorensen D | β | 2009 | β |
| Discovering novel risk factors for venous thrombosis: a candidate-gene approach. | Smith NL et al. | β | 2009 | β |
| Discovering the genetics underlying foetal haemoglobin production in adults. | Thein SL et al. | β | 2009 | β |
| Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions. | Higasa K et al. | β | 2009 | β |
| Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. | RibasΓ©s M et al. | β | 2009 | β |
| Family-based association of FKBP5 in bipolar disorder. | Willour VL et al. | β | 2009 | β |
| Family-based association study of Neuregulin 1 with psychotic bipolar disorder. | Goes FS et al. | β | 2009 | β |
| Finding common susceptibility variants for complex disease: past, present and future. | Panoutsopoulou K et al. | β | 2009 | β |
| Fine mapping and association analysis of a quantitative trait locus for milk production traits on Bos taurus autosome 4. | RincΓ³n G et al. | β | 2009 | β |
| Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. | Lou H et al. | β | 2009 | β |
| Fully non-homogeneous hidden Markov model double net: a generative model for haplotype reconstruction and block discovery. | Perina A et al. | β | 2009 | β |
| Galanin preproprotein is associated with elevated plasma triglycerides. | Plaisier CL et al. | β | 2009 | β |
| Gene mapping in the wild with SNPs: guidelines and future directions. | Slate J et al. | β | 2009 | β |
| Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility. | Pereira AC et al. | β | 2009 | β |
| Genetic epidemiology in aging research. | Fallin MD et al. | β | 2009 | β |
| Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. | Han X et al. | β | 2009 | β |
| Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. | Breyer JP et al. | β | 2009 | β |
| Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. | Anand SS et al. | β | 2009 | β |
| Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study. | Nan H et al. | β | 2009 | β |
| Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. | Ross CJ et al. | β | 2009 | β |
| Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. | Zheng Z et al. | β | 2009 | β |
| Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. | Sotoodehnia N et al. | β | 2009 | β |
| Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. | Novak AJ et al. | β | 2009 | β |
| Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk. | Hosgood HD et al. | β | 2009 | β |
| Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study. | Maley SN et al. | β | 2009 | β |
| Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk. | Han J et al. | β | 2009 | β |
| Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. | Campa D et al. | β | 2009 | β |
| Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. | Becker ML et al. | β | 2009 | β |
| Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus. | Becker ML et al. | β | 2009 | β |
| Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | Sullivan PF et al. | β | 2009 | β |
| Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. | Paterson AD et al. | β | 2009 | β |
| Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. | Org E et al. | β | 2009 | β |
| Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. | Liang X et al. | β | 2009 | β |
| Global haplotype partitioning for maximal associated SNP pairs. | Katanforoush A et al. | β | 2009 | β |
| Human genetic variation and its contribution to complex traits. | Frazer KA et al. | β | 2009 | β |
| Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. | GratacΓ²s M et al. | β | 2009 | β |
| Identifying rarer genetic variants for common complex diseases: diseased versus neutral discovery panels. | Curtin K et al. | β | 2009 | β |
| IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study. | Enquobahrie DA et al. | β | 2009 | β |
| Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. | Walston JD et al. | β | 2009 | β |
| Integrative predictive model of coronary artery calcification in atherosclerosis. | McGeachie M et al. | β | 2009 | β |
| Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease. | Amre DK et al. | β | 2009 | β |
| Is there still a need for candidate gene approaches in the era of genome-wide association studies? | Wilkening S et al. | β | 2009 | β |
| Maximizing power in association studies. | Halperin E et al. | β | 2009 | β |
| Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. | Saccone NL et al. | β | 2009 | β |
| Next generation tools for the annotation of human SNPs. | Karchin R | β | 2009 | β |
| No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. | Teras LR et al. | β | 2009 | β |
| Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. | Arnett DK et al. | β | 2009 | β |
| Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. | Shaw DM et al. | β | 2009 | β |
| Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. | Wu X et al. | β | 2009 | β |
| Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L. | McWilliams RR et al. | β | 2009 | β |
| Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. | McWilliams RR et al. | β | 2009 | β |
| Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer. | White KL et al. | β | 2009 | β |
| Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. | Peedicayil A et al. | β | 2009 | β |
| Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium. | Johnatty SE et al. | β | 2009 | β |
| PPARΞ³2 polymorphism and human health. | He W | β | 2009 | β |
| Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans. | Perera MA et al. | β | 2009 | β |
| Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). | Ahn J et al. | β | 2009 | β |
| Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans. | Flibotte S et al. | β | 2009 | β |
| Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study. | MacClellan LR et al. | β | 2009 | β |
| Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. | Peters EJ et al. | β | 2009 | β |
| Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. | Morton LM et al. | β | 2009 | β |
| Signals of recent positive selection in a worldwide sample of human populations. | Pickrell JK et al. | β | 2009 | β |
| Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population. | Kim E et al. | β | 2009 | β |
| Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. | Schildkraut JM et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population. | Lins TC et al. | β | 2009 | β |
| TGFBR1 haplotypes and risk of non-small-cell lung cancer. | Lei Z et al. | β | 2009 | β |
| The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis. | Chen YC et al. | β | 2009 | β |
| The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations. | Schnabel RB et al. | β | 2009 | β |
| Tissue factor gene polymorphisms and haplotypes and the risk of ischemic vascular events: four studies and a meta-analysis. | DE Gaetano M et al. | β | 2009 | β |
| Two-stage case-control association study of dopamine-related genes and migraine. | Corominas R et al. | β | 2009 | β |
| Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation. | Egyud MR et al. | β | 2009 | β |
| Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. | Lemaitre RN et al. | β | 2009 | β |
| Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. | Ahn J et al. | β | 2009 | β |
| X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. | Siddiqui RA et al. | β | 2009 | β |
| Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer. | Koutros S et al. | β | 2009 | β |
| XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study. | Zhou K et al. | β | 2009 | β |
| Ability of whole-genome SNP arrays to capture 'must have' pharmacogenomic variants. | Peters EJ et al. | β | 2008 | β |
| A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. | GratacΓ²s M et al. | β | 2008 | β |
| A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. | Weiss RB et al. | β | 2008 | β |
| Accounting for haplotype phase uncertainty in linkage disequilibrium estimation. | Kulle B et al. | β | 2008 | β |
| A common haplotype within the PON1 promoter region is associated with sporadic ALS. | Landers JE et al. | β | 2008 | β |
| A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. | Crawford DC et al. | β | 2008 | β |
| A comparison of methods to detect recombination hotspots. | Tapper W et al. | β | 2008 | β |
| Adaptations to climate in candidate genes for common metabolic disorders. | Hancock AM et al. | β | 2008 | β |
| Admixture mapping and the role of population structure for localizing disease genes. | Zhu X et al. | β | 2008 | β |
| A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer. | Campa D et al. | β | 2008 | β |
| A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer. | Yaspan BL et al. | β | 2008 | β |
| A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women. | Agueda L et al. | β | 2008 | β |
| A high-density association screen of 155 ion transport genes for involvement with common migraine. | Nyholt DR et al. | β | 2008 | β |
| An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome 1q21-q25. | Hu C et al. | β | 2008 | β |
| A new framework for the selection of tag SNPs by multimarker haplotypes. | Huang YT et al. | β | 2008 | β |
| A powerful and flexible multilocus association test for quantitative traits. | Kwee LC et al. | β | 2008 | β |
| Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design. | Sun YV et al. | β | 2008 | β |
| Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. | Levan TD et al. | β | 2008 | β |
| Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. | He JQ et al. | β | 2008 | β |
| Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults. | Kullo IJ et al. | β | 2008 | β |
| Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects. | Grarup N et al. | β | 2008 | β |
| Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. | RibasΓ©s M et al. | β | 2008 | β |
| Association study of Wnt signaling pathway genes in bipolar disorder. | Zandi PP et al. | β | 2008 | β |
| A statistical method for predicting classical HLA alleles from SNP data. | Leslie S et al. | β | 2008 | β |
| A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. | Dick DM et al. | β | 2008 | β |
| beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke. | Lemaitre RN et al. | β | 2008 | β |
| Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study. | Fornage M et al. | β | 2008 | β |
| Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. | Figueroa JD et al. | β | 2008 | β |
| Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms. | Ji Y et al. | β | 2008 | β |
| Can genes for mammographic density inform cancer aetiology? | Kelemen LE et al. | β | 2008 | β |
| Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2. | Hussain SK et al. | β | 2008 | β |
| Characterization of LD structures and the utility of HapMap in genetic association studies. | Gu CC et al. | β | 2008 | β |
| Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. | Enquobahrie DA et al. | β | 2008 | β |
| Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction. | Meiner V et al. | β | 2008 | β |
| Clinical and genetic correlates of soluble P-selectin in the community. | Lee DS et al. | β | 2008 | β |
| Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. | Shi J et al. | β | 2008 | β |
| Combining association tests across multiple genetic markers in case-control studies. | Zhou H et al. | β | 2008 | β |
| Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults. | Lange LA et al. | β | 2008 | β |
| Common genetic variation and human disease. | Orr N et al. | β | 2008 | β |
| Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke. | Hindorff LA et al. | β | 2008 | β |
| Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. | Assimes TL et al. | β | 2008 | β |
| Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. | Teo YY | β | 2008 | β |
| Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. | Marciante KD et al. | β | 2008 | β |
| Comprehensive analysis of DNA repair gene variants and risk of meningioma. | Bethke L et al. | β | 2008 | β |
| Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma. | Bethke L et al. | β | 2008 | β |
| Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA. | Leduc MS et al. | β | 2008 | β |
| Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers. | Yeager M et al. | β | 2008 | β |
| Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. | Keating BJ et al. | β | 2008 | β |
| Correction of population stratification in large multi-ethnic association studies. | Serre D et al. | β | 2008 | β |
| CYBB, an NADPH-oxidase gene: restricted diversity in humans and evidence for differential long-term purifying selection on transmembrane and cytosolic domains. | Tarazona-Santos E et al. | β | 2008 | β |
| Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. | Krjutskov K et al. | β | 2008 | β |
| Does strong linkage disequilibrium guarantee redundant association results? | Nielsen DM et al. | β | 2008 | β |
| Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. | Leng S et al. | β | 2008 | β |
| Effect of genetic divergence in identifying ancestral origin using HAPAA. | Sundquist A et al. | β | 2008 | β |
| Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population. | Hu C et al. | β | 2008 | β |
| Efficient association study design via power-optimized tag SNP selection. | Han B et al. | β | 2008 | β |
| Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. | Leak TS et al. | β | 2008 | β |
| Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study. | Edwards AO et al. | β | 2008 | β |
| Examining the statistical properties of fine-scale mapping in large-scale association studies. | Wiltshire S et al. | β | 2008 | β |
| Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder. | Alonso P et al. | β | 2008 | β |
| Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. | Knowles JW et al. | β | 2008 | β |
| Family-based SNP association study on 8q24 in bipolar disorder. | Zandi PP et al. | β | 2008 | β |
| FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. | Rakovski CS et al. | β | 2008 | β |
| Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. | Johanneson B et al. | β | 2008 | β |
| Gender differences in genetic risk profiles for cardiovascular disease. | Silander K et al. | β | 2008 | β |
| Genetic association studies. | Lunetta KL | β | 2008 | β |
