A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.
paper
Cited
Public
Unavailable
- Authors
- Davies, Andrew G; Pierce-Shimomura, Jonathan T; Kim, Hongkyun; VanHoven, Miri K; Thiele, Tod R; Bonci, Antonello; Bargmann, Cornelia I; McIntire, Steven L
- Year
- 2003
- Journal
- Cell
- PMID
- 14675531
- DOI
- 10.1016/s0092-8674(03)00979-6
The activities of many neuronal proteins are modulated by ethanol, but the fundamental mechanisms underlying behavioral effects of ethanol remain unclear. To identify mechanisms responsible for intoxication, we screened for Caenorhabditis elegans mutants with altered behavioral responses to ethanol. We found that slo-1 mutants, which were previously recognized as having slightly uncoordinated movement, are highly resistant to ethanol in two behavioral assays. Numerous loss-of-function slo-1 alleles emerged from our screens, indicating that slo-1 has a central role in ethanol responses. slo-1 encodes the BK potassium channel. Electrophysiological analysis shows that ethanol activates the channel in vivo, which would inhibit neuronal activity. Moreover, behaviors of slo-1 gain-of-function mutants resemble those of ethanol-intoxicated animals. These results demonstrate that selective activation of BK channels is responsible for acute intoxicating effects of ethanol in C. elegans. BK channel activation may explain a variety of behavioral responses to ethanol in invertebrate and vertebrate systems.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson's disease. | Ngana GS et al. | β | 2025 | β |
| Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans. | Xue W et al. | β | 2025 | β |
| C. elegans as a powerful model for neurotoxicity assessment. | Barbosa DJ et al. | β | 2025 | β |
| Ethanol alters mechanosensory habituation in C. elegans by way of the BK potassium channel through a novel mechanism. | Kokan N et al. | β | 2025 | β |
| High-throughput assessment of the behavioral responses to toxic organic solvents in Caenorhabditis elegans. | Tomioka M | β | 2025 | β |
| Role of dopamine in responsiveness to acute ethanol exposure in <i>Caenorhabditis elegans</i>. | Gayadin D et al. | β | 2025 | β |
| Studying the mechanisms of neurodegeneration: <i>C. elegans</i> advantages and opportunities. | Torres AK et al. | β | 2025 | β |
| Synthetic Cathinones Induce Developmental Arrest, Reduce Reproductive Capacity, and Shorten Lifespan in the <i>C. elegans</i> Model. | Mendes C et al. | β | 2025 | β |
| Concentration- and time-dependent behavioural effects of ethanol on Lumbriculus variegatus. | Seeley A et al. | β | 2024 | β |
| Ethanol's interaction with BK channel Ξ± subunit residue K361 does not mediate behavioral responses to alcohol in mice. | Okhuarobo A et al. | β | 2024 | β |
| Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model. | HernΓ‘ndez-GarcΓa S et al. | β | 2024 | β |
| Hispidol Regulates Behavioral Responses to Ethanol through Modulation of BK Channels: A Novel Candidate for the Treatment of Alcohol Use Disorder. | Yang W et al. | β | 2024 | β |
| JNK Signaling Positively Regulates Acute Ethanol Tolerance in <i>C. elegans</i>. | Jee C et al. | β | 2024 | β |
| Nicotine Motivated Behavior in <i>C. elegans</i>. | Salim C et al. | β | 2024 | β |
| Protocol to synthesize the auxin analog 5-Ph-IAA for conditional protein depletion in C.Β elegans using the AID2 system. | Sural S et al. | β | 2024 | β |
| Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity. | Koopman M et al. | β | 2024 | β |
| Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models. | Bhandari A et al. | β | 2024 | β |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach. | Gentry AE et al. | β | 2023 | β |
| Electric shock causes a fleeing-like persistent behavioral response in the nematode Caenorhabditis elegans. | Tee LF et al. | β | 2023 | β |
| Evidence for Involvement of<i>WDPCP</i>Gene in Alcohol Consumption, Lipid Metabolism, and Liver Cirrhosis | OβFarrell F et al. | β | 2023 | β |
| Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis. | O'Farrell F et al. | β | 2023 | β |
| Inner pore hydration free energy controls theΒ activation of big potassium channels. | Nordquist EB et al. | β | 2023 | β |
| Mitochondria in the Spotlight: <i>C. elegans</i> as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction. | Martins AC et al. | β | 2023 | β |
| mScarlet and split fluorophore mScarlet resources for plasmid-based CRISPR/Cas9 knock-in in <i>C. elegans</i>. | Witten G et al. | β | 2023 | β |
