Population stratification and spurious allelic association.
paper
Cited
Public
Unavailable
- Authors
- Cardon, Lon R; Palmer, Lyle J
- Year
- 2003
- Journal
- Lancet (London, England)
- PMID
- 12598158
- DOI
- 10.1016/S0140-6736(03)12520-2
Great efforts and expense have been expended in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Concomitantly, technology for detection and scoring of single nucleotide polymorphisms (SNPs) has undergone rapid development, extensive catalogues of SNPs across the genome have been constructed, and SNPs have been increasingly used as a means for investigation of the genetic causes of complex human diseases. For many diseases, population-based studies of unrelated individuals--in which case-control and cohort studies serve as standard designs for genetic association analysis--can be the most practical and powerful approach. However, extensive debate has arisen about optimum study design, and considerable concern has been expressed that these approaches are prone to population stratification, which can lead to biased or spurious results. Over the past decade, a great shift has been noted, away from case-control and cohort studies, towards family-based association designs. These designs have fewer problems with population stratification but have greater genotyping and sampling requirements, and data can be difficult or impossible to gather. We discuss past evidence for population stratification on genotype-phenotype association studies, review methods to detect and account for it, and present suggestions for future study design and analysis.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor. | Skyberg AM et al. | β | 2026 | β |
| OmiGA for ultra-efficient molecular quantitative trait loci mapping. | Teng J et al. | β | 2026 | β |
| Personality Genomics. | Schwaba T et al. | β | 2026 | β |
| Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review. | Rao H et al. | β | 2025 | β |
| A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes. | Eltaher S et al. | β | 2025 | β |
| Education and cardiovascular disease: a within-family Mendelian randomization analysis. | Jones PR et al. | β | 2025 | β |
| Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects. | Zhang L et al. | β | 2025 | β |
| No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank. | Centorame G et al. | β | 2025 | β |
| Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence. | Sun KY et al. | β | 2025 | β |
| Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits. | KriΕΎanac AM et al. | β | 2025 | β |
| Snoring as a Possible Protective Factor for Temporomandibular Joint Disorders. | Wu Y et al. | β | 2025 | β |
| The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample. | Kuo SI et al. | β | 2025 | β |
| Understanding the epidemiology and pathogenesis of Mycobacterium tuberculosis with non-redundant pangenome of epidemic strains in China. | Zhou Y et al. | β | 2025 | β |
| Genetically predicted effects of 10 sleep phenotypes on revision of knee arthroplasty: a mendelian randomization study. | Bi Z et al. | β | 2024 | β |
| Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses. | Liu M et al. | β | 2024 | β |
| Polygenic Indices (a.k.a. Polygenic Scores) in Social Science: A Guide for Interpretation and Evaluation. | Burt CH | β | 2024 | β |
| Public Attitudes, Interests, and Concerns Regarding Polygenic Embryo Screening. | Furrer RA et al. | β | 2024 | β |
| Risk Factors for Increased Opioid Use During Postoperative Intensive Care. | Guichard L et al. | β | 2024 | β |
| Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations. | Schraiber JG et al. | β | 2024 | β |
| A Guide to Genome-Wide Association Study Design for Diabetic Retinopathy. | Gurung RL et al. | β | 2023 | β |
| Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data. | McAdams TA et al. | β | 2023 | β |
| A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure. | Handley ED et al. | β | 2023 | β |
| Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder. | Kuo SI et al. | β | 2023 | β |
| Causal Effects of Plasma Proteome on Osteoporosis and Osteoarthritis. | Han BX et al. | β | 2023 | β |
| Evidence for Epistatic Interaction between <i>HLA-G</i> and <i>LILRB1</i> in the Pathogenesis of Nonsegmental Vitiligo. | Oliveira-Caramez ML et al. | β | 2023 | β |
| Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review. | Khani P et al. | β | 2023 | β |
| Genetic nurture effects for alcohol use disorder. | Thomas NS et al. | β | 2023 | β |
| Genome-Wide Association Study of Fiber Diameter in Alpacas. | More M et al. | β | 2023 | β |
| Genome-wide case-only analysis of gene-gene interactions with known Parkinson's disease risk variants reveals link between LRRK2 and SYT10. | AleknonytΔ-Resch M et al. | β | 2023 | β |
| Learning the kernel for rare variant genetic association test. | Falk I et al. | β | 2023 | β |
| Maternal Education Potentially Moderates the <i>MAOA</i> uVNTR Effects on Externalizing Behavior in Black South African Children. | Wessels SH et al. | β | 2023 | β |
| Sex differences in associations between APOE Ξ΅2 and longitudinal cognitive decline. | Wood ME et al. | β | 2023 | β |
| The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study. | Pang L et al. | β | 2023 | β |
| Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility. | Albahlol IA et al. | β | 2023 | β |
| Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample. | Thomas NS et al. | β | 2022 | β |
| Association of <i>ARRDC3</i> and <i>NFIA</i> variants with bovine congestive heart failure in feedlot cattle. | Heaton MP et al. | β | 2022 | β |
| Associations between alcohol consumption and gray and white matter volumes in the UK Biobank. | Daviet R et al. | β | 2022 | β |
| Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19? | Szyda J et al. | β | 2022 | β |
| Building causal knowledge in behavior genetics. | Madole JW et al. | β | 2022 | β |
| Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology. | Burt CH | β | 2022 | β |
| Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification. | Dapas M et al. | β | 2022 | β |
| Defining biologically relevant and hierarchically nested population units to inform wildlife management. | O'Donnell MS et al. | β | 2022 | β |
| Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing. | Qiao J et al. | β | 2022 | β |
| Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data. | Guo F et al. | β | 2022 | β |
| Efficient approaches for large-scale GWAS with genotype uncertainty. | JΓΈrsboe E et al. | β | 2022 | β |
| Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality. | Zhang M et al. | β | 2022 | β |
| Gene-based association tests using GWAS summary statistics and incorporating eQTL. | Cao X et al. | β | 2022 | β |
| Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention. | McCaffery JM et al. | β | 2022 | β |
| Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials in <i>Mycoplasma bovis</i>. | Waldner M et al. | β | 2022 | β |
| Genome-Wide Association Study Reveals the Genetic Basis of Five Quality Traits in Chinese Wheat. | Hao S et al. | β | 2022 | β |
| Interleukin-1 receptor antagonist, mode of analgesia and risk of Caesarean delivery after onset of labour: a Mendelian randomisation analysis. | Ackland GL et al. | β | 2022 | β |
| KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients. | Terrelonge M et al. | β | 2022 | β |
| Mendelian randomization. | Sanderson E et al. | β | 2022 | β |
| Meta-analysis of genome-wide association studies uncovers shared candidate genes across breeds for pig fatness trait. | Zeng H et al. | β | 2022 | β |
| Open problems in human trait genetics. | Brandes N et al. | β | 2022 | β |
| Parsimonious model for mass-univariate vertexwise analysis. | Couvy-Duchesne B et al. | β | 2022 | β |
| Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals. | PerkiΓΆ A et al. | β | 2022 | β |
| The Genetic Architecture of Juvenile Growth Traits in the Conifer <i>Torreya grandis</i> as Revealed by Joint Linkage and Linkage Disequilibrium Mapping. | Chen W et al. | β | 2022 | β |
| The influence of genetic structure on phenotypic diversity in the Australian mango (Mangifera indica) gene pool. | Wilkinson MJ et al. | β | 2022 | β |
| The influence of harshness and unpredictability on female sexual development: Addressing gene-environment interplay using a polygenic score. | Schlomer GL et al. | β | 2022 | β |
| The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance. | Kuo SI et al. | β | 2022 | β |
| Association of single nucleotide polymorphisms with taste and food preferences of the Hungarian general and Roma populations. | DiΓ³szegi J et al. | β | 2021 | β |
| Association of variants in IL1B, TLR9, TREM1, IL10RA, and CD3G and Native American ancestry on malaria susceptibility in Colombian populations. | Mario-VΓ‘squez JE et al. | β | 2021 | β |
| A systematic review of gene-by-intervention studies of alcohol and other substance use. | Neale ZE et al. | β | 2021 | β |
| Common variants of EDA are associated with non-syndromic hypodontia. | Al-Ani AH et al. | β | 2021 | β |
| Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics. | Lu H et al. | β | 2021 | β |
| Dissecting polygenic signals from genome-wide association studies on human behaviour. | Abdellaoui A et al. | β | 2021 | β |
| Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study. | Mitchell A et al. | β | 2021 | β |
| Genetic Evidence on the Association of Interleukin (IL)-1-Mediated Chronic Inflammation with Airflow Obstruction: A Mendelian Randomization Study. | Yang Z et al. | β | 2021 | β |
| Genetic underpinnings of risky behaviour relate to altered neuroanatomy. | Aydogan G et al. | β | 2021 | β |
| <i>COMT</i> Genotype and Efficacy of Propranolol for TMD Pain: A Randomized Trial. | Slade GD et al. | β | 2021 | β |
| KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis. | Hares K et al. | β | 2021 | β |
| Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. | Kuo SI et al. | β | 2021 | β |
| Mendelian Randomization Analysis as a Tool to Gain Insights into Causes of Diseases: A Primer. | Tin A et al. | β | 2021 | β |
| Mendelian Randomization in Cardiovascular Research: Establishing Causality When There Are Unmeasured Confounders. | Bell KJL et al. | β | 2021 | β |
| Problems and promises: How to tell the story of a Genome Wide Association Study? | Heeney C | β | 2021 | β |
| Sleep deficits and cannabis use behaviors: an analysis of shared genetics using linkage disequilibrium score regression and polygenic risk prediction. | Winiger EA et al. | β | 2021 | β |
| The use of negative control outcomes in Mendelian randomization to detect potential population stratification. | Sanderson E et al. | β | 2021 | β |
| Toward the identification of molecular markers associated with phytochemical traits in the Iranian sumac (<i>Rhus coriaria</i> L.) population. | Mohammadi Alaghuz R et al. | β | 2021 | β |
| Variant-specific inflation factors for assessing population stratification at the phenotypic variance level. | Sofer T et al. | β | 2021 | β |
| A pseudolikelihood approach for assessing genetic association in case-control studies with unmeasured population structure. | Chen Y et al. | β | 2020 | β |
| Eagle: multi-locus association mapping on a genome-wide scale made routine. | George AW et al. | β | 2020 | β |
| Ethnic differences in genetic polymorphism associated with irritable bowel syndrome. | Xiao QY et al. | β | 2020 | β |
| Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes. | Katz DC et al. | β | 2020 | β |
| Genetic structure, gene flow pattern, and association analysis of superior germplasm resources in domesticated upland cotton (<i>Gossypium hirsutum</i> L.). | Zhang TT et al. | β | 2020 | β |
| Genomics and Liver Transplantation: Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection. | Kohut TJ et al. | β | 2020 | β |
| Hidden Stratification Causes Clinically Meaningful Failures in Machine Learning for Medical Imaging. | Oakden-Rayner L et al. | β | 2020 | β |
| Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity? | Lawson DJ et al. | β | 2020 | β |
| Mendelian Randomization analysis of the causal effect of adiposity on hospital costs. | Dixon P et al. | β | 2020 | β |
| Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample. | Rabinowitz JA et al. | β | 2020 | β |
| Persistent and Widespread Pain Among African-Americans Six Weeks after MVC: Emergency Department-based Cohort Study. | Beaudoin FL et al. | β | 2020 | β |
| Ranking evidence in substance use and addiction. | Reddon H et al. | β | 2020 | β |
| Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. | Salvatore JE et al. | β | 2020 | β |
| The impact of BMI on mental health: Further evidence from genetic markers. | Amin V et al. | β | 2020 | β |
| Advances in genetics of migraine. | Sutherland HG et al. | β | 2019 | β |
| Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis. | Haworth S et al. | β | 2019 | β |
| Are Bigger Brains Smarter? Evidence From a Large-Scale Preregistered Study. | Nave G et al. | β | 2019 | β |
| A resource-efficient tool for mixed model association analysis of large-scale data. | Jiang L et al. | β | 2019 | β |
| Association between sequence variants in cadmium-related genes and the cadmium accumulation trait in thermo-sensitive genic male sterile rice. | Hao X et al. | β | 2019 | β |
| A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes. | Pereira FDSCF et al. | β | 2019 | β |
| Combined genome-wide association analysis and transcriptome sequencing to identify candidate genes for flax seed fatty acid metabolism. | Xie D et al. | β | 2019 | β |
| Discovering genetic interactions bridging pathways in genome-wide association studies. | Fang G et al. | β | 2019 | β |
| Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees. | Gonzalez S et al. | β | 2019 | β |
| Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese population. | Deng C et al. | β | 2019 | β |
| Genomic evidence for MHC disassortative mating in humans. | Dandine-Roulland C et al. | β | 2019 | β |
| LEI: A Novel Allele Frequency-Based Feature Selection Method for Multi-ancestry Admixed Populations. | Wathen MJ et al. | β | 2019 | β |
| Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. | Sadeh N et al. | β | 2019 | β |
| microRNA-27a and microRNA-146a SNP in cerebral malaria. | Wah ST et al. | β | 2019 | β |
| Quality of methods and reporting in association studies of chronic periodontitis and IL1A -889 and IL1B +3953/4 SNPs: A systematic review. | Citterio F et al. | β | 2019 | β |
| Romantic Partner Alcohol Misuse Interacts with <i>GABRA2</i> Genotype to Predict Frequency of Drunkenness in Young Adulthood. | Gajos JM et al. | β | 2019 | β |
| Significance testing and genomic inflation factor using high-density genotypes or whole-genome sequence data. | van den Berg S et al. | β | 2019 | β |
| Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence? | Panagiotou OA et al. | β | 2019 | β |
| Statistical Association Mapping of Population-Structured Genetic Data. | Najafi A et al. | β | 2019 | β |
| The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial. | Kuo SI et al. | β | 2019 | β |
| An introduction to Mendelian randomization with applications in neurology. | Allman PH et al. | β | 2018 | β |
| Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization. | Katikireddi SV et al. | β | 2018 | β |
| Association of functional markers with flowering time in lentil. | Kumar J et al. | β | 2018 | β |
| Comparing SNP panels and statistical methods for estimating genomic breed composition of individual animals in ten cattle breeds. | He J et al. | β | 2018 | β |
| Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk. | Marini S et al. | β | 2018 | β |
| Copy Number Variation. | MacΓ© A et al. | β | 2018 | β |
| Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins. | Amin V et al. | β | 2018 | β |
| Dopamine receptor D2 (DRD2), dopamine transporter solute carrier family C6, member 4 (SLC6A3), and catechol-O-methyltransferase (COMT) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation. | Villani V et al. | β | 2018 | β |
| Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: Implications for HLA-G transcriptional control and for case-control association studies. | Oliveira MLG et al. | β | 2018 | β |
| Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. | Ganjgahi H et al. | β | 2018 | β |
| Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. | Gaydosh L et al. | β | 2018 | β |
| Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing. | Wehby GL et al. | β | 2018 | β |
| Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. | Tedja MS et al. | β | 2018 | β |
| Global analysis of population stratification using a smart panel of 27 continental ancestry-informative SNPs. | Jiang L et al. | β | 2018 | β |
| Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. | Zheng Y et al. | β | 2018 | β |
| Key Concepts in Genetic Epidemiology. | Panoutsopoulou K et al. | β | 2018 | β |
| Mendelian Randomization Studies Promise to Shorten the Journey to FDAΒ Approval. | Roberts R | β | 2018 | β |
| Multi-Environmental Trials Reveal Genetic Plasticity of Oat Agronomic Traits Associated With Climate Variable Changes. | Rispail N et al. | β | 2018 | β |
| On the substructure controls in rare variant analysis: Principal components or variance components? | Luo Y et al. | β | 2018 | β |
| PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age. | Russell MA et al. | β | 2018 | β |
| Racial differences in presentations and predictors of acute pain after motor vehicle collision. | Beaudoin FL et al. | β | 2018 | β |
| Relations between early maternal sensitivity and toddler self-regulation: Exploring variation by oxytocin and dopamine D2 receptor genes. | Augustine ME et al. | β | 2018 | β |
| The BDNF rs6265 variant may interact with overweight and obesity to influence obesity-related physical, metabolic and behavioural traits in Pakistani individuals. | Rana S et al. | β | 2018 | β |
| The Implications of Genetics for Prevention and Intervention Programming. | Musci RJ et al. | β | 2018 | β |
| Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use. | Cleveland HH et al. | β | 2018 | β |
| Vitamin D receptor gene polymorphisms and susceptibility for primary osteoarthritis of the knee in a Latin American population. | GonzΓ‘lez-Huerta NC et al. | β | 2018 | β |
| Whole-genome association and genome partitioning revealed variants and explained heritability for total number of teats in a Yorkshire pig population. | Uzzaman MR et al. | β | 2018 | β |
| A Highly Specific Genome-Wide Association Study Integrated with Transcriptome Data Reveals the Contribution of Copy Number Variations to Specialized Metabolites in Arabidopsis thaliana Accessions. | Shirai K et al. | β | 2017 | β |
| Ancestry Informative Marker Panel to Estimate Population Stratification Using Genome-wide Human Array. | Barbosa FB et al. | β | 2017 | β |
| Application of t-SNE to human genetic data. | Li W et al. | β | 2017 | β |
| A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information. | Silva-Alves MS et al. | β | 2017 | β |
| Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population. | Mehrbod P et al. | β | 2017 | β |
| D14 repeat polymorphism of the asporin gene is associated with primary osteoarthritis of the knee in a Mexican Mestizo population. | GonzΓ‘lez-Huerta NC et al. | β | 2017 | β |
| Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility. | Archer NP et al. | β | 2017 | β |
| Further evidence of the limited role of candidate genes in relation to infant-mother attachment outcomes. | Leerkes EM et al. | β | 2017 | β |
| Genetic Predisposition to Obesity and Medicare Expenditures. | Wehby GL et al. | β | 2017 | β |
| Genetic Programming of Hypertension. | Ahn SY et al. | β | 2017 | β |
| Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies. | Santos BPD et al. | β | 2017 | β |
| Genome-wide association study for 13 agronomic traits reveals distribution of superior alleles in bread wheat from the Yellow and Huai Valley of China. | Sun C et al. | β | 2017 | β |
| GWAS, QTL mapping and gene expression analyses in Brassica napus reveal genetic control of branching morphogenesis. | He Y et al. | β | 2017 | β |
| Immunology and genetics of tumour necrosis factor in allergic contact dermatitis. | Dittmar D et al. | β | 2017 | β |
| Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis. | Ideozu JE et al. | β | 2017 | β |
| Joint genotype- and ancestry-based genome-wide association studies in admixed populations. | Szulc P et al. | β | 2017 | β |
| Parenting and adolescents' psychological adjustment: Longitudinal moderation by adolescents' genetic sensitivity. | Stocker CM et al. | β | 2017 | β |
| Persistent pain after motor vehicle collision: comparative effectiveness of opioids vs nonsteroidal antiinflammatory drugs prescribed from the emergency department-a propensity matched analysis. | Beaudoin FL et al. | β | 2017 | β |
| Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. | Schuit E et al. | β | 2017 | β |
| Population Stratification in Genetic Association Studies. | Hellwege JN et al. | β | 2017 | β |
| PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study. | Hamet P et al. | β | 2017 | β |
| Structured mating: Patterns and implications. | Sebro R et al. | β | 2017 | β |
| Transferability of genome-wide associated loci for asthma in African Americans. | Faruque MU et al. | β | 2017 | β |
| Type 1 diabetes genome-wide association studies: not to be lost in translation. | Pociot F | β | 2017 | β |
| Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 genes predicts maternal sensitivity via social cognition. | Leerkes EM et al. | β | 2017 | β |
| A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription. | Song WH et al. | β | 2016 | β |
| Alcohol-related genes show an enrichment of associations with a persistent externalizing factor. | Ashenhurst JR et al. | β | 2016 | β |
| A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. | Bodea CA et al. | β | 2016 | β |
| Apolipoprotein E Ξ΅4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population. | Li Z et al. | β | 2016 | β |
| Common variant in OXTR predicts growth in positive emotions from loving-kindness training. | Isgett SF et al. | β | 2016 | β |
| Constructing a linkage-linkage disequilibrium map using dominant-segregating markers. | Zhu X et al. | β | 2016 | β |
| CYP2C9 variants as a risk modifier of NSAID-related gastrointestinal bleeding: a case-control study. | Figueiras A et al. | β | 2016 | β |
| Does 5HTTLPR Genotype Moderate the Association of Family Environment With Child Attention-Deficit Hyperactivity Disorder Symptomatology? | Elmore AL et al. | β | 2016 | β |
| Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics. | Archer NP et al. | β | 2016 | β |
| Genetic Component of Type 2 Diabetes in a Mexican Population. | SΓ‘nchez-Pozos K et al. | β | 2016 | β |
| Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. | Conomos MP et al. | β | 2016 | β |
| Genome-wide association studies in pediatric chronic kidney disease. | Gupta J et al. | β | 2016 | β |
| Inference of kinship using spatial distributions of SNPs for genome-wide association studies. | Lee H et al. | β | 2016 | β |
| Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study. | Trotta A et al. | β | 2016 | β |
| Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults. | Rees JR et al. | β | 2016 | β |
| Limitations of GCTA as a solution to the missing heritability problem. | Krishna Kumar S et al. | β | 2016 | β |
| New insights into the genetic basis of natural chilling and cold shock tolerance in rice by genome-wide association analysis. | Lv Y et al. | β | 2016 | β |
| On causality of extreme events. | Zanin M | β | 2016 | β |
| Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data. | Oetjens MT et al. | β | 2016 | β |
| Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations. | Dinov ID et al. | β | 2016 | β |
| Socio-Genomics and Structural Competency. | Conley D et al. | β | 2016 | β |
| Variability in Dopamine Genes Dissociates Model-Based and Model-Free Reinforcement Learning. | Doll BB et al. | β | 2016 | β |
| Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene-environment interaction in a 30-day ecological momentary assessment study. | Russell MA et al. | β | 2016 | β |
| A mixed model reduces spurious genetic associations produced by population stratification in genome-wide association studies. | Shin J et al. | β | 2015 | β |
| A powerful nonparametric statistical framework for family-based association analyses. | Li M et al. | β | 2015 | β |
| Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder. | Park S et al. | β | 2015 | β |
| A unifying experimental design for dissecting tree genomes. | Sun L et al. | β | 2015 | β |
| Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial. | Albert D et al. | β | 2015 | β |
| Developmental psychopathology in an era of molecular genetics and neuroimaging: A developmental neurogenetics approach. | Hyde LW | β | 2015 | β |
| Differential Susceptibility: The Genetic Moderation of Peer Pressure on Alcohol Use. | Griffin AM et al. | β | 2015 | β |
| Explaining the Persistence of Health Disparities: Social Stratification and the Efficiency-Equity Trade-off in the Kidney Transplantation System. | Daw J | β | 2015 | β |
| Fast individual ancestry inference from DNA sequence data leveraging allele frequencies for multiple populations. | Bansal V et al. | β | 2015 | β |
| Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population. | Tan GK et al. | β | 2015 | β |
| Genetic Geostatistical Framework for Spatial Analysis of Fine-Scale Genetic Heterogeneity in Modern Populations: Results from the KORA Study. | Diaz-Lacava AN et al. | β | 2015 | β |
| Global Individual Ancestry Using Principal Components for Family Data. | de Andrade M et al. | β | 2015 | β |
| Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation. | Wang C et al. | β | 2015 | β |
| Native American ancestry leads to complexity in 5-HTTLPR polymorphism association studies. | HΓΌnemeier T et al. | β | 2015 | β |
| Neurogenetics in Peru: clinical, scientific and ethical perspectives. | Cornejo-Olivas M et al. | β | 2015 | β |
| Polygenic Influence on Educational Attainment: New evidence from The National Longitudinal Study of Adolescent to Adult Health. | Domingue BW et al. | β | 2015 | β |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | β | 2015 | β |
| Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs. | Zhou D et al. | β | 2015 | β |
| Reply: To PMID 25302781. | Sookoian S et al. | β | 2015 | β |
| Serotonin transporter polymorphism (5-HTTLPR) in Croatian population. | Culej J et al. | β | 2015 | β |
| Solution to Statistical Challenges in Proteomics Is More Statistics, Not Less. | Serang O et al. | β | 2015 | β |
| Statistical analysis for genome-wide association study. | Zeng P et al. | β | 2015 | β |
| The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants. | Cleveland HH et al. | β | 2015 | β |
| The effect of rare variants on inflation of the test statistics in case-control analyses. | Pirie A et al. | β | 2015 | β |
| The Essentiality of Reporting Hardy-Weinberg Equilibrium Calculations in Population-Based Genetic Association Studies. | Namipashaki A et al. | β | 2015 | β |
| Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. | Li Q et al. | β | 2015 | β |
| Validation of candidate anxiety disorder genes using a carbon dioxide challenge task. | Savage JE et al. | β | 2015 | β |
| What can genes tell us about the relationship between education and health? | Boardman JD et al. | β | 2015 | β |
| ΞΌ-Opioid Receptor Gene A118Β G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor VehicleΒ Collision. | Linnstaedt SD et al. | β | 2015 | β |
| A genome-wide association study for canine cryptorchidism in Siberian Huskies. | Zhao X et al. | β | 2014 | β |
| A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. | Luo C et al. | β | 2014 | β |
| Alcohol consumption and cognitive performance: a Mendelian randomization study. | Kumari M et al. | β | 2014 | β |
| Aldehyde dehydrogenase 2-a potential genetic risk factor for lung function among southern Chinese: evidence from the Guangzhou Biobank Cohort Study. | Au Yeung SL et al. | β | 2014 | β |
| Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women. | VelΓ‘zquez-Cruz R et al. | β | 2014 | β |
| Ancestry estimation and control of population stratification for sequence-based association studies. | Wang C et al. | β | 2014 | β |
| APOE Ο΅4, rated life experiences, and affect among centenarians. | Martin P et al. | β | 2014 | β |
| A Preliminary Examination of the Relationship Between the <i>5-HTTLPR</i> and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth. | Banducci AN et al. | β | 2014 | β |
| Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. | Yang J et al. | β | 2014 | β |
| Association of vWA and TPOX polymorphisms with venous thrombosis in Mexican mestizos. | Meraz-RΓos MA et al. | β | 2014 | β |
| Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population. | Hara M et al. | β | 2014 | β |
| Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis. | Sava GP et al. | β | 2014 | β |
| Candidate genes for aggression and antisocial behavior: a meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR. | Ficks CA et al. | β | 2014 | β |
| Comparison of genome-wide association methods in analyses of admixed populations with complex familial relationships. | Kadri NK et al. | β | 2014 | β |
| Confounding in association studies: month of birth and multiple sclerosis. | Fiddes B et al. | β | 2014 | β |
| Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype. | Conway CC et al. | β | 2014 | β |
| Dark matter RNA illuminates the puzzle of genome-wide association studies. | St Laurent G et al. | β | 2014 | β |
| Genetic susceptibility to male infertility: news from genome-wide association studies. | Aston KI | β | 2014 | β |
| Genome-wide prediction methods in highly diverse and heterozygous species: proof-of-concept through simulation in grapevine. | Fodor A et al. | β | 2014 | β |
| Haplotype association analysis of combining unrelated case-control and triads with consideration of population stratification. | Wen SH et al. | β | 2014 | β |
| iNJclust: Iterative Neighbor-Joining Tree Clustering Framework for Inferring Population Structure. | Limpiti T et al. | β | 2014 | β |
| Integrating genetics and social science: genetic risk scores. | Belsky DW et al. | β | 2014 | β |
| Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma. | Li YF et al. | β | 2014 | β |
| Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology. | Li A et al. | β | 2014 | β |
| Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. | Moeller SJ et al. | β | 2014 | β |
| No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision. | Ulirsch JC et al. | β | 2014 | β |
| Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: exploratory findings. | Kenna GA et al. | β | 2014 | β |
| Polygenic risk predicts obesity in both white and black young adults. | Domingue BW et al. | β | 2014 | β |
| Race moderates the association of Catechol-O-methyltransferase genotype and posttraumatic stress disorder in preschool children. | Humphreys KL et al. | β | 2014 | β |
| Replicability and robustness of genome-wide-association studies for behavioral traits. | Rietveld CA et al. | β | 2014 | β |
| Single nucleotide polymorphism and haplotype effects associated with somatic cell score in German Holstein cattle. | Abdel-Shafy H et al. | β | 2014 | β |
| Statistical genetics with application to population-based study design: a primer for clinicians. | Beyene J et al. | β | 2014 | β |
| The long arm of adolescence: school health behavioral environments, tobacco and alcohol co-use, and the 5HTTLPR gene. | Daw J et al. | β | 2014 | β |
| Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal. | Tabak BA et al. | β | 2014 | β |
| WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening. | VelΓ‘zquez-Cruz R et al. | β | 2014 | β |
| African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations. | Vergara C et al. | β | 2013 | β |
| Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. | Smith CE et al. | β | 2013 | β |
| A roadmap for the integration of culture into developmental psychopathology. | Causadias JM | β | 2013 | β |
| Assessing the impact of population stratification on association studies of rare variation. | Jiang Y et al. | β | 2013 | β |
| Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. | Buentello-Volante B et al. | β | 2013 | β |
| Challenges in drug target discovery in bipolar disorder. | Alsaif M et al. | β | 2013 | β |
| Challenges in reproducibility of genetic association studies: lessons learned from the obesity field. | Li A et al. | β | 2013 | β |
| Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. | Moya PR et al. | β | 2013 | β |
| Confounding underlies the apparent month of birth effect in multiple sclerosis. | Fiddes B et al. | β | 2013 | β |
| Defining the environment in gene-environment research: lessons from social epidemiology. | Boardman JD et al. | β | 2013 | β |
| Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population. | Nakaoka H et al. | β | 2013 | β |
| Diagnostic tools for hypertension and salt sensitivity testing. | Felder RA et al. | β | 2013 | β |
| DNA double-strand break repair genotype and phenotype and breast cancer risk within sisters from the New York site of the Breast Cancer Family Registry (BCFR). | Wu HC et al. | β | 2013 | β |
| Effect of genetic polymorphism +294T/C in peroxisome proliferator-activated receptor delta on the risk of ischemic stroke in a Tunisian population. | Chehaibi K et al. | β | 2013 | β |
| ETHNOPRED: a novel machine learning method for accurate continental and sub-continental ancestry identification and population stratification correction. | Hajiloo M et al. | β | 2013 | β |
| Fine-scale patterns of population stratification confound rare variant association tests. | O'Connor TD et al. | β | 2013 | β |
| Ghrelin gene variants and eating disorders. | Ando T | β | 2013 | β |
| Interleukin-6 polymorphisms are associated with obesity and hyperglycemia in Mexican adolescents. | RamΓrez-LΓ³pez G et al. | β | 2013 | β |
| Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans. | Smith CE et al. | β | 2013 | β |
| Meta-analysis of the influence of DRD3 Ser9Gly variant on susceptibility for essential tremor. | Mao X et al. | β | 2013 | β |
