Evaluating the glucose tolerance test in mice.
paper
Cited
Public
Unavailable
- Authors
- Andrikopoulos, Sofianos; Blair, Amy R; Deluca, Nadia; Fam, Barbara C; Proietto, Joseph
- Year
- 2008
- Journal
- American journal of physiology. Endocrinology and metabolism
- PMID
- 18812462
- DOI
- 10.1152/ajpendo.90617.2008
The objective of this study was to determine the optimal conditions under which to assess glucose tolerance in chow- and high-fat-fed C57BL/6J mice. Mice were fed either chow or high-fat diet for 8 wk. Variables tested were fasting duration (0-, 3-, 6-, and 24-h and overnight fasting), route of administration (intraperitoneal vs. oral) load of glucose given (2, 1, or 0.5 g/kg and fixed 50-mg dose), and state of consciousness. Basal glucose concentrations were increased in high-fat- compared with chow-fed mice following 6 h of fasting (9.1 +/- 0.3 vs. 7.9 +/- 0.4 mmol/l P = 0.01). Glucose tolerance was most different and therefore significant (P = 0.001) in high-fat-fed mice after 6 h of fasting (1,973 +/- 96 vs. 1,248 +/- 83 mmol.l(-1).120 min(-1)). The difference in glucose tolerance was greater following an OGTT (142%), in contrast to an IPGTT, with a 127% difference between high fat and chow. We also found that administering 2 g/kg of glucose resulted in a greater level of significance (P = 0.0008) in glucose intolerance in high-fat- compared with chow-fed mice. A fixed dose of 50 mg glucose regardless of body weight was enough to show glucose intolerance in high-fat- vs. chow-fed mice. Finally, high-fat-fed mice showed glucose intolerance compared with their chow-fed counterparts whether they were tested under conscious or anesthetized conditions. We conclude that 2 g/kg glucose administered orally following 6 h of fasting is best to assess glucose tolerance in mice under these conditions.
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| The effect of green coffee and/or endurance exercise on sperm function in pre-diabetic mice. | Karevanpour F et al. | β | 2022 | β |
| The glucose tolerance test in mice: Sex, drugs and protocol. | Kennard MR et al. | β | 2022 | β |
| Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity. | Brustolin B et al. | β | 2022 | β |
| Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats. | Zhou S et al. | β | 2022 | β |
| AB-Kefir Reduced Body Weight and Ameliorated Inflammation in Adipose Tissue of Obese Mice Fed a High-Fat Diet, but Not a High-Sucrose Diet. | Chen YT et al. | β | 2021 | β |
| A Comparison of Two Structurally Related Human Milk Oligosaccharide Conjugates in a Model of Diet-Induced Obesity. | Ramadhin J et al. | β | 2021 | β |
| A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility. | Bunay J et al. | β | 2021 | β |
| A high-fat diet and high-fat and high-cholesterol diet may affect glucose and lipid metabolism differentially through gut microbiota in mice. | Liang H et al. | β | 2021 | β |
| Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. | Cho IJ et al. | β | 2021 | β |
| Alterations of lung microbial communities in obese allergic asthma and metabolic potential. | Lee J et al. | β | 2021 | β |
| Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice. | Park E et al. | β | 2021 | β |
| Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice. | Worley BL et al. | β | 2021 | β |
| Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice. | Ress C et al. | β | 2021 | β |
| A subset of Kupffer cells regulates metabolism through the expression of CD36. | BlΓ©riot C et al. | β | 2021 | β |
| Bacteria - derived short chain fatty acids restore sympathoadrenal responsiveness to hypoglycemia after antibiotic-induced gut microbiota depletion. | LaGamma EF et al. | β | 2021 | β |
| Bone marrow-derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1. | Wang Y et al. | β | 2021 | β |
| Circadian rhythm disruption with high-fat diet impairs glycemic control and bone quality. | LLabre JE et al. | β | 2021 | β |
| Circulating <b>innate lymphoid cell subtypes and altered cytokine profiles following an atherogenic high-fat diet</b>. | Mxinwa V et al. | β | 2021 | β |
| Combination of <i>Limosilactobacillus fermentum</i> MG4231 and MG4244 attenuates lipid accumulation in high-fat diet-fed obese mice. | Kim SJ et al. | β | 2021 | β |
| Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice. | Hsu JW et al. | β | 2021 | β |
| Diet-Induced Obesity Promotes the Upregulation of Fas Expression on T-cells. | Nyambuya TM et al. | β | 2021 | β |
| Dynamic change of MMP-9 in diabetic stroke visualized by optical imaging and treated with CD28 superagonist. | Cai Y et al. | β | 2021 | β |
| Effect of Different High-Fat and Advanced Glycation End-Products Diets in Obesity and Diabetes-Prone C57BL/6 Mice on Sperm Function. | Akbarian F et al. | β | 2021 | β |
| Effects of Naringin on Cardiomyocytes From a Rodent Model of Type 2 Diabetes. | Uryash A et al. | β | 2021 | β |
| Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice. | Fukumura K et al. | β | 2021 | β |
| Gastric bypass prevents diabetes in genetically modified mice and chemically induced diabetic mice. | Zhu C et al. | β | 2021 | β |
| GLP-1 receptor signaling increases PCSK1 and Ξ² cell features in human Ξ± cells. | Saikia M et al. | β | 2021 | β |
| Glucose and pH Dual-Responsive Polymersomes with Multilevel Self-Regulation of Blood Glucose for Insulin Delivery. | Zhou D et al. | β | 2021 | β |
| High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling. | Chakraborti A et al. | β | 2021 | β |
| Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome. | Chappell NR et al. | β | 2021 | β |
| Hypoglycemic active principles from the leaves of Bauhinia holophylla: Comprehensive phytochemical characterization and in vivo activity profile. | Saldanha LL et al. | β | 2021 | β |
| Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice. | de Souza Cordeiro LM et al. | β | 2021 | β |
| <i>Allium</i>-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. | Vezza T et al. | β | 2021 | β |
| INPP4B protects from metabolicΒ syndrome and associated disorders. | Zhang M et al. | β | 2021 | β |
| <i>Weissella cibaria</i> MG5285 and <i>Lactobacillus reuteri</i> MG5149 attenuated fat accumulation in adipose and hepatic steatosis in high-fat diet-induced C57BL/6J obese mice. | Choi SI et al. | β | 2021 | β |
| Lactobacillus plantarum Reduces Low-Grade Inflammation and Glucose Levels in a Mouse Model of Chronic Stress and Diabetes. | Youn HS et al. | β | 2021 | β |
| Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice. | Clarkson-Townsend DA et al. | β | 2021 | β |
| Liver Phosphoenolpyruvate Carboxykinase-1 Downregulation via siRNA-Functionalized Graphene Oxide Nanosheets Restores Glucose Homeostasis in a Type 2 Diabetes Mellitus <i>In Vivo</i> Model. | Singh V et al. | β | 2021 | β |
| Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. | Qu J et al. | β | 2021 | β |
| Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity. | Cao E et al. | β | 2021 | β |
| Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice. | Marcouiller F et al. | β | 2021 | β |
| Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding. | Alsheikh HAM et al. | β | 2021 | β |
| Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice. | Zeng Q et al. | β | 2021 | β |
| Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. | Xu H et al. | β | 2021 | β |
| Pepsin-digested chicken-liver hydrolysate attenuates hepatosteatosis by relieving hepatic and peripheral insulin resistance in long-term high-fat dietary habit. | Wu YS et al. | β | 2021 | β |
| Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice. | Kotagale N et al. | β | 2021 | β |
| Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from <i>Californiconus californicus</i>, for Treating Type 2 Diabetes. | Lugo-Fabres PH et al. | β | 2021 | β |
| Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. | Sinha R et al. | β | 2021 | β |
| Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice. | Franczyk MP et al. | β | 2021 | β |
| Sex-specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse. | Narapareddy L et al. | β | 2021 | β |
| Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice. | Umek N et al. | β | 2021 | β |
| STAT3 Regulates Mitochondrial Gene Expression in Pancreatic Ξ²-Cells and Its Deficiency Induces Glucose Intolerance in Obesity. | Schaschkow A et al. | β | 2021 | β |
| Streptozotocin-induced type 1 and 2 diabetes in rodents: a model for studying diabetic cardiac autonomic neuropathy. | Akinlade OM et al. | β | 2021 | β |
| The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. | AhrΓ©n B et al. | β | 2021 | β |
| Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests. | Bruce CR et al. | β | 2021 | β |
| Uninephrectomy and class II PI3K-C2Ξ² inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice. | Alliouachene S et al. | β | 2021 | β |
| Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice. | Wu Y et al. | β | 2021 | β |
| Ξ±,Ξ²-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. | Lima RP et al. | β | 2021 | β |
| Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice. | Siddiqui SA et al. | β | 2020 | β |
| Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice. | Zhou X et al. | β | 2020 | β |
| Consuming Diet Supplemented with Either Red Wheat Bran or Soy Extract Changes Glucose and Insulin Levels in Female Obese Zucker Rats. | Stamatikos AD et al. | β | 2020 | β |
| Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. | Varghese J et al. | β | 2020 | β |
| Diet-induced rodent models of obesity-related metabolic disorders-A guide to a translational perspective. | PreguiΓ§a I et al. | β | 2020 | β |
| Differential expression of glycoprotein IV on monocyte subsets following high-fat diet feeding and the impact of short-term low-dose aspirin treatment. | Mokgalaboni K et al. | β | 2020 | β |
| E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia. | Yang CH et al. | β | 2020 | β |
| Elevated T-helper 2 cytokine levels in high fat diet-fed C57BL/6 mice are attenuated by short-term 6-week treatment with a combination of low-dose aspirin and metformin. | Mahlangu TJ et al. | β | 2020 | β |
| Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. | Yang J et al. | β | 2020 | β |
| Enhanced alcohol degradation and hepatic protective effects of an <i>Acetobacter Pasteurianus</i>-derived product, CureZyme-ACE, in an acute intoxication rat model. | Jeon EJ et al. | β | 2020 | β |
| Evaluating the appropriate oral lipid tolerance test model for investigating plasma triglyceride elevation in mice. | Ochiai M | β | 2020 | β |
| Evaluation of Antidiabetic Activity of <i>Ajuga integrifolia</i> (Lamiaceae) Root Extract and Solvent Fractions in Mice. | Alene M et al. | β | 2020 | β |
| Exosomal MicroRNA Expression Profiling Analysis of the Effects of Lycium Barbarum Polysaccharide on Gestational Diabetes Mellitus Mice. | Xiao Y et al. | β | 2020 | β |
| Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance. | Brandt A et al. | β | 2020 | β |
| Gastric Bypass Improves Obesity and Glucose Tolerance Independent of Gastric Pouch Size. | Xu R et al. | β | 2020 | β |
| Glucose regulation is a repeatable trait affected by successive handling in zebra finches. | Montoya B et al. | β | 2020 | β |
| Guidelines and Considerations for Metabolic Tolerance Tests in Mice. | BenedΓ©-Ubieto R et al. | β | 2020 | β |
| Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation. | Yao H et al. | β | 2020 | β |
| High-fat diet affects skeletal muscle mitochondria comparable to pressure overload-induced heart failure. | Heyne E et al. | β | 2020 | β |
| <i>Lespedeza bicolor</i> Extract Ameliorated Renal Inflammation by Regulation of NLRP3 Inflammasome-Associated Hyperinflammation in Type 2 Diabetic Mice. | Park JE et al. | β | 2020 | β |
| Immune-enhancing effects of gamma-irradiated sericin. | Song IB et al. | β | 2020 | β |
| Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle. | MΓΈller LLV et al. | β | 2020 | β |
| <i>Porphyromonas gingivalis</i> Induces Insulin Resistance by Increasing BCAA Levels in Mice. | Tian J et al. | β | 2020 | β |
| Lancing Drug Reservoirs into Subcutaneous Fat to Combat Obesity and Associated Metabolic Diseases. | Than A et al. | β | 2020 | β |
| Metabolic changes during pregnancy in glucose-intolerant NZO mice: A polygenic model with prediabetic metabolism. | Grupe K et al. | β | 2020 | β |
| Mouse models in burns research: Characterisation of the hypermetabolic response to burn injury. | Hew JJ et al. | β | 2020 | β |
| Nicotine triggers islet Ξ² cell senescence to facilitate the progression of type 2 diabetes. | Sun L et al. | β | 2020 | β |
| Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes. | Nguyen-Ngo C et al. | β | 2020 | β |
| Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane. | Isaacson RH et al. | β | 2020 | β |
| Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver. | Chen X et al. | β | 2020 | β |