| Natural allelic variation modifies acute ethanol response phenotypes in wild strains of C. elegans. | van Wijk MH et al. | β | 2023 | β |
| An allosteric modulator activates BK channels by perturbing coupling between Ca<sup>2+</sup> binding and pore opening. | Zhang G et al. | β | 2022 | β |
| A neuropeptide signal confers ethanol state dependency during olfactory learning in <i>Caenorhabditis elegans</i>. | Lindsay JH et al. | β | 2022 | β |
| Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson's Disease-like Symptoms in <i>C. elegans</i>. | de Guzman ACV et al. | β | 2022 | β |
| Developmental lead exposure affects dopaminergic neuron morphology and modifies basal slowing response in Caenorhabditis elegans: Effects of ethanol. | Albrecht PA et al. | β | 2022 | β |
| Food-Grade Quercetin-Loaded Nanoemulsion Ameliorates Effects Associated with Parkinson's Disease and Cancer: Studies Employing a Transgenic <i>C. elegans</i> Model and Human Cancer Cell Lines. | Das SS et al. | β | 2022 | β |
| Neurobiological Basis of Aversion-Resistant Ethanol Seeking in <i>C. elegans</i>. | Jee C et al. | β | 2022 | β |
| Neuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression. | Rose JK et al. | β | 2022 | β |
| Neuropeptidergic regulation of compulsive ethanol seeking in C. elegans. | Salim C et al. | β | 2022 | β |
| Reduced acute functional tolerance and enhanced preference for ethanol in Caenorhabditis elegans exposed to lead during development: Potential role of alcohol dehydrogenase. | Albrecht PA et al. | β | 2022 | β |
| The intertwining between lead and ethanol in the model organism <i>Caenorhabditis elegans</i>. | Albrecht PA et al. | β | 2022 | β |
| Transgenerational effects of alcohol on behavioral sensitivity to alcohol in Caenorhabditis elegans. | Guzman DM et al. | β | 2022 | β |
| Translational relevance of forward genetic screens in animal models for the study of psychiatric disease. | Sheardown E et al. | β | 2022 | β |
| Alcohol metabolite acetic acid activates BK channels in a pH-dependent manner and decreases calcium oscillations and exocytosis of secretory granules in rat pituitary GH3 cells. | Shaidullov I et al. | β | 2021 | β |
| Ethanol-induced Sedative Behavior: An Assay to Investigate Increased Dopamine Signaling in <i>Caenorhabditis elegans</i>. | Singh A et al. | β | 2021 | β |
| <i>Drosophila</i> Corazonin Neurons as a Hub for Regulating Growth, Stress Responses, Ethanol-Related Behaviors, Copulation Persistence and Sexually Dimorphic Reward Pathways. | Khan Z et al. | β | 2021 | β |
| Impact of drug solvents on <i>C. elegans</i> pharyngeal pumping. | Calahorro F et al. | β | 2021 | β |
| Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans. | Pandey P et al. | β | 2021 | β |
| Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside. | Wit J et al. | β | 2021 | β |
| Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs. | Bhat US et al. | β | 2021 | β |
| N-Ξ³-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans. | Chang CH et al. | β | 2021 | β |
| Receptors and Channels Associated with Alcohol Use: Contributions from <i>Drosophila</i>. | Scaplen KM et al. | β | 2021 | β |
| Transcriptional analysis of the response of C. elegans to ethanol exposure. | Sterken MG et al. | β | 2021 | β |
| Xenobiotic metabolism and transport in <i>Caenorhabditis elegans</i>. | Hartman JH et al. | β | 2021 | β |
| BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor. | Cheung TP et al. | β | 2020 | β |
| Cutting off ciliary protein import: intraflagellar transport after dendritic femtosecond-laser ablation. | Mijalkovic J et al. | β | 2020 | β |
| Dugesia japonica is the best suited of three planarian species for high-throughput toxicology screening. | Ireland D et al. | β | 2020 | β |
| Melatonin promotes sleep by activating the BK channel in <i>C. elegans</i>. | Niu L et al. | β | 2020 | β |
| Schisandra chinensis water extract protects ethanol-induced neurotoxicity in Caenorhabditis elegans. | Wu ZQ et al. | β | 2020 | β |
| SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol. | Mathies LD et al. | β | 2020 | β |
| A C. elegans Model for the Study of RAGE-Related Neurodegeneration. | Pinkas A et al. | β | 2019 | β |
| BK channel clustering is required for normal behavioral alcohol sensitivity in C. elegans. | Oh KH et al. | β | 2019 | β |
| Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders. | Katner SN et al. | β | 2019 | β |
| Evaluation of the pharmacological involvement of ATP-sensitive potassium (K<sub>ATP</sub>) channels in the antidepressant-like effects of topiramate on mice. | Shakiba S et al. | β | 2019 | β |
