Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.
paper
Cited
Public
Unavailable
- Authors
- Slesinger, P A; Patil, N; Liao, Y J; Jan, Y N; Jan, L Y; Cox, D R
- Year
- 1996
- Journal
- Neuron
- PMID
- 8789947
- DOI
- 10.1016/s0896-6273(00)80050-1
The weaver mutation corresponds to a substitution of glycine to serine in the H5 region of a G protein-gated inwardly rectifying K+ channel gene (GIRK2). By studying mutant GIRK2 weaver homomultimeric channels and heteromultimeric channels comprised of GIRK2 weaver and GIRK1 in Xenopus oocytes, we found that GIRK2 weaver homomultimeric channels lose their selectivity for K+ ions, giving rise to inappropriate receptor-activated and basally active Na+ currents, whereas heteromultimers of GIRK2 weaver and GIRK1 appeared to have reduced current. Immunohistochemical localization indicates that GIRK2 and GIRK1 proteins are expressed in the cerebellar neurons of mice at postnatal day 4, at a time when these neurons normally undergo differentiation. Thus, the aberrant behavior of mutant GIRK2 weaver channels could affect the development of weaver mice in at least two distinct ways.
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| Identification of the weaver mouse mutation: the end of the beginning. | Hess EJ | β | 1996 | β |
| Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. | Kennedy ME et al. | β | 1996 | β |
| Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic. | Oo TF et al. | β | 1996 | β |
| Regions responsible for the assembly of inwardly rectifying potassium channels. | Tinker A et al. | β | 1996 | β |
| The weaver mouse: a most cantankerous rodent. | Herrup K | β | 1996 | β |
| The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2. | Tong Y et al. | β | 1996 | β |
| The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells. | Surmeier DJ et al. | β | 1996 | β |
| Weaver granule neurons are rescued by calcium channel antagonists and antibodies against a neurite outgrowth domain of the B2 chain of laminin. | Liesi P et al. | β | 1996 | β |