A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
paper
Cited
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- Authors
- Hageman, Gregory S; Anderson, Don H; Johnson, Lincoln V; Hancox, Lisa S; Taiber, Andrew J; Hardisty, Lisa I; Hageman, Jill L; Stockman, Heather A; Borchardt, James D; Gehrs, Karen M; Smith, Richard J H; Silvestri, Giuliana; Russell, Stephen R; Klaver, Caroline C W; Barbazetto, Irene; Chang, Stanley; Yannuzzi, Lawrence A; Barile, Gaetano R; Merriam, John C; Smith, R Theodore; Olsh, Adam K; Bergeron, Julie; Zernant, Jana; Merriam, Joanna E; Gold, Bert; Dean, Michael; Allikmets, Rando
- Year
- 2005
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 15870199
- DOI
- 10.1073/pnas.0501536102
- PMCID
- PMC1088171
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD. Here, we show that factor H (HF1), the major inhibitor of the alternative complement pathway, accumulates within drusen and is synthesized by the retinal pigmented epithelium. Because previous linkage analyses identified chromosome 1q25-32, which harbors the factor H gene (HF1/CFH), as an AMD susceptibility locus, we analyzed HF1 for genetic variation in two independent cohorts comprised of approximately 900 AMD cases and 400 matched controls. We found association of eight common HF1 SNPs with AMD; two common missense variants exhibit highly significant associations (I62V, chi2 = 26.1 and P = 3.2 x 10(-7) and Y402H, chi2 = 54.4 and P = 1.6 x 10(-13)). Haplotype analysis reveals that multiple HF1 variants confer elevated or reduced risk of AMD. One common at-risk haplotype is present at a frequency of 50% in AMD cases and 29% in controls [odds ratio (OR) = 2.46, 95% confidence interval (1.95-3.11)]. Homozygotes for this haplotype account for 24% of cases and 8% of controls [OR = 3.51, 95% confidence interval (2.13-5.78)]. Several protective haplotypes are also identified (OR = 0.44-0.55), further implicating HF1 function in the pathogenetic mechanisms underlying AMD. We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Advances in Complement Research: from Pathophysiology to Precision Medicine. | Thurman JM | — | 2026 | → |
| Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation. | Stuard Sambhariya W et al. | — | 2026 | → |
| Avacincaptad Pegol for Geographic Atrophy Secondary to Age-Related Macular Degeneration: Two-Year Efficacy and Safety Results from the GATHER2 Phase 3 Trial. | Khanani AM et al. | — | 2026 | → |
| Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration. | Villarruel Hinnerskov JM et al. | — | 2026 | → |
| Obstructive sleep apnea and risk of age-related macular degeneration: A systematic review and meta-analysis. | Yaldo L et al. | — | 2026 | → |
| Outer retinal tubulation associated with photoreceptor degeneration. | Lin V et al. | — | 2026 | → |
| Safety and tolerability of avacincaptad pegol in combination with ranibizumab in treatment-naïve patients with neovascular age-related macular degeneration: results from a phase 1 and phase 2a study. | Patel SS et al. | — | 2026 | → |
| TEP-1, a glial thioester protein is required for cilia organization and intraflagellar transport in ensheathed sensory neurons in <i>Caenorhabditis elegans</i>. | Oshima Y et al. | — | 2026 | → |
| A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration. | Yang H et al. | — | 2025 | → |
| Age-Related Macular Degeneration: Cellular and Molecular Signaling Mechanisms. | Jiang F et al. | — | 2025 | → |
| Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update. | Sadikan MZ et al. | — | 2025 | → |
| Antioxidants in Age-Related Macular Degeneration: Lights and Shadows. | Parmar UPS et al. | — | 2025 | → |
| Characterizing Bruch's membrane: State-of-the-art imaging, computational segmentation, and biologic models in retinal disease and health. | Ong J et al. | — | 2025 | → |
| Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes. | Thomsen AK et al. | — | 2025 | → |
| Chronic kidney disease enhances alternative pathway activity: a new paradigm. | Jalal DI et al. | — | 2025 | → |
| Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family. | Veuskens BRJ et al. | — | 2025 | → |
| Complement and local ocular inflammatory response: Chronic immune factors in myopia. | Zhang M et al. | — | 2025 | → |
| Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review. | Larsen PP et al. | — | 2025 | → |
| CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system. | Salman A et al. | — | 2025 | → |
| Differential analysis of core complement components expression and localization across rodent, non-human primate, and human ocular tissues. | Jones A et al. | — | 2025 | → |
| Early-onset macular drusen, a monogenic form of age-related macular degeneration. | George LM et al. | — | 2025 | → |
| Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G. | Tschongov T et al. | — | 2025 | → |
| Epigenetic Alterations in Age-Related Macular Degeneration: Mechanisms and Implications. | Kisswani D et al. | — | 2025 | → |
| Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration. | Sekulic A et al. | — | 2025 | → |
| Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration. | Hou J et al. | — | 2025 | → |
| Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration. | Curcio CA et al. | — | 2025 | → |
| Genetic Distinctions Between Reticular Pseudodrusen and Drusen: A Genome-Wide Association Study. | Schwartz R et al. | — | 2025 | → |
| Genotype Prediction from Retinal Fundus Images Using Deep Learning in Eyes with Age-Related Macular Degeneration. | Halev A et al. | — | 2025 | → |
| HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization. | Katschke KJ et al. | — | 2025 | → |
| International consensuses and guidelines on etiology, diagnosis, treatment, and future developments of neovascular age-related macular degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO). | Lai TYY et al. | — | 2025 | → |
| iPSC-derived retinal pigment epithelium: an in vitro platform to reproduce key cellular phenotypes and pathophysiology of retinal degenerative diseases. | Li H et al. | — | 2025 | → |
| Isolation and Characterization of Mouse Choroidal Melanocytes and Their Proinflammatory Characteristics. | Song YS et al. | — | 2025 | → |
| Loss of CFHR5 function reduces the risk for age-related macular degeneration. | Reeve MP et al. | — | 2025 | → |
| Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration. | Hector M et al. | — | 2025 | → |
| Neuroretinal and Retinal Pigment Epithelium Changes and Susceptibility to Age-Related Macular Degeneration: Insights from the Longitudinal ALIENOR Study. | Larsen PP et al. | — | 2025 | → |
| Ocular Localization of Complement Factor H and Its Association with Diseases in the Eye. | Lim RR et al. | — | 2025 | → |
| Oral Ursodeoxycholic Acid Is Associated With Decreased Rate of AMD. | Zhang KR et al. | — | 2025 | → |
| Pediatric Immunodeficiency Caused by Complement Classical and Alternative Pathway Defects Due to a Homozygous CFI Variant: A Case Report. | Wei J et al. | — | 2025 | → |
| Photobiomodulation Therapy for Non-exudative Age-related Macular Degeneration. | Rodriguez DA et al. | — | 2025 | → |
| Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration. | Thomsen AK et al. | — | 2025 | → |
| Progression to complete retinal pigment epithelium and outer retinal atrophy (cRORA): post hoc analysis of the GATHER1 trial. | Corradetti G et al. | — | 2025 | → |
| Roles of MASP-1 and MASP-3 in the development of retinal degeneration in a murine model of dry age-related macular degeneration. | Omori T et al. | — | 2025 | → |
| Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface. | Hulleman JD et al. | — | 2025 | → |
| The Complement System. | Revel M et al. | — | 2025 | → |
| Translational Molecular and Fluid Biomarkers for Age-Related Macular Degeneration: Practical Insights from Animal Models and Humans. | Intonti S et al. | — | 2025 | → |
| Truncated complement factor H Y402 gene therapy rescues C3 glomerulonephritis. | Chew LA et al. | — | 2025 | → |
| Zinc deficiency as possible link between immunosenescence and age-related diseases. | Schulz MT et al. | — | 2025 | → |
| Age-Related Macular Degeneration: A Review. | Fleckenstein M et al. | — | 2024 | → |
| A guide to complement biology, pathology and therapeutic opportunity. | Mastellos DC et al. | — | 2024 | → |
| A potential bimodal interplay between heme and complement factor H 402H in the deregulation of the complement alternative pathway by SARS-CoV-2. | Tsiftsoglou SA et al. | — | 2024 | → |
| C5 inhibitor avacincaptad pegol treatment for geographic atrophy: A comprehensive review. | Danzig CJ et al. | — | 2024 | → |
| CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration. | Lim RR et al. | — | 2024 | → |
| Chemokine Receptor Profile of T Cells and Progression Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration. | Martinez Villarruel Hinnerskov J et al. | — | 2024 | → |
| Complement activation products in tears of dry eye and meibomian gland dysfunction. | Maehara H et al. | — | 2024 | → |
| Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response. | Thomsen AK et al. | — | 2024 | → |
| Comprehensive functional characterization of complement factor I rare variant genotypes identified in the SCOPE geographic atrophy cohort. | Hallam TM et al. | — | 2024 | → |
| Correlations Between the Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Serum Lipid Fractions With Neovascular Age-Related Macular Degeneration. | Tricorache DF et al. | — | 2024 | → |
| CRISPR Manipulation of Age-Related Macular Degeneration Haplotypes in the Complement System: Potential Future Therapeutic Applications/Avenues. | Salman A et al. | — | 2024 | → |
| Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration: A Secondary Analysis of the ASPREE Randomized Clinical Trial. | Robman LD et al. | — | 2024 | → |
| Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population. | Huang YC et al. | — | 2024 | → |
| Inflammation in Fabry disease: stages, molecular pathways, and therapeutic implications. | Kurdi H et al. | — | 2024 | → |
| Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression. | Zouache MA et al. | — | 2024 | → |
| Mitochondrial damage and clearance in retinal pigment epithelial cells. | Gurubaran IS | — | 2024 | → |
| Modeling complex age-related eye disease. | Becker S et al. | — | 2024 | → |
| Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity. | Tschongov T et al. | — | 2024 | → |
| Natural products for the treatment of age-related macular degeneration. | Wang D et al. | — | 2024 | → |
| Potential Causal Association between C-Reactive Protein Levels in Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study. | Yoon BW et al. | — | 2024 | → |
| Productive infection of the retinal pigment epithelium by SARS-CoV-2: Initial effects and consideration of long-term consequences. | Hultgren NW et al. | — | 2024 | → |
| Retinal Pigment Epithelium Pigment Granules: Norms, Age Relations and Pathology. | Dontsov A et al. | — | 2024 | → |
| Role of <i>ARMS2/HTRA1</i> risk alleles in the pathogenesis of neovascular age-related macular degeneration. | Pan Y et al. | — | 2024 | → |
| The complement system in lipid-mediated pathologies. | Alic L et al. | — | 2024 | → |
| The human factor H protein family - an update. | Sándor N et al. | — | 2024 | → |
| The hypothetical molecular mechanism of the ethnic variations in the manifestation of age-related macular degeneration; focuses on the functions of the most significant susceptibility genes. | Honda S et al. | — | 2024 | → |
| The quantification of zebrafish ocular-associated proteins provides hints for sex-biased visual impairments and perception. | Niksirat H et al. | — | 2024 | → |
| The Role of Complement Dysregulation in Glaucoma. | Hoppe C et al. | — | 2024 | → |
| The role of the cytokine TNF-α in choroidal neovascularization: a systematic review. | Papadopoulos Z | — | 2024 | → |
| Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH). | Petrow E et al. | — | 2024 | → |
| AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model. | Grigsby D et al. | — | 2023 | → |
| Adverse COVID-19 outcomes in American Veterans with age-related macular degeneration: a case-control study. | Armbrust KR et al. | — | 2023 | → |
| Age-related macular degeneration. | Guymer RH et al. | — | 2023 | → |
| Age-related macular degeneration: A disease of extracellular complement amplification. | de Jong S et al. | — | 2023 | → |
| Bruch's Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration. | Hammadi S et al. | — | 2023 | → |
| Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel? | Cruz-Pimentel M et al. | — | 2023 | → |
| Complement inhibitors for age-related macular degeneration. | Tzoumas N et al. | — | 2023 | → |
| Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative Disorders Related? | Latifi-Navid H et al. | — | 2023 | → |
| Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)-driven Complement-mediated Diseases. | Gibson BG et al. | — | 2023 | → |
| Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration. | Gogna N et al. | — | 2023 | → |
| Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H Variant. | Velazquez-Soto H et al. | — | 2023 | → |
| Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration. | Pan Y et al. | — | 2023 | → |
| Gene-agnostic approaches to treating inherited retinal degenerations. | Chew LA et al. | — | 2023 | → |
| Genetic and molecular biomarkers for geographic atrophy. | Riley-Gillis B et al. | — | 2023 | → |
| Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness. | Fenner BJ et al. | — | 2023 | → |
| Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases. | Rodríguez de Córdoba S | — | 2023 | → |
| Geographic atrophy: pathophysiology and current therapeutic strategies. | Rajanala K et al. | — | 2023 | → |
| Histological Manifestations of Diabetic Kidney Disease and its Relationship with Insulin Resistance. | Adeva-Andany MM et al. | — | 2023 | → |
