Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.
paper
Cited
Public
Unavailable
- Authors
- Covault, Jonathan; Gelernter, Joel; Jensen, Kevin; Anton, Raymond; Kranzler, Henry R
- Year
- 2008
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 17507911
- DOI
- 10.1038/sj.npp.1301456
- PMCID
- PMC2743531
Following an initial report, there have been multiple replications of an association of alcohol dependence (AD) to markers within a haplotype block that includes the 3'-half of the gene encoding the GABA(A) alpha-2 subunit (GABRA2), on chromosome 4p. We examined the intergenic extent of this haplotype block and the association to AD of markers in the adjacent 5' haplotype block in GABRG1, which encodes the GABA(A) receptor gamma-1 subunit. We genotyped 15 single nucleotide polymorphisms in the GABRG1-GABRA2 interval as well as at 34 ancestry informative markers in three samples: 435 AD and 635 screened control subjects from Connecticut and 812 participants from a multicenter AD treatment trial. We observed two large haplotype blocks in the GABRG1-GABRA2 intergenic interval with a region of increased recombination midway between the two genes. Markers in the two haplotype blocks were in moderate linkage disequilibrium. Compared with markers in the GABRA2 haplotype block, markers in the 5' GABRG1 haplotype showed greater allelic, genotypic and haplotypic association with AD in European Americans from both AD samples. Logistic regression analysis indicated that genetic elements in the GABRG1 haplotype block likely contribute to AD risk in an additive manner, whereas those in the GABRA2 haplotype block may act in a dominant manner in relation to risk of AD.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Multi-omics and electrophysiological examination of GABA<sub>A</sub> receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder. | Granchi J et al. | β | 2026 | β |
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | β | 2025 | β |
| Multi-omics analysis reveals the cerebral sex-specific responses to chronic hypoxia in yellow catfish (Pelteobagrus fulvidraco). | Yin D et al. | β | 2025 | β |
| GABAergic mechanisms in alcohol dependence. | Uusi-Oukari M et al. | β | 2024 | β |
| Early-life stress and ovarian hormones alter transcriptional regulation in the nucleus accumbens resulting in sex-specific responses to cocaine. | Rocks D et al. | β | 2023 | β |
| Sex differences in GABA<sub>A</sub> receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver. | Ashton MK et al. | β | 2022 | β |
| Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder. | Fish KN et al. | β | 2022 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABA<sub>A</sub> subunit gene expression in the context of alcohol use disorder. | Goetjen A et al. | β | 2020 | β |
| Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. | Deak JD et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | β | 2018 | β |
| GABA<sub>A</sub> Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence. | Chandler CM et al. | β | 2018 | β |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor subtype involvement in addictive behaviour. | Stephens DN et al. | β | 2017 | β |
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | β | 2016 | β |
| Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected? | FΓΆrstera B et al. | β | 2016 | β |
| Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. | Kosobud AE et al. | β | 2015 | β |
| Association of GABAA receptor Ξ±2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. | Strac DS et al. | β | 2015 | β |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | β | 2015 | β |
| GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. | Lieberman R et al. | β | 2015 | β |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | β | 2015 | β |
| Ξ±2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. | Newman EL et al. | β | 2015 | β |
| A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. | Arias AJ et al. | β | 2014 | β |
| Association of gamma-aminobutyric acid A receptor Ξ±2 gene (GABRA2) with alcohol use disorder. | Li D et al. | β | 2014 | β |
| Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. | Melroy WE et al. | β | 2014 | β |
| Family-based association analysis of alcohol dependence criteria and severity. | Wetherill L et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples. | Pan Y et al. | β | 2013 | β |
| Decreased GABA(A) benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics. | Laukkanen V et al. | β | 2013 | β |
| GABRA2 markers moderate the subjective effects of alcohol. | Uhart M et al. | β | 2013 | β |
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | Perry BL et al. | β | 2013 | β |
| Genetic influences on the development of alcoholism. | Enoch MA | β | 2013 | β |
| Genetics and alcoholism. | Edenberg HJ et al. | β | 2013 | β |
| Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study. | Plawecki MH et al. | β | 2013 | β |
| Alcohol Dependence and Genes Encoding Ξ±2 and Ξ³1 GABAA Receptor Subunits: Insights from Humans and Mice. | Borghese CM et al. | β | 2012 | β |
| Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. | Yang BZ et al. | β | 2012 | β |
| GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. | Grzywacz A et al. | β | 2012 | β |
| GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. | Ittiwut C et al. | β | 2012 | β |
| Genetics of GABAergic signaling in nicotine and alcohol dependence. | Cui WY et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. | Li SM et al. | β | 2012 | β |
| Ξ±2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. | Engin E et al. | β | 2012 | β |
| Agitated depression in substance dependence. | Leventhal AM et al. | β | 2011 | β |
| Genetic association of recovery from eating disorders: the role of GABA receptor SNPs. | Bloss CS et al. | β | 2011 | β |
| Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. | Lydall GJ et al. | β | 2011 | β |
| Genetics of alcohol dependence. | Kimura M et al. | β | 2011 | β |
| Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. | Cosgrove KP et al. | β | 2011 | β |
| Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics. | Herman AI et al. | β | 2011 | β |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | β | 2010 | β |
| A genome-wide association study of alcohol dependence. | Bierut LJ et al. | β | 2010 | β |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | β | 2010 | β |
| ChIP-chip analysis of neurexins and other candidate genes for addiction and neuropsychiatric disorders. | Pedrosa E et al. | β | 2010 | β |
| GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. | Onori N et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. | Enoch MA et al. | β | 2010 | β |
| Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. | Kranzler HR et al. | β | 2009 | β |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | β | 2009 | β |
| GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. | Charych EI et al. | β | 2009 | β |
| GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. | Enoch MA et al. | β | 2009 | β |
| Genetics of alcohol dependence. | Gelernter J et al. | β | 2009 | β |
| Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity. | Wang LL et al. | β | 2009 | β |
| Subtypes of major depression in substance dependence. | Niciu MJ et al. | β | 2009 | β |
| The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. | Kumar S et al. | β | 2009 | β |
| The role of GABA(A) receptors in the development of alcoholism. | Enoch MA | β | 2008 | β |
| The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. | Lind PA et al. | β | 2008 | β |
| Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol. | Helms CM et al. | β | 2008 | β |
| Pharmacogenetic aspects of addictive behaviors. | Hejazi NS | β | 2007 | β |
| Variation in GABRA2 predicts drinking behavior in project MATCH subjects. | Bauer LO et al. | β | 2007 | β |