Replication validity of genetic association studies.
paper
Cited
Public
Unavailable
- Authors
- Ioannidis, J P; Ntzani, E E; Trikalinos, T A; Contopoulos-Ioannidis, D G
- Year
- 2001
- Journal
- Nature genetics
- PMID
- 11600885
- DOI
- 10.1038/ng749
The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical outcomes to which these may be linked, the testing and validation of statistical hypotheses in genetic epidemiology is a task of unprecedented scale. Meta-analysis provides a quantitative approach for combining the results of various studies on the same topic, and for estimating and explaining their diversity. Here, we have evaluated by meta-analysis 370 studies addressing 36 genetic associations for various outcomes of disease. We show that significant between-study heterogeneity (diversity) is frequent, and that the results of the first study correlate only modestly with subsequent research on the same association. The first study often suggests a stronger genetic effect than is found by subsequent studies. Both bias and genuine population diversity might explain why early association studies tend to overestimate the disease protection or predisposition conferred by a genetic polymorphism. We conclude that a systematic meta-analytic approach may assist in estimating population-wide effects of genetic risk factors in human disease.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis. | Orellana P et al. | β | 2026 | β |
| LncRNA CCAT2 role in female-related cancer progression and diagnosis: a comprehensive review. | Vanan AG et al. | β | 2026 | β |
| Modifiable methodological and reporting practices are associated with reproducibility of health sciences research: a systematic review and evidence and gap map. | Kennett J et al. | β | 2026 | β |
| Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci. | Zhang M et al. | β | 2025 | β |
| Integrating -Omic Technologies across Modality, Space, and Time to Decipher Remodeling in Cardiac Disease. | Mulvey JF et al. | β | 2025 | β |
| "Limits to medicine" still needed after 50 years. | Hofmann B | β | 2025 | β |
| Prediction Performance of Earlier Studies for Later Studies in Cochrane Reviews. | Al Amer FM et al. | β | 2025 | β |
| Putting computational models of immunity to the test-An invited challenge to predict B.pertussis vaccination responses. | Shinde P et al. | β | 2025 | β |
| Spatial Frequency Maps in Human Visual Cortex: A Replication and Extension | Ha J et al. | β | 2025 | β |
| The impact of genetic variants in folliculogenesis and steroidogenesis pathways on ovarian response: a post hoc multicenter multiethnic cohort study. | Neves AR et al. | β | 2025 | β |
| The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review. | Bolier M et al. | β | 2025 | β |
| A multi-omics systems vaccinology resource to develop and test computational models of immunity. | Shinde P et al. | β | 2024 | β |
| A powerful approach to identify replicable variants in genome-wide association studies. | Li Y et al. | β | 2024 | β |
| Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis. | Huang J et al. | β | 2024 | β |
| Reproducibility in chemistry research. | Ciriminna R et al. | β | 2024 | β |
| The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review. | Zhang Y et al. | β | 2024 | β |
| From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies? | Defo J et al. | β | 2023 | β |
| Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage. | Dhote VV et al. | β | 2023 | β |
| Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review. | van der Meer R et al. | β | 2023 | β |
| Genome-Wide Association Study of CKD Progression. | Robinson-Cohen C et al. | β | 2023 | β |
| Meta-QTL analysis in wheat: progress, challenges and opportunities. | Sharma D et al. | β | 2023 | β |
| A Comparison of Individuals with Diabetes and EMPA-REG Trial Participants: Exploring Aspects of External Validity. | Chaitoff A et al. | β | 2022 | β |
| Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package. | Lin L et al. | β | 2022 | β |
| Association Between Systemic Lupus Erythematosus and Cancer Morbidity and Mortality: Findings From Cohort Studies. | Zhang M et al. | β | 2022 | β |
| [Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia]. | Sofronov AG et al. | β | 2022 | β |
| Beyond GWAS: from simple associations to functional insights. | Ishigaki K | β | 2022 | β |
| Evaluating replicability in microbiome data. | Clausen DS et al. | β | 2022 | β |