| Kidney diseases. | Daina E et al. | — | 2023 | → |
| Knockout of AMD-associated gene <i>POLDIP2</i> reduces mitochondrial superoxide in human retinal pigment epithelial cells. | Nguyen T et al. | — | 2023 | → |
| Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration. | Anderson DMG et al. | — | 2023 | → |
| Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines. | Yee WX et al. | — | 2023 | → |
| Multiplexed plasma protein classifiers for the diagnosis of age-related macular degeneration. | Ahn HS et al. | — | 2023 | → |
| Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation. | Wang X et al. | — | 2023 | → |
| Potential therapeutic targets for age-related macular degeneration: The nuclear option. | Choudhary M et al. | — | 2023 | → |
| Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review. | Finocchio L et al. | — | 2023 | → |
| Rethinking the potential and necessity of drug delivery systems in neovascular age-related macular degeneration therapy. | Huang X et al. | — | 2023 | → |
| Role of Complement in the Onset of Age-Related Macular Degeneration. | Piri N et al. | — | 2023 | → |
| Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration. | Shome I et al. | — | 2023 | → |
| Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate. | Vofo BN et al. | — | 2023 | → |
| Tear fluid and complement activation products in tears after ocular surgery. | Maehara H et al. | — | 2023 | → |
| The application and progression of CRISPR/Cas9 technology in ophthalmological diseases. | Hu X et al. | — | 2023 | → |
| The Factor H protein family: The switchers of the complement alternative pathway. | Lucientes-Continente L et al. | — | 2023 | → |
| The roadmap to geographic atrophy treatment: A journey of trials and promise. | Trivizki O et al. | — | 2023 | → |
| The Role of Inflammation in Age-Related Macular Degeneration: Updates and Possible Therapeutic Approaches. | Arrigo A et al. | — | 2023 | → |
| The susceptibility of the kidney to alternative pathway activation-A hypothesis. | Thurman JM et al. | — | 2023 | → |
| Voluntary exercise modulates pathways associated with amelioration of retinal degenerative diseases. | Chu-Tan JA et al. | — | 2023 | → |
| WITHDRAWN: Pegcetacoplan in the treatment of geographic atrophy. | Kumar M et al. | — | 2023 | → |
| A Clinical and Preclinical Assessment of Clinical Trials for Dry Age-Related Macular Degeneration. | Abidi M et al. | — | 2022 | → |
| AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets. | Zhang C et al. | — | 2022 | → |
| An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration. | Biggs RM et al. | — | 2022 | → |
| A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative <i>CFI</i> variants in age-related macular degeneration. | Hallam TM et al. | — | 2022 | → |
| A proteogenomic signature of age-related macular degeneration in blood. | Emilsson V et al. | — | 2022 | → |
| Association of Blood Group Antigen CD59 with Disease. | Weinstock C | — | 2022 | → |
| Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population. | Karkhaneh R et al. | — | 2022 | → |
| Association of Systemic Inflammatory Factors with Progression to Advanced Age-related Macular Degeneration. | Wagner BD et al. | — | 2022 | → |
| Biomarkers as Predictive Factors of Anti-VEGF Response. | Bobadilla M et al. | — | 2022 | → |
| C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration. | Yednock T et al. | — | 2022 | → |
| Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration. | Bharti K et al. | — | 2022 | → |
| Characterization of West African Crystalline Macular Dystrophy in the Ghanaian Population. | Amoaku WM et al. | — | 2022 | → |
| Complement cascade functions during brain development and neurodegeneration. | Fatoba O et al. | — | 2022 | → |
| Complement cascade inhibition in geographic atrophy: a review. | Desai D et al. | — | 2022 | → |
| Complement Mediators in Development to Treat Age-Related Macular Degeneration. | Nebbioso M et al. | — | 2022 | → |
| Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish. | Waksmunski AR et al. | — | 2022 | → |
| Contribution of Interleukin-17A to Retinal Degenerative Diseases. | Zhong H et al. | — | 2022 | → |
| Dabigatran and Wet AMD, Results From Retinal Pigment Epithelial Cell Monolayers, the Mouse Model of Choroidal Neovascularization, and Patients From the Medicare Data Base. | Akter T et al. | — | 2022 | → |
| Emerging therapies and their delivery for treating age-related macular degeneration. | Thomas CN et al. | — | 2022 | → |
| Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization. | Jones AV et al. | — | 2022 | → |
| Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system. | Wong JHC et al. | — | 2022 | → |
| Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options. | Fernandes AR et al. | — | 2022 | → |
| Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. | Parker A et al. | — | 2022 | → |
| From Genes, Proteins, and Clinical Manifestation: Why Do We Need to Better Understand Age-Related Macular Degeneration? | Schmitz-Valckenberg S et al. | — | 2022 | → |
| Gene-independent therapeutic interventions to maintain and restore light sensitivity in degenerating photoreceptors. | Zuzic M et al. | — | 2022 | → |
| Genetic and Functional Evidence of Complement Dysregulation in Multiple Myeloma Patients with Carfilzomib-Induced Thrombotic Microangiopathy Compared to Controls. | Gavriilaki E et al. | — | 2022 | → |
| Genetic Aspects of Age-Related Macular Degeneration and Their Therapeutic Potential. | Stradiotto E et al. | — | 2022 | → |
| Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. | Osterman MD et al. | — | 2022 | → |
| Human pluripotent stem cells for the modelling of retinal pigment epithelium homeostasis and disease: A review. | Hall JC et al. | — | 2022 | → |
| <i>HTRA1</i> Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid. | Ahamed W et al. | — | 2022 | → |
| Impact of Primary RPE Cells in a Porcine Organotypic Co-Cultivation Model. | Wagner N et al. | — | 2022 | → |
| Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis. | Harraka P et al. | — | 2022 | → |
| Knockout of AMD-associated gene <i>POLDIP2</i> reduces mitochondrial superoxide in human retinal pigment epithelial cells | Nguyen T et al. | — | 2022 | — |
| Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration. | Mulfaul K et al. | — | 2022 | → |
| LRG1 as a novel therapeutic target in eye disease. | De Rossi G et al. | — | 2022 | → |
| Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration. | Ng ESY et al. | — | 2022 | → |
| Molecular Genetic Mechanisms in Age-Related Macular Degeneration. | Shughoury A et al. | — | 2022 | → |
| [New findings on pathogenetic mechanisms in the development of age-related macular degeneration]. | Fursova AZ et al. | — | 2022 | → |
| Not All Genes Are Created Equal in Age-Related Macular Degeneration. | Sobrin L et al. | — | 2022 | → |
| Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells. | Chen L et al. | — | 2022 | → |
| Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation. | Liisborg C et al. | — | 2022 | → |
| Polygenic Risk Score Impact on Susceptibility to Age-Related Macular Degeneration in Polish Patients. | Wąsowska A et al. | — | 2022 | → |
| Potential gene identification and pathway crosstalk analysis of age-related macular degeneration. | Ren C et al. | — | 2022 | → |
| Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration. | Shinomiya K et al. | — | 2022 | → |
| Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both. | Schmitz-Valckenberg S et al. | — | 2022 | → |
| Reticular pseudodrusen: A critical phenotype in age-related macular degeneration. | Wu Z et al. | — | 2022 | → |
| Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment. | Ham YJ et al. | — | 2022 | → |
| Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis. | Nicklason E et al. | — | 2022 | → |
| Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis. | Harraka P et al. | — | 2022 | → |
| Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. | Marin AI et al. | — | 2022 | → |
| Small hard drusen and associated factors in early seniority. | Belmouhand M et al. | — | 2022 | → |
| Systems genomics in age-related macular degeneration. | den Hollander AI et al. | — | 2022 | → |
| Targeted Genotyping of MIS-C Patients Reveals a Potential Alternative Pathway Mediated Complement Dysregulation during COVID-19 Infection. | Gavriilaki E et al. | — | 2022 | → |
| Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models. | Landowski M et al. | — | 2022 | → |
| The role of properdin and Factor H in disease. | Cortes C et al. | — | 2022 | → |
| The Role of Sulfation in Nematode Development and Phenotypic Plasticity. | Igreja C et al. | — | 2022 | → |
| Water-Soluble Products of Photooxidative Destruction of the Bisretinoid A2E Cause Proteins Modification in the Dark. | Dontsov A et al. | — | 2022 | → |
| Aberrant Complement System Activation in Neurological Disorders. | Ziabska K et al. | — | 2021 | → |
| A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in <i>C. elegans</i> cilia. | Acker N et al. | — | 2021 | → |
| Adeno-Associated Virus Vector Gene Delivery Elevates Factor I Levels and Downregulates the Complement Alternative Pathway <i>In Vivo</i>. | Ahmad A et al. | — | 2021 | → |
| Age-related macular degeneration. | Fleckenstein M et al. | — | 2021 | → |
| Age-Related Macular Degeneration: Epidemiology and Clinical Aspects. | Keenan TDL et al. | — | 2021 | → |
| Antisense Oligonucleotide Therapy for Ophthalmic Conditions. | Ferenchak K et al. | — | 2021 | → |
| Association of HTRA1 and CFH gene polymorphisms with age-related macular degeneration in Ningbo, China. | Gong Y et al. | — | 2021 | → |
| Association of imaging biomarkers and local activation of complement in aqueous humor of patients with early forms of age-related macular degeneration. | Sitnilska V et al. | — | 2021 | → |
| Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations. | Cipriani V et al. | — | 2021 | → |
| C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. | Jaffe GJ et al. | — | 2021 | → |
| Cell-Matrix Interactions in the Eye: From Cornea to Choroid. | Pouw AE et al. | — | 2021 | → |
| Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of <i>HTRA1</i> in human retinal pigment epithelium. | Williams BL et al. | — | 2021 | → |
| Clinical Characteristics of Neovascular Age-Related Macular Degeneration without Typical Drusen. | Kamao H et al. | — | 2021 | → |
| Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration. | Lorés-Motta L et al. | — | 2021 | → |
| Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice. | Garland DL et al. | — | 2021 | → |
| Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway. | Murray H et al. | — | 2021 | → |
| Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells. | Schäfer N et al. | — | 2021 | → |
| Complement Inhibitors in Age-Related Macular Degeneration: A Potential Therapeutic Option. | Qin S et al. | — | 2021 | → |
| Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease. | Gu BJ et al. | — | 2021 | → |
| Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina. | Farhan F et al. | — | 2021 | → |
| Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration. | Demirs JT et al. | — | 2021 | → |
| Differential Mechanisms of Action and Efficacy of Vitamin E Components in Antioxidant Cytoprotection of Human Retinal Pigment Epithelium. | Duncan RS et al. | — | 2021 | → |
| Effect of Reading Rehabilitation for Age-Related Macular Degeneration on Cognitive Functioning: Protocol for a Nonrandomized Pre-Post Intervention Study. | Wittich W et al. | — | 2021 | → |
| Functional microRNA targetome undergoes degeneration-induced shift in the retina. | Chu-Tan JA et al. | — | 2021 | → |
| Genetic Association between <i>MMP9</i> and Choroidal Neovascularization in Age-Related Macular Degeneration. | Sohn EH et al. | — | 2021 | → |
| Genetic justification of severe COVID-19 using a rigorous algorithm. | Gavriilaki E et al. | — | 2021 | → |
| HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review. | Kjeldsen EW et al. | — | 2021 | → |
| High Myopia and the Complement System: Factor H in Myopic Maculopathy. | García-Gen E et al. | — | 2021 | → |
| Hijacking Factor H for Complement Immune Evasion. | Moore SR et al. | — | 2021 | → |
| Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy. | Chee RI et al. | — | 2021 | → |
| IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium. | Cheng X et al. | — | 2021 | → |
| Immunological Aspects of Age-Related Macular Degeneration. | Allingham MJ et al. | — | 2021 | → |
| Implications of genetic variation in the complement system in age-related macular degeneration. | de Jong S et al. | — | 2021 | → |
| Inhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration. | Aggio-Bruce R et al. | — | 2021 | → |
| Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration. | Hu ML et al. | — | 2021 | → |
| Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H. | Romero-Vazquez S et al. | — | 2021 | → |
| Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration. | Singh N et al. | — | 2021 | → |
| Oligomeric Aβ<sub>1-42</sub> Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function. | Lynn SA et al. | — | 2021 | → |
| Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration. | May A et al. | — | 2021 | → |
| Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like <i>NFE2L2/PGC-1α</i> <i><sup>-/-</sup></i> Mouse Model Evoke Complement Component C5a Independent of C3. | Sridevi Gurubaran I et al. | — | 2021 | → |
| Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy. | Kumar A et al. | — | 2021 | → |
| Progress in developing rodent models of age-related macular degeneration (AMD). | Soundara Pandi SP et al. | — | 2021 | → |
| Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci. | Pappas CM et al. | — | 2021 | → |
| Proteomics-based approach for differentiation of age-related macular degeneration sub-types. | Sivagurunathan S et al. | — | 2021 | → |
| Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. | Tzoumas N et al. | — | 2021 | → |
| Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy. | Varin J et al. | — | 2021 | → |
| Role of retinal pigment epithelium in age-related macular disease: a systematic review. | Bird A | — | 2021 | → |
| Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration. | Acar IE et al. | — | 2021 | → |
| Sphingolipids as critical players in retinal physiology and pathology. | Simon MV et al. | — | 2021 | → |
| Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease. | Hevey R et al. | — | 2021 | → |
| Systemic complement activation levels in Stargardt disease. | Dhooge PPA et al. | — | 2021 | → |
| Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. | Kim BJ et al. | — | 2021 | → |
| Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration. | Chae JB et al. | — | 2021 | → |
| The 100 most-cited papers on age-related macular degeneration: a bibliographic perspective. | Grzybowski A et al. | — | 2021 | → |
| The complement system in age-related macular degeneration. | Armento A et al. | — | 2021 | → |
| The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy. | Stravalaci M et al. | — | 2021 | → |
| The pathogenesis of age-related macular degeneration is not inflammatory mediated but is instead due to immunosenescence-related failure of tissue repair. | Kent D | — | 2021 | → |
| Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy. | Kim JB et al. | — | 2021 | → |
| Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics. | Garred P et al. | — | 2021 | → |
| The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. | McMahon O et al. | — | 2021 | → |
| The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems. | George SM et al. | — | 2021 | → |
| Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye. | Koponen S et al. | — | 2021 | → |
| Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration. | Kaynezhad P et al. | — | 2021 | → |
| Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. | Efstathiou NE et al. | — | 2020 | → |
| Age-related macular degeneration: A two-level model hypothesis. | Rozing MP et al. | — | 2020 | → |
| Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVI Edward Jackson Memorial Lecture. | Chew EY | — | 2020 | → |
| Age-Related Macular Degeneration Preferred Practice Pattern®. | Flaxel CJ et al. | — | 2020 | → |
| Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies. | Hadziahmetovic M et al. | — | 2020 | → |
| Anti-VEGF Treatment and Response in Age-related Macular Degeneration: Disease's Susceptibility, Pharmacogenetics and Pharmacokinetics. | Maroñas O et al. | — | 2020 | → |
| Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration. | Jensen EG et al. | — | 2020 | → |
| Coculture techniques for modeling retinal development and disease, and enabling regenerative medicine. | Ghareeb AE et al. | — | 2020 | → |
| Complement Activation Levels Are Related to Disease Stage in AMD. | Heesterbeek TJ et al. | — | 2020 | → |
| Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis. | Yu Q et al. | — | 2020 | → |
| Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System. | Borucki DM et al. | — | 2020 | → |
| Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration. | Simmons KT et al. | — | 2020 | → |
| Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration. | Stravalaci M et al. | — | 2020 | → |
| Cross-sectional study of the association between age-related macular degeneration and arthritis in the National Health and Nutrition Examination Survey 2005-2008. | Zhu Z et al. | — | 2020 | → |
| Dengue virus and the complement alternative pathway. | Carr JM et al. | — | 2020 | → |
| EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration. | Cheng L et al. | — | 2020 | → |
| Effects of a Newly Developed Enzyme-Assisted Extraction Method on the Biological Activities of Fucoidans in Ocular Cells. | Dörschmann P et al. | — | 2020 | → |
| Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes. | Hu J et al. | — | 2020 | → |
| Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. | Ratnapriya R et al. | — | 2020 | → |
| Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD. | Wong EKS et al. | — | 2020 | → |
| Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits. | Meri S et al. | — | 2020 | → |
| Genotypes and Phenotypes: A Search for Influential Genes in Diabetic Retinopathy. | Cabrera AP et al. | — | 2020 | → |
| Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions. | Bonilha VL et al. | — | 2020 | → |
| Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study. | Kong M et al. | — | 2020 | → |
| High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. | Kelly UL et al. | — | 2020 | → |
| Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. | Cipriani V et al. | — | 2020 | → |
| Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration. | Shen Y et al. | — | 2020 | → |
| Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10. | Zouache MA et al. | — | 2020 | → |
| Mathematical Modelling of Alternative Pathway of Complement System. | Bakshi S et al. | — | 2020 | → |
| Mechanisms of FH Protection Against Neovascular AMD. | Borras C et al. | — | 2020 | → |
| MiRNA Regulatory Functions in Photoreceptors. | Pawlick JS et al. | — | 2020 | → |
| Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease. | Caruso A et al. | — | 2020 | → |
| NEI-Supported Age-Related Macular Degeneration Research: Past, Present, and Future. | Wright C et al. | — | 2020 | → |
| Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches. | Ricci F et al. | — | 2020 | → |
| New Technologies to Study Functional Genomics of Age-Related Macular Degeneration. | Nguyen T et al. | — | 2020 | → |
| Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia. | Kumar A et al. | — | 2020 | → |
| Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration. | Lynch AM et al. | — | 2020 | → |
| Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention. | Gorin MB et al. | — | 2020 | → |
| Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. | Hughes S et al. | — | 2020 | → |
| Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration. | Hallam TM et al. | — | 2020 | → |
| Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration. | Pool FM et al. | — | 2020 | → |
| Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. | Wang L et al. | — | 2020 | → |
| Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study. | Roshanipour N et al. | — | 2020 | → |
| Systemic activation of the complement system in patients with advanced age-related macular degeneration. | Lynch AM et al. | — | 2020 | → |
| Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease. | Schnabolk G et al. | — | 2020 | → |
| The Diagnosis and Treatment of Age-Related Macular Degeneration. | Stahl A | — | 2020 | → |
| The effect of long-term systemic immunosuppressive drug use on druse formation: a new perspective to age-related macular degeneration | Sever Ö et al. | — | 2020 | → |
| The Expression of Decidual Protein Induced by Progesterone (DEPP) is Controlled by Three Distal Consensus Hypoxia Responsive Element (HRE) in Hypoxic Retinal Epithelial Cells. | Klee K et al. | — | 2020 | → |
| The Relationship Between Cognitive Status and Known Single Nucleotide Polymorphisms in Age-Related Macular Degeneration. | Murphy C et al. | — | 2020 | → |
| Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. | Mulfaul K et al. | — | 2020 | → |
| Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions. | Mannes M et al. | — | 2020 | → |
| Adaptive and Maladaptive Complement Activation in the Retina. | Silverman SM et al. | — | 2019 | → |
| Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent. | Rohrer B et al. | — | 2019 | → |
| CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex. | Borras C et al. | — | 2019 | → |
| Characterization of Retinal Pigment Epithelial Melanin and Degraded Synthetic Melanin Using Mass Spectrometry and In Vitro Biochemical Diagnostics. | Yacout SM et al. | — | 2019 | → |
| Clinical promise of next-generation complement therapeutics. | Mastellos DC et al. | — | 2019 | → |
| Compendium of current complement therapeutics. | Zelek WM et al. | — | 2019 | → |
| Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration. | Sivapathasuntharam C et al. | — | 2019 | → |
| Deletion of miR-182 Leads to Retinal Dysfunction in Mice. | Wu KC et al. | — | 2019 | → |
| Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. | Zelek WM et al. | — | 2019 | → |
| Effects of Sulfated Fucans from <i>Laminaria hyperborea</i> Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight. | Dörschmann P et al. | — | 2019 | → |
| Gene and Induced Pluripotent Stem Cell Therapy for Retinal Diseases. | Maeda A et al. | — | 2019 | → |
| Genetic association with intravitreal ranibizumab response for neovascular age-related macular degeneration in Hispanic population. | Rodríguez FJ et al. | — | 2019 | → |
| GPR143 Signaling and Retinal Degeneration. | Figueroa AG et al. | — | 2019 | → |
| Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. | Landowski M et al. | — | 2019 | → |
| Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life. | Curtin K et al. | — | 2019 | → |
| Inflammatory Ocular Diseases and Sphingolipid Signaling. | Grambergs R et al. | — | 2019 | → |
| Loss-of-Function Mutations in the CFH Gene Affecting Alternatively Encoded Factor H-like 1 Protein Cause Dominant Early-Onset Macular Drusen. | Taylor RL et al. | — | 2019 | → |
| Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions. | Lipecz A et al. | — | 2019 | → |
| Molecular crypsis by pathogenic fungi using human factor H. A numerical model. | Lang SN et al. | — | 2019 | → |
| On the origin of proteins in human drusen: The meet, greet and stick hypothesis. | Bergen AA et al. | — | 2019 | → |
| Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. | Waksmunski AR et al. | — | 2019 | → |
| Regulation of regulators: Role of the complement factor H-related proteins. | Cserhalmi M et al. | — | 2019 | → |
| Regulation of the Complement System by Pentraxins. | Haapasalo K et al. | — | 2019 | → |
| Role of Bioactive Sphingolipids in Inflammation and Eye Diseases. | Mondal K et al. | — | 2019 | → |
| Role of the Choroid in Age-related Macular Degeneration: A Current Review. | Farazdaghi MK et al. | — | 2019 | → |
| Sub-threshold nanosecond laser (SNL) treatment in intermediate AMD (IAMD). | Theodore Smith R | — | 2019 | → |
| Systemic expression of Alu RNA in patients with geographic atrophy secondary to age-related macular degeneration. | Yoshida H et al. | — | 2019 | → |
| Systemic Inflammatory Disease and AMD Comorbidity. | Schnabolk G | — | 2019 | → |
| The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity. | Maugeri A et al. | — | 2019 | → |
| The Challenges and Promise of Complement Therapeutics for Ocular Diseases. | Park DH et al. | — | 2019 | → |
| The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE. | Jun S et al. | — | 2019 | → |
| Zinc Nutrition and Inflammation in the Aging Retina. | Gilbert R et al. | — | 2019 | → |
| A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells. | Parmar VM et al. | — | 2018 | → |
| Activation of the ERK1/2-MAPK Signaling Pathway by Complement Serum in UV-POS-Pretreated ARPE-19 Cells. | Busch M et al. | — | 2018 | → |
| A model to study complement involvement in experimental retinal degeneration. | Mohlin C et al. | — | 2018 | → |
| A Perspective of AMD Through the Eyes of Immunology. | Copland DA et al. | — | 2018 | → |
| Association Between Complement Factor C2/C3/CFB/CFH Polymorphisms and Age-Related Macular Degeneration: A Meta-Analysis. | Lu F et al. | — | 2018 | → |
| Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis. | Zhang J et al. | — | 2018 | → |
| C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway. | Fernandez-Godino R et al. | — | 2018 | → |
| Calf melanin immunomodulates RPE cell attachment to extracellular matrix protein. | Yacout SM et al. | — | 2018 | → |
| Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway. | Fernandez-Godino R et al. | — | 2018 | → |
| Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy. | Katschke KJ et al. | — | 2018 | → |
| Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages. | Nissilä E et al. | — | 2018 | → |
| Complement factor H in AMD: Bridging genetic associations and pathobiology. | Toomey CB et al. | — | 2018 | → |
| Complement Factor H Inhibits Anti-Neutrophil Cytoplasmic Autoantibody-Induced Neutrophil Activation by Interacting With Neutrophils. | Chen SF et al. | — | 2018 | → |
| Complement in the pathogenesis of Alzheimer's disease. | Morgan BP | — | 2018 | → |
| Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. | Maugeri A et al. | — | 2018 | → |
| Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy. | Wu X et al. | — | 2018 | → |
| C-Reactive Protein As a Mediator of Complement Activation and Inflammatory Signaling in Age-Related Macular Degeneration. | Chirco KR et al. | — | 2018 | → |
| C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration. | Molins B et al. | — | 2018 | → |
| Developments in anti-complement therapy; from disease to clinical trial. | Harris CL et al. | — | 2018 | → |
| Distribution of exogenous complement factor H in mice in vivo. | Koskinen AR et al. | — | 2018 | → |
| Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome. | Natoli R et al. | — | 2018 | → |
| FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. | Rudnick RB et al. | — | 2018 | → |
| Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders. | Singh M et al. | — | 2018 | → |
| Genetics and genetic testing for age-related macular degeneration. | Warwick A et al. | — | 2018 | → |
| Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration. | Lorés-Motta L et al. | — | 2018 | → |
| Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration. | Geerlings MJ et al. | — | 2018 | → |
| Geographic atrophy: Etiopathogenesis and current therapies. | Sastre-Ibáñez M et al. | — | 2018 | → |
| HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1. | Lin MK et al. | — | 2018 | → |
| Identification of complement inhibitory activities of two chemotherapeutic agents using a high-throughput cell imaging-based screening assay. | Zhang L et al. | — | 2018 | → |
| Improved retinal and visual function following panmacular subthreshold diode micropulse laser for retinitis pigmentosa. | Luttrull JK | — | 2018 | → |
| Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features. | Kara C et al. | — | 2018 | → |
| Melatonin antagonizes oxidative stress-induced mitochondrial dysfunction in retinal pigmented epithelium cells via melatonin receptor 1 (MT1). | Yan G et al. | — | 2018 | → |
| Metabolomics and Age-Related Macular Degeneration. | Brown CN et al. | — | 2018 | → |
| MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina. | Chu-Tan JA et al. | — | 2018 | → |
| Models of retinal diseases and their applicability in drug discovery. | Malek G et al. | — | 2018 | → |
| NAD<sup>+</sup> and sirtuins in retinal degenerative diseases: A look at future therapies. | Lin JB et al. | — | 2018 | → |
| Pharmacogenetic Aspect of Intravitreal Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Five-Year Follow-Up. | Sengul EA et al. | — | 2018 | → |
| Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. | Hummert S et al. | — | 2018 | → |
| PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: An Optical Coherence Tomographic Angiography Analysis. | Christenbury JG et al. | — | 2018 | → |
| Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (<i>CFH</i>) gene family. | Cantsilieris S et al. | — | 2018 | → |
| Role of the Complement System in Chronic Central Serous Chorioretinopathy: A Genome-Wide Association Study. | Schellevis RL et al. | — | 2018 | → |
| Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family. | Sánchez-Corral P et al. | — | 2018 | → |
| The effects of zinc supplementation on primary human retinal pigment epithelium. | Pao PJ et al. | — | 2018 | → |
| The eye as a complement dysregulation hotspot. | Clark SJ et al. | — | 2018 | → |
| The use of the vaccinia virus complement control protein (VCP) in the rat retina. | Fernando N et al. | — | 2018 | → |
| Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces. | Osborne AJ et al. | — | 2018 | → |
| Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN. | Xu Q et al. | — | 2018 | → |
| Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro. | Neun BW et al. | — | 2018 | → |
| What do we know about the macular pigment in AMD: the past, the present, and the future. | Arunkumar R et al. | — | 2018 | → |
| 2016 Glenn A. Fry Award Lecture: Mechanisms and Potential Treatments of Early Age-Related Macular Degeneration. | Fletcher EL | — | 2017 | → |
| Advances in Age-related Macular Degeneration Understanding and Therapy. | Miller JW et al. | — | 2017 | → |
| Age-related macular degeneration and mortality: the Melbourne Collaborative Cohort Study. | McGuinness MB et al. | — | 2017 | → |
| AICAR suppresses TNF-α-induced complement factor B in RPE cells. | Chung EJ et al. | — | 2017 | → |
| An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. | Hallam D et al. | — | 2017 | → |
| A Novel 3D Cultured Model for Studying Early Changes in Age-Related Macular Degeneration. | Shokoohmand A et al. | — | 2017 | → |
| A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma. | Zhang P et al. | — | 2017 | → |
| Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal neovascularization. | Jo DH et al. | — | 2017 | → |
| A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration. | Feng L et al. | — | 2017 | → |
| Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. | Jabbarpoor Bonyadi MH et al. | — | 2017 | → |
| Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population. | Bonyadi M et al. | — | 2017 | → |
| Benefits, Potential Harms, and Optimal Use of Nutritional Supplementation for Preventing Progression of Age-Related Macular Degeneration. | Rojas-Fernandez CH et al. | — | 2017 | → |
| C3 Glomerulopathy. | Riedl M et al. | — | 2017 | → |
| Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration? | Adamus G | — | 2017 | → |
| Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases. | Jones MK et al. | — | 2017 | → |
| Complement Dysregulation and Disease: Insights from Contemporary Genetics. | Liszewski MK et al. | — | 2017 | → |
| Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. | Calippe B et al. | — | 2017 | → |
| Complement factor H in host defense and immune evasion. | Parente R et al. | — | 2017 | → |
| Complement in clinical medicine: Clinical trials, case reports and therapy monitoring. | Ricklin D et al. | — | 2017 | → |
| Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells. | Yang P et al. | — | 2017 | → |
| Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. | Lenis TL et al. | — | 2017 | → |
| Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis. | Kane SJ et al. | — | 2017 | → |
| C-reactive protein and complement factor H polymorphism interaction in advanced exudative age-related macular degeneration. | Soheilian R et al. | — | 2017 | → |
| C-reactive protein isoforms differentially affect outer blood-retinal barrier integrity and function. | Molins B et al. | — | 2017 | → |
| Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. | Li H et al. | — | 2017 | → |
| Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation. | Kerr H et al. | — | 2017 | → |
| Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis). | van Kuijk FJGM et al. | — | 2017 | → |
| Exploring the cross talk between ER stress and inflammation in age-related macular degeneration. | Kheitan S et al. | — | 2017 | → |
| Frequent hypomorphic alleles account for a significant fraction of ABCA4 disease and distinguish it from age-related macular degeneration. | Zernant J et al. | — | 2017 | → |
| From compliment to insult: genetics of the complement system in physiology and disease in the human retina. | Mullins RF et al. | — | 2017 | → |
| Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. | Grassmann F et al. | — | 2017 | → |
| Genetics of age-related macular degeneration (AMD). | DeAngelis MM et al. | — | 2017 | → |
| Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis. | Salminen A et al. | — | 2017 | → |
| Genetic variants in FH are associated with renal histopathologic subtypes of lupus nephritis: a large cohort study from China. | Tan M et al. | — | 2017 | → |
| Genome-wide analyses identify common variants associated with macular telangiectasia type 2. | Scerri TS et al. | — | 2017 | → |
| Ischemic Retinopathies: Oxidative Stress and Inflammation. | Rivera JC et al. | — | 2017 | → |
| Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration. | Bonyadi M et al. | — | 2017 | → |
| Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration. | Handa JT et al. | — | 2017 | → |
| Macrophage physiology in the eye. | Chinnery HR et al. | — | 2017 | → |
| Macular Degeneration Epidemiology: Nature-Nurture, Lifestyle Factors, Genetic Risk, and Gene-Environment Interactions - The Weisenfeld Award Lecture. | Seddon JM | — | 2017 | → |
| Major review: Molecular genetics of primary open-angle glaucoma. | Liu Y et al. | — | 2017 | → |
| New insights into mononuclear phagocyte biology from the visual system. | Reyes NJ et al. | — | 2017 | → |
| New Treatment Modalities for Geographic Atrophy. | Kandasamy R et al. | — | 2017 | → |
| Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration. | Krilis M et al. | — | 2017 | → |
| Novel mechanisms and functions of complement. | Hajishengallis G et al. | — | 2017 | → |
| On phagocytes and macular degeneration. | Guillonneau X et al. | — | 2017 | → |
| Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders. | Ferluga J et al. | — | 2017 | → |
| Proteomic analysis of human lacrimal and tear fluid in dry eye disease. | Jung JH et al. | — | 2017 | → |
| Recent developments in age-related macular degeneration: a review. | Al-Zamil WM et al. | — | 2017 | → |
| Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. | Iannaccone A et al. | — | 2017 | → |
| Structural and molecular changes in the aging choroid: implications for age-related macular degeneration. | Chirco KR et al. | — | 2017 | → |
| Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. | Tan PL et al. | — | 2017 | → |
| The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment. | Geerlings MJ et al. | — | 2017 | → |
| The functional activities of complement factor H are impaired in patients with ANCA-positive vasculitis. | Chen SF et al. | — | 2017 | → |
| The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. | Datta S et al. | — | 2017 | → |
| The lectin self of complement factor H. | Blaum BS | — | 2017 | → |
| The link between morphology and complement in ocular disease. | Mohlin C et al. | — | 2017 | → |
| THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET. | Boyer DS et al. | — | 2017 | → |
| Adrenomedullin: A potential therapeutic target for retinochoroidal disease. | Iesato Y et al. | — | 2016 | → |
| Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology. | Hoh Kam J et al. | — | 2016 | → |
| Age-related macular degeneration: Complement in action. | van Lookeren Campagne M et al. | — | 2016 | → |
| Age-related macular degeneration: genome-wide association studies to translation. | Black JR et al. | — | 2016 | → |
| AMD and the alternative complement pathway: genetics and functional implications. | Tan PL et al. | — | 2016 | → |
| AMD-like retinopathy associated with intravenous iron. | Song D et al. | — | 2016 | → |
| Amyloidosis in Retinal Neurodegenerative Diseases. | Masuzzo A et al. | — | 2016 | → |
| Analysis of copy number variation at DMBT1 and age-related macular degeneration. | Polley S et al. | — | 2016 | → |
| Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration. | Saksens NT et al. | — | 2016 | → |
| Annexin A2 Enhances Complement Activation by Inhibiting Factor H. | Renner B et al. | — | 2016 | → |
| A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo. | Paun CC et al. | — | 2016 | → |
| Anti-complement activity of the Ixodes scapularis salivary protein Salp20. | Hourcade DE et al. | — | 2016 | → |
| Association of age-related macular degeneration and reticular macular disease with cardiovascular disease. | Rastogi N et al. | — | 2016 | → |
| Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. | Al Gwairi O et al. | — | 2016 | → |
| CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation. | Cao S et al. | — | 2016 | → |
| Complement Activation and Inhibition in Retinal Diseases. | Kleinman ME et al. | — | 2016 | → |
| Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease. | Hakobyan S et al. | — | 2016 | → |
| Complement genetics and susceptibility to inflammatory disease. Lessons from genotype-phenotype correlations. | de Córdoba SR | — | 2016 | → |
| Complement in disease: a defence system turning offensive. | Ricklin D et al. | — | 2016 | → |
| Complement in removal of the dead - balancing inflammation. | Martin M et al. | — | 2016 | → |
| Complement pathway biomarkers and age-related macular degeneration. | Gemenetzi M et al. | — | 2016 | → |
| Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells. | Coughlin B et al. | — | 2016 | → |
| Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. | Khan KN et al. | — | 2016 | → |
| Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration. | McLeod DS et al. | — | 2016 | → |
| Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. | Estrago-Franco MF et al. | — | 2016 | → |
| Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes. | Martin M et al. | — | 2016 | → |
| Four complement factor H gene polymorphisms in association with AMD: A meta-analysis. | Liao X et al. | — | 2016 | → |
| Fucoidan as a Potential Therapeutic for Major Blinding Diseases--A Hypothesis. | Klettner A | — | 2016 | → |
| Genetic Association Analysis of Drusen Progression. | Hoffman JD et al. | — | 2016 | → |
| Genetics and age-related macular degeneration: a practical review for the clinician. | Schwartz SG et al. | — | 2016 | → |
| Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. | Andriessen EM et al. | — | 2016 | → |
| Inflammation and its role in age-related macular degeneration. | Kauppinen A et al. | — | 2016 | → |
| Influence of CFH, HTRA1 and ARMS2 polymorphisms in the response to intravitreal ranibizumab treatment for wet age-related macular degeneration in a Spanish population. | Cruz-Gonzalez F et al. | — | 2016 | → |
| Investigating the CFH Gene Polymorphisms as a Risk Factor for Age-related Macular Degeneration in an Iranian Population. | Babanejad M et al. | — | 2016 | → |
| Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD. | Wagner EK et al. | — | 2016 | → |
| miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. | Tian B et al. | — | 2016 | → |
| Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases. | Recalde S et al. | — | 2016 | → |
| Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration. | Zeng S et al. | — | 2016 | → |
| Monomeric C-reactive protein and inflammation in age-related macular degeneration. | Chirco KR et al. | — | 2016 | → |
| Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD). | Grassmann F et al. | — | 2016 | → |
| New milestones ahead in complement-targeted therapy. | Ricklin D et al. | — | 2016 | → |
| Overview of Laboratory Testing and Clinical Presentations of Complement Deficiencies and Dysregulation. | Frazer-Abel A et al. | — | 2016 | → |
| Oxidative stress, innate immunity, and age-related macular degeneration. | Shaw PX et al. | — | 2016 | → |
| Pentraxins in the activation and regulation of innate immunity. | Daigo K et al. | — | 2016 | → |
| Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. | Mohan RR et al. | — | 2016 | → |
| Pluripotent Stem Cell-Based Therapies in Combination with Substrate for the Treatment of Age-Related Macular Degeneration. | Pennington BO et al. | — | 2016 | → |
| Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. | Sardell RJ et al. | — | 2016 | → |
