Reward circuitry dopaminergic activation regulates food and drug craving behavior.
paper
Cited
Public
Unavailable
- Authors
- Blum, Kenneth; Liu, Yijun; Shriner, Richard; Gold, Mark S
- Year
- 2011
- Journal
- Current pharmaceutical design
- PMID
- 21492092
- DOI
- 10.2174/138161211795656819
Neural circuits implicated in drug conditioning, craving and relapse overlap extensively with those involved in natural reward and reinforcement like food. Exposure to drug-related cues in human addicts results in drug craving and localized activation of central circuits that are known to mediate cue-induced reinstatement of drug-seeking behavior in animal models of relapse. Similar regional activation patterns occur in humans in response to cues associated with foods. Furthermore, drug- and food-related cues not only activate common neuroanatomical regions but also result in similar activity-regulated gene expression programs within these shared areas. Cues predictive of food availability are powerful modulators of appetite as well as food-seeking and ingestive behaviors. The upregulation of a number of early genes in unique patterns within corticostriatal, thalamic, and hypothalamic networks suggests that food cues are capable of powerfully altering neuronal processing in areas mediating the integration of emotion, cognition, arousal, and the regulation of energy balance. The dopaminergic, enkephalinergic, and fos gene expressions are important regulatory genetic pathways for food craving behaviors. An umbrella term to describe common genetic antecedents of multiple impulsive, compulsive and addictive behaviors is Reward Deficiency Syndrome (RDS). Individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the COMT gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. Finally, utilizing the long term dopaminergic activation approach will ultimately lead to a common safe and effective modality to treat RDS behaviors including aberrant food and drug craving behaviors.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic influences on craving for alcohol. | 2013 | 22481050 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Lower-Limb Muscle Impairments in Patients with COPD: An Overview of the Past Decade. | Brauwers B et al. | — | 2026 | → |
| Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions. | Vakili O et al. | — | 2026 | → |
| Association of homozygous fat mass and obesity-associated (FTO rs9939609) gene with body mass, body mass index (BMI), and the binge eating scale in women: A cross-sectional study. | Bressan Rente Ferreira Marum A et al. | — | 2025 | → |
| Partial Dopamine D2/3 Agonists and Dual Disorders: A Retrospective-Cohort Study in a Real-World Clinical Setting on Patients with Schizophrenia Spectrum Disorders and Cannabis Use Disorder. | Trovini G et al. | — | 2025 | → |
| A historical perspective on clonidine as an alpha-2A receptor agonist in the treatment of addictive behaviors: Focus on opioid dependence. | Gold MS et al. | — | 2024 | → |
| "Healthier health in more ways than one": Perspectives on a program for changing both smoking and obesity-related health behaviors. | Murphy CM et al. | — | 2024 | → |
| Imagine chocolate: The craving experience questionnaire in the food domain. | Röttger M et al. | — | 2024 | → |
| The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats. | Schoukroun F et al. | — | 2024 | → |
| Behavioral activation for smoking cessation and the prevention of smoking cessation-related weight gain: A randomized trial. | Audrain-McGovern J et al. | — | 2023 | → |
| High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. | Tyler J et al. | — | 2023 | → |
| Mechanism and treatments of antipsychotic-induced weight gain. | Ye W et al. | — | 2023 | → |
| DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave<sup>®</sup> and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of "Dopamine Homeostasis" in the Face of the Opioid Crisis. | Bajaj A et al. | — | 2022 | → |
| Elevated ad libitum alcohol consumption following continuous theta burst stimulation to the left-dorsolateral prefrontal cortex is partially mediated by changes in craving. | McNeill AM et al. | — | 2022 | → |
| Illicit Drug Use and Smell and Taste Dysfunction: A National Health and Nutrition Examination Survey 2013-2014. | Kao HH et al. | — | 2022 | → |
| Mendelian randomization analyses reveal novel drug targets for anorexia nervosa. | Yang J et al. | — | 2022 | → |
| Understanding the role of smoking and chronic excess alcohol consumption on reduced caloric intake and the development of sarcopenia. | Prokopidis K et al. | — | 2022 | → |
| Weighing the Risk: Developmental Pathways and Processes Underlying Obesity to Substance Use in Adolescence. | Lanza HI | — | 2022 | → |
| Food reinforcement and habituation to food are processes related to initiation and cessation of eating. | Epstein LH et al. | — | 2021 | → |
| Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment. | Onaolapo OJ et al. | — | 2021 | → |
| Expression of Dopamine-Related Genes in Four Human Brain Regions. | Stanfill AG et al. | — | 2020 | → |
| 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications. | Morales I et al. | — | 2020 | → |
| Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome? | Gold MS et al. | — | 2020 | → |
| Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women. | Campos-Ramírez C et al. | — | 2020 | → |
| The Transdiagnostic Nature of Cravings: Smoking Cessation and Food Craving in Pregnancy. | Blau LE et al. | — | 2020 | → |