| Evaluating the validity of animal models of mental disorder: from modeling syndromes to modeling endophenotypes. | van den Berg H | β | 2022 | β |
| Genetic architecture of tuberculosis susceptibility: A comprehensive research synopsis, meta-analyses, and epidemiological evidence. | Jiao L et al. | β | 2022 | β |
| Genetic risk for subjective reports of insomnia associates only weakly with polygraphic measures of insomnia in 2,770 adults. | Foldager J et al. | β | 2022 | β |
| <i>IFITM3</i>, <i>FURIN</i>, <i>ACE1</i>, and <i>TNF-Ξ±</i> Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis. | de AraΓΊjo JLF et al. | β | 2022 | β |
| Polymorphic Variants of <i>AGT, ABCA1</i>, and <i>CYBA</i> Genes Influence the Survival of Patients with Coronary Artery Disease: A Prospective Cohort Study. | Balcerzyk-MatiΔ A et al. | β | 2022 | β |
| Replicability in cancer omics data analysis: measures and empirical explorations. | Wang J et al. | β | 2022 | β |
| A biomarker-guided, prospective, phase 2 trial of pre-emptive graft-versus-host disease therapy using anti-thymocyte globulin. | Khanolkar RA et al. | β | 2021 | β |
| Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era. | Hai Q et al. | β | 2021 | β |
| Genetic Architecture of Depression: Where Do We Stand Now? | Unal-Aydin P et al. | β | 2021 | β |
| Genetic contributions to autism spectrum disorder. | Havdahl A et al. | β | 2021 | β |
| Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank. | Yanik EL et al. | β | 2021 | β |
| Impact of modular mitochondrial epistatic interactions on the evolution of human subpopulations. | Shinde P et al. | β | 2021 | β |
| Meta-Analysis of Microdissected Breast Tumors Reveals Genes Regulated in the Stroma but Hidden in Bulk Analysis. | Savino A et al. | β | 2021 | β |
| Moderators of gene-outcome associations following traumatic brain injury. | Carmichael J et al. | β | 2021 | β |
| Multisystem inflammatory syndrome in children: a microcosm of challenges and opportunities for translational bioinformatics in pediatric research. | Murphy Jones L et al. | β | 2021 | β |
| Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines. | WeiΓbach S et al. | β | 2021 | β |
| The "replication crisis" in the public eye: Germans' awareness and perceptions of the (ir)reproducibility of scientific research. | Mede NG et al. | β | 2021 | β |
| Effect Sizes, Power, and Biases in Intelligence Research: A Meta-Meta-Analysis. | Nuijten MB et al. | β | 2020 | β |
| Filaggrin gene defects are associated with eczema, wheeze, and nasal disease during infancy: Prospective study. | Basu K et al. | β | 2020 | β |
| Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis. | Alter BP et al. | β | 2020 | β |
| Insights into the genetic basis of retinal detachment. | Boutin TS et al. | β | 2020 | β |
| Interactions of childhood maltreatment and genetic variations in adult depression: A systematic review. | Li M et al. | β | 2020 | β |
| Investigation of the association of endothelial nitric oxide synthase (eNOS)-T786C gene polymorphism with the risk of male infertility in an Iranian population. | Mousavi-Nasab FS et al. | β | 2020 | β |
| Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. | Sofer T et al. | β | 2020 | β |
| Messaging in Biological Psychiatry: Misrepresentations, Their Causes, and Potential Consequences. | Dumas-Mallet E et al. | β | 2020 | β |
| One Single Nucleotide Polymorphism of the <i>TRPM2</i> Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population. | Mahmuda NA et al. | β | 2020 | β |
| Residential neighborhood features associated with objectively measured walking near home: Revisiting walkability using the Automatic Context Measurement Tool (ACMT). | Mooney SJ et al. | β | 2020 | β |
| Systematic Review and Meta-Analysis of Candidate Gene Association Studies With Fracture Risk in Physically Active Participants. | Ryan-Moore E et al. | β | 2020 | β |
| The BRCA1 and BRCA2 Genes in Early-Onset Breast Cancer Patients. | Saleem M et al. | β | 2020 | β |
| The effects of age at menarche and first sexual intercourse on reproductive and behavioural outcomes: A Mendelian randomization study. | Lawn RB et al. | β | 2020 | β |
| Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis. | Knevel R et al. | β | 2020 | β |
| Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case-control studies. | Zhang ML et al. | β | 2019 | β |
| C9orf72 intermediate expansions of 24-30 repeats are associated with ALS. | Iacoangeli A et al. | β | 2019 | β |