| Protection of host cells by complement regulators. | Schmidt CQ et al. | — | 2016 | → |
| Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†. | Yu Y et al. | — | 2016 | → |
| Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina. | Williams JA et al. | — | 2016 | → |
| Regulation of signaling events involved in the pathophysiology of neovascular AMD. | Wang H et al. | — | 2016 | → |
| Retinal Remodeling and Metabolic Alterations in Human AMD. | Jones BW et al. | — | 2016 | → |
| Risk factors and biomarkers of age-related macular degeneration. | Lambert NG et al. | — | 2016 | → |
| Selective accumulation of the complement membrane attack complex in aging choriocapillaris. | Chirco KR et al. | — | 2016 | → |
| Self-nonself discrimination by the complement system. | Meri S | — | 2016 | → |
| The continuum of causality in human genetic disorders. | Katsanis N | — | 2016 | → |
| Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration. | Wang H et al. | — | 2016 | → |
| TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation. | Wang H et al. | — | 2016 | → |
| Whole exome sequencing of extreme age-related macular degeneration phenotypes. | Sardell RJ et al. | — | 2016 | → |
| A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. | Aredo B et al. | — | 2015 | → |
| Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. | Genewsky A et al. | — | 2015 | → |
| Age-related macular degeneration and the role of the complement system. | McHarg S et al. | — | 2015 | → |
| Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study. | Chong EW et al. | — | 2015 | → |
| Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease. | Williams MA et al. | — | 2015 | → |
| Age-related macular degeneration phenotypes associated with mutually exclusive homozygous risk variants in CFH and HTRA1 genes. | Chong EW et al. | — | 2015 | → |
| A local complement response by RPE causes early-stage macular degeneration. | Fernandez-Godino R et al. | — | 2015 | → |
| Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world. | Morrison MA et al. | — | 2015 | → |
| An efficient weighted tag SNP-set analytical method in genome-wide association studies. | Yan B et al. | — | 2015 | → |
| Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesis. | Bertram P et al. | — | 2015 | → |
| Association of complement factor H gene polymorphisms with age-related macular egeneration susceptibility. | Hao XF et al. | — | 2015 | → |
| Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis. | Ma L et al. | — | 2015 | → |
| Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. | Chavali VR et al. | — | 2015 | → |
| Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways. | Hise AG et al. | — | 2015 | → |
| At the interface of sensory and motor dysfunctions and Alzheimer's disease. | Albers MW et al. | — | 2015 | → |
| Calcium, ARMS2 genotype, and Chlamydia pneumoniae infection in early age-related macular degeneration: a multivariate analysis from the Nagahama study. | Nakata I et al. | — | 2015 | → |
| Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab. | Greenwood GT | — | 2015 | → |
| Cellular models and therapies for age-related macular degeneration. | Forest DL et al. | — | 2015 | → |
| CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration. | García M et al. | — | 2015 | → |
| CFH Y402H and ARMS2 A69S Polymorphisms and Oral Supplementation with Docosahexaenoic Acid in Neovascular Age-Related Macular Degeneration Patients: The NAT2 Study. | Merle BM et al. | — | 2015 | → |
| CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye. | Wang JC et al. | — | 2015 | → |
| Changes of the complement system and rheological indicators after therapy with rheohemapheresis. | Blaha M et al. | — | 2015 | → |
| Chronic central serous chorioretinopathy is associated with genetic variants implicated in age-related macular degeneration. | de Jong EK et al. | — | 2015 | → |
| Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. | Iannaccone A et al. | — | 2015 | → |
| Combination of Aflibercept and Bromfenac Therapy in Age-Related Macular Degeneration: A Pilot Study Aflibercept and Bromfenac in AMD. | Wyględowska-Promieńska D et al. | — | 2015 | → |
| Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration. | Sohn EH et al. | — | 2015 | → |
| Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. | Whitmore SS et al. | — | 2015 | → |
| Complement, a target for therapy in inflammatory and degenerative diseases. | Morgan BP et al. | — | 2015 | → |
| Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement. | Herbert AP et al. | — | 2015 | → |
| Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles. | Haapasalo K et al. | — | 2015 | → |
| Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics. | Melis JP et al. | — | 2015 | → |
| Complement regulators in human disease: lessons from modern genetics. | Liszewski MK et al. | — | 2015 | → |
| Complement System Part II: Role in Immunity. | Merle NS et al. | — | 2015 | → |
| Complement System Part I - Molecular Mechanisms of Activation and Regulation. | Merle NS et al. | — | 2015 | → |
| Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. | Mastellos DC et al. | — | 2015 | → |
| CONDITIONAL DISTANCE CORRELATION. | Wang X et al. | — | 2015 | → |
| Dementia of the eye: the role of amyloid beta in retinal degeneration. | Ratnayaka JA et al. | — | 2015 | → |
| Drugs in Phase II clinical trials for the treatment of age-related macular degeneration. | Tolentino MJ et al. | — | 2015 | → |
| Effects of aflibercept for ranibizumab-resistant neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. | Kawashima Y et al. | — | 2015 | → |
| Enrichment of Bruch's Membrane from Human Donor Eyes. | McHarg S et al. | — | 2015 | → |
| Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. | Ding JD et al. | — | 2015 | → |
| Factor H-related proteins determine complement-activating surfaces. | Józsi M et al. | — | 2015 | → |
| Gene-gene interaction of CFH, ARMS2, and ARMS2/HTRA1 on the risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese population. | Huang L et al. | — | 2015 | → |
| Genetic predictive biomarkers of anti-VEGF treatment response in patients with neovascular age-related macular degeneration. | Fauser S et al. | — | 2015 | → |
| HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age-related macular degeneration? | Okur V et al. | — | 2015 | → |
| HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration. | Iejima D et al. | — | 2015 | → |
| Identification of genome-wide SNP-SNP and SNP-clinical Boolean interactions in age-related macular degeneration. | Riveros C et al. | — | 2015 | → |
| Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. | Thompson RB et al. | — | 2015 | → |
| IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. | Nakamura R et al. | — | 2015 | → |
| Immune mechanisms in inflammatory and degenerative eye disease. | Perez VL et al. | — | 2015 | → |
| Impact of visceral fat and pro-inflammatory factors on the pathogenesis of age-related macular degeneration. | Haas P et al. | — | 2015 | → |
| Inflammatory Mechanisms of Age-related Macular Degeneration. | Knickelbein JE et al. | — | 2015 | → |
| Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). | Handa JT et al. | — | 2015 | → |
| Localization of complement factor H gene expression and protein distribution in the mouse outer retina. | Smit-McBride Z et al. | — | 2015 | → |
| Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization. | Schnabolk G et al. | — | 2015 | → |
| Mitochondrial DNA has a pro-inflammatory role in AMD. | Dib B et al. | — | 2015 | → |
| Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. | Kanan Y et al. | — | 2015 | → |
| Nonsynonymous single nucleotide polymorphisms in the complement component 3 gene are associated with risk of age-related macular degeneration: a meta-analysis. | Qian-Qian Y et al. | — | 2015 | → |
| Novel association of FCGR2A polymorphism with age-related macular degeneration (AMD) and development of a novel CFH real-time genotyping method. | Velissari A et al. | — | 2015 | → |
| Nutritional supplements in age-related macular degeneration. | Schmidl D et al. | — | 2015 | → |
| Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium. | Dinculescu A et al. | — | 2015 | → |
| PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. | Stiles M et al. | — | 2015 | → |
| Pharmacogenetic Effect of Complement Factor H Gene Polymorphism in Response to the Initial Intravitreal Injection of Bevacizumab for Wet Age-Related Macular Degeneration. | Medina FM et al. | — | 2015 | → |
| Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis. | Chen G et al. | — | 2015 | → |
| Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration. | Ferrara D et al. | — | 2015 | → |
| Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration. | Guymer R et al. | — | 2015 | → |
| Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration. | Triebwasser MP et al. | — | 2015 | → |
| Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88. | Syeda S et al. | — | 2015 | → |
| Regulation of age-related macular degeneration-like pathology by complement factor H. | Toomey CB et al. | — | 2015 | → |
| Relationship between the complement system, risk factors and prediction models in age-related macular degeneration. | Bora NS et al. | — | 2015 | → |
| Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration. | Radeke MJ et al. | — | 2015 | → |
| Retinal microglia: just bystander or target for therapy? | Karlstetter M et al. | — | 2015 | → |
| Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9. | Georgiannakis A et al. | — | 2015 | → |
| Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration. | Clark SJ et al. | — | 2015 | → |
| Role of tyrosine-sulfated proteins in retinal structure and function. | Kanan Y et al. | — | 2015 | → |
| Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. | Bradley DT et al. | — | 2015 | → |
| The genetics of age-related macular degeneration (AMD)--Novel targets for designing treatment options? | Grassmann F et al. | — | 2015 | → |
| The local complement activation on vascular bed of patients with systemic sclerosis: a hypothesis-generating study. | Scambi C et al. | — | 2015 | → |
| The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases. | Loeven MA et al. | — | 2015 | → |
| The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity. | Kent D | — | 2015 | → |
| Thrombotic Microangiopathy with Complement Factor H Gene Mutations Unassociated with Atypical Hemolytic Uremic Syndrome. | Oymak Y et al. | — | 2015 | → |
| Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. | Yang HJ et al. | — | 2015 | → |
| What Animal Models Can Tell Us About Glaucoma. | Struebing FL et al. | — | 2015 | → |
| What Does Genetics Tell Us About Age-Related Macular Degeneration? | Grassmann F et al. | — | 2015 | → |
| Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation? | Warwick A et al. | — | 2014 | → |
| Age-related macular degeneration and changes in the extracellular matrix. | Nita M et al. | — | 2014 | → |
| Age-related macular degeneration and the incidence of cardiovascular disease: a systematic review and meta-analysis. | Wu J et al. | — | 2014 | → |
| Age-related macular degeneration: beyond anti-angiogenesis. | Kent DL | — | 2014 | → |
| Age-related macular degeneration: genetics and biology coming together. | Fritsche LG et al. | — | 2014 | → |
| Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). | Nita M et al. | — | 2014 | → |
| Age-related macular degeneration: what's new and on the horizon. | Fletcher EL et al. | — | 2014 | → |
| A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. | Pauly D et al. | — | 2014 | → |
| Association between complement factor H Val62Ile polymorphism and age-related macular degeneration susceptibility: a meta-analysis. | Wang X et al. | — | 2014 | → |
| Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway. | Ma W et al. | — | 2014 | → |
| Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype. | Radu RA et al. | — | 2014 | → |
| Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. | Rowan S et al. | — | 2014 | → |
| CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans. | Contreras AV et al. | — | 2014 | → |
| CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) gene polymorphisms are associated with AMD risk in Spanish patients. | Cruz-González F et al. | — | 2014 | → |
| Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration. | Garcia Filho CA et al. | — | 2014 | → |
| Chromosome 10q26 locus and age-related macular degeneration: a progress update. | Wang G | — | 2014 | → |
| Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study. | Havvas I et al. | — | 2014 | → |
| Complement factor B polymorphism and the phenotype of early age-related macular degeneration. | Mantel I et al. | — | 2014 | → |
| Complement factor H and related proteins in age-related macular degeneration. | Calippe B et al. | — | 2014 | → |
| Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium. | Kanan Y et al. | — | 2014 | → |
| Complement inhibitors for age-related macular degeneration. | Williams MA et al. | — | 2014 | → |
| Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue. | Kawa MP et al. | — | 2014 | → |
| Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention. | Velez-Montoya R et al. | — | 2014 | → |
| Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. | Malek G et al. | — | 2014 | → |
| Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease. | Gorin MB et al. | — | 2014 | → |
| Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. | Lee MS et al. | — | 2014 | → |
| Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration. | Sparrow JR et al. | — | 2014 | → |
| Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy. | Liu K et al. | — | 2014 | → |
| Genetic factors associated with response to intravitreal ranibizumab in Korean patients with neovascular age-related macular degeneration. | Park UC et al. | — | 2014 | → |
| Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis. | Won J et al. | — | 2014 | → |
| Genetic variants in the complement system predisposing to age-related macular degeneration: a review. | Schramm EC et al. | — | 2014 | → |
| Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration. | Cooke Bailey JN et al. | — | 2014 | → |
| Genome-wide association studies using haplotypes and individual SNPs in Simmental cattle. | Wu Y et al. | — | 2014 | → |
| Genomic aspects of age-related macular degeneration. | Horie-Inoue K et al. | — | 2014 | → |
| Geographic atrophy: a histopathological assessment. | Bird AC et al. | — | 2014 | → |
| Highly penetrant alleles in age-related macular degeneration. | den Hollander AI et al. | — | 2014 | → |
| How genetic studies have advanced our understanding of age-related macular degeneration and their impact on patient care: a review. | Baird PN et al. | — | 2014 | → |
| Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. | Weinberger AW et al. | — | 2014 | → |
| Humanized cobra venom factor: structure, activity, and therapeutic efficacy in preclinical disease models. | Vogel CW et al. | — | 2014 | → |
| Human pluripotent stem cell strategies for age-related macular degeneration. | Davidson KC et al. | — | 2014 | → |
| Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. | Clark SJ et al. | — | 2014 | → |
| IKK2 inhibition attenuates laser-induced choroidal neovascularization. | Lu H et al. | — | 2014 | → |
| In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. | Chu XK et al. | — | 2014 | → |
| Inflammatory biomarkers for AMD. | Stanton CM et al. | — | 2014 | → |
| Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. | Kenney MC et al. | — | 2014 | → |
| Interactive Hangman teaches amino acid structures and abbreviations. | Pennington BO et al. | — | 2014 | → |
| Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis. | Caminsky N et al. | — | 2014 | → |
| Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. | Cheung CM et al. | — | 2014 | → |
| Is age-related macular degeneration a microvascular disease? | Mullins RF et al. | — | 2014 | → |
| Is renal function associated with early age-related macular degeneration? | Chong EW et al. | — | 2014 | → |
| Macular dystrophies mimicking age-related macular degeneration. | Saksens NT et al. | — | 2014 | → |
| Mechanisms of age-related macular degeneration and therapeutic opportunities. | van Lookeren Campagne M et al. | — | 2014 | → |
| Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans. | Shen L et al. | — | 2014 | → |
| Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands. | Perkins SJ et al. | — | 2014 | → |
| Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration. | Garland DL et al. | — | 2014 | → |
| Nature and nurture- genes and environment- predict onset and progression of macular degeneration. | Sobrin L et al. | — | 2014 | → |
| New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3. | Rodriguez E et al. | — | 2014 | → |
| New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. | Mehta G et al. | — | 2014 | → |
| Ocular surface temperature in age-related macular degeneration. | Sodi A et al. | — | 2014 | → |
| Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release. | Ebrahimi KB et al. | — | 2014 | → |
| Pharmacogenetic associations with long-term response to anti-vascular endothelial growth factor treatment in neovascular AMD patients. | Park UC et al. | — | 2014 | → |
| Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration. | Tsuchihashi T et al. | — | 2014 | → |
| Recent developments in the treatment of age-related macular degeneration. | Holz FG et al. | — | 2014 | → |
| Reticular macular lesions: a review of the phenotypic hallmarks and their clinical significance. | Saade C et al. | — | 2014 | → |
| Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. | Yang P et al. | — | 2014 | → |
| Set-based joint test of interaction between SNPs in the VEGF pathway and exogenous estrogen finds association with age-related macular degeneration. | Courtenay MD et al. | — | 2014 | → |
| Should I stay or should I go? Trafficking of sub-lytic MAC in the retinal pigment epithelium. | Lakkaraju A et al. | — | 2014 | → |
| Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. | Kunchithapautham K et al. | — | 2014 | → |
| Studying age-related macular degeneration using animal models. | Fletcher EL et al. | — | 2014 | → |
| Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina. | Rutar M et al. | — | 2014 | → |
| Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study. | Yehoshua Z et al. | — | 2014 | → |
| T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. | Cruz-Guilloty F et al. | — | 2014 | → |
| The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization. | Schnabolk G et al. | — | 2014 | → |
| The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration. | Dietzel M et al. | — | 2014 | → |
| The Immune System and AMD. | Frederick PA et al. | — | 2014 | → |
| The impact of the human genome project on complex disease. | Bailey JN et al. | — | 2014 | → |
| The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. | Mullins RF et al. | — | 2014 | → |
| The proteomics of drusen. | Crabb JW | — | 2014 | → |
| The use of cultured human fetal retinal pigment epithelium in studies of the classical retinoid visual cycle and retinoid-based disease processes. | Hu J et al. | — | 2014 | → |
| Using current data to define new approach in age related macular degeneration: need to accelerate translational research. | Anand A et al. | — | 2014 | → |
| Vitreoretinal interface changes in geographic atrophy. | Abdillahi H et al. | — | 2014 | → |
| Zinc supplementation inhibits complement activation in age-related macular degeneration. | Smailhodzic D et al. | — | 2014 | → |
| 670 nm LED ameliorates inflammation in the CFH(-/-) mouse neural retina. | Kokkinopoulos I | — | 2013 | → |
| A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. | Anderson OA et al. | — | 2013 | → |
| Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. | Chen M et al. | — | 2013 | → |
| Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. | Zhao H et al. | — | 2013 | → |
| A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. | Scheetz TE et al. | — | 2013 | → |
| Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. | Keilhauer CN et al. | — | 2013 | → |
| Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation. | Khandhadia S et al. | — | 2013 | → |
| Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. | Jacobo SM et al. | — | 2013 | → |
| Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lecture. | Miller JW | — | 2013 | → |
| All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death. | Berchuck JE et al. | — | 2013 | → |
| Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury. | Woodell A et al. | — | 2013 | → |
| ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study. | Chakravarthy U et al. | — | 2013 | → |
| Association analysis of CFH and ARMS2 gene polymorphisms in a Brazilian cohort with age-related macular degeneration. | Almeida LN et al. | — | 2013 | → |
| Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population. | Wu L et al. | — | 2013 | → |
| Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis. | Thompson IA et al. | — | 2013 | → |
| Association of LIPC and advanced age-related macular degeneration. | Lee J et al. | — | 2013 | → |
| Aurintricarboxylic acid inhibits complement activation, membrane attack complex, and choroidal neovascularization in a model of macular degeneration. | Lipo E et al. | — | 2013 | → |
| CEP biomarkers as potential tools for monitoring therapeutics. | Renganathan K et al. | — | 2013 | → |
| Complement activation in diseases presenting with thrombotic microangiopathy. | Meri S | — | 2013 | → |
| Complement alternative pathway genetic variation and Dengue infection in the Thai population. | Kraivong R et al. | — | 2013 | → |
| Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. | Hoh Kam J et al. | — | 2013 | → |
| Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis. | Yuan D et al. | — | 2013 | → |
| Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. | Kandasamy M et al. | — | 2013 | → |
| Complement regulation in renal disease models. | Naik A et al. | — | 2013 | → |
| Cuticular drusen: stars in the sky. | Boon CJ et al. | — | 2013 | → |
| Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. | Ebrahimi KB et al. | — | 2013 | → |
| Dense deposit disease and C3 glomerulopathy. | Barbour TD et al. | — | 2013 | → |
| Diminishing risk for age-related macular degeneration with nutrition: a current view. | Schleicher M et al. | — | 2013 | → |
| Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay. | Sofat R et al. | — | 2013 | → |
| Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. | Bowes Rickman C et al. | — | 2013 | → |
| Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells. | van der Burght BW et al. | — | 2013 | → |
| Episodic neurologic disorders: syndromes, genes, and mechanisms. | Russell JF et al. | — | 2013 | → |
| Exon-level expression profiling of ocular tissues. | Wagner AH et al. | — | 2013 | → |
| eyeGENE®: a vision community resource facilitating patient care and paving the path for research through molecular diagnostic testing. | Blain D et al. | — | 2013 | → |
| Eyes on 3D-current 3D biomimetic disease concept models and potential applications in age-related macular degeneration. | Feigl B et al. | — | 2013 | → |
| Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation. | Ma W et al. | — | 2013 | → |
| Gene-gene interactions of CFH and LOC387715/ARMS2 with Korean exudative age-related macular degeneration patients. | Kim YH et al. | — | 2013 | → |
| Genetic and Epigenetic Regulation in Age-related Macular Degeneration. | Wei L et al. | — | 2013 | → |
| Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. | Naj AC et al. | — | 2013 | → |
| Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy. | Kuo JZ et al. | — | 2013 | → |
| Immunology of age-related macular degeneration. | Ambati J et al. | — | 2013 | → |
| Inclusion of genotype with fundus phenotype improves accuracy of predicting choroidal neovascularization and geographic atrophy. | Perlee LT et al. | — | 2013 | → |
| Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. | Cruz-Guilloty F et al. | — | 2013 | → |
| Inflammation in retinal disease. | Whitcup SM et al. | — | 2013 | → |
| Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease. | Cruz-González F et al. | — | 2013 | → |
| Innate immune network in the retina activated by optic nerve crush. | Templeton JP et al. | — | 2013 | → |
| Interaction of complement factor h and fibulin3 in age-related macular degeneration. | Wyatt MK et al. | — | 2013 | → |
| Intravitreal tumor necrosis factor-alpha inhibitors for neovascular age-related macular degeneration suboptimally responsive to antivascular endothelial growth factor agents: a pilot study from the Pan American Collaborative Retina Study Group. | Wu L et al. | — | 2013 | → |
| In vitro secretion deficits are common among human coagulation factor XIII subunit B missense mutants: correlations with patient phenotypes and molecular models. | Biswas A et al. | — | 2013 | → |
| Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks. | Parmeggiani F et al. | — | 2013 | → |
| Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. | Gordon WC et al. | — | 2013 | → |
| Molecular genetic testing and the future of clinical genomics. | Katsanis SH et al. | — | 2013 | → |
| Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. | Broderick L et al. | — | 2013 | → |
| Neurologic involvement in atypical hemolytic uremic syndrome and successful treatment with eculizumab. | Gulleroglu K et al. | — | 2013 | → |
| Nitrate-nitrogen levels in rural drinking water: Is there an association with age-related macular degeneration? | Klein BE et al. | — | 2013 | → |
| NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. | Tseng WA et al. | — | 2013 | → |
| Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. | Joseph K et al. | — | 2013 | → |
| Pentraxins: structure, function, and role in inflammation. | Du Clos TW | — | 2013 | → |
| Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. | Kohno H et al. | — | 2013 | → |
| Predictive model for earlier diagnosis of suspected age-related macular degeneration patients. | Sharma NK et al. | — | 2013 | → |
| Prevalence and genomic association of reticular pseudodrusen in age-related macular degeneration. | Ueda-Arakawa N et al. | — | 2013 | → |
| Prioritization of retinal disease genes: an integrative approach. | Wagner AH et al. | — | 2013 | → |
| Properdin and factor h: opposing players on the alternative complement pathway "see-saw". | Kouser L et al. | — | 2013 | → |
| Rat retinal transcriptome: effects of aging and AMD-like retinopathy. | Kozhevnikova OS et al. | — | 2013 | → |
| Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD). | Oczos J et al. | — | 2013 | → |
| Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. | Cao S et al. | — | 2013 | → |
| Retinal changes precede visual dysfunction in the complement factor H knockout mouse. | Williams JA et al. | — | 2013 | → |
| Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review. | Barnett BP et al. | — | 2013 | → |
| Role of heparan sulfate in ocular diseases. | Park PJ et al. | — | 2013 | → |
| Seven new loci associated with age-related macular degeneration. | Fritsche LG et al. | — | 2013 | → |
| The eye: A window to the soul of the immune system. | Perez VL et al. | — | 2013 | → |
| The golden era of ocular disease gene discovery: race to the finish. | Swaroop A et al. | — | 2013 | → |
| The immunological basis of degenerative diseases of the eye. | Nussenblatt RB et al. | — | 2013 | → |
| The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation. | Clark SJ et al. | — | 2013 | → |
| Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease. | McDowell RE et al. | — | 2013 | → |
