Genetic studies on alcohol-metabolizing enzymes: detection of isozymes in human hair roots.
paper
Cited
Public
Unavailable
- Authors
- Goedde, H W; Agarwal, D P; Harada, S
- Year
- 1980
- Journal
- Enzyme
- PMID
- 6998700
- DOI
- 10.1159/000459265
Human liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play an important role in alcohol metabolism. It has been shown that both enzymes are polymorphic and that different variants may be responsible for individual and racial differences in biological sensitivity to ethanol. However, for lack of a suitable peripheral enzyme source, no information is available regarding family data and the mode of inheritance of ADH and ALDH. Using sensitive micro-methods, we report here the detection of these enzymes and their variant forms in human hair root cells. The isozyme pattern of both enzymes obtained by isoelectric focusing from human liver, cultured fibroblast and hair root cell extracts are presented. Several German, Japanese and Vietnamese families were investigated. ALDH was found polymorphic only in Mongoloid populations. Phenotype distribution in a random Japanese population and families suggest a direct relationship between the absence of ALDH I isozyme and alcohol-induced biological sensitivity commonly observed in individuals of Mongoloid origin.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells. | Liu Y et al. | — | 2017 | → |
| Allergic or irritant contact dermatitis after patch testing with alcohol--that is the point. | Löffler H et al. | — | 2012 | → |
| Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers. | Jäckh C et al. | — | 2012 | → |
| Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? | Israel Y et al. | — | 2011 | → |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | — | 2011 | → |
| Genetics of addictions. | Hartz SM et al. | — | 2010 | → |
| Genetics of addictions. | Hartz SM et al. | — | 2010 | → |
| Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men. | Assanangkornchai S et al. | — | 2003 | → |
| Regulation of the mammalian alcohol dehydrogenase genes. | Edenberg HJ | — | 2000 | → |
| Alcohol interactions with drugs and its effect on the treatment of skin diseases. | Zachariae H | — | 1999 | → |
| Aldehyde dehydrogenase genotypes and male alcohol use disorders: a case-control study in Khon Kaen, north-east Thailand. | Nanakorn S et al. | — | 1999 | → |
| Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin. | Cheung C et al. | — | 1999 | → |
| Ethanol metabolism, toxicity and genetic polymorphism. | Iwahashi K et al. | — | 1998 | → |
| Biochemical approach on the conservation of drug molecules during hair fiber formation. | Pötsch L et al. | — | 1997 | → |
| Effects of genetic polymorphisms in alcohol-metabolizing enzymes on alcohol hypersensitivity and alcohol-related health problems in orientals. | Takeshita T et al. | — | 1996 | → |
| Detection of aldehyde dehydrogenase deficiency in Chachi Indians, Ecuador. | Novoradovsky AG et al. | — | 1995 | → |
| Polymorphism of a class 3 aldehyde dehydrogenase present in human saliva and in hair roots. | Dyck LE | — | 1995 | → |
| Genetic polymorphisms in xenobiotic metabolism. | Smith CA et al. | — | 1994 | → |
| Overexpression or polycyclic aromatic hydrocarbon-mediated induction of an apparently novel class 3 aldehyde dehydrogenase in human breast adenocarcinoma cells and its relationship to oxazaphosphorine-specific acquired resistance. | Sreerama L et al. | — | 1993 | → |
| Asians, Asian-Americans and alcohol. | Johnson RC et al. | — | 1990 | → |
| Cutaneous vasomotor sensitivity to ethanol and acetaldehyde: subtypes of alcohol-flushing response among Chinese. | Yu PH et al. | — | 1990 | → |
| [Genetically-induced variability of alcohol metabolism and its effect on drinking behavior and predisposition to alcoholism]. | Eckey R et al. | — | 1990 | → |
| Hypertrophic scar: a genetic hypothesis. | Lewis WH et al. | — | 1990 | → |
| Pharmacogenetics of aldehyde dehydrogenase (ALDH). | Goedde HW et al. | — | 1990 | → |
| Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. | Crabb DW et al. | — | 1989 | → |
| Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots. | Goedde HW et al. | — | 1989 | → |
| Hepatic aldehyde dehydrogenase activity in liver diseases, with particular emphasis on alcoholic liver disease. | Takase S et al. | — | 1989 | → |
| Human aldehyde dehydrogenases: their role in alcoholism. | Agarwal DP et al. | — | 1989 | → |
| Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. | Singh S et al. | — | 1989 | → |
| Polymorphism of aldehyde dehydrogenase and its application to alcoholism. | Harada S | — | 1989 | → |
| Subcellular localization of aldehyde dehydrogenase isozymes in human liver. | Takase S et al. | — | 1989 | → |
| Human stomach alcohol and aldehyde dehydrogenases (ALDH): a genetic model proposed for ALDH III isozymes. | Yin SJ et al. | — | 1988 | → |