| Caring helps: Trait empathy is related to better coping strategies and differs in the poor versus the rich. | Sun R et al. | β | 2019 | β |
| Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk. | Said MA et al. | β | 2019 | β |
| Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies. | Kraaijenvanger EJ et al. | β | 2019 | β |
| Gene-environment interactions between HPA-axis genes and stressful life events in depression: a systematic review. | Normann C et al. | β | 2019 | β |
| General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. | Elliott ML et al. | β | 2019 | β |
| Genetically Determined Levels of Circulating Cytokines and Risk of Stroke. | Georgakis MK et al. | β | 2019 | β |
| Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies. | Tian J et al. | β | 2019 | β |
| Genetics and the heart rate response to exercise. | van de Vegte YJ et al. | β | 2019 | β |
| Genetics of diabetic neuropathy: Systematic review, meta-analysis and trial sequential analysis. | Zhao Y et al. | β | 2019 | β |
| <i>CACNA1C rs1006737</i>, Threatening Life Events, and Gene-Environment Interaction Predict Major Depressive Disorder. | Zhao M et al. | β | 2019 | β |
| IMI - Myopia Genetics Report. | Tedja MS et al. | β | 2019 | β |
| Physician Empathy Is Not Associated with Laboratory Outcomes in Diabetes: a Cross-sectional Study. | Chaitoff A et al. | β | 2019 | β |
| Predicting the replicability of social science lab experiments. | Altmejd A et al. | β | 2019 | β |
| Presidential address: Six open questions to genetic epidemiologists. | KΓΆnig IR | β | 2019 | β |
| Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway. | Ge L et al. | β | 2019 | β |
| The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights. | LaganΓ AS et al. | β | 2019 | β |
| A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations. | Kiddle SJ et al. | β | 2018 | β |
| Age at menarche and adult body mass index: a Mendelian randomization study. | Gill D et al. | β | 2018 | β |
| Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. | Taylor S | β | 2018 | β |
| Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children. | Oliveira DSB et al. | β | 2018 | β |
| Bipartite graphs in systems biology and medicine: a survey of methods and applications. | Pavlopoulos GA et al. | β | 2018 | β |
| Critical Issues in the Inclusion of Genetic and Epigenetic Information in Prevention and Intervention Trials. | Latendresse SJ et al. | β | 2018 | β |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | β | 2018 | β |
| Gene-based GWAS analysis for consecutive studies of GEFOS. | Zhu W et al. | β | 2018 | β |
| Genetics of Hypercoagulable and Hypocoagulable States. | Singh D et al. | β | 2018 | β |
| Genetics of Multiple Sclerosis: An Overview and New Directions. | Patsopoulos NA | β | 2018 | β |
| Genome-Wide Association Study in Acute Respiratory Distress Syndrome. Finding the Needle in the Haystack to Advance Our Understanding of Acute Respiratory Distress Syndrome. | Rogers AJ | β | 2018 | β |
| Hypothesis-driven versus hypothesis-free approaches to the identification of genes for cleft lip and palate. | Vieira AR | β | 2018 | β |
| Intakes of citrus fruit and risk of esophageal cancer: A meta-analysis. | Zhao W et al. | β | 2018 | β |
| Negative Urgency Mediates the Relation between Genetically-Influenced Serotonin Functioning and Alcohol Problems. | Wang FL et al. | β | 2018 | β |
| Neuroanatomy of developmental dyslexia: Pitfalls and promise. | Ramus F et al. | β | 2018 | β |
| Prognostic value and susceptibility of BAX rs4645878 polymorphism in cancer: A systematic review and meta-analysis. | Feng Y et al. | β | 2018 | β |
| Quality Improvement in Perinatal Medicine and Translation of Preterm Birth Research Findings into Clinical Care. | Manuck TA et al. | β | 2018 | β |
| Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. | Sloan ME et al. | β | 2018 | β |
| Shortcut to success? Negotiating genetic uniqueness in global biomedicine. | Tarkkala H et al. | β | 2018 | β |
| The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis: A meta-analysis of case-control studies. | Shi J et al. | β | 2018 | β |
| The Genetics and Genomics of Asthma. | Willis-Owen SAG et al. | β | 2018 | β |
| The Oxytocin Receptor Gene (<i>OXTR</i>) Variant rs53576 Is Not Related to Emotional Traits or States in Young Adults. | Conner TS et al. | β | 2018 | β |
| The SNP g.4667G>A at 3'-UTR of IFNG gene is associated with susceptibility to bovine tuberculosis in Mediterranean water buffalo (Bubalus bubalis). | Iannaccone M et al. | β | 2018 | β |