| Modern vitiligo genetics sheds new light on an ancient disease. | Spritz RA | β | 2013 | β |
| Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. | Wu JM et al. | β | 2013 | β |
| Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. | Tomita LY et al. | β | 2013 | β |
| Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure. | Bortsov AV et al. | β | 2013 | β |
| Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction. | Larruskain A et al. | β | 2013 | β |
| The effect of genetic admixture in an association study: genetic polymorphisms and chromosome aberrations in a Colombian population exposed to organic solvents. | Hoyos-Giraldo LS et al. | β | 2013 | β |
| The Growing Importance of CNVs: New Insights for Detection and Clinical Interpretation. | Valsesia A et al. | β | 2013 | β |
| Theodosius Dobzhansky and the genetic race concept. | Gannett L | β | 2013 | β |
| The role of GHR and IGF1 genes in the genetic determination of African pygmies' short stature. | Becker NS et al. | β | 2013 | β |
| The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction. | Guadarrama-Vallejo D et al. | β | 2013 | β |
| WITHDRAWN: Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma. | Naykoo NA et al. | β | 2013 | β |
| A high-performance computing toolset for relatedness and principal component analysis of SNP data. | Zheng X et al. | β | 2012 | β |
| A Method for Inferring an Individual's Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations. | Libiger O et al. | β | 2012 | β |
| An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations. | Segura V et al. | β | 2012 | β |
| A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. | Casey JP et al. | β | 2012 | β |
| Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. | Hsieh YC et al. | β | 2012 | β |
| Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations. | Ben Hamad M et al. | β | 2012 | β |
| BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity. | Molendijk ML et al. | β | 2012 | β |
| Chapter 13: Mining electronic health records in the genomics era. | Denny JC | β | 2012 | β |
| Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. | Wu JM et al. | β | 2012 | β |
| Differential confounding of rare and common variants in spatially structured populations. | Mathieson I et al. | β | 2012 | β |
| Double genomic control is not effective to correct for population stratification in meta-analysis for genome-wide association studies. | Wang S et al. | β | 2012 | β |
| Effect of genetic variants, especially CYP2C9 and VKORC1, on the pharmacology of warfarin. | Fung E et al. | β | 2012 | β |
| Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations. | Levran O et al. | β | 2012 | β |
| Gene Γ environment interaction models in psychiatric genetics. | Karg K et al. | β | 2012 | β |
| Gene-environment interactions in the development of asthma and atopy. | Custovic A et al. | β | 2012 | β |
| Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges. | Cornelis MC et al. | β | 2012 | β |
| Genetic variation in telomere maintenance genes, telomere length and breast cancer risk. | Shen J et al. | β | 2012 | β |
| Genomic scan as a tool for assessing the genetic component of phenotypic variance in wild populations. | Herrera CM | β | 2012 | β |
| High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions. | Fang G et al. | β | 2012 | β |
| HLA-DRB1*15:01 and multiple sclerosis: a female association? | Irizar H et al. | β | 2012 | β |
| Lack of Association of Vitamin D Receptor FokI (rs10735810) (C/T) and BsmI (rs1544410) (A/G) Genetic Variations with Polycystic Ovary Syndrome Risk: a Case-control Study from Iranian Azeri Turkish Women. | Bagheri M et al. | β | 2012 | β |
| Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse. | Wu JM et al. | β | 2012 | β |
| Methods for detecting and correcting for population stratification. | Edwards TL et al. | β | 2012 | β |
| Promises and challenges of pharmacogenetics: an overview of study design, methodological and statistical issues. | Ross S et al. | β | 2012 | β |
| Rare and low frequency variant stratification in the UK population: description and impact on association tests. | Babron MC et al. | β | 2012 | β |
| Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study. | LΓ‘zΓ‘r AS et al. | β | 2012 | β |
| Statistical distributions of test statistics used for quantitative trait association mapping in structured populations. | TeyssΓ¨dre S et al. | β | 2012 | β |
| Study designs and methods post genome-wide association studies. | Ziegler A et al. | β | 2012 | β |
| The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations. | Andersson LS et al. | β | 2012 | β |
| Using multiple genetic variants as instrumental variables for modifiable risk factors. | Palmer TM et al. | β | 2012 | β |
| Accounting for population stratification in practice: a comparison of the main strategies dedicated to genome-wide association studies. | Bouaziz M et al. | β | 2011 | β |
| Admixed ancestry and stratification of Quebec regional populations. | Bherer C et al. | β | 2011 | β |
| A genome-wide screen of gene-gene interactions for rheumatoid arthritis susceptibility. | Liu C et al. | β | 2011 | β |
| Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations. | Mikhak B et al. | β | 2011 | β |
| A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd. | Driscoll EE et al. | β | 2011 | β |
| A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families. | Li X et al. | β | 2011 | β |
| A robust statistical method for association-based eQTL analysis. | Jiang N et al. | β | 2011 | β |
| Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. | Ke X et al. | β | 2011 | β |
| Association mapping. | Painter JN et al. | β | 2011 | β |
| Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. | Faruque MU et al. | β | 2011 | β |
| Association of candidate genes with phenotypic traits relevant to anorexia nervosa. | Root TL et al. | β | 2011 | β |
| Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer. | Dhillon PK et al. | β | 2011 | β |
| COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. | Finan PH et al. | β | 2011 | β |
| Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis. | Wang J et al. | β | 2011 | β |
| Evolving knowledge of opioid genetics in cancer pain. | Droney J et al. | β | 2011 | β |
| GCH1, BH4 and pain. | Latremoliere A et al. | β | 2011 | β |
| GCTA: a tool for genome-wide complex trait analysis. | Yang J et al. | β | 2011 | β |
| Genetic heterogeneity of self-reported ancestry groups in an admixed Brazilian population. | Lins TC et al. | β | 2011 | β |
| Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes. | Liu B et al. | β | 2011 | β |
| Genomic inflation factors under polygenic inheritance. | Yang J et al. | β | 2011 | β |
| Integrating social science and genetics: news from the political front. | Hatemi PK et al. | β | 2011 | β |
| Investigation of the domestication of common bean (Phaseolus vulgaris) using multilocus sequence data. | Mamidi S et al. | β | 2011 | β |
| Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. | Zill P et al. | β | 2011 | β |
| Large scale association analysis identifies three susceptibility loci for coronary artery disease. | Saade S et al. | β | 2011 | β |
| No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. | Hashimoto R et al. | β | 2011 | β |
| Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. | SillanpÀÀ MJ | β | 2011 | β |
| Participant identification in genetic association studies: improved methods and practical implications. | Masca N et al. | β | 2011 | β |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | β | 2011 | β |
| Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population. | Lins TC et al. | β | 2011 | β |
| Pseudosibship methods in the case-parents design. | Yu Z et al. | β | 2011 | β |
| Quality control procedures for genome-wide association studies. | Turner S et al. | β | 2011 | β |
| Robust linear regression methods in association studies. | LourenΓ§o VM et al. | β | 2011 | β |
| Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC). | Xun WW et al. | β | 2011 | β |
| Single nucleotide polymorphisms in collagenous lectins and other innate immune genes in pigs with common infectious diseases. | Keirstead ND et al. | β | 2011 | β |
| Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. | Heck A et al. | β | 2011 | β |
| The cyclooxygenase-2-765C promoter polymorphism protects against the development of chronic obstructive pulmonary disease. | Wu L et al. | β | 2011 | β |
| The effect of population stratification on the frequency of compound heterozygosity. | Overall AD | β | 2011 | β |
| The influence of three genes on whether adolescents use contraception, USA 1994-2002. | Daw J et al. | β | 2011 | β |
| The meta-analysis of genome-wide association studies. | Thompson JR et al. | β | 2011 | β |
| The use of race, ethnicity and ancestry in human genetic research. | Ali-Khan SE et al. | β | 2011 | β |
| Understanding risk for psychopathology through imaging gene-environment interactions. | Hyde LW et al. | β | 2011 | β |
| +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians. | Jguirim-Souissi I et al. | β | 2010 | β |
| ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis. | Haerian BS et al. | β | 2010 | β |
| A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. | Chen J et al. | β | 2010 | β |
| Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. | Hong H et al. | β | 2010 | β |
| Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. | Dumitrescu L et al. | β | 2010 | β |
| Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. | Gadow KD et al. | β | 2010 | β |
| Bovine tuberculosis: the genetic basis of host susceptibility. | Allen AR et al. | β | 2010 | β |
| Data quality control in genetic case-control association studies. | Anderson CA et al. | β | 2010 | β |
| Deciphering the molecular basis of venous thromboembolism: where are we and where should we go? | Morange PE et al. | β | 2010 | β |
| Effects of age and MAOA genotype on the neural processing of social rejection. | Sebastian CL et al. | β | 2010 | β |
| Estimation of TGF-Ξ²1 genotypes in Egyptian smokers; association with FEV(1) in COPD patients. | Bohy ME et al. | β | 2010 | β |
| European ancestry is positively associated with breast cancer risk in Mexican women. | Fejerman L et al. | β | 2010 | β |
| Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. | Brophy K et al. | β | 2010 | β |
| Genetic variation in the vascular endothelial growth factor gene is associated with biliary atresia. | Lee HC et al. | β | 2010 | β |
| Gene variants of the renin-angiotensin system and hypertension: from a trough of disillusionment to a welcome phase of enlightenment? | Norton GR et al. | β | 2010 | β |
| Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data. | Yoshimi A et al. | β | 2010 | β |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | β | 2010 | β |
| Genome-wide association studies of hypertension: light at the end of the tunnel. | Hastie CE et al. | β | 2010 | β |
| Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. | Nielsen DA et al. | β | 2010 | β |
| HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer. | Martin MP et al. | β | 2010 | β |
| Human studies on genetics of the age at natural menopause: a systematic review. | Voorhuis M et al. | β | 2010 | β |
| Inferring linkage disequilibrium from non-random samples. | Wang M et al. | β | 2010 | β |