| Studying biological vulnerability and heterogeneity--a long way ahead. | Propping P | — | 1987 | → |
| Substrate specificity of human cutaneous alcohol dehydrogenase and erythema provoked by lower aliphatic alcohols. | Wilkin JK et al. | — | 1987 | → |
| 13C-ethanol and 13C-acetate breath tests in normal and aldehyde dehydrogenase deficient individuals. | Lehmann WD et al. | — | 1986 | → |
| Activities of ethanol-metabolizing enzymes in liver diseases. | Nuutinen HU | — | 1986 | → |
| Aldehyde dehydrogenase polymorphism in North American, South American, and Mexican Indian populations. | Goedde HW et al. | — | 1986 | → |
| Identification and selective precipitation of human aldehyde dehydrogenase isozymes using antibodies raised to horse liver aldehyde dehydrogenase isozymes. | McMichael M et al. | — | 1986 | → |
| Organ-specific human alcohol dehydrogenase: isolation and characterization of isozymes from testis. | Dafeldecker WP et al. | — | 1986 | → |
| Application of a high performance liquid chromatography method for screening of aldehyde dehydrogenase isozyme deficiency in hair roots from different ethnic groups. | Tottmar O et al. | — | 1985 | → |
| Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3. | Santisteban I et al. | — | 1985 | → |
| Cutaneous vascular sensitivity to lower aliphatic alcohols and aldehydes in Orientals. | Wilkin JK et al. | — | 1985 | → |
| Ethanol feeding can produce secondary alterations in aldehyde dehydrogenase isozymes. | Alderman JA et al. | — | 1985 | → |
| Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity. | Goedde HW et al. | — | 1985 | → |
| Basis of aldehyde dehydrogenase deficiency in Orientals: immunochemical studies. | Agarwal DP et al. | — | 1984 | → |
| Determination of aldehyde dehydrogenase phenotypes using hair roots: re-examination. | Yoshida A | — | 1984 | → |
| Ecogenetic studies in Atacameño Indians. | Goedde HW et al. | — | 1984 | → |
| Alcohol dehydrogenase isozymes in the clawed frog, Xenopus laevis. | Wesolowski MH et al. | — | 1983 | → |
| Aldehyde dehydrogenase isozyme variation and alcoholism in Japan. | Harada S et al. | — | 1983 | → |
| Bovine lens aldehyde dehydrogenase. Purification and preliminary characterization. | Ting HH et al. | — | 1983 | → |
| Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay. | Böhlke JU et al. | — | 1983 | → |
| [Detection of esterase D and glyoxalase I in human hair roots using agarose gel thin-layer electrophoresis]. | Gertler A et al. | — | 1983 | → |
| Determination of genotypes of human aldehyde dehydrogenase ALDH2 locus. | Yoshida A et al. | — | 1983 | → |
| Hepatic ADH and ALDH isoenzymes in different racial groups and in chronic alcoholism. | Ricciardi BR et al. | — | 1983 | → |
| Identification of alcohol dehydrogenase and aldehyde dehydrogenase isoenzymes in human liver biopsy specimens. | Ricciardi BR et al. | — | 1983 | → |
| Pharmacogenetics of alcohol sensitivity. | Goedde HW et al. | — | 1983 | → |
| Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. | Goedde HW et al. | — | 1983 | → |
| Two-dimensional electrophoresis of soluble and structure-bound proteins from cultured human fibroblasts and hair root cells: qualitative and quantitative variation. | Klose J et al. | — | 1983 | → |
| Beta-adrenoreceptor antagonists and diplopia. | Weber JC | — | 1982 | → |
| Familial resemblances in flushing following alcohol use. | Schwitters SY et al. | — | 1982 | → |
| Molecular basis of difference in alcohol metabolism between orientals and caucasians. | Yoshida A | — | 1982 | → |
| Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. | Harada S et al. | — | 1982 | → |
| Role of hepatic acetaldehyde dehydrogenase in alcoholism: demonstration of persistent reduction of cytosolic activity in abstaining patients. | Thomas M et al. | — | 1982 | → |
| Suppression of alcohol-induced flushing by a combination of H1 and H2 histamine antagonists. | Tan OT et al. | — | 1982 | → |
| Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. | Harada S et al. | — | 1981 | → |
| A radioenzymatic assay of catechol-O-methyltransferase in hair root cells: comparison with erythrocyte activity. | Hoo JJ et al. | — | 1981 | → |
| Enzymatic and structural differences between usual and atypical human liver alcohol dehydrogenases. | Yoshida A et al. | — | 1981 | → |
| Genetic disposition to alcoholism. An EEG study in alcoholics and their relatives. | Propping P et al. | — | 1981 | → |
| High resolution protein mapping in fibroblast cell lines and hair roots from patients with genetic disease. | Willers I et al. | — | 1981 | → |
| High-resolution protein mapping of human fibroblasts and hair root cells: a standardized reproducible procedure considering the effect of cell culture parameters. | Singh S et al. | — | 1981 | → |
| Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes. | Agarwal DP et al. | — | 1981 | → |