| The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. | Jawad S et al. | — | 2013 | → |
| The role of the immune response in age-related macular degeneration. | Whitcup SM et al. | — | 2013 | → |
| Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. | Clark SJ et al. | — | 2013 | → |
| Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration. | Birke K et al. | — | 2013 | → |
| Validation of a prediction algorithm for progression to advanced macular degeneration subtypes. | Seddon JM et al. | — | 2013 | → |
| Y402H polymorphism in complement factor H and age-related macular degeneration in the Tunisian population. | Habibi I et al. | — | 2013 | → |
| Younger siblings, C-reactive protein, and risk of age-related macular degeneration. | Cohn AC et al. | — | 2013 | → |
| Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. | Nan R et al. | — | 2013 | → |
| 670-nm light treatment reduces complement propagation following retinal degeneration. | Rutar M et al. | — | 2012 | → |
| Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. | Servais A et al. | — | 2012 | → |
| Acquisition of complement factor H is important for pathogenesis of Streptococcus pyogenes infections: evidence from bacterial in vitro survival and human genetic association. | Haapasalo K et al. | — | 2012 | → |
| Adrenomedullin inhibits choroidal neovascularization via CCL2 in the retinal pigment epithelium. | Yuda K et al. | — | 2012 | → |
| Age-related macular degeneration and association of CFH Y402H and LOC387715 A69S polymorphisms in a Turkish population. | Soysal Y et al. | — | 2012 | → |
| Age-related macular degeneration and the complement system. | Khandhadia S et al. | — | 2012 | → |
| A layered approach to raising public awareness of macular degeneration in Australia. | Heraghty J et al. | — | 2012 | → |
| A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. | Piccardi M et al. | — | 2012 | → |
| Altered expression of CD46 and CD59 on leukocytes in neovascular age-related macular degeneration. | Singh A et al. | — | 2012 | → |
| Animal models of age related macular degeneration. | Pennesi ME et al. | — | 2012 | → |
| A novel role of complement in retinal degeneration. | Yu M et al. | — | 2012 | → |
| A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration. | Yoon KD et al. | — | 2012 | → |
| A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates. | Lomniczi A et al. | — | 2012 | → |
| Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration. | Orlin A et al. | — | 2012 | → |
| Association of CFH Y402H polymorphism with both forms of advanced age-related macular degeneration in Turkish patients. | Yücel D et al. | — | 2012 | → |
| Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population. | Gan W et al. | — | 2012 | → |
| Autoimmunity: homeostasis of innate immunity gone awry. | Park HJ et al. | — | 2012 | → |
| Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization. | Mullins RF et al. | — | 2012 | → |
| Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin. | Khan S et al. | — | 2012 | → |
| C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up. | Sethi S et al. | — | 2012 | → |
| Can genetic associations change with age? CFH and age-related macular degeneration. | Adams MK et al. | — | 2012 | → |
| Chlamydia infection status, genotype, and age-related macular degeneration. | Khandhadia S et al. | — | 2012 | → |
| Complement dysregulation and disease: from genes and proteins to diagnostics and drugs. | de Cordoba SR et al. | — | 2012 | → |
| Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. | Sparrow JR et al. | — | 2012 | → |
| Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. | Yang MM et al. | — | 2012 | → |
| Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. | Sofat R et al. | — | 2012 | → |
| Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. | Shaw PX et al. | — | 2012 | → |
| Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. | Tortajada A et al. | — | 2012 | → |
| Complement involvement in neovascular ocular diseases. | Yanai R et al. | — | 2012 | → |
| Complement system activation and endothelial dysfunction in patients with age-related macular degeneration (AMD): possible relationship between AMD and atherosclerosis. | Machalińska A et al. | — | 2012 | → |
| Comprehensive analysis of Copy Number Variation of genes at chromosome 1 and 10 loci associated with late age related macular degeneration. | Cantsilieris S et al. | — | 2012 | → |
| Deciphering the complexities of human diseases and disorders by coupling induced-pluripotent stem cells and systems genetics. | Chang WY et al. | — | 2012 | → |
| Dry age-related macular degeneration: A currently unmet clinical need. | Girmens JF et al. | — | 2012 | → |
| Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. | Malek G et al. | — | 2012 | → |
| Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. | Kopp A et al. | — | 2012 | → |
| Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis. | Chen H et al. | — | 2012 | → |
| Genetics of immunological and inflammatory components in age-related macular degeneration. | Tuo J et al. | — | 2012 | → |
| Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. | Cipriani V et al. | — | 2012 | → |
| Genotype-phenotype associations in neovascular age-related macular degeneration. | Hogg RE et al. | — | 2012 | → |
| Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. | Sobrin L et al. | — | 2012 | → |
| Heritability of the spatial distribution and peak density of macular pigment: a classical twin study. | Hogg RE et al. | — | 2012 | → |
| Impact of loading phase, initial response and CFH genotype on the long-term outcome of treatment for neovascular age-related macular degeneration. | Menghini M et al. | — | 2012 | → |
| Interleukin 27 induces the expression of complement factor H (CFH) in the retina. | Amadi-Obi A et al. | — | 2012 | → |
| Is drusen area really so important? An assessment of risk of conversion to neovascular AMD based on computerized measurements of drusen. | Friberg TR et al. | — | 2012 | → |
| Low-dose lipopolysaccharide pretreatment suppresses choroidal neovascularization via IL-10 induction. | Matsumura N et al. | — | 2012 | → |
| Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement. | Bandyopadhyay M et al. | — | 2012 | → |
| Mechanism of inflammation in age-related macular degeneration. | Parmeggiani F et al. | — | 2012 | → |
| Mechanisms of age-related macular degeneration. | Ambati J et al. | — | 2012 | → |
| Modelling the genetic risk in age-related macular degeneration. | Grassmann F et al. | — | 2012 | → |
| Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. | Kinnunen K et al. | — | 2012 | → |
| Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration. | Baas DC et al. | — | 2012 | → |
| Nutritional modulation of age-related macular degeneration. | Weikel KA et al. | — | 2012 | → |
| Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. | Zhang K et al. | — | 2012 | → |
| Pharmacogenetic influence of LOC387715/HTRA1 on the efficacy of bevacizumab treatment for age-related macular degeneration in a Korean population. | Kang HK et al. | — | 2012 | → |
| Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration. | Agosta E et al. | — | 2012 | → |
| Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. | Brantley MA et al. | — | 2012 | → |
| Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism. | Silva AS et al. | — | 2012 | → |
| Pluripotent human stem cells for the treatment of retinal disease. | Rowland TJ et al. | — | 2012 | → |
| Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. | Sundaresan P et al. | — | 2012 | → |
| Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. | Yu Y et al. | — | 2012 | → |
| Purification and biochemical characterization of functional complement factor H from human plasma fractions. | Brandstätter H et al. | — | 2012 | → |
| Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration. | Nagineni CN et al. | — | 2012 | → |
| Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients. | Capoluongo E et al. | — | 2012 | → |
| Retinal remodeling. | Jones BW et al. | — | 2012 | → |
| Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. | Smailhodzic D et al. | — | 2012 | → |
| Road to fulfilment: taming the immune response to restore vision. | Dick AD | — | 2012 | → |
| Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. | Makou E et al. | — | 2012 | → |
| Structural and functional characterization of the product of disease-related factor H gene conversion. | Herbert AP et al. | — | 2012 | → |
| Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. | Kunchithapautham K et al. | — | 2012 | → |
| Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. | Buentello-Volante B et al. | — | 2012 | → |
| Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. | Rohrer B et al. | — | 2012 | → |
| Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. | Newman AM et al. | — | 2012 | → |
| Technical brief: isolation of total DNA from postmortem human eye tissues and quality comparison between iris and retina. | Wang JC et al. | — | 2012 | → |
| The ARMS2 A69S variant and bilateral advanced age-related macular degeneration. | Schwartz SG et al. | — | 2012 | → |
| The bisretinoids of retinal pigment epithelium. | Sparrow JR et al. | — | 2012 | → |
| The chromosome 10q26 susceptibility locus in age-related macular degeneration. | Stanton CM et al. | — | 2012 | → |
| The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. | Risitano AM et al. | — | 2012 | → |
| The complotype: dictating risk for inflammation and infection. | Harris CL et al. | — | 2012 | → |
| The innate immune response to products of phospholipid peroxidation. | Weismann D et al. | — | 2012 | → |
| Therapeutic targeting of the complement system in age-related macular degeneration: a review. | Troutbeck R et al. | — | 2012 | → |
| The role of amyloid-β in retinal degeneration. | Bruban J et al. | — | 2012 | → |
| WITHDRAWN: Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. | Sparrow JR et al. | — | 2012 | → |
| A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. | Sivakumaran TA et al. | — | 2011 | → |
| Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data. | He Y et al. | — | 2011 | → |
| Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein. | Hourcade DE et al. | — | 2011 | → |
| Activation of P2X receptors induces apoptosis in human retinal pigment epithelium. | Yang D et al. | — | 2011 | → |
| Advanced glycation endproduct changes to Bruch's membrane promotes lipoprotein retention by lipoprotein lipase. | Cano M et al. | — | 2011 | → |
| Age related macular degeneration and drusen: neuroinflammation in the retina. | Buschini E et al. | — | 2011 | → |
| Age-related macular degeneration: genetic and clinical findings. | Kokotas H et al. | — | 2011 | → |
| Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients. | Losonczy G et al. | — | 2011 | → |
| Animal models of retinal disease. | Fletcher EL et al. | — | 2011 | → |
| A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration. | Cashman SM et al. | — | 2011 | → |
| Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. | Ding JD et al. | — | 2011 | → |
| A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. | Raychaudhuri S et al. | — | 2011 | → |
| A review and meta-analysis of the association between C-reactive protein and age-related macular degeneration. | Hong T et al. | — | 2011 | → |
| A review: role of ultraviolet radiation in age-related macular degeneration. | Chalam KV et al. | — | 2011 | → |
| ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. | Sobrin L et al. | — | 2011 | → |
| Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. | Zhao J et al. | — | 2011 | → |
| Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. | Yu Y et al. | — | 2011 | → |
| [Atypical hemolytic-uremic syndrome related to abnormalities within the complement system]. | Frémeaux-Bacchi V et al. | — | 2011 | → |
| Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration. | Wang H et al. | — | 2011 | → |
| CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis. | Bruban J et al. | — | 2011 | → |
| Cell-deposited matrix improves retinal pigment epithelium survival on aged submacular human Bruch's membrane. | Sugino IK et al. | — | 2011 | → |
| Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration. | Mullins RF et al. | — | 2011 | → |
| c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes. | Fraczek LA et al. | — | 2011 | → |
| Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. | Hageman GS et al. | — | 2011 | → |
| Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. | Heurich M et al. | — | 2011 | → |
| Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. | Yu Y et al. | — | 2011 | → |
| Comparison of FRPE and human embryonic stem cell-derived RPE behavior on aged human Bruch's membrane. | Sugino IK et al. | — | 2011 | → |
| Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. | Liu B et al. | — | 2011 | → |
| Complement factor H 402H variant and reticular macular disease. | Smith RT et al. | — | 2011 | → |
| Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration. | Tsuchihashi T et al. | — | 2011 | → |
| Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. | Weismann D et al. | — | 2011 | → |
| Complement factor H Y402H gene polymorphism and response to intravitreal bevacizumab in exudative age-related macular degeneration. | Nischler C et al. | — | 2011 | → |
| Complement in age-related macular degeneration: a focus on function. | Bradley DT et al. | — | 2011 | → |
| Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. | Radu RA et al. | — | 2011 | → |
| Computational quantification of complex fundus phenotypes in age-related macular degeneration and Stargardt disease. | Quellec G et al. | — | 2011 | → |
| Copy number variation in the complement factor H-related genes and age-related macular degeneration. | Kubista KE et al. | — | 2011 | → |
| Correlation of complement factor H gene polymorphisms with exudative age-related macular degeneration in a Chinese cohort. | Dong L et al. | — | 2011 | → |
