Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: a pilot SPECT study.
paper
Cited
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- Authors
- Gansler, D A; Harris, G J; Oscar-Berman, M; Streeter, C; Lewis, R F; Ahmed, I; Achong, D
- Year
- 2000
- Journal
- Journal of studies on alcohol
- PMID
- 10627094
- DOI
- 10.15288/jsa.2000.61.32
OBJECTIVE: This pilot study evaluated hypotheses concerning the relationship between cerebral hypoperfusion and residual deficits in the functioning of frontal brain systems in abstinent long-term alcoholics. METHOD: The participants (N = 22) were 10 healthy, abstinent alcoholics (9 men) and 12 age-equivalent nonalcoholic controls (10 men). Cerebral blood flow was observed through the use of regionally specific computer-derived quantitative analysis of single photon emission computed tomography (SPECT) perfusion images. Measures of alcohol use, abstinence and neuropsychological functioning were also obtained to relate to SPECT findings. RESULTS: A positive relationship was observed between perfusion levels in the left inferior frontal brain region and years of sobriety. Alcoholics with less than 4 years of sobriety had significantly reduced left inferior frontal perfusion compared with both nonalcoholic controls and alcoholics having longer periods of sobriety. CONCLUSIONS: The findings support the hypothesis that frontal brain abnormalities in alcoholics may subside with extended abstinence.
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