| Transethnic differences in GWAS signals: A simulation study. | Zanetti D et al. | β | 2018 | β |
| Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults. | MΓΌhle C et al. | β | 2017 | β |
| Age at menarche and lung function: a Mendelian randomization study. | Gill D et al. | β | 2017 | β |
| Age at Menarche and Time Spent in Education: A Mendelian Randomization Study. | Gill D et al. | β | 2017 | β |
| A meta-analysis of the association of CKM gene rs8111989 polymorphism with sport performance. | Chen C et al. | β | 2017 | β |
| A multianalytical approach to evaluate the association of 55 SNPs in 28 genes with obesity risk in North Indian adults. | Srivastava A et al. | β | 2017 | β |
| Apolipoprotein E Polymorphism and Left Ventricular Failure in Beta-Thalassemia: A Multivariate Meta-Analysis. | Dimou NL et al. | β | 2017 | β |
| Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects. | Zhu M et al. | β | 2017 | β |
| Association of <i>MTRR</i> A66G polymorphism with cancer susceptibility: Evidence from 85 studies. | Wang P et al. | β | 2017 | β |
| Association of single nucleotide polymorphisms in candidate genes previously related to genetic variation in fertility with phenotypic measurements of reproductive function in Holstein cows. | Ortega MS et al. | β | 2017 | β |
| Benchmarking Sepsis Gene Expression Diagnostics Using Public Data. | Sweeney TE et al. | β | 2017 | β |
| Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers. | Sulkava S et al. | β | 2017 | β |
| Effect of co-culture of mesenchymal stem/stromal cells with pancreatic islets on viability and function outcomes: a systematic review and meta-analysis. | de Souza BM et al. | β | 2017 | β |
| EMPOWERING MULTI-COHORT GENE EXPRESSION ANALYSIS TO INCREASE REPRODUCIBILITY. | Haynes WA et al. | β | 2017 | β |
| Equipoise on the Use of Steroids in Systemic Inflammatory Response Syndrome? | Jardine D | β | 2017 | β |
| Generalizable Biomarkers in Critical Care: Toward Precision Medicine. | Sweeney TE et al. | β | 2017 | β |
| Genetic association studies in cardiovascular diseases: Do we have enough power? | Auer PL et al. | β | 2017 | β |
| Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study. | Mossey PA et al. | β | 2017 | β |
| Genetic polymorphisms and lung cancer risk: Evidence from meta-analyses and genome-wide association studies. | Liu C et al. | β | 2017 | β |
| Genetics of neurodegenerative diseases: an overview. | PihlstrΓΈm L et al. | β | 2017 | β |
| Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies. | Santos BPD et al. | β | 2017 | β |
| Genetic variants in long noncoding RNA <i>H19</i> contribute to the risk of breast cancer in a southeast China Han population. | Lin Y et al. | β | 2017 | β |
| Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. | Wells QS et al. | β | 2017 | β |
| Genome-wide association studies of cancer: current insights and future perspectives. | Sud A et al. | β | 2017 | β |
| Genome-wide association study identifies a locus associated with rotator cuff injury. | Roos TR et al. | β | 2017 | β |
| Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. | Manrai AK et al. | β | 2017 | β |
| Mendelian randomization incorporating uncertainty about pleiotropy. | Thompson JR et al. | β | 2017 | β |
| Meta-analysis reveals no significant association between ERCC6 polymorphisms and bladder cancer risk. | Hong Z et al. | β | 2017 | β |
| Methods to increase reproducibility in differential gene expression via meta-analysis. | Sweeney TE et al. | β | 2017 | β |
| No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes. | Johnson EC et al. | β | 2017 | β |
| Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. | Patel CJ et al. | β | 2017 | β |
| Pannexin1 Single Nucleotide Polymorphism and Platelet Reactivity in a Cohort of Cardiovascular Patients. | Stierlin FB et al. | β | 2017 | β |
| Personalized medicine-a modern approach for the diagnosis and management of hypertension. | Savoia C et al. | β | 2017 | β |
| Poor replication validity of biomedical association studies reported by newspapers. | Dumas-Mallet E et al. | β | 2017 | β |
| Precision Dentistry in Early Childhood: The Central Role of Genomics. | Divaris K | β | 2017 | β |
| Prioritizing covariates in the planning of future studies in the meta-analytic framework. | Karvanen J et al. | β | 2017 | β |
| Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant. | Karaesmen E et al. | β | 2017 | β |