| Impacts of methamphetamine and ketamine on C.elegans's physiological functions at environmentally relevant concentrations and eco-risk assessment in surface waters. | Wang Z et al. | β | 2019 | β |
| Long-Chain Ο-3 Levels Are Associated With Increased Alcohol Sensitivity in a Population-Based Sample of Adolescents. | Edwards AC et al. | β | 2019 | β |
| Unraveling the Mechanisms of Behaviors Associated With AUDs Using Flies and Worms. | Scholz H | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo. | Scott LL et al. | β | 2018 | β |
| Biochemical and Functional Interplay Between Ion Channels and the Components of the Dystrophin-Associated Glycoprotein Complex. | Leyva-Leyva M et al. | β | 2018 | β |
| Calnexin revealed as an ether-a-go-go chaperone by getting mutant worms up and going. | Pierce JT | β | 2018 | β |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | β | 2018 | β |
| Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in <i>Drosophila</i>. | Xu S et al. | β | 2018 | β |
| GCY-35/GCY-36-TAX-2/TAX-4 Signalling in O<sub>2</sub> Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans. | Chen YH et al. | β | 2018 | β |
| Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. | van der Vaart A et al. | β | 2018 | β |
| <i>Caenorhabditis elegans</i> Show Preference for Stimulants and Potential as a Model Organism for Medications Screening. | Engleman EA et al. | β | 2018 | β |
| Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model. | Bravo FV et al. | β | 2018 | β |
| Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons. | Dopico AM et al. | β | 2018 | β |
| An emerging model organism Caenorhabditis elegans for alternative pre-mRNA processing in vivo. | Wani S et al. | β | 2017 | β |
| A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus. | Scott LL et al. | β | 2017 | β |
| Anti-Parkinsonian effects of Ξ²-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. | Wei CC et al. | β | 2017 | β |
| Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in <i>Caenorhabditis elegans</i>. | Scott LL et al. | β | 2017 | β |
| BKIP-1, an auxiliary subunit critical to SLO-1 function, inhibits SLO-2 potassium channel in vivo. | Niu LG et al. | β | 2017 | β |
| ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in <i>C. elegans</i>. | Oh KH et al. | β | 2017 | β |
| Ethanol Stimulates Locomotion via a G<sub>Ξ±s</sub>-Signaling Pathway in IL2 Neurons in <i>Caenorhabditis elegans</i>. | Johnson JR et al. | β | 2017 | β |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | β | 2017 | β |
| Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans. | Nicholl GC et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| Role of GABA<sub>A</sub> receptors in alcohol use disorders suggested by chronic intermittent ethanol (CIE) rodent model. | Olsen RW et al. | β | 2017 | β |
| The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. | Shah A et al. | β | 2017 | β |
| Advanced Behavioral Analyses Show that the Presence of Food Causes Subtle Changes in C. elegans Movement. | Angstman NB et al. | β | 2016 | β |
| BK Channels in the Central Nervous System. | Contet C et al. | β | 2016 | β |
| Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction. | Engleman EA et al. | β | 2016 | β |
| Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. | Derksen M et al. | β | 2016 | β |
| ChIP and Chips: Introducing the WormPharm for correlative studies employing pharmacology and genome-wide analyses in <i>C. elegans</i>. | Doh JH et al. | β | 2016 | β |
| From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning. | McDowell G et al. | β | 2016 | β |
| Inhibitors of Calcium-Activated Anion Channels Modulate Hypnotic Ethanol Responses in Adult Sprague Dawley Rats. | Carter JM et al. | β | 2016 | β |
| Insulin signaling genes modulate nicotine-induced behavioral responses in Caenorhabditis elegans. | Wescott SA et al. | β | 2016 | β |
| Maintenance of Membrane Integrity and Permeability Depends on a Patched-Related Protein in Caenorhabditis elegans. | Choi MK et al. | β | 2016 | β |
| Modulation of BK Channels by Ethanol. | Dopico AM et al. | β | 2016 | β |
| Protein Network Interacting with BK Channels. | Kim H et al. | β | 2016 | β |
| Slo1 regulates ethanol-induced scrunching in freshwater planarians. | Cochet-Escartin O et al. | β | 2016 | β |
| SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification. | Alqadah A et al. | β | 2016 | β |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | β | 2016 | β |
| The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols. | Xie C et al. | β | 2016 | β |
