Increase in GSK3beta gene copy number variation in bipolar disorder.
paper
Cited
Public
Unavailable
- Authors
- Lachman, Herbert M; Pedrosa, Erika; Petruolo, Oriana A; Cockerham, Melissa; Papolos, Alexander; Novak, Tomas; Papolos, Demitri F; Stopkova, Pavla
- Year
- 2007
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 17357145
- DOI
- 10.1002/ajmg.b.30498
The analysis of submicroscopic copy number variations (CNVs), also known as copy number polymorphisms (CNPs), is emerging as a new tool for understanding the genetic basis of cancer, developmental disorders, and complex traits. One area where this may be particularly useful is in the identification of genetic variants underlying schizophrenia (SZ) and bipolar disorder (BD). Linkage analysis and pharmacological studies carried out over the past decade have implicated a number of positional and physiological candidate genes. Yet, despite extensive analysis, the underlying allelic variants responsible for disease susceptibility have remained, largely, elusive. Although the borders of most CNV have not been precisely mapped, it appears that a considerable number of SZ and BD candidate genes have their coding elements disrupted by polymorphic CNVs, suggesting that these would be good variants to consider for underlying disease susceptibility. One such gene is GSK3beta, which codes for glycogen synthase kinase, a key component of the Wnt signaling pathway and a target of lithium salts. A CNV in the GSK3beta locus at chromosome 3q13.3 appears to disrupt the gene's 3'-coding elements. The CNV also affects two other annotated genes. We now report that patients with BD have an increased frequency of this CNV-primarily the duplication variant-compared with controls (P = 0.002). The finding suggests that GSK3beta may be involved in BD susceptibility in some individuals and that CNVs in this and other candidate genes for psychiatric disorders should be analyzed as causative functional genetic variants.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. | 2012 | 22702843 |
| Genome-wide association studies in ADHD. | 2009 | 19384554 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The spectrum of bipolar disorder in older adults. | Eyler LT et al. | β | 2026 | β |
| Copy number variations in the Brazilian High-Risk Cohort for Mental Conditions. | Arendt J et al. | β | 2025 | β |
| Copy Number Variations in Neuropsychiatric Disorders. | BΓΌki G et al. | β | 2023 | β |
| Factors associated with psychiatric and physical comorbidities in bipolar disorder: a nationwide multicenter cross-sectional observational study. | Dragasek J et al. | β | 2023 | β |
| Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology. | McCarthy MJ et al. | β | 2022 | β |
| Population Genomic Sequencing Delineates Global Landscape of Copy Number Variations that Drive Domestication and Breed Formation of in Chicken. | Chen X et al. | β | 2022 | β |
| Dissecting Molecular Genetic Mechanisms of 1q21.1 CNV in Neuropsychiatric Disorders. | Yoon J et al. | β | 2021 | β |
| Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings. | Scaini G et al. | β | 2020 | β |
| Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine. | Takaki M et al. | β | 2018 | β |
| Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder. | McLean CK et al. | β | 2018 | β |
| Perspective: DNA Copy Number Variations in Cardiovascular Diseases. | Vijay A et al. | β | 2018 | β |
| Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling. | Sorokina AM et al. | β | 2018 | β |
| Chromosome copy number variants in fetuses with syndromic malformations. | Wang H et al. | β | 2017 | β |
| Psychiatric Disorders and Quality of Life in the Offspring of Parents with Bipolar Disorder. | Goetz M et al. | β | 2017 | β |
| The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. | Amare AT et al. | β | 2017 | β |
| A cAMP and CREB-mediated feed-forward mechanism regulates GSK3Ξ² in polycystic kidney disease. | Kakade VR et al. | β | 2016 | β |
| An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia. | Yan P et al. | β | 2016 | β |
| A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis. | Lekman M et al. | β | 2015 | β |
| Chronobiology of bipolar disorder: therapeutic implication. | Dallaspezia S et al. | β | 2015 | β |
| [Circadian markers and genes in bipolar disorder]. | Yeim S et al. | β | 2015 | β |
| Connecting Anxiety and Genomic Copy Number Variation: A Genome-Wide Analysis in CD-1 Mice. | BrenndΓΆrfer J et al. | β | 2015 | β |
| Genomic structural variation in affective, anxiety, and stress-related disorders. | Ono S et al. | β | 2015 | β |
| Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders. | O'Leary O et al. | β | 2015 | β |
| Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. | Beurel E et al. | β | 2015 | β |
| Lithium increases platelet serine-9 phosphorylated GSK-3Ξ² levels in drug-free bipolar disorder during depressive episodes. | de Sousa RT et al. | β | 2015 | β |
| Region-specific dysregulation of glycogen synthase kinase-3Ξ² and Ξ²-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia. | Pandey GN et al. | β | 2015 | β |
| Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex. | Garcia-Oscos F et al. | β | 2015 | β |
| Association between circadian genes, bipolar disorders and chronotypes. | Etain B et al. | β | 2014 | β |
| Glycogen synthase kinase 3 beta gene structural variants as possible risk factors of bipolar depression. | Ronai Z et al. | β | 2014 | β |
| Identifying Potential Regions of Copy Number Variation for Bipolar Disorder. | Chen YH et al. | β | 2014 | β |
| Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder. | Chen G et al. | β | 2014 | β |
| Wnt and lithium: a common destiny in the therapy of nervous system pathologies? | Meffre D et al. | β | 2014 | β |
| Convergent functional genomics of psychiatric disorders. | Niculescu AB | β | 2013 | β |