| C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration. | Bhutto IA et al. | — | 2011 | → |
| Dark matters in AMD genetics: epigenetics and stochasticity. | Hjelmeland LM | — | 2011 | → |
| Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids. | Salomon RG et al. | — | 2011 | → |
| Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. | Pechtl IC et al. | — | 2011 | → |
| Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome? | Poolpol K et al. | — | 2011 | → |
| Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. | Bazan NG et al. | — | 2011 | → |
| Dynamic control of the complement system by modulated expression of regulatory proteins. | Thurman JM et al. | — | 2011 | → |
| Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. | Chen M et al. | — | 2011 | → |
| Early biosignature of oxidative stress in the retinal pigment epithelium. | Arnouk H et al. | — | 2011 | → |
| Effects of smoking on ocular health. | Galor A et al. | — | 2011 | → |
| Elastin rs2301995 polymorphism is not associated with polypoidal choroidal vasculopathy in caucasians. | Lima LH et al. | — | 2011 | → |
| Elevated membrane attack complex in human choroid with high risk complement factor H genotypes. | Mullins RF et al. | — | 2011 | → |
| Emerging therapeutic approaches in the management of retinal angiogenesis and edema. | Truong A et al. | — | 2011 | → |
| Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. | Peter I et al. | — | 2011 | → |
| Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. | McKay GJ et al. | — | 2011 | → |
| Genetic association study of age-related macular degeneration in the Spanish population. | Brión M et al. | — | 2011 | → |
| Genetic factors associated with age-related macular degeneration. | Leveziel N et al. | — | 2011 | → |
| Genetic predictors of response to photodynamictherapy. | Parmeggiani F et al. | — | 2011 | → |
| Genetics in ocular inflammation--basic principles. | Wallace GR et al. | — | 2011 | → |
| Genetics of age-related macular degeneration: current concepts, future directions. | Deangelis MM et al. | — | 2011 | → |
| Genome-wide analysis of copy number variants in age-related macular degeneration. | Meyer KJ et al. | — | 2011 | → |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | — | 2011 | → |
| Genomics and the eye. | Sheffield VC et al. | — | 2011 | → |
| Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. | Feehan M et al. | — | 2011 | → |
| Implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration. | Haas P et al. | — | 2011 | → |
| Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3. | Ebrahem Q et al. | — | 2011 | → |
| Inflammation and age-related macular degeneration (AMD). | Telander DG | — | 2011 | → |
| Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology. | Jun G et al. | — | 2011 | → |
| Interaction of human complement factor H variants Tyr⁴⁰² and His⁴⁰² with Leptospira spp. | Silva AS et al. | — | 2011 | → |
| Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway. | Rodríguez de Córdoba S et al. | — | 2011 | → |
| Light filtering in a retinal pigment epithelial cell culture model. | Zhou J et al. | — | 2011 | → |
| Lipids, lipoproteins, and age-related macular degeneration. | Ebrahimi KB et al. | — | 2011 | → |
| Mitochondrial dysfunction in retinal diseases. | Barot M et al. | — | 2011 | → |
| Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. | Jönsen A et al. | — | 2011 | → |
| Parallel findings in age-related macular degeneration and Alzheimer's disease. | Ohno-Matsui K | — | 2011 | → |
| Pharmacogenetics and age-related macular degeneration. | Schwartz SG et al. | — | 2011 | → |
| Prevention of age-related macular degeneration. | Wong IY et al. | — | 2011 | → |
| Primary open-angle glaucoma genes. | Fingert JH | — | 2011 | → |
| Production of biologically active complement factor H in therapeutically useful quantities. | Schmidt CQ et al. | — | 2011 | → |
| Quantitative detection of single amino acid polymorphisms by targeted proteomics. | Su ZD et al. | — | 2011 | → |
| Reconsidering the connection between vitamin D levels and age-related macular degeneration. | Golan S et al. | — | 2011 | → |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | — | 2011 | → |
| Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. | Dwyer MA et al. | — | 2011 | → |
| Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. | Vogt SD et al. | — | 2011 | → |
| Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency. | Friedrich U et al. | — | 2011 | → |
| Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. | Seddon JM et al. | — | 2011 | → |
| Serum VEGF and CFH in exudative age-related macular degeneration. | Haas P et al. | — | 2011 | → |
| Smoking, dietary betaine, methionine, and vitamin D in monozygotic twins with discordant macular degeneration: epigenetic implications. | Seddon JM et al. | — | 2011 | → |
| Structural basis for engagement by complement factor H of C3b on a self surface. | Morgan HP et al. | — | 2011 | → |
| Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration. | Lueck K et al. | — | 2011 | → |
| Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. | Kunchithapautham K et al. | — | 2011 | → |
| Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. | Morrison MA et al. | — | 2011 | → |
| Systems genetics for drug target discovery. | Penrod NM et al. | — | 2011 | → |
| The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. | Rohrer B et al. | — | 2011 | → |
| The challenge of predicting macular degeneration. | Feigl B et al. | — | 2011 | → |
| The effect of electrostatics on factor H function and related pathologies. | Kieslich CA et al. | — | 2011 | → |
| The influence of genetics on response to treatment with ranibizumab (Lucentis) for age-related macular degeneration: the Lucentis Genotype Study (an American Ophthalmological Society thesis). | Francis PJ | — | 2011 | → |
| The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA). | Trouw LA et al. | — | 2011 | → |
| The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. | Friedrich U et al. | — | 2011 | → |
| The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application. | Charbel Issa P et al. | — | 2011 | → |
| Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. | Shiose S et al. | — | 2011 | → |
| Update on geographic atrophy in age-related macular degeneration. | Biarnés M et al. | — | 2011 | → |
| Update on the role of genetics in the onset of age-related macular degeneration. | Francis PJ et al. | — | 2011 | → |
| Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling. | Wang H et al. | — | 2011 | → |
| Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus). | Pechtl IC et al. | — | 2011 | → |
| Vitamin D status and early age-related macular degeneration in postmenopausal women. | Millen AE et al. | — | 2011 | → |
| Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration. | Nan R et al. | — | 2011 | → |
| Abundant lipid and protein components of drusen. | Wang L et al. | — | 2010 | → |
| Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane. | Murdaugh LS et al. | — | 2010 | → |
| Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina. | Kanda A et al. | — | 2010 | → |
| Age-related macular degeneration: genetic and environmental factors of disease. | Chen Y et al. | — | 2010 | → |
| A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. | Hollyfield JG et al. | — | 2010 | → |
| Analysis of candidate genes for macular telangiectasia type 2. | Parmalee NL et al. | — | 2010 | → |
| Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. | Wang G et al. | — | 2010 | → |
| Animals as models of age-related macular degeneration: an imperfect measure of the truth. | Zeiss CJ | — | 2010 | → |
| An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). | Fritsche LG et al. | — | 2010 | → |
| A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization. | Nussenblatt RB et al. | — | 2010 | → |
| A rat model for choroidal neovascularization using subretinal lipid hydroperoxide injection. | Baba T et al. | — | 2010 | → |
| Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients. | Teixeira AG et al. | — | 2010 | → |
| Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. | Seddon JM et al. | — | 2010 | → |
| Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population. | Liu X et al. | — | 2010 | → |
| Bioinformatics and the eye. | Smith JR | — | 2010 | → |
| Case-control design: making the case. | Fletcher AE | — | 2010 | → |
| CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration. | Imai D et al. | — | 2010 | → |
| Cobra venom factor: Structure, function, and humanization for therapeutic complement depletion. | Vogel CW et al. | — | 2010 | → |
| Complement, age-related macular degeneration and a vision of the future. | Gehrs KM et al. | — | 2010 | → |
| Complement: a key system for immune surveillance and homeostasis. | Ricklin D et al. | — | 2010 | → |
| Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. | McKay GJ et al. | — | 2010 | → |
| Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells. | Skeie JM et al. | — | 2010 | → |
| Complement control protein factor H: the good, the bad, and the inadequate. | Ferreira VP et al. | — | 2010 | → |
| Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology. | Clark SJ et al. | — | 2010 | → |
| C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. | Seddon JM et al. | — | 2010 | → |
| C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. | Robman L et al. | — | 2010 | → |
| Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degeneration. | Ma KN et al. | — | 2010 | → |
| Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration. | Molday RS et al. | — | 2010 | → |
| Effects of vitrectomy on age-related macular degeneration. | Roller AB et al. | — | 2010 | → |
| Enhanced expression of the complement factor H mRNA in proliferating human RPE cells. | Kociok N et al. | — | 2010 | → |
| Factor H facilitates adherence of Neisseria gonorrhoeae to complement receptor 3 on eukaryotic cells. | Agarwal S et al. | — | 2010 | → |
| Functional modules, mutational load and human genetic disease. | Zaghloul NA et al. | — | 2010 | → |
| Genetic epidemiology: successes and challenges of genome-wide association studies using the example of age-related macular degeneration. | Peter I et al. | — | 2010 | → |
| Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. | Sofat R et al. | — | 2010 | → |
| Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. | Kopplin LJ et al. | — | 2010 | → |
| Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). | Neale BM et al. | — | 2010 | → |
| Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration. | Kelly U et al. | — | 2010 | → |
| Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. | Gale DP et al. | — | 2010 | → |
| Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. | An E et al. | — | 2010 | → |
| Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. | Clark SJ et al. | — | 2010 | → |
| Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. | Campa C et al. | — | 2010 | → |
| Lack of association of CFD polymorphisms with advanced age-related macular degeneration. | Zeng J et al. | — | 2010 | → |
| LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population. | Lee SJ et al. | — | 2010 | → |
| Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction. | Blaum BS et al. | — | 2010 | → |
| Monozygotic twins with polypoidal choroidal vasuculopathy. | Machida S et al. | — | 2010 | → |
| Mutation screen of beta-crystallin genes in 274 patients with age-related macular degeneration. | Sturgill GM et al. | — | 2010 | → |
| Oxidative stress and the regulation of complement activation in human glaucoma. | Tezel G et al. | — | 2010 | → |
| Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternatives. | Zarbin MA et al. | — | 2010 | → |
| Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. | Wright AF et al. | — | 2010 | → |
| Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration. | Javadzadeh A et al. | — | 2010 | → |
| Progression of geographic atrophy and genotype in age-related macular degeneration. | Klein ML et al. | — | 2010 | → |
| Prospective study of common variants in the retinoic acid receptor-related orphan receptor α gene and risk of neovascular age-related macular degeneration. | Schaumberg DA et al. | — | 2010 | → |
| Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes. | Yuan X et al. | — | 2010 | → |
| Ranibizumab therapy for neovascular age-related macular degeneration. | Folk JC et al. | — | 2010 | → |
| Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. | Bazan NG et al. | — | 2010 | → |
| Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). | Ramkumar HL et al. | — | 2010 | → |
| Role of ocular complement factor H in a murine model of choroidal neovascularization. | Lyzogubov VV et al. | — | 2010 | → |
| Saturation of the human phenome. | Samuels ME | — | 2010 | → |
| Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. | Reynolds R et al. | — | 2010 | → |
| Targeting immune privilege to prevent pathogenic neovascularization. | Roychoudhury J et al. | — | 2010 | → |
| The ERCC6 gene and age-related macular degeneration. | Baas DC et al. | — | 2010 | → |
| The molecular basis of human retinal and vitreoretinal diseases. | Berger W et al. | — | 2010 | → |
| Therapeutic targets in age-related macular disease. | Bird AC | — | 2010 | → |
| [Therapy approaches for geographic atrophy]. | Schmitz-Valckenberg S et al. | — | 2010 | → |
| The retinal pigment epithelium in health and disease. | Sparrow JR et al. | — | 2010 | → |
| The role of complement Factor H in age-related macular degeneration: a review. | Donoso LA et al. | — | 2010 | → |
| Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. | Lima LH et al. | — | 2010 | → |
| Treatment of age-related macular degeneration: beyond VEGF. | Miller JW | — | 2010 | → |
| Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage. | Sakamoto T et al. | — | 2010 | → |