Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons.
paper
Cited
Public
Unavailable
- Authors
- Aguayo, L G
- Year
- 1990
- Journal
- European journal of pharmacology
- PMID
- 1703076
- DOI
- 10.1016/0014-2999(90)90349-b
The effects of ethanol (1-80 mM) on GABA-activated Cl- current (IGABA) were studied in cultured mammalian hippocampal and cortical neurons. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner (1-40 mM) in the majority of the cells studied. No higher degree of potentiation was found by increasing the concentration of ethanol to 80 mM. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Changes in the Properties of Ethanol-Sensitive Molecular Targets During Maturation and Aging. | Aguayo LG et al. | β | 2025 | β |
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | β | 2025 | β |
| Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder. | Fish KN et al. | β | 2022 | β |
| The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. | Marcos A et al. | β | 2022 | β |
| UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats. | GΓ‘lvez G et al. | β | 2022 | β |
| Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit. | Venuti LS et al. | β | 2021 | β |
| Differential sensitivity of human neurons carrying ΞΌ opioid receptor (MOR) N40D variants in response to ethanol. | Scarnati MS et al. | β | 2020 | β |
| One Is Not Enough: Understanding and Modeling Polysubstance Use. | Crummy EA et al. | β | 2020 | β |
| Prenatal Exposure to Ethanol Alters Synaptic Activity in Layer V/VI Pyramidal Neurons of the Somatosensory Cortex. | Delatour LC et al. | β | 2020 | β |
| The Influence of Recreational Substance Use in TMS Research. | Turco CV et al. | β | 2020 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. | Quiroz G et al. | β | 2018 | β |
| Examining the effects of alcohol on GABA<sub>A</sub> receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. | Lieberman R et al. | β | 2018 | β |
| Effects of acute alcohol on excitability in the CNS. | Harrison NL et al. | β | 2017 | β |
| Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study. | Jamal M et al. | β | 2016 | β |
| Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected? | FΓΆrstera B et al. | β | 2016 | β |
| Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission. | Park HJ et al. | β | 2016 | β |
| Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors. | Burgos CF et al. | β | 2016 | β |
| The Long and Winding Road to Gamma-Amino-Butyric Acid as Neurotransmitter. | Avoli M et al. | β | 2016 | β |
| Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses. | Burgos CF et al. | β | 2015 | β |
| Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice. | Fritz BM et al. | β | 2014 | β |
| Acute effects of ethanol on GABA<sub>A</sub> and glycine currents in the lateral habenula neurons of young rats. | Xie Z et al. | β | 2013 | β |
| Ethanol reduces amyloid aggregation in vitro and prevents toxicity in cell lines. | OrmeΓ±o D et al. | β | 2013 | β |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | β | 2013 | β |
| The neurobiology of alcohol consumption and alcoholism: an integrative history. | Tabakoff B et al. | β | 2013 | β |
| GABA(A) receptors in the dorsal raphΓ© nucleus of mice: escalation of aggression after alcohol consumption. | Takahashi A et al. | β | 2010 | β |
| Insights into the structure and pharmacology of GABA(A) receptors. | Carter CR et al. | β | 2010 | β |
| Acute alcohol action and desensitization of ligand-gated ion channels. | Dopico AM et al. | β | 2009 | β |
| Impact of ethanol on the developing GABAergic system. | Isayama RN et al. | β | 2009 | β |
| The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons. | Fleming RL et al. | β | 2009 | β |
| Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals. | Criswell HE et al. | β | 2008 | β |
| Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex. | Cuzon VC et al. | β | 2008 | β |
| GABA(A) receptors and alcohol. | Lobo IA et al. | β | 2008 | β |
| A new meaning for "Gin & Tonic": tonic inhibition as the target for ethanol action in the brain. | Mody I et al. | β | 2007 | β |
| Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons. | Kelm MK et al. | β | 2007 | β |
| Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons. | Moriguchi S et al. | β | 2007 | β |
| Ethanol reduces motoneuronal excitability and increases presynaptic inhibition of Ia afferents in the human spinal cord. | von Dincklage F et al. | β | 2007 | β |
| GABAA receptor subtypes: the "one glass of wine" receptors. | Olsen RW et al. | β | 2007 | β |
| Tonic for what ails us? high-affinity GABAA receptors and alcohol. | Lovinger DM et al. | β | 2007 | β |
| Ethanol modulation of GABAergic transmission: the view from the slice. | Weiner JL et al. | β | 2006 | β |
| Low dose acute alcohol effects on GABA A receptor subtypes. | Wallner M et al. | β | 2006 | β |
| RACK1 has the nerve to act: structure meets function in the nervous system. | Sklan EH et al. | β | 2006 | β |