| An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans. | Davies AG et al. | β | 2015 | β |
| A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans. | Hawkins EG et al. | β | 2015 | β |
| BK channels: multiple sensors, one activation gate. | Yang H et al. | β | 2015 | β |
| BK Channel Ξ²1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure. | Kreifeldt M et al. | β | 2015 | β |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | β | 2015 | β |
| Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans. | Patananan AN et al. | β | 2015 | β |
| Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels. | Oh KH et al. | β | 2015 | β |
| Putative calcium-binding domains of the Caenorhabditis elegans BK channel are dispensable for intoxication and ethanol activation. | Davis SJ et al. | β | 2015 | β |
| Starvation-induced collective behavior in C. elegans. | Artyukhin AB et al. | β | 2015 | β |
| SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. | Mathies LD et al. | β | 2015 | β |
| Transcriptome organization for chronic alcohol abuse in human brain. | Farris SP et al. | β | 2015 | β |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | β | 2014 | β |
| Alcohol disinhibition of behaviors in C. elegans. | Topper SM et al. | β | 2014 | β |
| Alcohol withdrawal is associated with a downregulation of large-conductance CaΒ²βΊ-activated KβΊ channels in rat inferior colliculus neurons. | N'Gouemo P et al. | β | 2014 | β |
| C. elegans in high-throughput drug discovery. | O'Reilly LP et al. | β | 2014 | β |
| Cellular stress induces a protective sleep-like state in C. elegans. | Hill AJ et al. | β | 2014 | β |
| Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans. | Davis SJ et al. | β | 2014 | β |
| Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. | Roy S et al. | β | 2014 | β |
| Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs. | Dwyer DS et al. | β | 2014 | β |
| Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior. | Dopico AM et al. | β | 2014 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| Large conductance voltage- and Ca2+-gated potassium (BK) channel Ξ²4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases. | VelΓ‘zquez-Marrero C et al. | β | 2014 | β |
| Molecular basis of alcoholism. | Most D et al. | β | 2014 | β |
| Nematodes feel a craving--using Caenorhabditis elegans as a model to study alcohol addiction. | Zhu G et al. | β | 2014 | β |
| Regulation of synaptic transmission at the Caenorhabditis elegans M4 neuromuscular junction by an antagonistic relationship between two calcium channels. | Steciuk M et al. | β | 2014 | β |
| RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain. | Farris SP et al. | β | 2014 | β |
| SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans. | Liu P et al. | β | 2014 | β |
| Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation. | Most D et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| The omega-3 fatty acid eicosapentaenoic acid is required for normal alcohol response behaviors in C. elegans. | Raabe RC et al. | β | 2014 | β |
| The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies. | Bettinger JC et al. | β | 2014 | β |
| Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways. | O'Reilly LP et al. | β | 2014 | β |
| Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells. | Handlechner AG et al. | β | 2013 | β |
| Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance. | Ghezzi A et al. | β | 2013 | β |
| An evolutionarily conserved mode of modulation of Shaw-like KβΊ channels. | Cotella D et al. | β | 2013 | β |
| BK channel Ξ²1 and Ξ²4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. | Kreifeldt M et al. | β | 2013 | β |
| Chronic ethanol exposure increases cytochrome P-450 and decreases activated in blocked unfolded protein response gene family transcripts in caenorhabditis elegans. | Peltonen J et al. | β | 2013 | β |
| Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans. | Dillon J et al. | β | 2013 | β |
| Fyn-dependent gene networks in acute ethanol sensitivity. | Farris SP et al. | β | 2013 | β |
| Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans. | Wang Y et al. | β | 2013 | β |
| Rab-3 and unc-18 interactions in alcohol sensitivity are distinct from synaptic transmission. | Johnson JR et al. | β | 2013 | β |
| SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans. | Jee C et al. | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| The migration of neural progenitor cell mediated by SDF-1 is NF-ΞΊB/HIF-1Ξ± dependent upon hypoxia. | Yin W et al. | β | 2013 | β |