| Influence of population stratification on population-based marker-disease association analysis. | Li T et al. | β | 2010 | β |
| Interaction of child maltreatment and 5-HTT polymorphisms: suicidal ideation among children from low-SES backgrounds. | Cicchetti D et al. | β | 2010 | β |
| Leprosy and the adaptation of human toll-like receptor 1. | Wong SH et al. | β | 2010 | β |
| Lower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important? | Gruber R et al. | β | 2010 | β |
| Mapping genes that predict treatment outcome in admixed populations. | Baye TM et al. | β | 2010 | β |
| Mendelian randomization: use of genetics to enable causal inference in observational studies. | Verduijn M et al. | β | 2010 | β |
| Methodological and statistical issues in pharmacogenomics. | Peters BJ et al. | β | 2010 | β |
| Parent-child DRD4 genotype as a potential biomarker for oppositional, anxiety, and repetitive behaviors in children with autism spectrum disorder. | Gadow KD et al. | β | 2010 | β |
| Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate. | Suazo J et al. | β | 2010 | β |
| PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake. | Bailey JN et al. | β | 2010 | β |
| Quality control and quality assurance in genotypic data for genome-wide association studies. | Laurie CC et al. | β | 2010 | β |
| Quantification of population structure using correlated SNPs by shrinkage principal components. | Zou F et al. | β | 2010 | β |
| Statistical genetic issues for genome-wide association studies. | Weir BS | β | 2010 | β |
| Systems biology and heart failure: concepts, methods, and potential research applications. | Adams KF | β | 2010 | β |
| Ξ±β-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts. | SΓΈrheim IC et al. | β | 2010 | β |
| African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia. | Vergara C et al. | β | 2009 | β |
| A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. | Wendland JR et al. | β | 2009 | β |
| Approaches to the identification of susceptibility genes. | Collins A | β | 2009 | β |
| Association of a monoamine oxidase-a gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. | Roohi J et al. | β | 2009 | β |
| Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. | Gadow KD et al. | β | 2009 | β |
| Association of genetic ancestry with preterm delivery and related traits among African American mothers. | Tsai HJ et al. | β | 2009 | β |
| Association of the 17-hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) with hyperandrogenemia in polycystic ovary syndrome (PCOS). | Marioli DJ et al. | β | 2009 | β |
| Association of the -243 A-->G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche. | Witchel SF et al. | β | 2009 | β |
| Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness. | Joffe RT et al. | β | 2009 | β |
| CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections. | Debette S et al. | β | 2009 | β |
| Current concepts in genetics of nonsyndromic clefts. | Murthy J et al. | β | 2009 | β |
| CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. | Zhuo W et al. | β | 2009 | β |
| Discovery of rare variants via sequencing: implications for the design of complex trait association studies. | Li B et al. | β | 2009 | β |
| Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. | Rouault K et al. | β | 2009 | β |
| Drug-diagnostic codevelopment strategies: FDA and industry dialog at the 4th FDA/DIA/PhRMA/PWG/BIO Pharmacogenomics Workshop. | Hinman L et al. | β | 2009 | β |
| European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. | Chung SA et al. | β | 2009 | β |
| From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. | Wei Z et al. | β | 2009 | β |
| Gene-environment interactions and alcohol use and dependence: current status and future challenges. | van der Zwaluw CS et al. | β | 2009 | β |
| Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. | Forton JT et al. | β | 2009 | β |
| Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. | Sinotte M et al. | β | 2009 | β |
| Genome-wide association studies for atherosclerotic vascular disease and its risk factors. | Ding K et al. | β | 2009 | β |
| Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations. | Potkin SG et al. | β | 2009 | β |
| Indirect effects of FRIGIDA: floral trait (co)variances are altered by seasonally variable abiotic factors associated with flowering time. | Brock MT et al. | β | 2009 | β |
| Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. | Salas A et al. | β | 2009 | β |
| Iterative pruning PCA improves resolution of highly structured populations. | Intarapanich A et al. | β | 2009 | β |
| Lactase persistence-related genetic variant: population substructure and health outcomes. | Smith GD et al. | β | 2009 | β |
| Mendelian randomization in nutritional epidemiology. | Qi L | β | 2009 | β |
| Meta-analysis in genome-wide association studies. | Zeggini E et al. | β | 2009 | β |
| Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. | Nakaoka H et al. | β | 2009 | β |
| Methodological issues in evaluating environmental risk factors: a response to Ivanovski et al. | Spector LG | β | 2009 | β |
| No Association of Obesity and Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer. | Thompson CL et al. | β | 2009 | β |
| No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population. | Xu Y et al. | β | 2009 | β |
| No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. | Schrauwen I et al. | β | 2009 | β |
| Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. | Campbell CM et al. | β | 2009 | β |
| Population admixture associated with disease prevalence in the Boston Puerto Rican health study. | Lai CQ et al. | β | 2009 | β |
| Protective KIR-HLA interactions for HCV infection in intravenous drug users. | ZΓΊΓ±iga J et al. | β | 2009 | β |
| PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population. | PΕoski R et al. | β | 2009 | β |
| Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada. | Burman D et al. | β | 2009 | β |
| Replication of genes for asthma: the importance of well-designed studies. | Litonjua AA et al. | β | 2009 | β |
| Reporting and evaluating genetic association studies. | Peters SP | β | 2009 | β |
| Robust quantitative trait association tests in the parent-offspring triad design: conditional likelihood-based approaches. | Wang JY et al. | β | 2009 | β |
| Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. | Gallicchio L et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. | Rasmussen-Torvik LJ et al. | β | 2009 | β |
| The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension. | Wang X et al. | β | 2009 | β |
| Understanding genetics of sepsis: will new technology help? | Yende S et al. | β | 2009 | β |
| Univariate/multivariate genome-wide association scans using data from families and unrelated samples. | Zhang L et al. | β | 2009 | β |
| Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES). | Shtir CJ et al. | β | 2009 | β |
| XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study. | Zhou K et al. | β | 2009 | β |
| A comparison of the genetic and clinical profile of men that respond and do not respond to the immediate antihypertensive effects of aerobic exercise. | Pescatello LS et al. | β | 2008 | β |
| Admixture and population stratification in African Caribbean populations. | Benn-Torres J et al. | β | 2008 | β |
| Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. | Zill P et al. | β | 2008 | β |
| A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. | Kissling C et al. | β | 2008 | β |
| Association between PPARalpha gene polymorphisms and myocardial infarction. | Reinhard W et al. | β | 2008 | β |
| Association of bone morphogenetic proteins with otosclerosis. | Schrauwen I et al. | β | 2008 | β |
| Case-control studies compare "apples and pears": Proposal for a retrospective cohort study in the USA of vaccination history in relation to subsequent childhood leukemia. | Ivanovski P et al. | β | 2008 | β |
| Cohort profile: The Western Australian Family Connections Genealogical Project. | Glasson EJ et al. | β | 2008 | β |
| Combining population genomics and quantitative genetics: finding the genes underlying ecologically important traits. | Stinchcombe JR et al. | β | 2008 | β |
| Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. | Pescatello LS | β | 2008 | β |
| Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study. | Rahman T et al. | β | 2008 | β |
| Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. | Teo YY | β | 2008 | β |
| Comparison of population-based association study methods correcting for population stratification. | Zhang F et al. | β | 2008 | β |
| Correction of population stratification in large multi-ethnic association studies. | Serre D et al. | β | 2008 | β |
| COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. | Fernandez P et al. | β | 2008 | β |
| Discordant longitudinal clines in flowering time and phytochrome C in Arabidopsis thaliana. | Samis KE et al. | β | 2008 | β |
| Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. | KivimΓ€ki M et al. | β | 2008 | β |
| Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury. | Barber RC et al. | β | 2008 | β |
| Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. | Hong LE et al. | β | 2008 | β |
| Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan. | Chen PL et al. | β | 2008 | β |
| Gene by social context interactions for number of sexual partners among white male youths: genetics-informed sociology. | Guo G et al. | β | 2008 | β |
| Gene-environment contributions to the development of infant vagal reactivity: the interaction of dopamine and maternal sensitivity. | Propper C et al. | β | 2008 | β |
| Genes encoding longevity: from model organisms to humans. | Kuningas M et al. | β | 2008 | β |
| Genetic ancestry and risk of breast cancer among U.S. Latinas. | Fejerman L et al. | β | 2008 | β |
| Genetic association analysis: a primer on how it works, its strengths and its weaknesses. | Rodriguez-Murillo L et al. | β | 2008 | β |
| Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. | Shi J et al. | β | 2008 | β |
| Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women. | Riancho JA et al. | β | 2008 | β |
| Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease. | Wong C et al. | β | 2008 | β |
| Genetic predictors of renal failure. | Buraczynska M | β | 2008 | β |
| Genetics of sudden cardiac arrest. | Prutkin JM et al. | β | 2008 | β |
| Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection. | Sindhi R et al. | β | 2008 | β |
| Genetic variation and atherosclerosis. | Biros E et al. | β | 2008 | β |
| Genome-wide association studies: progress and potential for drug discovery and development. | Kingsmore SF et al. | β | 2008 | β |
| Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. | Choudhry S et al. | β | 2008 | β |
| Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. | Mudge J et al. | β | 2008 | β |
| How should we use information about HWE in the meta-analyses of genetic association studies? | Minelli C et al. | β | 2008 | β |
| Identifying modifier genes of monogenic disease: strategies and difficulties. | GΓ©nin E et al. | β | 2008 | β |
| Inference of population structure using genetic markers and a Bayesian model averaging approach for clustering. | SantafΓ© G et al. | β | 2008 | β |
| Influence of cytokine and intercellular adhesion molecule-1 gene polymorphisms on acute rejection in pediatric renal transplantation. | Mendoza-Carrera F et al. | β | 2008 | β |
| Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study. | MacΓas-Reyes A et al. | β | 2008 | β |
| Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. | Romero V et al. | β | 2008 | β |
| Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). | Hemmings SM et al. | β | 2008 | β |
| Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. | Maalej A et al. | β | 2008 | β |
| Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease. | Hutter CM et al. | β | 2008 | β |
| Lack of replication of genetic associations with human longevity. | Novelli V et al. | β | 2008 | β |
| Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. | KivimΓ€ki M et al. | β | 2008 | β |
| Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. | Dudbridge F | β | 2008 | β |
| Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. | Lawlor DA et al. | β | 2008 | β |
| Methodological quality of pharmacogenetic studies: issues of concern. | Jorgensen AL et al. | β | 2008 | β |
| Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. | Li B et al. | β | 2008 | β |
| Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. | Kavvoura FK et al. | β | 2008 | β |
| Molecular genetics of anxiety in mice and men. | Hovatta I et al. | β | 2008 | β |
| Natural genetic variation of Arabidopsis thaliana is geographically structured in the Iberian peninsula. | PicΓ³ FX et al. | β | 2008 | β |
| No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population. | Meng J et al. | β | 2008 | β |
| ORMDL3 gene is associated with asthma in three ethnically diverse populations. | Galanter J et al. | β | 2008 | β |
| Polymorphisms in the IGF1 and IGF1R genes and children born small for gestational age: results of large population studies. | Ester WA et al. | β | 2008 | β |
| Population stratification in a case-control study of brain arteriovenous malformation in Latinos. | Kim H et al. | β | 2008 | β |
| Population structure and inbreeding from pedigree analysis of purebred dogs. | Calboli FC et al. | β | 2008 | β |
| Population substructure and control selection in genome-wide association studies. | Yu K et al. | β | 2008 | β |
| Portability of tag SNPs across isolated population groups: an example from India. | Sarkar Roy N et al. | β | 2008 | β |
| Power of transmission/disequilibrium tests in admixed populations. | Li MX et al. | β | 2008 | β |
| Reappraisal of the role of the DRD3 gene in essential tremor. | Blair MA et al. | β | 2008 | β |
| Recreational genomics; what's in it for you? | Evans JP | β | 2008 | β |
| Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. | Yesupriya A et al. | β | 2008 | β |
| The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients. | Smits KM et al. | β | 2008 | β |
| The molecular epidemiology of pain: a new discipline for drug discovery. | Max MB et al. | β | 2008 | β |
| The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. | Li HY et al. | β | 2008 | β |
| Trends in meta-analysis of genetic association studies. | Zintzaras E et al. | β | 2008 | β |
| Two-stage group sequential robust tests in family-based association studies: controlling type I error. | Yan LK et al. | β | 2008 | β |
| Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian population. | Sinotte M et al. | β | 2008 | β |
| A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. | Huang H et al. | β | 2007 | β |
| A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. | Kurreeman FA et al. | β | 2007 | β |
| A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate. | Parsons MJ et al. | β | 2007 | β |
| Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. | Lorenz S et al. | β | 2007 | β |
| Association between vitamin-D receptor gene FokI polymorphism and Graves' disease among Taiwanese Chinese. | Chen RH et al. | β | 2007 | β |
| Association of AGTR1 with 18-month treatment outcome in late-life depression. | Kondo DG et al. | β | 2007 | β |
| Association of the VDR translation start site polymorphism and fracture risk in older women. | Moffett SP et al. | β | 2007 | β |
| A unified approach for quantifying, testing and correcting population stratification in case-control association studies. | Gorroochurn P et al. | β | 2007 | β |
| Bias in association studies of systemic lupus erythematosus susceptibility due to geographical variation in the frequency of a programmed cell death 1 polymorphism across Europe. | Ferreiros-Vidal I et al. | β | 2007 | β |
| Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. | Smith GD et al. | β | 2007 | β |
| Coronary heart disease aetiology: associations and causality. | DucimetiΓ¨re P et al. | β | 2007 | β |
| Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese. | Niu W et al. | β | 2007 | β |
| DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease. | Chun LS et al. | β | 2007 | β |
| Designing candidate gene and genome-wide case-control association studies. | Zondervan KT et al. | β | 2007 | β |
| Dissecting complex diseases in complex populations: asthma in latino americans. | Choudhry S et al. | β | 2007 | β |
| Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women. | Lian K et al. | β | 2007 | β |
| Evidence of a gene x environment interaction in the creation of victimization: results from a longitudinal sample of adolescents. | Beaver KM et al. | β | 2007 | β |
| Family-based association tests for genomewide association scans. | Chen WM et al. | β | 2007 | β |
| Farnesyl diphosphate synthase: a novel genotype association with bone mineral density in elderly women. | Levy ME et al. | β | 2007 | β |
| Fitness effects associated with the major flowering time gene FRIGIDA in Arabidopsis thaliana in the field. | Korves TM et al. | β | 2007 | β |
| Gene discovery in diabetic nephropathy. | Savage DA et al. | β | 2007 | β |
| Gene-environment contributions to young adult sexual partnering. | Halpern CT et al. | β | 2007 | β |
| Gene, phenotype and function: GLABROUS1 and resistance to herbivory in natural populations of Arabidopsis lyrata. | KivimΓ€ki M et al. | β | 2007 | β |
| Generalized analysis of molecular variance. | Nievergelt CM et al. | β | 2007 | β |
| Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study. | Reiner AP et al. | β | 2007 | β |
| Genetic polymorphisms and idiopathic generalized epilepsies. | Lucarini N et al. | β | 2007 | β |
| Genetics in psychosomatic medicine: research designs and statistical approaches. | McCaffery JM et al. | β | 2007 | β |
| Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery. | Mathew JP et al. | β | 2007 | β |
| Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. | Blair MA et al. | β | 2007 | β |
| Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. | Kiel DP et al. | β | 2007 | β |
| Genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases. | Kingsmore SF et al. | β | 2007 | β |
| Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. | Crawford DC et al. | β | 2007 | β |
| Innate immunogenetics: a tool for exploring new frontiers of host defence. | Bochud PY et al. | β | 2007 | β |
| Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds. | Cicchetti D et al. | β | 2007 | β |
| Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy. | Hempelmann A et al. | β | 2007 | β |
| Latino populations: a unique opportunity for epidemiological research of asthma. | Salari K et al. | β | 2007 | β |
| Mechanisms of disease: The genetic basis of coronary heart disease. | Kullo IJ et al. | β | 2007 | β |
| Multiple sclerosis: the environment and causation. | Giovannoni G et al. | β | 2007 | β |
| No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. | Meng J et al. | β | 2007 | β |
| Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations. | Krekels EH et al. | β | 2007 | β |
| Pharmacogenetics and smoking cessation with nicotine replacement therapy. | Ray R et al. | β | 2007 | β |
| Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles. | Craddock N et al. | β | 2007 | β |
| RhoA, encoding a Rho GTPase, is associated with smoking initiation. | Chen X et al. | β | 2007 | β |
| Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population. | Plant BJ et al. | β | 2007 | β |
| Searching for alleles associated with complicated outcomes after burn injury. | Barber RC et al. | β | 2007 | β |
| Sequence diversity and haplotype associations with phenotypic responses to crowding: GIGANTEA affects fruit set in Arabidopsis thaliana. | Brock MT et al. | β | 2007 | β |
| Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy. | Manna I et al. | β | 2007 | β |
| Serotonin transporter polymorphisms and the occurrence of adverse events during treatment with selective serotonin reuptake inhibitors. | Smits K et al. | β | 2007 | β |
| Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study. | Leung KH et al. | β | 2007 | β |
| Short telomere length and breast cancer risk: a study in sister sets. | Shen J et al. | β | 2007 | β |
| Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment. | Ohlendorff SD et al. | β | 2007 | β |
| SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. | Zill P et al. | β | 2007 | β |
| Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution. | Qian YS et al. | β | 2007 | β |
| The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults. | Surtees PG et al. | β | 2007 | β |
| The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. | Alizadeh BZ et al. | β | 2007 | β |
| Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study. | Brennan P et al. | β | 2007 | β |
| Understanding genetic risk for aggression: clues from the brain's response to social exclusion. | Eisenberger NI et al. | β | 2007 | β |
| VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies. | Xie J et al. | β | 2007 | β |
| Accurate and efficient power calculations for 2 x m tables in unmatched case-control designs. | BukszΓ‘r J et al. | β | 2006 | β |
| Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations. | Tsai HJ et al. | β | 2006 | β |
| Age at first sexual intercourse, genes, and social context: evidence from twins and the dopamine D4 receptor gene. | Guo G et al. | β | 2006 | β |
| A quantitative trait locus for recognition of foreign eggs in the host of a brood parasite. | MartΓn-GΓ‘lvez D et al. | β | 2006 | β |
| Association mapping of complex trait loci with context-dependent effects and unknown context variable. | SillanpÀÀ MJ et al. | β | 2006 | β |
| Association of BRD2 polymorphisms with photoparoxysmal response. | Lorenz S et al. | β | 2006 | β |
| Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. | Liu Z et al. | β | 2006 | β |
| Association of endometriosis risk and genetic polymorphisms involving sex steroid biosynthesis and their receptors: a meta-analysis. | Guo SW | β | 2006 | β |
| Association of improved pulmonary phenotype in Irish cystic fibrosis patients with a 3' enhancer polymorphism in alpha-1-antitrypsin. | Courtney JM et al. | β | 2006 | β |
| Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic Substudy. | Baessler A et al. | β | 2006 | β |
| Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus. | Gouni-Berthold I et al. | β | 2006 | β |
| Associations between DNA markers and resistance to diseases in sugarcane and effects of population substructure. | Wei X et al. | β | 2006 | β |
| A tutorial on statistical methods for population association studies. | Balding DJ | β | 2006 | β |
| BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study. | Herbert A et al. | β | 2006 | β |
| Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity. | Lorenz S et al. | β | 2006 | β |