| Practical Considerations when Using Mouse Models of Diabetes. | King AJF et al. | β | 2020 | β |
| Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes. | Chappell NR et al. | β | 2020 | β |
| Reappraisal of the optimal fasting time for insulin tolerance tests in mice. | Carper D et al. | β | 2020 | β |
| Reduction of Polyunsaturated Fatty Acids with Tumor Progression in a Lean Non-Alcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Mouse Model. | Vlock EM et al. | β | 2020 | β |
| Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution. | Yap YW et al. | β | 2020 | β |
| RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis. | Sugisawa E et al. | β | 2020 | β |
| Small intestine proteomics coupled with serum metabolomics reveal disruption of amino acid metabolism in Chinese hamsters with type 2 diabetes mellitus. | Wang C et al. | β | 2020 | β |
| Strychnos nux-vomica L. seed preparation promotes functional recovery and attenuates oxidative stress in a mouse model of sciatic nerve crush injury. | Razzaq A et al. | β | 2020 | β |
| Supplementation with beta-hydroxy-beta-methylbutyrate impacts glucose homeostasis and increases liver size in trained mice. | Schadock I et al. | β | 2020 | β |
| Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice. | Nishimura M et al. | β | 2020 | β |
| The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice. | Yoshida S et al. | β | 2020 | β |
| The Effect of Isoleucine Supplementation on Body Weight Gain and Blood Glucose Response in Lean and Obese Mice. | O'Rielly R et al. | β | 2020 | β |
| The Effect of Lactobacillus fermentum ME-3 Treatment on Glycation and Diabetes Complications. | Guilbaud A et al. | β | 2020 | β |
| The effects of myo-inositol and probiotic supplementation in a high-fat-fed preclinical model of glucose intolerance in pregnancy. | Plows JF et al. | β | 2020 | β |
| The Glucose Tolerance Test in Mice. | Pedro PF et al. | β | 2020 | β |
| The Long Noncoding RNA Blnc1 Protects Against Diet-Induced Obesity by Promoting Mitochondrial Function in White Fat. | Tang S et al. | β | 2020 | β |
| The Measurement of Whole-Body Glucose Homeostasis in Mice. | Xu YXZ et al. | β | 2020 | β |
| Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation. | Regmi P et al. | β | 2020 | β |
| Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice. | La QT et al. | β | 2020 | β |
| 3D analysis of capillary network in skeletal muscle of obese insulin-resistant mice. | Umek N et al. | β | 2019 | β |
| 4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement. | Zheng Z et al. | β | 2019 | β |
| Activation of PERK-eIF2Ξ±-ATF4 pathway contributes to diabetic hepatotoxicity: Attenuation of ER stress by Morin. | Pandey VK et al. | β | 2019 | β |
| Adverse effects of noise stress on glucose homeostasis and insulin resistance in Sprague-Dawley rats. | Morakinyo AO et al. | β | 2019 | β |
| A glucagon-like peptide-1 analog, liraglutide, ameliorates endothelial dysfunction through miRNAs to inhibit apoptosis in rats. | Zhang Q et al. | β | 2019 | β |
| Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice. | Srinivasan MP et al. | β | 2019 | β |
| Anti-Diabetic, Anti-Inflammatory, and Anti-Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus. | Nguyen-Ngo C et al. | β | 2019 | β |
| Anti-hyperglycemic and ameliorative effect of concentrated hot water-infusion of <i>Phragmanthera incana</i> leaves on type 2 diabetes and indices of complications in diabetic rats. | Sanni O et al. | β | 2019 | β |
| Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy. | Ludman T et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract. | Fang X et al. | β | 2019 | β |
| Diet-Induced Obesity in Cannabinoid-2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double-Knockout Mice. | Alshaarawy O et al. | β | 2019 | β |
| Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models. | Kitamura H | β | 2019 | β |
| Exposure to maternal obesity during suckling outweighs in utero exposure in programming for post-weaning adiposity and insulin resistance in rats. | George G et al. | β | 2019 | β |
| Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet. | Griffin LE et al. | β | 2019 | β |
| FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. | Rohrbach TD et al. | β | 2019 | β |
| Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion. | Zhuang A et al. | β | 2019 | β |
| Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis. | Kuk N et al. | β | 2019 | β |
| Impact of dietary sucrose on adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid. | Togo J et al. | β | 2019 | β |
| Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice. | Mkandla Z et al. | β | 2019 | β |
| Is malignant hyperthermia associated with hyperglycaemia? | Altamirano F et al. | β | 2019 | β |
| Jicama (<i>Pachyrhizus erosus</i>) fiber prevents excessive blood glucose and body weight increase without affecting food intake in mice fed with high-sugar diet. | Santoso P et al. | β | 2019 | β |
| Kidney osteoclast factors and matrix metalloproteinase expression in a mice model of diet-induced obesity and diabetes. | Dos Santos-Macedo F et al. | β | 2019 | β |
| Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic Ξ²-Cells. | Huang C et al. | β | 2019 | β |
| Lipotoxicity reduces Ξ² cell survival through islet stellate cell activation regulated by lipid metabolism-related molecules. | Zhou Y et al. | β | 2019 | β |
| Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway. | Peng J et al. | β | 2019 | β |
| Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice). | Smoothy J et al. | β | 2019 | β |
| miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells. | Sun Q et al. | β | 2019 | β |
| Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes. | Xu D et al. | β | 2019 | β |
| Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway. | Tian S et al. | β | 2019 | β |
| Multi-dimensional Transcriptional Remodeling by Physiological Insulin InΒ Vivo. | Batista TM et al. | β | 2019 | β |
| Novel ABCA1 peptide agonists with antidiabetic action. | Azhar S et al. | β | 2019 | β |
| Obesity dysregulates fasting-induced changes in glucagon secretion. | Stern JH et al. | β | 2019 | β |
| Palmitate-induced autophagy liberates monounsaturated fatty acids and increases <i>Agrp</i> expression in hypothalamic cells. | Park S et al. | β | 2019 | β |