| Reproducibility of biomedical research - The importance of editorial vigilance. | Bustin SA et al. | β | 2017 | β |
| Role of <i>UCP1</i> Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases. | Flouris AD et al. | β | 2017 | β |
| Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems. | Wang FL et al. | β | 2017 | β |
| Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning. | Maddox WT et al. | β | 2017 | β |
| Serum iron level and kidney function: a Mendelian randomization study. | Del Greco M F et al. | β | 2017 | β |
| The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study-Brief Report. | Gill D et al. | β | 2017 | β |
| The hypothesis that Helicobacter pylori predisposes to Alzheimer's disease is biologically plausible. | Contaldi F et al. | β | 2017 | β |
| The performance of a new local false discovery rate method on tests of association between coronary artery disease (CAD) and genome-wide genetic variants. | Mei S et al. | β | 2017 | β |
| TP53 Arg72Pro, mortality after cancer, and all-cause mortality in 105,200 individuals. | Kodal JB et al. | β | 2017 | β |
| What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits? | Josephs EB et al. | β | 2017 | β |
| A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese. | Zhang C et al. | β | 2016 | β |
| A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. | Li M et al. | β | 2016 | β |
| Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk. | Dabiri R et al. | β | 2016 | β |
| Analysis of Systemic Sclerosis-associated Genes in a Turkish Population. | Carmona FD et al. | β | 2016 | β |
| Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis. | Rao P et al. | β | 2016 | β |
| Association between Polymorphisms in Interleukins 4 and 13 Genes and Chronic Periodontitis in a Han Chinese Population. | Chen D et al. | β | 2016 | β |
| Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics. | Rico-Gomis JM et al. | β | 2016 | β |
| Association of polymorphisms of A260G and A386G in DAZL gene with male infertility: a meta-analysis and systemic review. | Chen P et al. | β | 2016 | β |
| C282Y and H63D Polymorphisms in Hemochromatosis Gene and Risk of Parkinson's Disease: A Meta-Analysis. | Duan C et al. | β | 2016 | β |
| Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. | Dungan JR et al. | β | 2016 | β |
| COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. | Corral-FrΓas NS et al. | β | 2016 | β |
| Dietary Flavonols Intake and Risk of Esophageal and Gastric Cancer: A Meta-Analysis of Epidemiological Studies. | Xie Y et al. | β | 2016 | β |
| Displacement behaviors in chimpanzees (Pan troglodytes): A neurogenomics investigation of the RDoC Negative Valence Systems domain. | Latzman RD et al. | β | 2016 | β |
| Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology. | Wang Z et al. | β | 2016 | β |
| Epistatic interaction between MyD88 and TIRAP against Helicobacter pylori. | Fulgione A et al. | β | 2016 | β |
| Gang Warfare: What are the criteria for deriving assertions from facts in science? | Weiss KM | β | 2016 | β |
| Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population. | Xia Z et al. | β | 2016 | β |
| Genetic variants in ANCA-associated vasculitis: a meta-analysis. | Rahmattulla C et al. | β | 2016 | β |
| Genetic variants in lncRNA SRA and risk of breast cancer. | Yan R et al. | β | 2016 | β |
| Genomics of Atrial Fibrillation. | Gutierrez A et al. | β | 2016 | β |
| Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects. | Mahmoudi T et al. | β | 2016 | β |
| Identification of diagnostic and prognostic biomarkers for cancer: Focusing on genetic variations in microRNA regulatory pathways (Review). | Guo Z et al. | β | 2016 | β |
| Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. | Celorrio D et al. | β | 2016 | β |
| Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. | Malik R et al. | β | 2016 | β |
| Multigene panels in prostate cancer risk assessment: a systematic review. | Little J et al. | β | 2016 | β |
| Personalized medicine and treatment approaches in hypertension: current perspectives. | Byrd JB | β | 2016 | β |
| Replicating Cardiovascular Condition-Birth Month Associations. | Li L et al. | β | 2016 | β |
| Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases. | Dumas-Mallet E et al. | β | 2016 | β |
| Reproducible Research Practices and Transparency across the Biomedical Literature. | Iqbal SA et al. | β | 2016 | β |
| Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry. | Gupta J et al. | β | 2016 | β |
