Genome-wide association study of panic disorder in the Japanese population.
paper
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- Authors
- Otowa, Takeshi; Yoshida, Eiji; Sugaya, Nagisa; Yasuda, Shin; Nishimura, Yukika; Inoue, Ken; Tochigi, Mamoru; Umekage, Tadashi; Miyagawa, Taku; Nishida, Nao; Tokunaga, Katsushi; Tanii, Hisashi; Sasaki, Tsukasa; Kaiya, Hisanobu; Okazaki, Yuji
- Year
- 2009
- Journal
- Journal of human genetics
- PMID
- 19165232
- DOI
- 10.1038/jhg.2008.17
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (>or=95%), Hardy-Weinberg equilibrium (P>or=0.1%) and minor allele frequency (>or=5%). The significance level of the allele P-value was set at 1.0 x 10(-6), to make false discovery rate (FDR) <0.05. As a result, seven SNPs were significantly associated with PD, which were located in or adjacent to genes including PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J). Studies with other samples are required to confirm the results.
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| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | 2012 | 22064162 |
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