| Genetic landscape of the people of India: a canvas for disease gene exploration. | Indian Genome Variation Consortium | β | 2008 | β |
| Genetic modifiers of the beta-haemoglobinopathies. | Thein SL | β | 2008 | β |
| Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans. | Huo D et al. | β | 2008 | β |
| Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease. | Wong C et al. | β | 2008 | β |
| Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy. | Simhan HN et al. | β | 2008 | β |
| Genetic susceptibility to childhood leukaemia. | Chokkalingam AP et al. | β | 2008 | β |
| Genetic susceptibility to infection-mediated preterm birth. | Himes KP et al. | β | 2008 | β |
| Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 gene. | Alonso P et al. | β | 2008 | β |
| Genetic susceptibility to occupational exposures. | Christiani DC et al. | β | 2008 | β |
| Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. | Qin L et al. | β | 2008 | β |
| Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. | Zhang Z et al. | β | 2008 | β |
| Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men. | Zhao HL et al. | β | 2008 | β |
| Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study. | He MA et al. | β | 2008 | β |
| Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors. | Figueroa JD et al. | β | 2008 | β |
| Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. | Garner CP et al. | β | 2008 | β |
| Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. | Tremblay K et al. | β | 2008 | β |
| Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies. | Kelemen LE et al. | β | 2008 | β |
| Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. | Purdue MP et al. | β | 2008 | β |
| Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. | Kelemen LE et al. | β | 2008 | β |
| Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck. | Basta PV et al. | β | 2008 | β |
| Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population. | Yea SS et al. | β | 2008 | β |
| Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis. | Kindmark A et al. | β | 2008 | β |
| Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. | Turner ST et al. | β | 2008 | β |
| Haplotype analysis of ABCA3: association with respiratory distress in very premature infants. | Karjalainen MK et al. | β | 2008 | β |
| HapMap tagSNP transferability in multiple populations: general guidelines. | Xing J et al. | β | 2008 | β |
| High altitude adaptation: genetic perspectives. | Stobdan T et al. | β | 2008 | β |
| Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. | Pardanani A et al. | β | 2008 | β |
| Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans. | Huang RS et al. | β | 2008 | β |
| Imputing missing genotypic data of single-nucleotide polymorphisms using neural networks. | Sun YV et al. | β | 2008 | β |
| Integrating host genomics with surveillance for invasive bacterial diseases. | Crawford DC et al. | β | 2008 | β |
| Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. | Zhu G et al. | β | 2008 | β |
| International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. | Hung RJ et al. | β | 2008 | β |
| Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. | Ittiwut C et al. | β | 2008 | β |
| Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites. | Kardia SL et al. | β | 2008 | β |
| Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach. | Amre DK et al. | β | 2008 | β |
| Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. | Wu H et al. | β | 2008 | β |
| Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. | ZΓΌchner S et al. | β | 2008 | β |
| Linkage disequilibrium between IRF6 variants and nonsyndromic cleft lip/palate in the Chilean population. | Suazo J et al. | β | 2008 | β |
| Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. | Slatkin M | β | 2008 | β |
| Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. | Chien JW et al. | β | 2008 | β |
| MarkerSet: a marker selection tool based on markers location and informativity in experimental designs. | Demeure O et al. | β | 2008 | β |
| Maternal and fetal C-reactive protein genotype and first trimester CRP concentrations in maternal plasma. | Hackney DN et al. | β | 2008 | β |
| Maternal and fetal Toll-like receptor 4 genotype and chorionic plate inflammatory lesions. | Simhan HN et al. | β | 2008 | β |
| Mathematical properties of the r2 measure of linkage disequilibrium. | VanLiere JM et al. | β | 2008 | β |
| Missing data imputation and haplotype phase inference for genome-wide association studies. | Browning SR | β | 2008 | β |
| Molecular population genetics of PCSK9: a signature of recent positive selection. | Ding K et al. | β | 2008 | β |
| Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele. | Niemann S et al. | β | 2008 | β |
| Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. | Al-Kateb H et al. | β | 2008 | β |