| Sports genetics: the PPARA gene and athletes' high ability in endurance sports. A systematic review and meta-analysis. | Lopez-Leon S et al. | β | 2016 | β |
| Testing the Relations Among Family Disorganization, Delay Discounting, and Adolescent Alcohol Use: A Genetically Informed Study. | Wang FL et al. | β | 2016 | β |
| The altered promoter methylation of oxytocin receptor gene in autism. | Elagoz Yuksel M et al. | β | 2016 | β |
| The BTNL2 G16071A gene polymorphism increases granulomatous disease susceptibility: A meta-analysis including FPRP test of 8710 participants. | Tong X et al. | β | 2016 | β |
| The genetics of drug efficacy: opportunities and challenges. | Nelson MR et al. | β | 2016 | β |
| The Neurobiology of "Food Addiction" and Its Implications for Obesity Treatment and Policy. | Carter A et al. | β | 2016 | β |
| The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants. | Tong X et al. | β | 2016 | β |
| The Use of Multiplicity Corrections, Order Statistics and Generalized Family-Wise Statistics with Application to Genome-Wide Studies. | Schrodi SJ | β | 2016 | β |
| Triangulating meta-analyses: the example of the serotonin transporter gene, stressful life events and major depression. | Taylor AE et al. | β | 2016 | β |
| Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study. | Zou W et al. | β | 2016 | β |
| A constructive replication of the association between the oxytocin receptor genotype and parenting. | Klahr AM et al. | β | 2015 | β |
| Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study. | Byrd JB et al. | β | 2015 | β |
| A Primer on Pattern-Based Approaches to fMRI: Principles, Pitfalls, and Perspectives. | Haynes JD | β | 2015 | β |
| Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis. | Lee YH et al. | β | 2015 | β |
| Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis. | Han X et al. | β | 2015 | β |
| A systematic appraisal of field synopses in genetic epidemiology: a HuGE review. | Belbasis L et al. | β | 2015 | β |
| Dopamine D4 receptor gene and religious affiliation correlate with dictator game altruism in males and not females: evidence for gender-sensitive gene Γ culture interaction. | Jiang Y et al. | β | 2015 | β |
| Dopamine receptor D4 (DRD4) gene modulates the influence of informational masking on speech recognition. | Xie Z et al. | β | 2015 | β |
| Elucidating the role of genomics in neonatal sepsis. | Srinivasan L et al. | β | 2015 | β |
| Endothelial nitric oxide synthase (eNOS) T-786C, 4a4b, and G894T polymorphisms and male infertility: study for idiopathic asthenozoospermia and meta-analysis. | Song P et al. | β | 2015 | β |
| Examining the Predictive Validity of NIH Peer Review Scores. | Lindner MD et al. | β | 2015 | β |
| G894T and 4a/b polymorphisms of NOS3 gene are not associated with cancer risk: a meta-analysis. | Haque S et al. | β | 2015 | β |
| Genetic factors associated with exercise performance in atmospheric hypoxia. | Hennis PJ et al. | β | 2015 | β |
| Genetics and brain morphology. | Strike LT et al. | β | 2015 | β |
| Genetics ignite focus on microglial inflammation in Alzheimer's disease. | Malik M et al. | β | 2015 | β |
| Genetics of Sleep Disorders. | Gehrman PR et al. | β | 2015 | β |
| I just ran a thousand analyses: benefits of multiple testing in understanding equivocal evidence on gene-environment interactions. | Heininga VE et al. | β | 2015 | β |
| Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy. | Gilbert R et al. | β | 2015 | β |
| Interaction of the 5-HTTLPR and childhood trauma influences memory bias in healthy individuals. | Vrijsen JN et al. | β | 2015 | β |
| Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis. | Wu N et al. | β | 2015 | β |
| Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. | Pedrera-Canal M et al. | β | 2015 | β |
| Polycyclic Aromatic Hydrocarbons and Breast Cancer: A Review of the Literature. | Korsh J et al. | β | 2015 | β |
| Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. | Yan R et al. | β | 2015 | β |
| Publication bias in meta-analyses from the Cochrane Database of Systematic Reviews. | Kicinski M et al. | β | 2015 | β |
| Radiogenomics helps to achieve personalized therapy by evaluating patient responses to radiation treatment. | Guo Z et al. | β | 2015 | β |
| Rs7574865 polymorphism in signal transducers and activators of transcription 4 gene and rheumatoid arthritis: an updated meta-analysis of 28 case-control comparisons. | Gu E et al. | β | 2015 | β |
| The C957T polymorphism in the dopamine receptor Dβ gene modulates domain-general category learning. | Xie Z et al. | β | 2015 | β |