| Phenotypic characterization of a novel type 2 diabetes animal model in a SHANXI MU colony of Chinese hamsters. | Wang L et al. | β | 2019 | β |
| Tamoxifen Improves Glucose Tolerance in a Delivery-, Sex-, and Strain-Dependent Manner in Mice. | Ceasrine AM et al. | β | 2019 | β |
| The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake. | Jensen CH et al. | β | 2019 | β |
| The LepR<sup>db/db</sup> mice model for studying glycation in the context of diabetes. | Guilbaud A et al. | β | 2019 | β |
| Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota. | Zhang L et al. | β | 2019 | β |
| Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet. | Whang E et al. | β | 2019 | β |
| Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr<sup>-/-</sup> Mice after Consumption of Guarana Soft Drinks. | ChistΓ© LA et al. | β | 2019 | β |
| 135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice. | Wu GC et al. | β | 2018 | β |
| 5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice. | Saitoh S et al. | β | 2018 | β |
| An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation. | Yu Y et al. | β | 2018 | β |
| Antidiabetic activity, glucose uptake stimulation and Ξ±-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract. | Doan HV et al. | β | 2018 | β |
| Antioxidant Activity of Royal Jelly Hydrolysates Obtained by Enzymatic Treatment. | Gu H et al. | β | 2018 | β |
| A Phenolic Fraction from <i>Catharanthus roseus</i> L. Stems Decreases Glycemia and Stimulates Insulin Secretion. | Espejel-Nava JA et al. | β | 2018 | β |
| At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice. | Vangoitsenhoven R et al. | β | 2018 | β |
| Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation. | Lee YH et al. | β | 2018 | β |
| Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism. | Ippagunta SM et al. | β | 2018 | β |
| Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model. | Liu L et al. | β | 2018 | β |
| Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus. | Han E et al. | β | 2018 | β |
| Comparison between pre-exercise casein peptide and intact casein supplementation on glucose tolerance in mice fed a high-fat diet. | Matsunaga Y et al. | β | 2018 | β |
| Considerations and guidelines for mouse metabolic phenotyping in diabetes research. | Alquier T et al. | β | 2018 | β |
| Contribution of Hepatic Retinaldehyde Dehydrogenase Induction to Impairment of Glucose Metabolism by High-Fat-Diet Feeding in C57BL/6J Mice. | Xu J et al. | β | 2018 | β |
| Effects of Frozen Storage on Phospholipid Content in Atlantic Cod Fillets and the Influence on Diet-Induced Obesity in Mice. | Fauske KR et al. | β | 2018 | β |
| Effects of Glucose with Casein Peptide Supplementation on Post-Exercise Muscle Glycogen Resynthesis in C57BL/6J Mice. | Matsunaga Y et al. | β | 2018 | β |
| Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat. | Ramachandran D et al. | β | 2018 | β |
| Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. | Xiao X et al. | β | 2018 | β |
| GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | Liu S et al. | β | 2018 | β |
| Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice. | Niedowicz DM et al. | β | 2018 | β |
| Glucometabolic effects of single and repeated exposure to forced-swimming stressor in Sprague-Dawley rats. | Morakinyo AO et al. | β | 2018 | β |
| Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons. | Lockie SH et al. | β | 2018 | β |
| Glycaemic Index of Maternal Dietary Carbohydrate Differentially Alters <i>Fto</i> and <i>Lep</i> Expression in Offspring in C57BL/6 Mice. | Sideratou T et al. | β | 2018 | β |
| GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr<sup>-/-</sup> mice. | Silva JC et al. | β | 2018 | β |
| Identification of a sustainable two-plant diet that effectively prevents age-related metabolic syndrome and extends lifespan in aged mice. | Li XY et al. | β | 2018 | β |
| Impaired Ξ²-cell glucokinase as an underlying mechanism in diet-induced diabetes. | Lu B et al. | β | 2018 | β |
| Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice. | Denver P et al. | β | 2018 | β |
| Intermittent Fasting with or without Exercise Prevents Weight Gain and Improves Lipids in Diet-Induced Obese Mice. | Wilson RA et al. | β | 2018 | β |
| Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion. | Du J et al. | β | 2018 | β |
| Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. | Robichaux WG et al. | β | 2018 | β |
| Mechanisms of Insulin Action and Insulin Resistance. | Petersen MC et al. | β | 2018 | β |
| Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance. | Yoneshiro T et al. | β | 2018 | β |
| Metabolic, stress, and inflammatory biomarker responses to glucose administration in Fischer-344 rats: intraperitoneal vs. oral delivery. | Pilon S et al. | β | 2018 | β |
| Modeling heart failure risk in diabetes and kidney disease: limitations and potential applications of transverse aortic constriction in high-fat-fed mice. | Tan WS et al. | β | 2018 | β |
| Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6Β J mice. | Soares AF et al. | β | 2018 | β |
| (p-ClPhSe)<sub>2</sub> stabilizes metabolic function in a rat model of neuroendocrine obesity induced by monosodium glutamate. | Quines CB et al. | β | 2018 | β |
| Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice. | Tarasco E et al. | β | 2018 | β |
| Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. | Yoneshiro T et al. | β | 2018 | β |
| Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT). | Nagy C et al. | β | 2018 | β |
| The Impact of Type 2 Diabetes on Bone Fracture Healing. | Marin C et al. | β | 2018 | β |
| Thermoneutral housing does not influence fat mass or glucose homeostasis in C57BL/6 mice. | Small L et al. | β | 2018 | β |
| Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD. | Araujo LCC et al. | β | 2018 | β |
| Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. | Celestini V et al. | β | 2018 | β |
| Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties. | Marin C et al. | β | 2018 | β |
| [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic Ξ²-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr<sup>db/db</sup> type 2 diabetic mice. | Samad MB et al. | β | 2017 | β |
| Absence of a gestational diabetes phenotype in the LepRdb/+ mouse is independent of control strain, diet, misty allele, or parity. | Plows JF et al. | β | 2017 | β |
| Absence of IQGAP1 Protein Leads to Insulin Resistance. | Chawla B et al. | β | 2017 | β |