| Case-control studies in the genomic era: a clinician's guide. | Healy DG | β | 2006 | β |
| Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. | Minzenberg MJ et al. | β | 2006 | β |
| CC-chemokine receptor five gene polymorphism in primary IgA nephropathy: the 32 bp deletion allele is associated with late progression to end-stage renal failure with dialysis. | Berthoux FC et al. | β | 2006 | β |
| Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. | Schaeffer L et al. | β | 2006 | β |
| Common variants in mismatch repair genes and risk of invasive ovarian cancer. | Song H et al. | β | 2006 | β |
| Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. | Fehr C et al. | β | 2006 | β |
| Confirmatory evidence for an association of the connexin-36 gene with juvenile myoclonic epilepsy. | Hempelmann A et al. | β | 2006 | β |
| DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype. | Barreiro LB et al. | β | 2006 | β |
| Detecting genetic predisposition for complicated clinical outcomes after burn injury. | Barber RC et al. | β | 2006 | β |
| Detecting multiple associations in genome-wide studies. | Dudbridge F et al. | β | 2006 | β |
| Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. | Jaramillo PC et al. | β | 2006 | β |
| Eotaxin polymorphisms and serum total IgE levels in children with asthma. | Raby BA et al. | β | 2006 | β |
| Family-based versus unrelated case-control designs for genetic associations. | Evangelou E et al. | β | 2006 | β |
| Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. | Larsson SC et al. | β | 2006 | β |
| From DNA to RNA to disease and back: the 'central dogma' of regulatory disease variation. | Stranger BE et al. | β | 2006 | β |
| G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. | Detera-Wadleigh SD et al. | β | 2006 | β |
| Gene-environment interplay and psychopathology: multiple varieties but real effects. | Rutter M et al. | β | 2006 | β |
| Gene mapping strategies for complex disease and drug response. | Jawaid A et al. | β | 2006 | β |
| Genes and environment in irritable bowel syndrome: one step forward. | Talley NJ | β | 2006 | β |
| Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area. | Ziv E et al. | β | 2006 | β |
| Genetic association studies in cancer: good, bad or no longer ugly? | Savage SA et al. | β | 2006 | β |
| Genetic association studies of complex neurological diseases. | Abou-Sleiman PM et al. | β | 2006 | β |
| Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas. | Droma Y et al. | β | 2006 | β |
| Genetic dissection of the common epilepsies. | Tan NC et al. | β | 2006 | β |
| Genetic polymorphisms that predict outcome and need for treatment in cardiovascular disease. | Yende S et al. | β | 2006 | β |
| Genetics and proteomics: deciphering gene association studies in critical illness. | Yende S et al. | β | 2006 | β |
| Genetics, epidemiology, and cancer disparities: is it black and white? | Rebbeck TR et al. | β | 2006 | β |
| Genetics of postoperative complications following thoracic surgery. | Shaw A | β | 2006 | β |
| Implications of genetic polymorphisms in drug transporters for pharmacotherapy. | Kerb R | β | 2006 | β |
| Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans. | Zuniga J et al. | β | 2006 | β |
| Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. | Casas JP et al. | β | 2006 | β |
| Logistic regression protects against population structure in genetic association studies. | Setakis E et al. | β | 2006 | β |
| Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. | Moffitt TE et al. | β | 2006 | β |
| Molecular genetic studies of gene identification for osteoporosis: a 2004 update. | Liu YJ et al. | β | 2006 | β |
| No association between selected candidate gene polymorphisms and severe chronic periodontitis. | Wohlfahrt JC et al. | β | 2006 | β |
| Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure. | Lohmueller KE et al. | β | 2006 | β |
| Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm. | Manunta P et al. | β | 2006 | β |
| Polymorphism in maternal LRP8 gene is associated with fetal growth. | Wang L et al. | β | 2006 | β |
| Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. | Shen J et al. | β | 2006 | β |
| Population stratification confounds genetic association studies among Latinos. | Choudhry S et al. | β | 2006 | β |
| Prospective study of one million deaths in India: rationale, design, and validation results. | Jha P et al. | β | 2006 | β |
| PSMIX: an R package for population structure inference via maximum likelihood method. | Wu B et al. | β | 2006 | β |
| Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. | Redden DT et al. | β | 2006 | β |
| Relationship between common functional polymorphisms of the p22phox gene (-930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population. | Lim SC et al. | β | 2006 | β |
| Reliability of self-reported ancestry among siblings: implications for genetic association studies. | Burnett MS et al. | β | 2006 | β |
| RGS4 polymorphisms and risk of schizophrenia: an association study in Han Chinese plus meta-analysis. | Guo S et al. | β | 2006 | β |
| Role of interferon-gamma gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study. | Schena FP et al. | β | 2006 | β |
| Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. | Alfirevic A et al. | β | 2006 | β |
| Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. | Surtees PG et al. | β | 2006 | β |
| Statistical power of association using the extreme discordant phenotype design. | Zhang G et al. | β | 2006 | β |
| Testing for association in the presence of population stratification: a simulation study comparing the S-TDT, STRAT and the GC. | Wawro N et al. | β | 2006 | β |
| The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. | Redden DT et al. | β | 2006 | β |
| The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility. | AlarcΓ³n-Riquelme ME | β | 2006 | β |
| The role of genetic polymorphisms in alcoholic liver disease. | Stickel F et al. | β | 2006 | β |
| Variable therapeutic response in asthma: a genetic perspective. | Bhatnagar P et al. | β | 2006 | β |
| Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. | McKone EF et al. | β | 2006 | β |
| ACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialysis. | van der Sman-de Beer F et al. | β | 2005 | β |
| Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: a study of adenosine deaminase and MN blood group genetic polymorphisms. | Bottini N et al. | β | 2005 | β |
| Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. | Lesueur F et al. | β | 2005 | β |
| APOE polymorphism is associated with risk of severe sepsis in surgical patients. | Moretti EW et al. | β | 2005 | β |
| Assessing the quality of case-control association studies on the genetic basis of sepsis. | Vitali SH et al. | β | 2005 | β |
| Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis. | Zintzaras E et al. | β | 2005 | β |
| Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. | Hersh CP et al. | β | 2005 | β |
| Bayesian association-based fine mapping in small chromosomal segments. | SillanpÀÀ MJ et al. | β | 2005 | β |
| Bias correction with a single null marker for population stratification in candidate gene association studies. | Wang Y et al. | β | 2005 | β |
| Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. | Redden DT et al. | β | 2005 | β |
| Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci. | Howson JM et al. | β | 2005 | β |
| Complex phenotypes and complex genetics: an introduction to genetic studies of complex traits. | Belmont JW et al. | β | 2005 | β |
| Definition and clinical importance of haplotypes. | Crawford DC et al. | β | 2005 | β |
| Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. | Hong LE et al. | β | 2005 | β |
| Ethnicity, ancestry, and race in molecular epidemiologic research. | Rebbeck TR et al. | β | 2005 | β |
| Gene-environment interactions in human diseases. | Hunter DJ | β | 2005 | β |
| Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. | Salari K et al. | β | 2005 | β |
| Genetic and clinical factors influence the baseline permeability of the peritoneal membrane. | Gillerot G et al. | β | 2005 | β |
| Genetic aspects of rheumatic diseases. | Steinsson K et al. | β | 2005 | β |
| Genetic association studies. | Cordell HJ et al. | β | 2005 | β |
| Genetic epidemiology of osteoporosis: past, present, and future. | Zmuda JM et al. | β | 2005 | β |
| Genetic modifiers of lung disease in cystic fibrosis. | Drumm ML et al. | β | 2005 | β |
| Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. | Hagiwara T et al. | β | 2005 | β |
| Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. | Lai R et al. | β | 2005 | β |
| Genetics and genotypes in irritable bowel syndrome: implications for diagnosis and treatment. | Park MI et al. | β | 2005 | β |
| Genetics of human hypertension. | Agarwal A et al. | β | 2005 | β |
| Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population. | Dolan C et al. | β | 2005 | β |
| Genetic susceptibility and single-nucleotide polymorphisms. | Hanchard NA | β | 2005 | β |
| Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. | Lea RA et al. | β | 2005 | β |
| Genetic variation at the estrogen receptor alpha locus in relation to venous thromboembolism risk among postmenopausal women. | Straczek C et al. | β | 2005 | β |
| Genetic variations related to hypertension: a review. | Tanira MO et al. | β | 2005 | β |
| Genome-wide association studies for common diseases and complex traits. | Hirschhorn JN et al. | β | 2005 | β |
| Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. | Salanti G et al. | β | 2005 | β |
| Integrating case-control and TDT studies. | Kazeem GR et al. | β | 2005 | β |
| Integrating epidemiology and genetic association: the challenge of gene-environment interaction. | Kraft P et al. | β | 2005 | β |
| Issues with polymorphism analysis in sepsis. | Sutherland AM et al. | β | 2005 | β |
| Is variation in the GABA(B) receptor 1 gene associated with temporal lobe epilepsy? | Tan NC et al. | β | 2005 | β |
| Key concepts in genetic epidemiology. | Burton PR et al. | β | 2005 | β |
| Lack of support for the association between GAD2 polymorphisms and severe human obesity. | Swarbrick MM et al. | β | 2005 | β |
| Looking forward in geriatric anxiety and depression: implications of basic science for the future. | Gershenfeld HK et al. | β | 2005 | β |
| Mapping quantitative trait loci in humans: achievements and limitations. | Majumder PP et al. | β | 2005 | β |
| Neuropsychological dysfunction in bipolar affective disorder: a critical opinion. | Savitz J et al. | β | 2005 | β |
| No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort. | Bennett A et al. | β | 2005 | β |
| No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians. | Bathum L et al. | β | 2005 | β |
| No evidence for linkage and association between 4q microsatellite markers and nonsyndromic cleft lip and palate in chilean case-parents trios. | Blanco R et al. | β | 2005 | β |
| Nonreplication in genetic studies of complex diseases--lessons learned from studies of osteoporosis and tentative remedies. | Shen H et al. | β | 2005 | β |
| Obstacles and opportunities in meta-analysis of genetic association studies. | Salanti G et al. | β | 2005 | β |
| Pharmacogenetics and nicotine addiction treatment. | MunafΓ² MR et al. | β | 2005 | β |
| Pharmacogenomics in hypertension: present practicalities and future potential. | Brain N et al. | β | 2005 | β |
