Mismatch negativity impairment associated with alcohol consumption in chronic alcoholics: a scalp current density study.
- Authors
- Marco-Pallarés, J; Ruffini, G; Polo, M D; Gual, A; Escera, C; Grau, C
- Year
- 2007
- Journal
- International journal of psychophysiology : official journal of the International Organization of Psychophysiology
- PMID
- 17449124
- DOI
- 10.1016/j.ijpsycho.2007.03.001
Previous studies, based on amplitude and latency measurements of auditory event-related brain potentials, yielded inconclusive results about the status of mismatch negativity (MMN) in chronic alcoholics. The present study explores scalp current density (SCD) dynamics during MMN latency range in alcoholics, and correlates electrical SCD results with clinical data of the patients. SCD was computed from 30 electrodes in 16 abstinent chronic alcoholics and 16 healthy control volunteers in a paradigm on MMN elicited by duration changes. Reduced activity was observed in left frontal and right anterior and posterior temporal areas during MMN in alcoholics. Alcohol consumption correlated negatively with SCD intensity in these regions. Delayed activation was observed in the left posterior temporal area in the patients. Alcohol abstinence duration correlated positively with SCD intensity in this region. These results point to an impairment of automatic brain processing mechanisms associated with auditory change detection in chronic alcoholism. The present results suggest a reorganization of the computational neurodynamics of automatic auditory change detection linked to the amount of alcohol consumed in abstinent chronic alcoholics.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Targeting electroencephalography for alcohol dependence: A narrative review. | Zhang H et al. | — | 2023 | → |
| Event-related potentials and use of psychotropic medication in major psychiatric disorders. | Kool L et al. | — | 2022 | → |
| Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult. | Chitty KM et al. | — | 2015 | → |
| Risky alcohol use predicts temporal mismatch negativity impairments in young people with bipolar disorder. | Chitty KM et al. | — | 2014 | → |
| Scalp current density mapping in the analysis of mismatch negativity paradigms. | Giard MH et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity. | Wen X et al. | — | 2012 | → |
| The mismatch negativity (MMN)--a unique window to disturbed central auditory processing in ageing and different clinical conditions. | Näätänen R et al. | — | 2012 | → |