| The primary open-angle african american glaucoma genetics study: baseline demographics. | Charlson ES et al. | β | 2015 | β |
| The SNP rs4804611 in ZNF627 gene and the risk of myocardial infarction: a meta-analysis. | Wu N et al. | β | 2015 | β |
| Why clinical translation cannot succeed without failure. | London AJ et al. | β | 2015 | β |
| Accounting for linkage disequilibrium in association analysis of diverse populations. | Charles BA et al. | β | 2014 | β |
| Angiotensin-converting enzyme insertion/deletion polymorphism is not a major determining factor in the development of sporadic Alzheimer disease: evidence from an updated meta-analysis. | Wang XB et al. | β | 2014 | β |
| An updated meta-analysis of the association between tumor necrosis factor-Ξ± -308G/A polymorphism and obstructive sleep apnea-hypopnea syndrome. | Zhong A et al. | β | 2014 | β |
| Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. | Cotten CM et al. | β | 2014 | β |
| Aquaporin-4 polymorphisms and brain/body weight ratio in sudden infant death syndrome (SIDS). | Studer J et al. | β | 2014 | β |
| Association between a polymorphism of the vasopressin 1B receptor gene and aggression in children. | Luppino D et al. | β | 2014 | β |
| Association claims in the sequencing era. | Pulit SL et al. | β | 2014 | β |
| Associations between TNF-Ξ±-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis. | Chen S et al. | β | 2014 | β |
| Association study between polymorphisms of PRMT6, PEX10, SOX5, and nonobstructive azoospermia in the Han Chinese population. | Zou S et al. | β | 2014 | β |
| Big data and large sample size: a cautionary note on the potential for bias. | Kaplan RM et al. | β | 2014 | β |
| Bringing rigour to translational medicine. | Howells DW et al. | β | 2014 | β |
| Collaboration in translational neuroscience: a call to arms. | Ivinson AJ | β | 2014 | β |
| Contribution of transforming growth factor Ξ± polymorphisms to nonsyndromic orofacial clefts: a HuGE review and meta-analysis. | Lu XC et al. | β | 2014 | β |
| Digging up the human genome: current progress in deciphering adverse drug reactions. | Su SC et al. | β | 2014 | β |
| Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. | Ciesielski TH et al. | β | 2014 | β |
| Editorial: Updated guidance on human genome epidemiology (HuGE) reviews and meta-analyses of genetic associations. | Gwinn M et al. | β | 2014 | β |
| Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis. | Yoon J et al. | β | 2014 | β |
| Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders. | Forni D et al. | β | 2014 | β |
| Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. | Buford TW et al. | β | 2014 | β |
| Genetic studies of Crohn's disease: past, present and future. | Liu JZ et al. | β | 2014 | β |
| Genetic variants and risk of cervical cancer: epidemiological evidence, meta-analysis and research review. | Zhang X et al. | β | 2014 | β |
| Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future. | Hysi PG et al. | β | 2014 | β |
| Host genetic susceptibility to oral cancer: evidence from meta-analyses and pooled analyses. | Liao G et al. | β | 2014 | β |
| How many effects can dance on the head of a SNP? | Hamilton RM | β | 2014 | β |
| Inconsistent inheritance of telomere length (TL): is offspring TL more strongly correlated with maternal or paternal TL? | Eisenberg DT | β | 2014 | β |
| Integrative genomic analysis for the discovery of biomarkers in prostate cancer. | Hicks C et al. | β | 2014 | β |
| Investigation of complement component C4 copy number variation in human longevity. | Flachsbart F et al. | β | 2014 | β |
| Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS). | ViladΓ©s C et al. | β | 2014 | β |
| Lack of association between DRD2 and OPRM1 genotypes and adiposity. | Hardman CA et al. | β | 2014 | β |
| Lack of associations between Vitamin D metabolism-related gene variants and risk of colorectal cancer. | Mahmoudi T et al. | β | 2014 | β |
| Meta-analysis of candidate gene effects using bayesian parametric and non-parametric approaches. | Wu XL et al. | β | 2014 | β |
| Molecular and genetic epidemiology of cancer in low- and medium-income countries. | Malhotra J | β | 2014 | β |
| Molecular basis and genetic predisposition to intracranial aneurysm. | Tromp G et al. | β | 2014 | β |
| No association between XRCC1 genetic polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis. | Li C et al. | β | 2014 | β |