| Polymorphism of the interleukin-1 receptor antagonist gene: a factor in susceptibility to rheumatoid arthritis in a Spanish population. | Carreira PE et al. | β | 2005 | β |
| Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. | Auranen A et al. | β | 2005 | β |
| Population-based family studies in genetic epidemiology. | Hopper JL et al. | β | 2005 | β |
| Population stratification and genetic association studies in South Asia. | Bittles AH | β | 2005 | β |
| Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. | Reiner AP et al. | β | 2005 | β |
| Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. | Yang BZ et al. | β | 2005 | β |
| Recent developments in genomewide association scans: a workshop summary and review. | Thomas DC et al. | β | 2005 | β |
| Shaking the tree: mapping complex disease genes with linkage disequilibrium. | Palmer LJ et al. | β | 2005 | β |
| Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. | Lenzen KP et al. | β | 2005 | β |
| Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles. | Roszkowski PI et al. | β | 2005 | β |
| The epidemiologic approach to pharmacogenomics. | Little J et al. | β | 2005 | β |
| The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. | Ma S et al. | β | 2005 | β |
| The genetics of systemic lupus erythematosus. | AlarcΓ³n-Riquelme ME | β | 2005 | β |
| The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population. | Gouni-Berthold I et al. | β | 2005 | β |
| The role of prostaglandin D receptor gene in asthma pathogenesis. | Lilly CM et al. | β | 2005 | β |
| The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. | Shields AE et al. | β | 2005 | β |
| The use of racial, ethnic, and ancestral categories in human genetics research. | Race et al. | β | 2005 | β |
| Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level. | Shearman AM et al. | β | 2005 | β |
| Validation of Dwarf8 polymorphisms associated with flowering time in elite European inbred lines of maize (Zea mays L.). | Andersen JR et al. | β | 2005 | β |
| What makes a good genetic association study? | Hattersley AT et al. | β | 2005 | β |
| Anaemia of chronic disease in AA amyloidosis is associated with allele 2 of the interleukin-1beta-511 promoter gene and raised levels of interleukin-1beta and interleukin-18. | Maury CP et al. | β | 2004 | β |
| Assessing pain candidate gene studies. | Max MB | β | 2004 | β |
| Assessing the impact of population stratification on genetic association studies. | Freedman ML et al. | β | 2004 | β |
| Association of CXCR2 polymorphisms with subclinical and clinical mastitis in dairy cattle. | Youngerman SM et al. | β | 2004 | β |
| Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects. | Ferreiros-Vidal I et al. | β | 2004 | β |
| Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg. | Nieters A et al. | β | 2004 | β |
| Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women. | Moffett SP et al. | β | 2004 | β |
| Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism. | Huizinga TW et al. | β | 2004 | β |
| Association studies for finding cancer-susceptibility genetic variants. | Pharoah PD et al. | β | 2004 | β |
| A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease. | PROCARDIS Consortium | β | 2004 | β |
| Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men. | Litonjua AA et al. | β | 2004 | β |
| Beyond race: towards a whole-genome perspective on human populations and genetic variation. | Foster MW et al. | β | 2004 | β |
| Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. | Belfer I et al. | β | 2004 | β |
| Case-control association studies with matching and genomic controlling. | Lee WC | β | 2004 | β |
| CC chemokine receptor 5 delta32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia. | Wasmuth HE et al. | β | 2004 | β |
| CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. | Zeigler-Johnson C et al. | β | 2004 | β |
| Cytokine gene polymorphisms in ischaemic heart disease: investigation using family-based tests of association. | McGlinchey PG et al. | β | 2004 | β |
| Ecogeographic and genetic determinants of kernal weight and color of wild barley (Hordeum spontaneum) populations in Israel. | Chen G et al. | β | 2004 | β |
| Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study). | Heiman GA et al. | β | 2004 | β |
| Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. | Casas JP et al. | β | 2004 | β |
| Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. | Serrano NC et al. | β | 2004 | β |
| Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study. | Shearman AM et al. | β | 2004 | β |
| Evaluating bias due to population stratification in case-control association studies of admixed populations. | Wang Y et al. | β | 2004 | β |
| False positive rates in association studies as a function of degree of stratification. | Koller DL et al. | β | 2004 | β |
| Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. | Chen YS et al. | β | 2004 | β |
| From genotypes to haplotypes in hepatobiliary diseases: one plus one equals (sometimes) more than two. | Wasmuth HE et al. | β | 2004 | β |
| Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy. | Hizawa N et al. | β | 2004 | β |
| Genetic association between EPHX1 and Crohn's disease: population stratification, genotyping error, or random chance? | Cuthbert AP et al. | β | 2004 | β |
| Genetic association studies in epilepsy: "the truth is out there". | Tan NC et al. | β | 2004 | β |
| Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step. | Christie JD | β | 2004 | β |
| Genetic polymorphisms and heart failure. | Bleumink GS et al. | β | 2004 | β |
| Genetic polymorphisms in GSTM1, GSTP1, and GSTT1 and the risk for breast cancer: results from the Shanghai Breast Cancer Study and meta-analysis. | Egan KM et al. | β | 2004 | β |
| Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. | van Onna M et al. | β | 2004 | β |
| Genetics and public health--evolution, or revolution? | Halliday JL et al. | β | 2004 | β |
| Genetics of tobacco use. | Maserejian NN et al. | β | 2004 | β |
| Genetic variants implicated in personality: a review of the more promising candidates. | Savitz JB et al. | β | 2004 | β |
| Genome scans for human nutritional traits: what have we learned? | Rankinen T et al. | β | 2004 | β |
| Genomics and the circulation. | Podgoreanu MV et al. | β | 2004 | β |
| Genomics in sudden cardiac death. | Arking DE et al. | β | 2004 | β |
| G protein beta3 subunit C825T polymorphism in primary IgA nephropathy. | Thibaudin L et al. | β | 2004 | β |
| Importance of allele frequency estimates in epidemiological studies. | Taioli E et al. | β | 2004 | β |
| Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. | Mueller T et al. | β | 2004 | β |
| Integrating ethics and science in the International HapMap Project. | International HapMap Consortium | β | 2004 | β |
| Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. | Franks PW et al. | β | 2004 | β |
| Investigation of serotonin-related genes in antidepressant response. | Peters EJ et al. | β | 2004 | β |
| Lack of a genetic association between the frizzled-3 gene and schizophrenia in a British population. | Wei J et al. | β | 2004 | β |
| Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population. | Liu LL et al. | β | 2004 | β |
| Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians. | Collins JE et al. | β | 2004 | β |
| Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. | Olsen KM et al. | β | 2004 | β |
| Matching strategies for genetic association studies in structured populations. | Hinds DA et al. | β | 2004 | β |
| No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. | Guo S et al. | β | 2004 | β |
| One potato, two potato: haplotype association mapping in autotetraploids. | Simko I | β | 2004 | β |
| Post-genome respiratory epidemiology: a multidisciplinary challenge. | Kauffmann F et al. | β | 2004 | β |
| Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. | Zill P et al. | β | 2004 | β |
| SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. | Zill P et al. | β | 2004 | β |
| SNPs, haplotypes, and cancer: applications in molecular epidemiology. | Rebbeck TR et al. | β | 2004 | β |
| STK15 polymorphisms and association with risk of invasive ovarian cancer. | Dicioccio RA et al. | β | 2004 | β |
| Susceptibility to cancer: why did this happen to my child? | Davies SM | β | 2004 | β |
| Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families. | Zhao LJ et al. | β | 2004 | β |
| The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. | Lerman C et al. | β | 2004 | β |
| The genetics and pathophysiology of diabetes mellitus type II. | Jenkins AB et al. | β | 2004 | β |
| The genetics of human longevity. | Browner WS et al. | β | 2004 | β |
| The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. | Lea RA et al. | β | 2004 | β |
| The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. | Brind AM et al. | β | 2004 | β |
| The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis. | Prokunina L et al. | β | 2004 | β |
| The thyroglobulin gene: the third locus for autoimmune thyroid disease or a false dawn? | Gough S | β | 2004 | β |
| TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. | Gordon AC et al. | β | 2004 | β |
| Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies. | Yang IA et al. | β | 2004 | β |
| Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease. | Wu L et al. | β | 2004 | β |
| Approaches to identifying genetic predictors of clinical outcome in rheumatoid arthritis. | Barton A et al. | β | 2003 | β |
| "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. | Page GP et al. | β | 2003 | β |
| Association between estrogen receptor alpha gene variation and cardiovascular disease. | Shearman AM et al. | β | 2003 | β |
| Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. | Lin RC et al. | β | 2003 | β |
| Bayesian spatial modeling of haplotype associations. | Thomas DC et al. | β | 2003 | β |
| Colon cancer and genetic variation in folate metabolism: the clinical bottom line. | Little J et al. | β | 2003 | β |
| Control of confounding of genetic associations in stratified populations. | Hoggart CJ et al. | β | 2003 | β |
| Do allelic variants of SLC6A14 predispose to obesity? | Tiwari HK et al. | β | 2003 | β |
| Freely associating with chemokine receptor 2 polymorphisms and atherosclerosis. | Luft FC | β | 2003 | β |
| Genetic factors in idiopathic pulmonary fibrosis: transforming growth factor-beta implicated at last. | Whyte MK | β | 2003 | β |
| Genetics of susceptibility to human helminth infection. | Quinnell RJ | β | 2003 | β |
| Genotype-phenotype correlations: how many disorders constitute inflammatory bowel disease? | Gasche C et al. | β | 2003 | β |
| Glucocorticoid receptor gene and coronary artery disease: right idea, wrong gene variant? | Rosmond R | β | 2003 | β |
| Human population structure and genetic association studies. | Ziv E et al. | β | 2003 | β |
| Mendelian randomisation: a new spin or real progress? | Little J et al. | β | 2003 | β |
| 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | Smith GD et al. | β | 2003 | β |
| Nonreplication in genetic association studies of obesity and diabetes research. | Redden DT et al. | β | 2003 | β |
| Optimal two-stage genotyping in population-based association studies. | Satagopan JM et al. | β | 2003 | β |
| Pharmacogenomic profiling in postmarketing surveillance: prospects and challenges. | Issa AM | β | 2003 | β |
| Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amyloidosis. | Maury CP et al. | β | 2003 | β |