| Detection and interpretation of genomic structural variation in health and disease. | Vandeweyer G et al. | β | 2013 | β |
| DISC1: a key lead in studying cortical development and associated brain disorders. | Narayan S et al. | β | 2013 | β |
| Ectopic KIT copy number variation underlies impaired migration of primordial germ cells associated with gonadal hypoplasia in cattle (Bos taurus). | Venhoranta H et al. | β | 2013 | β |
| FMR1, circadian genes and depression: suggestive associations or false discovery? | Kripke DF et al. | β | 2013 | β |
| Gene copy-number alterations: a cost-benefit analysis. | Tang YC et al. | β | 2013 | β |
| Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients. | McCarthy MJ et al. | β | 2013 | β |
| Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression. | Hickie IB et al. | β | 2013 | β |
| The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges. | Boonpeng H et al. | β | 2013 | β |
| A pilot study on collective effects of 22q13.31 deletions on gray matter concentration in schizophrenia. | Liu J et al. | β | 2012 | β |
| Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. | Lin P et al. | β | 2012 | β |
| Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder. | Priebe L et al. | β | 2012 | β |
| Implications of gene copy-number variation in health and diseases. | Almal SH et al. | β | 2012 | β |
| Possible association of the GSK3Ξ² gene with the anxiety symptoms of major depressive disorder and P300 waveform. | Liu S et al. | β | 2012 | β |
| Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours. | Keers R et al. | β | 2012 | β |
| The wnt pathway in mood disorders. | Sani G et al. | β | 2012 | β |
| Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample. | McQuillin A et al. | β | 2011 | β |
| Circadian biomarkers, circadian genes and bipolar disorders. | Milhiet V et al. | β | 2011 | β |
| Convergent functional genomic studies of Ο-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | Le-Niculescu H et al. | β | 2011 | β |
| Genetics of circadian rhythms and mood spectrum disorders. | Etain B et al. | β | 2011 | β |
| Glycogen synthase kinase-3 in the etiology and treatment of mood disorders. | Jope RS | β | 2011 | β |
| Synaptic Wnt signaling-a contributor to major psychiatric disorders? | Okerlund ND et al. | β | 2011 | β |
| A haplotype of glycogen synthase kinase 3Ξ² is associated with early onset of unipolar major depression. | Saus E et al. | β | 2010 | β |
| Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics. | Patel SD et al. | β | 2010 | β |
| Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. | Saus E et al. | β | 2010 | β |
| Copy number variation of the SELENBP1 gene in schizophrenia. | Amar S et al. | β | 2010 | β |
| Genome-wide scan of copy number variation in late-onset Alzheimer's disease. | Heinzen EL et al. | β | 2010 | β |
| Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype. | de Smith AJ et al. | β | 2010 | β |
| New findings in the genetics of major psychoses. | NΓΆthen MM et al. | β | 2010 | β |
| Optimal Sparse Segment Identification with Application in Copy Number Variation Analysis. | Jeng XJ et al. | β | 2010 | β |
| Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. | Grozeva D et al. | β | 2010 | β |
| The clinical context of copy number variation in the human genome. | Lee C et al. | β | 2010 | β |
| The impact of human copy number variation on a new era of genetic testing. | Choy KW et al. | β | 2010 | β |
| Ξ²-catenin promoter ChIP-chip reveals potential schizophrenia and bipolar disorder gene network. | Pedrosa E et al. | β | 2010 | β |
| Candidate gene copy number analysis by PCR and multicapillary electrophoresis. | Szantai E et al. | β | 2009 | β |
| Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. | Le-Niculescu H et al. | β | 2009 | β |
| Copy-number variants in neurodevelopmental disorders: promises and challenges. | Merikangas AK et al. | β | 2009 | β |
| (Epi)genomics and neurodevelopment in schizophrenia: monozygotic twins discordant for schizophrenia augment the search for disease-related (epi)genomic alterations. | Singh SM et al. | β | 2009 | β |
| Genome-wide association studies in ADHD. | Franke B et al. | β | 2009 | β |
| Genomic landscape of a three-generation pedigree segregating affective disorder. | Yang S et al. | β | 2009 | β |
| Imaging phenotypes of major depressive disorder: genetic correlates. | Savitz JB et al. | β | 2009 | β |
| Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future. | Alaerts M et al. | β | 2009 | β |
| Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip). | Pedrosa E et al. | β | 2009 | β |
| The genetics of bipolar disorder. | Barnett JH et al. | β | 2009 | β |
| Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia. | Lachman HM et al. | β | 2008 | β |
| Copy-number variations associated with neuropsychiatric conditions. | Cook EH et al. | β | 2008 | β |
| Copy variations in schizophrenia and bipolar disorder. | Lachman HM | β | 2008 | β |
| Genomic structural variation and schizophrenia. | Mulle JG | β | 2008 | β |
| Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. | de Smith AJ et al. | β | 2008 | β |
| Identification of SNP markers for common CNV regions and association analysis of risk of subarachnoid aneurysmal hemorrhage in Japanese population. | Bae JS et al. | β | 2008 | β |
| Molecular neurobiology of bipolar disorder: a disease of 'mood-stabilizing neurons'? | Kato T | β | 2008 | β |
| Statistical issues in the analysis of DNA Copy Number Variations. | Wineinger NE et al. | β | 2008 | β |
| The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions. | Serretti A et al. | β | 2008 | β |
| The success of the genome-wide association approach: a brief story of a long struggle. | Seng KC et al. | β | 2008 | β |
| Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. | Estivill X et al. | β | 2007 | β |
| Genetics of bipolar disorder. | Smoller JW et al. | β | 2007 | β |