| Activation of Estrogen Response Element-Independent ERΞ± Signaling Protects Female Mice From Diet-Induced Obesity. | Yasrebi A et al. | β | 2017 | β |
| AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. | BΓΆrgeson E et al. | β | 2017 | β |
| A maternal high-fat, high-sucrose diet has sex-specific effects on fetal glucocorticoids with little consequence for offspring metabolism and voluntary locomotor activity in mice. | Chin EH et al. | β | 2017 | β |
| Calculation of Glucose Dose for Intraperitoneal Glucose Tolerance Tests in Lean and Obese Mice. | JΓΈrgensen MS et al. | β | 2017 | β |
| Correlation of the plasma sphingoid base profile with results from oral glucose tolerance tests in gestational diabetes mellitus. | Khan A et al. | β | 2017 | β |
| Dapagliflozin improves insulin resistance and glucose intolerance in a novel transgenic rat model of chronic glucose overproduction and glucose toxicity. | Joannides CN et al. | β | 2017 | β |
| Dendritic cells that highly express SOCS1 induce T-cell hypo-responsiveness and prolong islet allograft survival. | Lu X et al. | β | 2017 | β |
| Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival. | Xue Z et al. | β | 2017 | β |
| Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists. | Cox JM et al. | β | 2017 | β |
| Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats. | Liu L et al. | β | 2017 | β |
| Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes. | Bachor TP et al. | β | 2017 | β |
| Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome. | Marcondes RR et al. | β | 2017 | β |
| Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. | Di Biase S et al. | β | 2017 | β |
| Glucose dysregulation and response to common anti-diabetic agents in the FATZO/Pco mouse. | Peterson RG et al. | β | 2017 | β |
| Glucose elicits cephalic-phase insulin release in mice by activating K<sub>ATP</sub> channels in taste cells. | Glendinning JI et al. | β | 2017 | β |
| Glucose tolerance in mice exposed to light-dark stimulus patterns mirroring dayshift and rotating shift schedules. | Figueiro MG et al. | β | 2017 | β |
| Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. | Blais A et al. | β | 2017 | β |
| Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. | Zhuang A et al. | β | 2017 | β |
| Lifetime Exposure to a Constant Environment Amplifies the Impact of a Fructose-Rich Diet on Glucose Homeostasis during Pregnancy. | Song A et al. | β | 2017 | β |
| Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice. | Kina-Tanada M et al. | β | 2017 | β |
| Maternal diethylhexyl phthalate exposure affects adiposity and insulin tolerance in offspring in a PCNA-dependent manner. | Hunt BG et al. | β | 2017 | β |
| MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). | Peng J et al. | β | 2017 | β |
| Obesity/Type II diabetes alters macrophage polarization resulting in a fibrotic tendon healing response. | Ackerman JE et al. | β | 2017 | β |
| Reduced islet function contributes to impaired glucose homeostasis in fructose-fed mice. | Asghar ZA et al. | β | 2017 | β |
| Resistant Starch but Not Enzymatically Modified Waxy Maize Delays Development of Diabetes in Zucker Diabetic Fatty Rats. | Hedemann MS et al. | β | 2017 | β |
| Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice. | Soares AF et al. | β | 2017 | β |
| Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. | CaparrΓ³s-MartΓn JA et al. | β | 2017 | β |
| Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARΞ³ Activation. | Iwase M et al. | β | 2017 | β |
| Survival and growth of C57BL/6J mice lacking the BK channel, <i>Kcnma1</i>: lower adult body weight occurs together with higher body fat. | Halm ST et al. | β | 2017 | β |
| Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice. | Albaghdadi AJ et al. | β | 2017 | β |
| The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus. | Plows JF et al. | β | 2017 | β |
| The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. | Arguin G et al. | β | 2017 | β |
| Acute intravenous glucose load impairs early insulin secretion and insulin content in islet Ξ² cells in mice. | Yan D et al. | β | 2016 | β |
| Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight. | Shamansurova Z et al. | β | 2016 | β |
| A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or Ξ²-cell mass in NZO mice. | Lamont BJ et al. | β | 2016 | β |
| A Mouse Model of Diet-Induced Obesity Resembling Most Features of Human Metabolic Syndrome. | Della Vedova MC et al. | β | 2016 | β |
| An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus. | Heydemann A | β | 2016 | β |
| Anti-diabetic Effect of Fermented Milk Containing Conjugated Linoleic Acid on Type II Diabetes Mellitus. | Song K et al. | β | 2016 | β |
| Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic). | Figueiredo D et al. | β | 2016 | β |
| Consumption of Quercetin and Quercetin-Containing Apple and Cherry Extracts Affects Blood Glucose Concentration, Hepatic Metabolism, and Gene Expression Patterns in Obese C57BL/6J High Fat-Fed Mice. | Snyder SM et al. | β | 2016 | β |
| Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. | Leung C et al. | β | 2016 | β |
| Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. | Lee IR et al. | β | 2016 | β |
| Early differences in metabolic flexibility between obesity-resistant and obesity-prone mice. | Bardova K et al. | β | 2016 | β |
| Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice. | Liu L et al. | β | 2016 | β |
| E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. | Ma S et al. | β | 2016 | β |
| Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes. | Nakhate KT et al. | β | 2016 | β |
| Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles. | Elshorbagy AK et al. | β | 2016 | β |
| Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice. | Panchenko PE et al. | β | 2016 | β |
| Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice. | MΓ‘rquez-Aguirre AL et al. | β | 2016 | β |
| Gene Expression Patterns Are Altered in Athymic Mice and Metabolic Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets Supplemented with Soy Isoflavones. | Luo T et al. | β | 2016 | β |
| Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice. | Geisler CE et al. | β | 2016 | β |
| Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice. | Ratner LD et al. | β | 2016 | β |
| Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria. | Chhabra KH et al. | β | 2016 | β |