| A low concentration of ethanol impairs learning but not motor and sensory behavior in Drosophila larvae. | Robinson BG et al. | β | 2012 | β |
| A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. | Dexter PM et al. | β | 2012 | β |
| Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae. | Castro PV et al. | β | 2012 | β |
| C. elegans feeding. | Avery L et al. | β | 2012 | β |
| Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels. | LeBoeuf B et al. | β | 2012 | β |
| Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. | Bhandari P et al. | β | 2012 | β |
| Coordination of behavioral hierarchies during environmental transitions in <i>Caenorhabditis elegans.</i> | Vidal-Gadea AG et al. | β | 2012 | β |
| Different genes influence toluene- and ethanol-induced locomotor impairment in C. elegans. | Davies AG et al. | β | 2012 | β |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | β | 2012 | β |
| Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. | Alaimo JT et al. | β | 2012 | β |
| Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. | Wolen AR et al. | β | 2012 | β |
| HSP-4 endoplasmic reticulum (ER) stress pathway is not activated in a C. elegans model of ethanol intoxication and withdrawal. | Ient B et al. | β | 2012 | β |
| Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans. | Schumacher JA et al. | β | 2012 | β |
| Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans. | Bettinger JC et al. | β | 2012 | β |
| MicroRNAs control neurobehavioral development and function in zebrafish. | Tal TL et al. | β | 2012 | β |
| Non-coding RNAs--novel targets in neurotoxicity. | Tal TL et al. | β | 2012 | β |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | β | 2012 | β |
| The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. | Joyce PI et al. | β | 2012 | β |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | β | 2012 | β |
| A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling? | NΓ€ssel DR et al. | β | 2011 | β |
| Advances in animal models of drug addiction. | Heidbreder C | β | 2011 | β |
| Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. | Karmacharya R et al. | β | 2011 | β |
| Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms. | Yu X et al. | β | 2011 | β |
| Big ideas for small brains: what can psychiatry learn from worms, flies, bees and fish? | Burne T et al. | β | 2011 | β |
| Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. | Wagle M et al. | β | 2011 | β |
| Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. | Pan CL et al. | β | 2011 | β |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | β | 2011 | β |
| Identification of the neuronal effects of ethanol on C. elegans by in vivo fluorescence imaging on a microfluidic chip. | Wang Y et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit. | Siehr MS et al. | β | 2011 | β |
| SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. | Welz C et al. | β | 2011 | β |
| The dystrophin-associated protein complex maintains muscle excitability by regulating Ca(2+)-dependent K(+) (BK) channel localization. | Sancar F et al. | β | 2011 | β |
| The relevance of Caenorhabditis elegans genetics for understanding human psychiatric disease. | Wang X et al. | β | 2011 | β |
| A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. | Mitchell P et al. | β | 2010 | β |
| A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. | Kullyev A et al. | β | 2010 | β |
| A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. | Lind PA et al. | β | 2010 | β |
| A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. | Boyd WA et al. | β | 2010 | β |
| A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. | Govorunova EG et al. | β | 2010 | β |
| An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans. | Abraham LS et al. | β | 2010 | β |
| An elegant mind: learning and memory in Caenorhabditis elegans. | Ardiel EL et al. | β | 2010 | β |
| A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. | Chen B et al. | β | 2010 | β |
| Antipsychotic drugs activate the C. elegans akt pathway via the DAF-2 insulin/IGF-1 receptor. | Weeks KR et al. | β | 2010 | β |
| C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. | Kang L et al. | β | 2010 | β |
| Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. | Kwon Y et al. | β | 2010 | β |
| Ethanol sensitizes the nervous system of Caenorhabditis elegans nematode to heat stress. | Gainutdinov MKh et al. | β | 2010 | β |
| Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. | BjΓΆrk K et al. | β | 2010 | β |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | β | 2010 | β |
| Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells. | Sitdikova GF et al. | β | 2010 | β |
| Molecular population genetics and phenotypic sensitivity to ethanol for a globally diverse sample of the nematode Caenorhabditis briggsae. | Cutter AD et al. | β | 2010 | β |
| Presynaptic targets for acute ethanol sensitivity. | Barclay JW et al. | β | 2010 | β |
| Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? | Van Raamsdonk JM et al. | β | 2010 | β |
| The behavior and social communication of honey bees (Apis mellifera carnica Poll.) under the influence of alcohol. | Mixson TA et al. | β | 2010 | β |
| The genetics of behavioral alcohol responses in Drosophila. | Rodan AR et al. | β | 2010 | β |
| The role of microRNAs in drug addiction: a big lesson from tiny molecules. | Pietrzykowski AZ | β | 2010 | β |
| Ξ±-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. | Chen B et al. | β | 2010 | β |
| An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance. | Bhandari P et al. | β | 2009 | β |
| BK Channels: mediators and models for alcohol tolerance. | Treistman SN et al. | β | 2009 | β |
| Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans. | Karmacharya R et al. | β | 2009 | β |
| Cocaine modulates locomotion behavior in C. elegans. | Ward A et al. | β | 2009 | β |
| CREB regulation of BK channel gene expression underlies rapid drug tolerance. | Wang Y et al. | β | 2009 | β |
| Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. | Peng J et al. | β | 2009 | β |
| Ethanol preference in C. elegans. | Lee J et al. | β | 2009 | β |
| In vitro and in vivo models of acute alcohol exposure. | Dolganiuc A et al. | β | 2009 | β |
| Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. | Mulholland PJ et al. | β | 2009 | β |
| The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans. | Kim H et al. | β | 2009 | β |
| The overlap in predicting alcohol outcome for two measures of the level of response to alcohol. | Schuckit MA et al. | β | 2009 | β |
| Tolerance in Drosophila. | Atkinson NS | β | 2009 | β |
| UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans. | Graham ME et al. | β | 2009 | β |
| Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment. | Yuan C et al. | β | 2008 | β |
| Acute ethanol ingestion impairs appetitive olfactory learning and odor discrimination in the honey bee. | Mustard JA et al. | β | 2008 | β |
| BK channel subunit composition modulates molecular tolerance to ethanol. | Feinberg-Zadek PL et al. | β | 2008 | β |
| Control of alternative pre-mRNA splicing by Ca(++) signals. | Xie J | β | 2008 | β |
| Effects of developmental exposure to ethanol on Caenorhabditis elegans. | Davis JR et al. | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. | Martin GE et al. | β | 2008 | β |
| Impulse control disorders in women with eating disorders. | FernΓ‘ndez-Aranda F et al. | β | 2008 | β |
| Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. | Kapfhamer D et al. | β | 2008 | β |
| miXED messages in ion channel modulation. | Levitan IB | β | 2008 | β |
| Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. | Pietrzykowski AZ et al. | β | 2008 | β |
| Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics. | Karbowski J et al. | β | 2008 | β |
| The anesthetic action of ethanol analyzed by genetics in Caenorhabditis elegans. | Hong M et al. | β | 2008 | β |
| The molecular basis of tolerance. | Pietrzykowski AZ et al. | β | 2008 | β |
| Beta-subunits are important modulators of the acute response to alcohol in human BK channels. | Feinberg-Zadek PL et al. | β | 2007 | β |
| Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone. | Torayama I et al. | β | 2007 | β |
| Effect of chronic administration of ethanol on the regulation of the delta-subunit of GABA(A) receptors in the rat brain. | Marutha Ravindran CR et al. | β | 2007 | β |
| Ethanol interactions with calcium-dependent potassium channels. | Brodie MS et al. | β | 2007 | β |
| KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. | Bloch M et al. | β | 2007 | β |
| Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. | Bauer Huang SL et al. | β | 2007 | β |
| Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans. | Tanaka D et al. | β | 2007 | β |
| Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction. | Liu Q et al. | β | 2007 | β |
| SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics. | Holden-Dye L et al. | β | 2007 | β |
| The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. | Guest M et al. | β | 2007 | β |