| Neurotransmission and bipolar disorder: a systematic family-based association study. | Shi J et al. | β | 2008 | β |
| On transferability of genome-wide tagSNPs. | Gu CC et al. | β | 2008 | β |
| Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS. | Wills AM et al. | β | 2008 | β |
| Patterns of linkage disequilibrium between SNPs in a Sardinian population isolate and the selection of markers for association studies. | Angius A et al. | β | 2008 | β |
| PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis. | Shi J et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study. | Golembesky AK et al. | β | 2008 | β |
| Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. | Palmieri RT et al. | β | 2008 | β |
| Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. | Shao M et al. | β | 2008 | β |
| Polymorphisms in mitochondrial genes and prostate cancer risk. | Wang L et al. | β | 2008 | β |
| Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). | Dossus L et al. | β | 2008 | β |
| Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma. | Liu Y et al. | β | 2008 | β |
| Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. | Reiner AP et al. | β | 2008 | β |
| Population differences in the International Multi-Centre ADHD Gene Project. | Neale BM et al. | β | 2008 | β |
| Population substructure and control selection in genome-wide association studies. | Yu K et al. | β | 2008 | β |
| Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene. | Juran BD et al. | β | 2008 | β |
| PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. | Reiner AP et al. | β | 2008 | β |
| PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging. | Hennig BJ et al. | β | 2008 | β |
| Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping. | Iles MM | β | 2008 | β |
| Refinement of 2q and 7p loci in a large multiplex NTD family. | Stamm DS et al. | β | 2008 | β |
| Reporting and interpretation in genome-wide association studies. | Wakefield J | β | 2008 | β |
| Selecting predictive markers for pharmacogenetic traits: tagging vs. data-mining approaches. | Sabbagh A et al. | β | 2008 | β |
| Sequence variants in the PLEKHH2 region are associated with diabetic nephropathy in the GoKinD study population. | Greene CN et al. | β | 2008 | β |
| Sequence variation in the human transcription factor gene POU5F1. | Hussain SK et al. | β | 2008 | β |
| Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene. | Innocenti F et al. | β | 2008 | β |
| Single-nucleotide polymorphisms and haplotypes in the VEGF receptor 3 gene and the haplotype GC in the VEGFA gene are associated with psoriasis in Koreans. | Lee JH et al. | β | 2008 | β |
| Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. | Ferguson LR et al. | β | 2008 | β |
| Singleton SNPs in the human genome and implications for genome-wide association studies. | Ke X et al. | β | 2008 | β |
| Snagger: a user-friendly program for incorporating additional information for tagSNP selection. | Edlund CK et al. | β | 2008 | β |
| SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis. | Constantine CC et al. | β | 2008 | β |
| SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. | Kollins SH et al. | β | 2008 | β |
| Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China. | Qin S et al. | β | 2008 | β |
| Tagging single nucleotide polymorphisms in MBD4 are associated with risk of lung cancer in a Chinese population. | Miao R et al. | β | 2008 | β |
| Testing for equality of standardized composite measures of linkage disequilibrium. | Hamilton DC et al. | β | 2008 | β |
| The environmental genome project: reference polymorphisms for drug metabolism genes and genome-wide association studies. | Rieder MJ et al. | β | 2008 | β |
| The genetic basis of primary biliary cirrhosis: premises, not promises. | Invernizzi P et al. | β | 2008 | β |
| The modifying effect of C-reactive protein gene polymorphisms on the association between central obesity and endometrial cancer risk. | Wen W et al. | β | 2008 | β |
| TNF polymorphisms and prostate cancer risk. | Danforth KN et al. | β | 2008 | β |
| Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. | Wurfel MM et al. | β | 2008 | β |
| Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India. | Pemberton TJ et al. | β | 2008 | β |
| Utilizing HapMap and tagging SNPs. | Haiman CA et al. | β | 2008 | β |
| Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. | Welch RA et al. | β | 2008 | β |
| Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. | Winkelmann J et al. | β | 2008 | β |
| Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke. | Smith NL et al. | β | 2008 | β |
| Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. | Bis JC et al. | β | 2008 | β |
| Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment. | Krauss RM et al. | β | 2008 | β |
| Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome. | Crowley JJ et al. | β | 2008 | β |
| Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases. | Yang HH et al. | β | 2008 | β |
| Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. | Gardner M et al. | β | 2008 | β |
| WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. | Lee JC et al. | β | 2008 | β |
| A Bayesian multilocus association method: allowing for higher-order interaction in association studies. | Albrechtsen A et al. | β | 2007 | β |
| Accounting for genotyping errors in tagging SNP selection. | Liu W et al. | β | 2007 | β |
| A comprehensive examination of CYP19 variation and breast density. | Olson JE et al. | β | 2007 | β |
| A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families. | Amundsen SS et al. | β | 2007 | β |
| A critical analysis of barriers to the clinical implementation of pharmacogenomics. | McKinnon RA et al. | β | 2007 | β |
| Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. | Mercader JM et al. | β | 2007 | β |
| A model-based approach to capture genetic variation for future association studies. | Eyheramendy S et al. | β | 2007 | β |
| Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. | Kraft JB et al. | β | 2007 | β |
| A new multimarker test for family-based association studies. | Rakovski CS et al. | β | 2007 | β |
| An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. | Giraud M et al. | β | 2007 | β |
| A novel method combining linkage disequilibrium information and imputed functional knowledge for tagSNP selection. | Rochat RH et al. | β | 2007 | β |
| A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression. | Bieli C et al. | β | 2007 | β |
| A review of feature selection techniques in bioinformatics. | Saeys Y et al. | β | 2007 | β |
| Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. | Zabetian CP et al. | β | 2007 | β |
| Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia. | Williams HJ et al. | β | 2007 | β |
| Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor. | Su X et al. | β | 2007 | β |
| Association mapping of susceptibility loci for rheumatoid arthritis. | Kuo TY et al. | β | 2007 | β |
| Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease. | Seo J et al. | β | 2007 | β |
| Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. | Paddock S et al. | β | 2007 | β |
| Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans. | Kim E et al. | β | 2007 | β |
| Building individualized medicine: prevention of adverse reactions to warfarin therapy. | Krynetskiy E et al. | β | 2007 | β |
| Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. | Saccone SF et al. | β | 2007 | β |
| Combining functional and linkage disequilibrium information in the selection of tag SNPs. | Sham PC et al. | β | 2007 | β |
| Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study. | Lu X et al. | β | 2007 | β |
| Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. | Owen KR et al. | β | 2007 | β |
| Comparative assessment of the association information captured by SNP tagging. | Nothnagel M et al. | β | 2007 | β |
| Comparison of ENCODE region SNPs between Cebu Filipino and Asian HapMap samples. | Marvelle AF et al. | β | 2007 | β |
| Comparison of tagging single-nucleotide polymorphism methods in association analyses. | Goode EL et al. | β | 2007 | β |
| Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. | Yu CE et al. | β | 2007 | β |
| Computer-aided identification of polymorphism sets diagnostic for groups of bacterial and viral genetic variants. | Price EP et al. | β | 2007 | β |
| COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. | Cheng I et al. | β | 2007 | β |
| C-Reactive protein haplotype predicts serum C-reactive protein levels but not cardiovascular disease risk in a dialysis cohort. | Zhang L et al. | β | 2007 | β |
| Cytokine gene polymorphism and progression of renal and cardiovascular diseases. | Rao M et al. | β | 2007 | β |
| Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction? | Meza M et al. | β | 2007 | β |
| D-HaploDB: a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples. | Higasa K et al. | β | 2007 | β |
| Dopamine genes and schizophrenia: case closed or evidence pending? | Talkowski ME et al. | β | 2007 | β |
| Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. | Vandenbergh DJ et al. | β | 2007 | β |
| DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene. | Duan J et al. | β | 2007 | β |
| Effectiveness of in silico tagSNP selection methods: virtual analysis of the genotypes of pharmacogenetic genes. | Nam MH et al. | β | 2007 | β |
| Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. | Zhang D et al. | β | 2007 | β |
