Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression.
paper
Cited
Public
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- Authors
- Overstreet, David H; Keeney, Adam; Hogg, Sandra
- Year
- 2004
- Journal
- European journal of pharmacology
- PMID
- 15178365
- DOI
- 10.1016/j.ejphar.2004.04.010
Due to the interest in the antidepressant potential of nonpeptide corticotropin-releasing factor (CRF)(1) receptor antagonists, the present investigation examined the antidepressant-like effects of the CRF(1) receptor antagonist CP-154,526 on the exaggerated swim test immobility in the Flinders Sensitive Line (FSL) rat, a genetic animal model of depression. Chronic treatment with CP-154,526 (10 mg/kg; 2x day) for 14 days increased swimming in the Flinders Sensitive Line rats. Citalopram (5 and 10 mg/kg; 2x day) and desipramine (5 mg/kg; 1x day) also significantly increased swimming in the Flinders Sensitive Line rats, as expected. However, neither CP-154,526 nor citalopram (10 mg/kg) altered swimming times in the control Flinders Resistant Line (FRL) rats. Citalopram (10 mg/kg) and CP-154,526 also increased the abnormally low level of social interaction behavior in the Flinders Sensitive Line rats. These findings indicate that citalopram and CP154,526, a CRF(1) receptor antagonist, have both antidepressant and anxiolytic effects that can be detected in an experimental model of depression only and not in "normal" control animals.
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|---|---|---|---|---|
| Drug development in psychiatry: 50 years of failure and how to resuscitate it. | Nutt DJ | β | 2025 | β |
| Investigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue. | Ates I et al. | β | 2025 | β |
| Comparative Efficacy of Animal Depression Models and Antidepressant Treatment: A Systematic Review and Meta-Analysis. | Ratajczak P et al. | β | 2024 | β |
| Evaluation of New Approaches to Depression Treatment Using an Animal Model of Pharmacoresistant Depression. | Zvozilova A et al. | β | 2024 | β |
| Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice. | Mueller LE et al. | β | 2024 | β |
| A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior. | Gao F et al. | β | 2022 | β |
| Partial resistance to citalopram in a Wistar-Kyoto rat model of depression: An evaluation using resting-state functional MRI and graph analysis. | Li Q et al. | β | 2022 | β |
| Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression. | Happ DF et al. | β | 2021 | β |
| Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. | Knudsen JK et al. | β | 2021 | β |
| The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression. | Melas PA et al. | β | 2021 | β |
| Corticotropin-releasing hormone 1 receptor antagonism attenuates chronic unpredictable mild stress-induced depressive-like behaviors in rats. | Wang XB et al. | β | 2020 | β |
| Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. | Daniels S et al. | β | 2020 | β |
| Role of corticotropin-releasing factor in alcohol and nicotine addiction. | Simpson S et al. | β | 2020 | β |
| High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats. | O'Flaherty B et al. | β | 2019 | β |
| Adolescent environmental enrichment prevents behavioral and physiological sequelae of adolescent chronic stress in female (but not male) rats. | Smith BL et al. | β | 2018 | β |
| Behavioral and physiological consequences of enrichment loss in rats. | Smith BL et al. | β | 2017 | β |
| Inhibition of the CRF<sub>1</sub> receptor influences the activity of antidepressant drugs in the forced swim test in rats. | WrΓ³bel A et al. | β | 2017 | β |
| Maternal separation increases later immobility during forced swim in guinea pig pups: evidence for sensitization of a depressive-like state. | Hennessy MB et al. | β | 2017 | β |
| Pathogenesis of depression: Insights from human and rodent studies. | MΓ©nard C et al. | β | 2016 | β |
| Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and red wavelengths. | Salehpour F et al. | β | 2016 | β |
| Altered explorative strategies and reactive coping style in the FSL rat model of depression. | Magara S et al. | β | 2015 | β |
| Decreased in vivo Ξ±2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression. | Landau AM et al. | β | 2015 | β |
| Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. | FemenΓa T et al. | β | 2015 | β |
| Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. | Mokoena ML et al. | β | 2015 | β |
| The forced swim test as a model of depressive-like behavior. | Yankelevitch-Yahav R et al. | β | 2015 | β |
| Ξ±2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats. | Lillethorup TP et al. | β | 2015 | β |
| Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity. | Howerton AR et al. | β | 2014 | β |
| Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. | Zorrilla EP et al. | β | 2013 | β |
| Effects of fluoxetine on CRF and CRF1 expression in rats exposed to the learned helplessness paradigm. | FernΓ‘ndez Macedo GV et al. | β | 2013 | β |
| Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala. | Flandreau EI et al. | β | 2013 | β |
| The flinders sensitive line rat model of depression--25 years and still producing. | Overstreet DH et al. | β | 2013 | β |
| Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. | Melas PA et al. | β | 2012 | β |
| Dysfunctional hippocampal activity affects emotion and cognition in mood disorders. | FemenΓa T et al. | β | 2012 | β |
| Modeling depression in animal models. | Overstreet DH | β | 2012 | β |
| Selectively bred rodents as models of depression and anxiety. | Wegener G et al. | β | 2012 | β |
| The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. | Skelin I et al. | β | 2012 | β |
| Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression. | Hascup KN et al. | β | 2011 | β |
| Behavioral effects of neuropeptides in rodent models of depression and anxiety. | Rotzinger S et al. | β | 2010 | β |
| Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner. | Allen PJ et al. | β | 2010 | β |
| Nerve growth factor (NGF) has novel antidepressant-like properties in rats. | Overstreet DH et al. | β | 2010 | β |
| Neural pathways in allergic inflammation. | Mirotti L et al. | β | 2010 | β |
| Prenatal alcohol exposure and chronic mild stress differentially alter depressive- and anxiety-like behaviors in male and female offspring. | Hellemans KG et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models. | Kehne JH et al. | β | 2010 | β |
| Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins. | Moulin-Sallanon M et al. | β | 2009 | β |
| Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats. | Kanemaru K et al. | β | 2009 | β |
| Sex-related differential response to clomipramine treatment in a rat model of depression. | Kokras N et al. | β | 2009 | β |
| The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. | Bosch OJ et al. | β | 2009 | β |
| Two different putative genetic animal models of childhood depression--a review. | Malkesman O et al. | β | 2009 | β |
| Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation. | Kanemaru K et al. | β | 2008 | β |
| A final common pathway for depression? Progress toward a general conceptual framework. | Stone EA et al. | β | 2008 | β |
| Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. | Overstreet DH et al. | β | 2008 | β |
| Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress. | Valentine G et al. | β | 2008 | β |
| Housing conditions modulate escitalopram effects on antidepressive-like behaviour and brain neurochemistry. | BjΓΈrnebekk A et al. | β | 2008 | β |
| A final common pathway for depression: implications for therapy. | Stone EA | β | 2007 | β |
| Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. | Hodgson RA et al. | β | 2007 | β |
| Different behaviors and different strains: potential new ways to model bipolar disorder. | Einat H | β | 2007 | β |
| Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. | Murray F et al. | β | 2007 | β |
| Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats. | Winter C et al. | β | 2007 | β |
| Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. | Conti B et al. | β | 2007 | β |
| Corticotropin-releasing factor type-1 receptor antagonists: the next class of antidepressants? | Nielsen DM | β | 2006 | β |
| Development of CRF1 receptor antagonists as antidepressants and anxiolytics: progress to date. | Valdez GR | β | 2006 | β |
| Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor. | Johnson SA et al. | β | 2006 | β |
| Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions. | WΓΆrtwein G et al. | β | 2006 | β |
| The corticotropin-releasing factor (CRF)(1) receptor antagonists CP154,526 and DMP695 inhibit light-induced phase advances of hamster circadian activity rhythms. | Gannon RL et al. | β | 2006 | β |
| Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat. | Overstreet DH et al. | β | 2005 | β |
| Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. | Cryan JF et al. | β | 2005 | β |
| Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. | Fagergren P et al. | β | 2005 | β |
| The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. | Jutkiewicz EM et al. | β | 2005 | β |
| The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. | Overstreet DH et al. | β | 2005 | β |
| The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence. | Bruijnzeel AW et al. | β | 2005 | β |
| Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression. | Overstreet DH et al. | β | 2004 | β |