| The concentration-dependent effects of ethanol on Caenorhabditis elegans behaviour. | Mitchell PH et al. | β | 2007 | β |
| A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. | Feng Z et al. | β | 2006 | β |
| Actions of acute and chronic ethanol on presynaptic terminals. | Roberto M et al. | β | 2006 | β |
| Acute ethanol ingestion produces dose-dependent effects on motor behavior in the honey bee (Apis mellifera). | Maze IS et al. | β | 2006 | β |
| Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay. | Mahoney TR et al. | β | 2006 | β |
| Ca2+ -activated K+ channels of the BK-type in the mouse brain. | Sausbier U et al. | β | 2006 | β |
| Caenorhabditis elegans: a versatile platform for drug discovery. | Artal-Sanz M et al. | β | 2006 | β |
| CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. | Liu J et al. | β | 2006 | β |
| Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. | Gill MS | β | 2006 | β |
| Ethanol tolerance caused by slowpoke induction in Drosophila. | Cowmeadow RB et al. | β | 2006 | β |
| High-conductance potassium channels of the SLO family. | Salkoff L et al. | β | 2006 | β |
| Hypotonicity and ethanol modulate BK channel activity and chloride currents in GH4/C1 pituitary tumour cells. | Jakab M et al. | β | 2006 | β |
| Low dose acute alcohol effects on GABA A receptor subtypes. | Wallner M et al. | β | 2006 | β |
| Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513. | Wallner M et al. | β | 2006 | β |
| Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans. | Lans H et al. | β | 2006 | β |
| Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. | Collins JJ et al. | β | 2006 | β |
| The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy. | Carre-Pierrat M et al. | β | 2006 | β |
| Tissue-specific alternative splicing of BK channel transcripts in Drosophila. | Yu JY et al. | β | 2006 | β |
| A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary. | Criswell HE et al. | β | 2005 | β |
| Activation of the BK (SLO1) potassium channel by mallotoxin. | Zakharov SI et al. | β | 2005 | β |
| Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. | Hanchar HJ et al. | β | 2005 | β |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | β | 2005 | β |
| A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. | Chuang CF et al. | β | 2005 | β |
| Autosomal linkage analysis for the level of response to alcohol. | Schuckit MA et al. | β | 2005 | β |
| Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. | Du W et al. | β | 2005 | β |
| Chemistry-to-gene screens in Caenorhabditis elegans. | Jones AK et al. | β | 2005 | β |
| Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels. | Crowley JJ et al. | β | 2005 | β |
| Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. | Kerns RT et al. | β | 2005 | β |
| Laboratory models of alcoholism: treatment target identification and insight into mechanisms. | Lovinger DM et al. | β | 2005 | β |
| Pharmacological intervention in invertebrate aging. | Lithgow GJ et al. | β | 2005 | β |
| The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila. | Cowmeadow RB et al. | β | 2005 | β |
| Addiction research in a simple animal model: the nematode Caenorhabditis elegans. | Schafer WR | β | 2004 | β |
| Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer? | Hanchar HJ et al. | β | 2004 | β |
| BK channel news: full coverage on the calcium bowl. | Moczydlowski EG | β | 2004 | β |
| Drug targets: turning the channel (on) for sedation. | Sandstrom DJ et al. | β | 2004 | β |
| Ethanol targets: a BK channel cocktail in C. elegans. | Crowder CM | β | 2004 | β |
| Genetics, pharmacokinetics, and neurobiology of adolescent alcohol use. | β | β | 2004 | β |
| Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. | Davies AG et al. | β | 2004 | β |
| Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans. | Hawasli AH et al. | β | 2004 | β |
| slo K(+) channel gene regulation mediates rapid drug tolerance. | Ghezzi A et al. | β | 2004 | β |
| SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans. | Kim H et al. | β | 2004 | β |
| Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. | Martin G et al. | β | 2004 | β |
| State-dependency in C. elegans. | Bettinger JC et al. | β | 2004 | β |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | β | 2004 | β |
| The use of Caenorhabditis elegans in molecular neuropharmacology. | Bettinger JC et al. | β | 2004 | β |
| Using C. elegans to screen for targets of ethanol and behavior-altering drugs. | Davies AG et al. | β | 2004 | β |