| <i>In vivo</i> Evaluation of Two Thiazolidin-4-one Derivatives in High Sucrose Diet Fed Pre-diabetic Mice and Their Modulatory Effect on AMPK, Akt and p38 MAP Kinase in L6 Cells. | Mudgal J et al. | β | 2016 | β |
| Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. | Xirouchaki CE et al. | β | 2016 | β |
| Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. | Deisl C et al. | β | 2016 | β |
| LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol. | NΓΈhr MK et al. | β | 2016 | β |
| Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice. | Peterson RL et al. | β | 2016 | β |
| Maternal oral administration of osteocalcin protects offspring from metabolic impairment in adulthood. | Kawakubo-Yasukochi T et al. | β | 2016 | β |
| Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity model. | Rendina-Ruedy E et al. | β | 2016 | β |
| Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes. | Shi T et al. | β | 2016 | β |
| Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions. | Tsend-Ayush E et al. | β | 2016 | β |
| Mouse Models of Diabetes, Obesity and Related Kidney Disease. | Glastras SJ et al. | β | 2016 | β |
| Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. | Choi J et al. | β | 2016 | β |
| New PPARΞ³ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr(-/-) mice. | Silva JC et al. | β | 2016 | β |
| Nuclear Export of FoxO1 Is Associated with ERK Signaling in Ξ²-Cells Lacking Insulin Receptors. | Mezza T et al. | β | 2016 | β |
| Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. | Gallo LA et al. | β | 2016 | β |
| Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model. | Huang CW et al. | β | 2016 | β |
| Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. | Ahmad F et al. | β | 2016 | β |
| Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-Ξ² levels in male mice. | Savignac HM et al. | β | 2016 | β |
| Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation. | Zhao Y et al. | β | 2016 | β |
| Role of glycogen metabolism in pancreatic islet beta cell function. | Malaisse WJ | β | 2016 | β |
| Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice. | Kim J et al. | β | 2016 | β |
| Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. | Xu MX et al. | β | 2016 | β |
| Uromastyx acanthinura as a natural treatment in a mouse model of type 2 diabetes. | Brito-Casillas Y et al. | β | 2016 | β |
| Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrous cycle. | Santiago AM et al. | β | 2016 | β |
| An infant formula toxicity and toxicokinetic feeding study on carrageenan in preweaning piglets with special attention to the immune system and gastrointestinal tract. | Weiner ML et al. | β | 2015 | β |
| A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors. | Schech A et al. | β | 2015 | β |
| Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse. | Kowalski GM et al. | β | 2015 | β |
| Aqueous fraction of Beta vulgaris ameliorates hyperglycemia in diabetic mice due to enhanced glucose stimulated insulin secretion, mediated by acetylcholine and GLP-1, and elevated glucose uptake via increased membrane bound GLUT4 transporters. | Ul Kabir A et al. | β | 2015 | β |
| BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1Ξ±-MODY diabetes. | Pfeiffer S et al. | β | 2015 | β |
| Biphasic decline of Ξ²-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset. | Cechin SR et al. | β | 2015 | β |
| Chronic exposure to low doses of lipopolysaccharide and high-fat feeding increases body mass without affecting glucose tolerance in female rats. | Dudele A et al. | β | 2015 | β |
| Cidea improves the metabolic profile through expansion of adipose tissue. | Abreu-Vieira G et al. | β | 2015 | β |
| Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes. | Liu P et al. | β | 2015 | β |
| Effects of ambient temperature on glucose tolerance and insulin sensitivity test outcomes in normal and obese C57 male mice. | Dudele A et al. | β | 2015 | β |
| Effects of genistein in combination with conjugated estrogens on endometrial hyperplasia and metabolic dysfunction in ovariectomized mice. | Kim JH et al. | β | 2015 | β |
| Effects of liquid konjac on parameters related to obesity in diet-induced obese mice. | Aoe S et al. | β | 2015 | β |
| Effects of postnatal growth restriction and subsequent catch-up growth on neurodevelopment and glucose homeostasis in rats. | Alexeev EE et al. | β | 2015 | β |
| Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats. | Shih SL et al. | β | 2015 | β |
| Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. | Al-Share QY et al. | β | 2015 | β |
| Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet. | Sheedfar F et al. | β | 2015 | β |
| Glucose and Insulin Tolerance Tests in the Mouse. | VinuΓ© Γ et al. | β | 2015 | β |
| Glucose tolerance tests for systematic screening of glucose homeostasis in mice. | Rozman J et al. | β | 2015 | β |
| Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice. | Pedersen BA et al. | β | 2015 | β |
| Identification and Antioxidant Activity of the Extracts of Eugenia uniflora Leaves. Characterization of the Anti-Inflammatory Properties of Aqueous Extract on Diabetes Expression in an Experimental Model of Spontaneous Type 1 Diabetes (NOD Mice). | Schumacher NS et al. | β | 2015 | β |
| Impaired Glucose Metabolism in Mice Lacking the Tas1r3 Taste Receptor Gene. | Murovets VO et al. | β | 2015 | β |
| Mouse handling limits the impact of stress on metabolic endpoints. | Ghosal S et al. | β | 2015 | β |
| Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation. | Pedersen BA et al. | β | 2015 | β |
| Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity. | Christians JK et al. | β | 2015 | β |
| Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fed rats. | Nakajima S et al. | β | 2015 | β |
| Sitagliptin protects proliferation of neural progenitor cells in diabetic mice. | Bachor TP et al. | β | 2015 | β |
| Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice. | Glendinning JI et al. | β | 2015 | β |
| The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. | King KB et al. | β | 2015 | β |
| The Intra- or Extracellular Redox State Was Not Affected by a High vs. Low Glycemic Response Diet in Mice. | Kleckner AS et al. | β | 2015 | β |
| Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity. | Karunakaran D et al. | β | 2015 | β |
| Voluntary physical activity prevents insulin resistance in a tissue specific manner. | Sarvas JL et al. | β | 2015 | β |