| Efficacy assessment of SNP sets for genome-wide disease association studies. | Wollstein A et al. | β | 2007 | β |
| Efficient multilocus association testing for whole genome association studies using localized haplotype clustering. | Browning BL et al. | β | 2007 | β |
| Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. | MΓ€gi R et al. | β | 2007 | β |
| Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. | Figueroa JD et al. | β | 2007 | β |
| Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project. | Nannya Y et al. | β | 2007 | β |
| Functional polymorphism in human CYP4F2 decreases 20-HETE production. | Stec DE et al. | β | 2007 | β |
| Gamma-glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose. | Rieder MJ et al. | β | 2007 | β |
| Gene-centric characteristics of genome-wide association studies. | Dong C et al. | β | 2007 | β |
| Gene discovery in diabetic nephropathy. | Savage DA et al. | β | 2007 | β |
| Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. | Pare G et al. | β | 2007 | β |
| Genetic association of complex traits: using idiopathic scoliosis as an example. | Cheng JC et al. | β | 2007 | β |
| Genetic association with rheumatoid arthritis-Genetic Analysis Workshop 15: summary of contributions from Group 2. | Wilcox MA et al. | β | 2007 | β |
| Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. | Laje G et al. | β | 2007 | β |
| Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. | Li H et al. | β | 2007 | β |
| Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. | Knowles JW et al. | β | 2007 | β |
| Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. | Wu H et al. | β | 2007 | β |
| Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk. | Gaudet MM et al. | β | 2007 | β |
| Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. | Russo P et al. | β | 2007 | β |
| Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. | Schymick JC et al. | β | 2007 | β |
| Genome-wide selection of tag SNPs using multiple-marker correlation. | Hao K | β | 2007 | β |
| Genomics: guilt by association. | Bowcock AM | β | 2007 | β |
| Genotyping of triallelic SNPs using TaqMan PCR. | Morita A et al. | β | 2007 | β |
| Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk. | Yaspan BL et al. | β | 2007 | β |
| Haplotype thinking in lung disease. | Silverman EK | β | 2007 | β |
| High-throughput SNP genotyping by SBE/SBH. | MΔndoiu II et al. | β | 2007 | β |
| IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. | Namkung JH et al. | β | 2007 | β |
| IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. | Walston JD et al. | β | 2007 | β |
| Impact of marker density on the accuracy of association mapping. | Zhang W et al. | β | 2007 | β |
| Imputation-based analysis of association studies: candidate regions and quantitative traits. | Servin B et al. | β | 2007 | β |
| Informative SNP selection methods based on SNP prediction. | He J et al. | β | 2007 | β |
| Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. | Thompson EE et al. | β | 2007 | β |
| Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. | Qi L et al. | β | 2007 | β |
| Intra- and interpopulation genotype reconstruction from tagging SNPs. | Paschou P et al. | β | 2007 | β |
| Introgression of Alectoris chukar genes into a Spanish wild Alectoris rufa population. | Tejedor MT et al. | β | 2007 | β |
| Investigation of the PARK10 gene in Parkinson disease. | Li YJ et al. | β | 2007 | β |
| Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk. | GarcΓa-Closas M et al. | β | 2007 | β |
| LdCompare: rapid computation of single- and multiple-marker r2 and genetic coverage. | Hao K et al. | β | 2007 | β |
| Leveraging the HapMap correlation structure in association studies. | Zaitlen N et al. | β | 2007 | β |
| Linkage analysis using principal components of gene expression data. | Atkinson EJ et al. | β | 2007 | β |
| Methods for the selection of tagging SNPs: a comparison of tagging efficiency and performance. | Ding K et al. | β | 2007 | β |
| Mitochondrial genetic background modifies breast cancer risk. | Bai RK et al. | β | 2007 | β |
| Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study. | Al-Kateb H et al. | β | 2007 | β |
| Multipoint linkage-disequilibrium mapping with haplotype-block structure. | Zheng M et al. | β | 2007 | β |
| Mycobacterial infections: PARK2 and PACRG associations in leprosy. | Schurr E et al. | β | 2007 | β |
| No association of trace amine receptor genes with bipolar disorder. | Liu C et al. | β | 2007 | β |
| No evidence for association between 19 cholinergic genes and bipolar disorder. | Shi J et al. | β | 2007 | β |
| Novel human pathological mutations. Gene symbol: NF1. Disease: neurofibromatosis 1. | Li SC et al. | β | 2007 | β |
| Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. | Wu H et al. | β | 2007 | β |
| Pattern-recognition techniques with haplotype analysis in pharmacogenomics. | Lin E et al. | β | 2007 | β |
| Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis. | Macaluso F et al. | β | 2007 | β |
| Polymorphisms of interleukin-10 and its receptor and lung function in COPD. | He JQ et al. | β | 2007 | β |
| Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits. | Meshkani R et al. | β | 2007 | β |
| Population genetic tools: application to cancer. | Gabriel S | β | 2007 | β |
| Power analysis for genome-wide association studies. | Klein RJ | β | 2007 | β |
| Power to detect risk alleles using genome-wide tag SNP panels. | Eberle MA et al. | β | 2007 | β |
| Prediction of complex traits based on the epistasis of multiple haplotypes. | Liang KH et al. | β | 2007 | β |
| Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Browning SR et al. | β | 2007 | β |
| Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients. | Marciante KD et al. | β | 2007 | β |
| Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. | Craig RL et al. | β | 2007 | β |
| Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. | Crawford NP et al. | β | 2007 | β |
| Selection of genes and single nucleotide polymorphisms for fine mapping starting from a broad linkage region. | Windelinckx A et al. | β | 2007 | β |
| Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. | Bai Y et al. | β | 2007 | β |
| Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. | Yasuno K et al. | β | 2007 | β |
| Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population. | Ma H et al. | β | 2007 | β |
| Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. | Pal P et al. | β | 2007 | β |
| Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. | Boonyasrisawat W et al. | β | 2007 | β |
| TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. | Carlson CS et al. | β | 2007 | β |
| Tag SNPs chosen from HapMap perform well in several population isolates. | Service S et al. | β | 2007 | β |
| Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data. | Xu Z et al. | β | 2007 | β |
| TAGster: efficient selection of LD tag SNPs in single or multiple populations. | Xu Z et al. | β | 2007 | β |
| TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach. | Cozza A et al. | β | 2007 | β |
| The alpha(1S) subunit of the L-type calcium channel is not a predisposition gene for thyrotoxic periodic paralysis. | Tang NL et al. | β | 2007 | β |
| The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies. | Pereira LH et al. | β | 2007 | β |
| The diploid genome sequence of an individual human. | Levy S et al. | β | 2007 | β |
| The extent of linkage disequilibrium in rice (Oryza sativa L.). | Mather KA et al. | β | 2007 | β |
| The future of pediatric cancer and complex diseases: aren't they all? | Chanock S et al. | β | 2007 | β |
| The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods. | de Andrade M et al. | β | 2007 | β |
| Understanding the accuracy of statistical haplotype inference with sequence data of known phase. | AndrΓ©s AM et al. | β | 2007 | β |
| Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. | Li GS et al. | β | 2007 | β |
| Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people. | Grarup N et al. | β | 2007 | β |
| Whole genome genotyping technologies on the BeadArray platform. | Steemers FJ et al. | β | 2007 | β |
| An efficient family-based association test using multiple markers. | Xu X et al. | β | 2006 | β |
| A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. | Conrad DF et al. | β | 2006 | β |
| Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. | Chi PB et al. | β | 2006 | β |
| Computation of haplotypes on SNPs subsets: advantage of the "global method". | Coulonges C et al. | β | 2006 | β |
| Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. | Crawford DC et al. | β | 2006 | β |
| Genome-wide tagging SNPs with entropy-based Monte Carlo method. | Liu Z et al. | β | 2006 | β |
| iHAP--integrated haplotype analysis pipeline for characterizing the haplotype structure of genes. | Song CM et al. | β | 2006 | β |
| Molecular evolution of 5' flanking regions of 87 candidate genes for atherosclerotic cardiovascular disease. | Ding K et al. | β | 2006 | β |
| Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15. | Boyles AL et al. | β | 2006 | β |
| Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. | Chatterjee N et al. | β | 2006 | β |
| Quantifying bias due to allele misclassification in case-control studies of haplotypes. | Govindarajulu US et al. | β | 2006 | β |
| Transferability of tag SNPs in genetic association studies in multiple populations. | de Bakker PI et al. | β | 2006 | β |