| A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary. | Criswell HE et al. | β | 2005 | β |
| Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons. | Wu PH et al. | β | 2005 | β |
| Differential effects of ethanol on GABA(A) and glycine receptor-mediated synaptic currents in brain stem motoneurons. | Sebe JY et al. | β | 2003 | β |
| Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. | Proctor WR et al. | β | 2003 | β |
| Ethanol dual modulatory actions on spontaneous postsynaptic currents in spinal motoneurons. | Ziskind-Conhaim L et al. | β | 2003 | β |
| Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. | Roberto M et al. | β | 2003 | β |
| Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. | Akk G et al. | β | 2003 | β |
| Nerve growth factor and chronic ethanol treatment alter calcium homeostasis in developing rat septal neurons. | Webb B et al. | β | 2003 | β |
| 5-HT-induced, 5-HT3 receptor-mediated, and ruthenium red- and capsaicin-sensitive positive chronotropic effects in the isolated guinea pig atrium. | Nishio H et al. | β | 2002 | β |
| When midazolam fails. | Cheng C et al. | β | 2002 | β |
| Sleep abnormalities during abstinence in alcohol-dependent patients. Aetiology and management. | Landolt HP et al. | β | 2001 | β |
| Basis of variable sensitivities of GABA(A) receptors to ethanol. | Mori T et al. | β | 2000 | β |
| Chronic exposure to ethanol alters GABA(A) receptor-mediated responses of layer II pyramidal cells in adult rat piriform cortex. | Signore AP et al. | β | 2000 | β |
| Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate. | Dahchour A et al. | β | 2000 | β |
| Acute effects of ethanol on GABAA and glycine receptor function. | Mihic SJ | β | 1999 | β |
| Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. | Grant KA | β | 1999 | β |
| Alcohol effects on the 5-HT3 ligand-gated ion channel. | Lovinger DM et al. | β | 1998 | β |
| Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. | Kang MH et al. | β | 1998 | β |
| Comparison of local and systemic ethanol effects on extracellular dopamine concentration in rat nucleus accumbens by microdialysis. | Yim HJ et al. | β | 1998 | β |
| Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. | Abe K et al. | β | 1998 | β |
| Effects of moderate alcohol consumption on the central nervous system. | Eckardt MJ et al. | β | 1998 | β |
| Ethanol modulation of excitatory and inhibitory synaptic interactions in cultured cortical neurons. | Marszalec W et al. | β | 1998 | β |
| Ethanol selectively enhances the hyperpolarizing component of neocortical neuronal responses to locally applied GABA. | Soldo BL et al. | β | 1998 | β |
| Cardiovascular effects of ethanol in rats selectively bred for high or low sensitivity to the hypnotic effects of ethanol. | Varga K et al. | β | 1997 | β |
| Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat hippocampal CA1 pyramidal neurons. | Weiner JL et al. | β | 1997 | β |
| Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. | Ibbotson T et al. | β | 1997 | β |
| Inhibitory effect of ethanol on the 5-HT3 receptor-mediated tachycardia in isolated guinea-pig atrium. | Nishio H et al. | β | 1997 | β |
| Molecular pathogenesis of alcohol withdrawal seizures: the modified lipid-protein interaction mechanism. | Tan CY et al. | β | 1997 | β |
| Potentiation by ethanol of GABA-induced current and facilitation of its desensitization in cultured rat cortical neurons. | Tsujiyama S et al. | β | 1997 | β |
| Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP rats. | Thielen RJ et al. | β | 1997 | β |
| The pharmacology of amino-acid responses in septal neurons. | Kumamoto E | β | 1997 | β |
| 8-Bromo-cAMP mimics beta-adrenergic sensitization of GABA responses to ethanol in cerebellar Purkinje neurons in vivo. | Freund RK et al. | β | 1996 | β |
| Brain regional pharmacology of GABA(A) receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. | Wong G et al. | β | 1996 | β |
| Effects of ethanol on ion channels. | Crews FT et al. | β | 1996 | β |
| Genetic models in the study of anesthetic drug action. | Simpson VJ et al. | β | 1996 | β |
| How has molecular pharmacology contributed to our understanding of the mechanism(s) of general anesthesia? | Little HJ | β | 1996 | β |
| Influence of age and of pre-treatment with D-cycloserine on the behavior of ethanol-treated rats tested in the elevated plus-maze apparatus. | Ferreira VM et al. | β | 1996 | β |
| Lanthanum and zinc sensitivity of GABAA-activated currents in adult medial septum/diagonal band neurons from ethanol dependent rats. | Frye GD et al. | β | 1996 | β |
| Structural and pharmacological aspects of the GABAA receptor: involvement in behavioral pathogenesis. | ClΓ©ment Y | β | 1996 | β |
| Acute alcohol blocks neurosteroid modulation of synaptic transmission and long-term potentiation in the rat hippocampal slice. | Randall RD et al. | β | 1995 | β |
| Alcohol and head injury: an issue revisited. | Kelly DF | β | 1995 | β |
| Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity. | Liu Y et al. | β | 1995 | β |
| Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied gamma-aminobutyric acid. | Lee RS et al. | β | 1995 | β |
| Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation. | Macdonald RL | β | 1995 | β |
| Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells. | Barann M et al. | β | 1995 | β |
| Methamphetamine facilitates ethanol-induced depressions in cerebellar Purkinje neurons of prazocin- or DSP4-treated rats. | Wang Y et al. | β | 1995 | β |
| Regulation of GABAA receptor function and gene expression in the central nervous system. | Morrow AL | β | 1995 | β |
| The attenuation of suppression of motility by triazolam in the conditioned fear stress task is exacerbated by ethanol in mice. | Kitaichi K et al. | β | 1995 | β |
| The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. | Downie DL et al. | β | 1995 | β |
| Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat. | Shindou T et al. | β | 1994 | β |
| Current concepts of ethanol dependence. | Littleton J et al. | β | 1994 | β |
| Differential effects of GABAergic ligands in mouse and rat hippocampal neurons. | Aguayo LG et al. | β | 1994 | β |
| Ethanol differentially modulates GABAA receptor-mediated chloride currents in hippocampal, cortical, and septal neurons in rat brain slices. | Soldo BL et al. | β | 1994 | β |
| Guanosine phosphate analogs modulate ethanol potentiation of GABAA-mediated synaptic currents in hippocampal CA1 neurons. | Weiner JL et al. | β | 1994 | β |
| Interaction of ethanol and allosteric modulators with GABAA-activated currents in adult medial septum/diagonal band neurons. | Frye GD et al. | β | 1994 | β |
| Role of the GTP-binding protein G(o) in the suppressant effect of ethanol on voltage-activated calcium channels of murine sensory neurons. | Huang GJ et al. | β | 1994 | β |
| Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. | Peoples RW et al. | β | 1994 | β |
| Alcohol modulation of cloned GABAA receptor-channel complex expressed in human kidney cell lines. | Kurata Y et al. | β | 1993 | β |
| Electrophysiological interactions of ethanol with GABAergic mechanisms in the rat cerebellum in vivo. | Freund RK et al. | β | 1993 | β |
| Ethanol inhibits the uptake of exogenous norepinephrine from the extracellular space of the rat cerebellum. | Lin AM et al. | β | 1993 | β |
| Excitotoxicity and alcohol-related brain damage. | Lovinger DM | β | 1993 | β |
| Barbiturate tolerance: effects on GABA-operated chloride channel function. | Allan AM et al. | β | 1992 | β |
| Brain region-dependent sensitivity of GABAA receptor-mediated responses to modulation by ethanol. | Proctor WR et al. | β | 1992 | β |
| Cellular and molecular physiology of alcohol actions in the nervous system. | Weight FF | β | 1992 | β |
| Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats. | Korpi ER et al. | β | 1992 | β |
| Changes in intrinsic inhibition in isolated hippocampal slices during ethanol withdrawal; lack of correlation with withdrawal hyperexcitability. | Whittington MA et al. | β | 1992 | β |
| Differential effects of chronic ethanol administration on GABA(A) receptor alpha1 and alpha6 subunit mRNA levels in rat cerebellum. | Morrow AL et al. | β | 1992 | β |
| Ethanol enhances synaptically evoked GABAA receptor-mediated responses in cerebral cortical neurons in rat brain slices. | Proctor WR et al. | β | 1992 | β |
| Ethanol modulation of GABA receptor-activated Cl- currents in neurons of the chick, rat and mouse central nervous system. | Reynolds JN et al. | β | 1992 | β |
| Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. | Wafford KA et al. | β | 1992 | β |
| Functional properties of GABAA receptors in two rat lines selected for high and low alcohol sensitivity. | Uusi-Oukari M et al. | β | 1992 | β |
| GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain. | Zahniser NR et al. | β | 1992 | β |
| Inhibition of baroreflex bradycardia by ethanol involves both GABAA and GABAB receptors in the brainstem of the rat. | Varga K et al. | β | 1992 | β |
| NMDA receptors: role in ethanol withdrawal seizures. | Hoffman PL et al. | β | 1992 | β |
| Potentiation of gamma-aminobutyric acid-mediated chloride flux by pentobarbital and diazepam but not ethanol. | Mihic SJ et al. | β | 1992 | β |
| Effect of ethanol dependence on GABAA antagonist-induced seizures and agonist-stimulated chloride uptake. | Frye GD et al. | β | 1991 | β |
| Effects of acute and chronic ethanol treatment on pre- and postsynaptic responses to baclofen in rat hippocampus. | Frye GD et al. | β | 1991 | β |
| Ethanol enhances GABAA receptor-activated chloride currents in chick cerebral cortical neurons. | Reynolds JN et al. | β | 1991 | β |
| Ethanol has no effect on cAMP-dependent protein kinase-, protein kinase C-, or Ca(2+)-calmodulin-dependent protein kinase II-stimulated phosphorylation of highly purified substrates in vitro. | Machu TK et al. | β | 1991 | β |
| Ethanol-induced Cl- flux in rat cerebellar granule cells as measured by a fluorescent probe. | Engblom AC et al. | β | 1991 | β |