| Weaning triggers a maturation step of pancreatic Ξ² cells. | Stolovich-Rain M et al. | β | 2015 | β |
| Allergen exposure induces adipose tissue inflammation and insulin resistance. | Jung CC et al. | β | 2014 | β |
| An oral vaccine for type 1 diabetes based on live attenuated Salmonella. | Husseiny MI et al. | β | 2014 | β |
| Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. | Maianti JP et al. | β | 2014 | β |
| Caprine pancreatic islet xenotransplantation into diabetic immunosuppressed BALB/c mice. | Hani H et al. | β | 2014 | β |
| Cyclic AMP sensor EPAC proteins and energy homeostasis. | Almahariq M et al. | β | 2014 | β |
| Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. | Brown ML et al. | β | 2014 | β |
| Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice. | Eskens BJ et al. | β | 2014 | β |
| Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes. | Rustenbeck I et al. | β | 2014 | β |
| Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. | Mayers JR et al. | β | 2014 | β |
| Endurance interval training in obese mice reduces muscle inflammation and macrophage content independently of weight loss. | Samaan MC et al. | β | 2014 | β |
| Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice. | Baltgalvis KA et al. | β | 2014 | β |
| Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. | GarcΓa-Arevalo M et al. | β | 2014 | β |
| Exposure to p,p'-dichlorodiphenyldichloroethylene (DDE) induces fasting hyperglycemia without insulin resistance in male C57BL/6H mice. | Howell GE et al. | β | 2014 | β |
| Extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity. | Kubow S et al. | β | 2014 | β |
| Fatty acid metabolism, energy expenditure and insulin resistance in muscle. | Turner N et al. | β | 2014 | β |
| Food additive carrageenan: Part I: A critical review of carrageenan in vitro studies, potential pitfalls, and implications for human health and safety. | McKim JM | β | 2014 | β |
| Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning. | Thiebaud N et al. | β | 2014 | β |
| Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats. | Gong YY et al. | β | 2014 | β |
| Impact of glucose dosing regimens on modeling of glucose tolerance and Ξ²-cell function by intravenous glucose tolerance test in diet-induced obese mice. | Omar BA et al. | β | 2014 | β |
| In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes. | Lee HY et al. | β | 2014 | β |
| Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. | FjΓ¦re E et al. | β | 2014 | β |
| Knockout mouse models of insulin signaling: Relevance past and future. | Bunner AE et al. | β | 2014 | β |
| Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice. | Dijkstra MH et al. | β | 2014 | β |
| Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. | van Donkelaar EL et al. | β | 2014 | β |
| Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models. | Bowe JE et al. | β | 2014 | β |
| Metabolic response to chronic bisphenol A exposure in C57bl/6n mice. | Patel BB et al. | β | 2014 | β |
| Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity. | Cao J et al. | β | 2014 | β |
| Mitochondrial-related proteomic changes during obesity and fasting in mice are greater in the liver than skeletal muscles. | Nesteruk M et al. | β | 2014 | β |
| Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. | Chen W et al. | β | 2014 | β |
| Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling. | Alrob OA et al. | β | 2014 | β |
| Oral administration of Bifidobacterium spp. improves insulin resistance, induces adiponectin, and prevents inflammatory adipokine expressions. | LE TK et al. | β | 2014 | β |
| Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats. | Jang M et al. | β | 2014 | β |
| Oxidative stress-associated protein tyrosine kinases and phosphatases in Fanconi anemia. | Li J et al. | β | 2014 | β |
| Pre-diabetes alters testicular PGC1-Ξ±/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. | Rato L et al. | β | 2014 | β |
| Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function. | Wang Y et al. | β | 2014 | β |
| The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia. | Shin MK et al. | β | 2014 | β |
| The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in aΒ preeclampsia-like murine model. | McDonnold M et al. | β | 2014 | β |
| The effects of equal caloric high fat and western diet on metabolic syndrome, oxidative stress and vascular endothelial function in mice. | Heinonen I et al. | β | 2014 | β |
| The Involvement of the T1R3 Receptor Protein in the Control of Glucose Metabolism in Mice at Different Levels of Glycemia. | Murovets VO et al. | β | 2014 | β |
| The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice. | Zhang Z et al. | β | 2014 | β |
| The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents. | Kowalski GM et al. | β | 2014 | β |
| Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. | Feuer SK et al. | β | 2014 | β |
| A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel. | Li K et al. | β | 2013 | β |
| A maternal high-protein diet predisposes female offspring to increased fat mass in adulthood whereas a prebiotic fibre diet decreases fat mass in rats. | Hallam MC et al. | β | 2013 | β |
| AMPK and insulin action--responses to ageing and high fat diet. | FrΓΈsig C et al. | β | 2013 | β |
| ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. | Mori J et al. | β | 2013 | β |
| A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. | Peserico A et al. | β | 2013 | β |
| A tripeptide Diapin effectively lowers blood glucose levels in male type 2 diabetes mice by increasing blood levels of insulin and GLP-1. | Zhang J et al. | β | 2013 | β |
| Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. | Kawasaki K et al. | β | 2013 | β |
| Connexin 36, a key element in pancreatic beta cell function. | PΓ©rez-Armendariz EM | β | 2013 | β |
| Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. | Dokas J et al. | β | 2013 | β |
| CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. | Peterson JM et al. | β | 2013 | β |
| Endurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant mice. | Pastore S et al. | β | 2013 | β |
| Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. | LΓΆffler MG et al. | β | 2013 | β |
| Functional Role of PPARs in Ruminants: Potential Targets for Fine-Tuning Metabolism during Growth and Lactation. | Bionaz M et al. | β | 2013 | β |
| Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis. | Czyzyk TA et al. | β | 2013 | β |