| Marijuana Use among African American Older Adults in Economically Challenged Areas of South Los Angeles. | Cobb S et al. | — | 2019 | → |
| Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents. | Okhuarobo A et al. | — | 2018 | → |
| Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats. | Ruda-Kucerova J et al. | — | 2018 | → |
| The computational form of craving is a selective multiplication of economic value. | Konova AB et al. | — | 2018 | → |
| Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. | Friend DM et al. | — | 2017 | → |
| Coping food craving with neurofeedback. Evaluation of the usefulness of alpha/theta training in a non-clinical sample. | Imperatori C et al. | — | 2017 | → |
| Gene polymorphisms associated with temperament. | Qiu X et al. | — | 2017 | → |
| Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking. | Cook JB et al. | — | 2017 | → |
| Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? | Joseph J et al. | — | 2017 | → |
| Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats. | Maddux JN et al. | — | 2017 | → |
| Pro-Dopamine Regulator - (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS). | Blum K et al. | — | 2017 | → |
| Role of olfactory reactions, nociception, and immunoendocrine shifts in addictive disorders. | Masterova E et al. | — | 2017 | → |
| Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior. | Thanos PK et al. | — | 2016 | → |
| Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. | Beeler JA et al. | — | 2016 | → |
| Pilot clinical observations between food and drug seeking derived from fifty cases attending an eating disorder clinic. | Beitscher-Campbell H et al. | — | 2016 | → |
| The effect of tobacco cessation on weight gain, obesity, and diabetes risk. | Bush T et al. | — | 2016 | → |
| A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy in Psychiatry. | Gold MS et al. | — | 2015 | → |
| Brain correlates of response inhibition in Internet gaming disorder. | Chen CY et al. | — | 2015 | → |
| Craving is an Affective State and Its Regulation Can Be Understood in Terms of the Extended Process Model of Emotion Regulation. | Giuliani NR et al. | — | 2015 | → |
| Impact of COMT Val158Met-polymorphism on appetitive conditioning and amygdala/prefrontal effective connectivity. | Klucken T et al. | — | 2015 | → |
| Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses. | Reichelt AC et al. | — | 2015 | → |
| Neurogenetic and Neuroimaging Evidence for a Conceptual Model of Dopaminergic Contributions to Obesity. | Stanfill AG et al. | — | 2015 | → |
| The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery. | Blum K et al. | — | 2015 | → |
| Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food. | Bodetto SP et al. | — | 2014 | → |
| Dopamine and glucose, obesity, and reward deficiency syndrome. | Blum K et al. | — | 2014 | → |
| Food addiction: an evolving nonlinear science. | Shriner R et al. | — | 2014 | → |
| Sex differences in addictive disorders. | Fattore L et al. | — | 2014 | → |
| The effects of prefrontal cortex transcranial direct current stimulation (tDCS) on food craving and temporal discounting in women with frequent food cravings. | Kekic M et al. | — | 2014 | → |
| A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder. | Trace SE et al. | — | 2013 | → |
| Common Phenotype in Patients with Both Food and Substance Dependence: Case Reports. | Campbell H et al. | — | 2013 | → |
| Cue-induced cigarette and food craving: a common effect? | Styn MA et al. | — | 2013 | → |
| Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: beyond the homeostatic control of food intake. | Monteleone P et al. | — | 2013 | → |
| Effects of non-invasive neurostimulation on craving: a meta-analysis. | Jansen JM et al. | — | 2013 | → |
| Genetic influences on craving for alcohol. | Agrawal A et al. | — | 2013 | → |
| Hypothesizing repetitive paraphilia behavior of a medication refractive Tourette's syndrome patient having rapid clinical attenuation with KB220Z-nutrigenomic amino-acid therapy (NAAT). | Mclaughlin T et al. | — | 2013 | → |
| Pharmacotherapies for Overeating and Obesity. | Yarnell S et al. | — | 2013 | → |
| Withdrawal from Buprenorphine/Naloxone and Maintenance with a Natural Dopaminergic Agonist: A Cautionary Note. | Blum K et al. | — | 2013 | → |
| Acupuncture at SI5 attenuates morphine seeking behavior after extinction. | Lee BH et al. | — | 2012 | → |
| Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats. | Gao J et al. | — | 2012 | → |
| Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse. | Zorick T et al. | — | 2012 | → |
| Parental substance abuse and function of the motivation and behavioral inhibition systems in drug-naïve youth. | Ivanov I et al. | — | 2012 | → |
| Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. | Beeler JA et al. | — | 2012 | → |
| The addictive brain: all roads lead to dopamine. | Blum K et al. | — | 2012 | → |
| Thorndike's Law 2.0: Dopamine and the Regulation of Thrift. | Beeler JA | — | 2012 | → |
| A short update on the structure of drug binding sites on neurotransmitter transporters. | Gabrielsen M et al. | — | 2011 | → |
| Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. | Blum K et al. | — | 2011 | → |
| Increased feeding and food hoarding following food deprivation are associated with activation of dopamine and orexin neurons in male Brandt's voles. | Zhang XY et al. | — | 2011 | → |
| Linking early brain and biological development to psychiatry: introduction and symposia review. | Attridge M et al. | — | 2011 | → |
| Mechanistic insights into nicotine withdrawal. | Paolini M et al. | — | 2011 | → |