| High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. | Rato L et al. | β | 2013 | β |
| Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice. | Tsuneki H et al. | β | 2013 | β |
| Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI. | Nasrallah FA et al. | β | 2013 | β |
| Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. | Cansby E et al. | β | 2013 | β |
| Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. | Clemmensen C et al. | β | 2013 | β |
| Intermittent hypoxia exacerbates pancreatic Ξ²-cell dysfunction in a mouse model of diabetes mellitus. | Sherwani SI et al. | β | 2013 | β |
| In vivo imaging of glucose uptake and metabolism in tumors. | Walker-Samuel S et al. | β | 2013 | β |
| Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs. | Schmidt RH et al. | β | 2013 | β |
| Significant improvement in islet yield and survival with modified ET-Kyoto solution: ET-Kyoto/Neutrophil elastase inhibitor. | Machida T et al. | β | 2013 | β |
| Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in Ξ²-cells. | Deisl C et al. | β | 2013 | β |
| Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allografts. | Hvid H et al. | β | 2013 | β |
| Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacity. | Shi YC et al. | β | 2012 | β |
| ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. | Erener S et al. | β | 2012 | β |
| Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age. | Guo T et al. | β | 2012 | β |
| Deviation of innate circadian period from 24 h reduces longevity in mice. | Libert S et al. | β | 2012 | β |
| Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor. | Baudry C et al. | β | 2012 | β |
| Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-Ξ³ KO Mice. | Dwiranti F et al. | β | 2012 | β |
| Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests. | Gerdin AK et al. | β | 2012 | β |
| Fanconi anemia links reactive oxygen species to insulin resistance and obesity. | Li J et al. | β | 2012 | β |
| Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice. | Yang GK et al. | β | 2012 | β |
| Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. | Lucas S et al. | β | 2012 | β |
| L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. | Clemmensen C et al. | β | 2012 | β |
| Lipocalin prostaglandin D synthase and PPARΞ³2 coordinate to regulate carbohydrate and lipid metabolism in vivo. | Virtue S et al. | β | 2012 | β |
| Manipulation of the gut microbiota in C57BL/6 mice changes glucose tolerance without affecting weight development and gut mucosal immunity. | Bech-Nielsen GV et al. | β | 2012 | β |
| Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period. | Carreras A et al. | β | 2012 | β |
| Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. | Gourineni V et al. | β | 2012 | β |
| Normal muscle glucose uptake in mice deficient in muscle GLUT4. | Fam BC et al. | β | 2012 | β |
| NPY modulates PYY function in the regulation of energy balance and glucose homeostasis. | Zhang L et al. | β | 2012 | β |
| Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice. | Zeng XY et al. | β | 2012 | β |
| Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis. | Massart J et al. | β | 2012 | β |
| Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo. | Tanemura M et al. | β | 2012 | β |
| Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. | Yang SB et al. | β | 2012 | β |
| Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. | Ahlkvist L et al. | β | 2012 | β |
| Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. | Hagberg CE et al. | β | 2012 | β |
| The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and Ξ² cell function in mice. | Zhang Y et al. | β | 2012 | β |
| Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice. | Ghosh S et al. | β | 2011 | β |
| A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion. | Mangiafico SP et al. | β | 2011 | β |
| Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. | Yin DP et al. | β | 2011 | β |
| A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis. | Xu K et al. | β | 2011 | β |
| B cell-activating factor controls the production of adipokines and induces insulin resistance. | Hamada M et al. | β | 2011 | β |
| Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice. | Naito E et al. | β | 2011 | β |
| Brain insulin controls adipose tissue lipolysis and lipogenesis. | Scherer T et al. | β | 2011 | β |
| Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice. | Wong N et al. | β | 2011 | β |
| Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. | Shertzer HG et al. | β | 2011 | β |
| Feeding cues and injected nutrients induce acute expression of multiple clock genes in the mouse liver. | Oike H et al. | β | 2011 | β |
| GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity. | Verhulst PJ et al. | β | 2011 | β |
| Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle. | Lau P et al. | β | 2011 | β |
| Impaired glucose tolerance in mice lacking cellular prion protein. | Strom A et al. | β | 2011 | β |
| Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. | Shabrova EV et al. | β | 2011 | β |
| Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity. | Kuhajda FP et al. | β | 2011 | β |
| Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS). | Solano ME et al. | β | 2011 | β |
| The arrestin domain-containing 3 protein regulates body mass and energy expenditure. | Patwari P et al. | β | 2011 | β |
| The Sweet Pee model for Sglt2 mutation. | Ly JP et al. | β | 2011 | β |
| Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model. | Li Y et al. | β | 2011 | β |
| Towards PET imaging of intact pancreatic beta cell mass: a transgenic strategy. | McGirr R et al. | β | 2011 | β |
| Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. | Perfield JW et al. | β | 2011 | β |
| Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin function of islet grafts in diabetic mice. | Ohmura Y et al. | β | 2010 | β |
| In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues. | Agouni A et al. | β | 2010 | β |
| Obesity and type 2 diabetes: slow down!--Can metabolic deceleration protect the islet beta cell from excess nutrient-induced damage? | Andrikopoulos S | β | 2010 | β |
| Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. | Ayala JE et al. | β | 2010 | β |
| The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose tolerance. | Wong N et al. | β | 2010 | β |
| NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. | McGuinness OP et al. | β | 2009 | β |