| On individual genome-wide association studies and their meta-analysis. | Pei YF et al. | β | 2014 | β |
| Personalized medicine to treat arrhythmias. | Roden DM | β | 2014 | β |
| Pharmacogenomics of heart failure. | Lymperopoulos A et al. | β | 2014 | β |
| Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention. | Ioannidis JP et al. | β | 2014 | β |
| Race moderates the association of Catechol-O-methyltransferase genotype and posttraumatic stress disorder in preschool children. | Humphreys KL et al. | β | 2014 | β |
| Resistin -420C>G promoter variant and colorectal cancer risk. | Mahmoudi T et al. | β | 2014 | β |
| Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic. | Kirkpatrick RM et al. | β | 2014 | β |
| Role of genetic factors in the pathogenesis of aggressive periodontitis. | Vieira AR et al. | β | 2014 | β |
| Scientific rigor and the art of motorcycle maintenance. | MunafΓ² M et al. | β | 2014 | β |
| Single nucleotide polymorphisms in nucleotide excision repair genes, cancer treatment, and head and neck cancer survival. | Wyss AB et al. | β | 2014 | β |
| Sodium/proton exchanger 3 (NHE3) and sudden infant death syndrome (SIDS). | Studer J et al. | β | 2014 | β |
| Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. | Chamorro AJ et al. | β | 2014 | β |
| The adolescent origins of substance use disorders: a behavioral genetic perspective. | McGue M et al. | β | 2014 | β |
| The association of CSF-1 gene polymorphism with chronic periodontitis in the Han Chinese population. | Chen D et al. | β | 2014 | β |
| The validity of circulating microRNAs in oncology: five years of challenges and contradictions. | Jarry J et al. | β | 2014 | β |
| TNF-Ξ± gene polymorphisms: association with disease susceptibility and response to anti-TNF-Ξ± treatment in psoriatic arthritis. | Murdaca G et al. | β | 2014 | β |
| Transcription Factor Activating Protein-2Ξ² (TFAP-2Ξ²) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples. | Nilsson KW et al. | β | 2014 | β |
| Understanding disease mechanisms with models of signaling pathway activities. | Sebastian-Leon P et al. | β | 2014 | β |
| Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery. | Langford DJ et al. | β | 2014 | β |
| XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: a meta-analysis. | Qin XP et al. | β | 2014 | β |
| A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1. | Tran C et al. | β | 2013 | β |
| A genetic association study of CCL5 -28 C>G (rs2280788) polymorphism with risk of tuberculosis: a meta-analysis. | Alqumber MA et al. | β | 2013 | β |
| An exon polymorphism of programmed cell death 1 gene is associated with both the susceptibility and thoracolumbar kyphosis severity of ankylosing spondylitis in a Chinese Han population. | Qian BP et al. | β | 2013 | β |
| A pilot study on low-density lipoprotein receptor-related protein-1 in Chinese patients with abdominal aortic aneurysm. | Chan CY et al. | β | 2013 | β |
| Assessment of systematic effects of methodological characteristics on candidate genetic associations. | Aljasir B et al. | β | 2013 | β |
| Association between genetic variants in pre-microRNAs and survival of early-stage NSCLC. | Hong MJ et al. | β | 2013 | β |
| Association of 8q24 rs13281615A > G polymorphism with breast cancer risk: evidence from 40,762 cases and 50,380 controls. | Dai G et al. | β | 2013 | β |
| Association of duffy blood group gene polymorphisms with IL8 gene in chronic periodontitis. | Sippert EΓ et al. | β | 2013 | β |
| Association of genetic risk severity with ADHD clinical characteristics. | Kotte A et al. | β | 2013 | β |
| Association of plasminogen activator inhibitor-type 1 (-675 4G/5G) polymorphism with pre-eclampsia: systematic review. | Morgan JA et al. | β | 2013 | β |
| Association of polymorphisms in the MCP-1 and CCR2 genes with the risk of cancer: a meta-analysis. | Cho YA et al. | β | 2013 | β |
| Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T polymorphisms and susceptibility to type 2 diabetes mellitus: case-control study and meta-analysis. | de Souza BM et al. | β | 2013 | β |
| Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics? | Roden DM | β | 2013 | β |
| Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood. | Sheikh HI et al. | β | 2013 | β |
| Child development and molecular genetics: 14 years later. | Plomin R | β | 2013 | β |
| Dopamine D4 receptor gene variation is associated with context-dependent attention for emotion stimuli. | Wells TT et al. | β | 2013 | β |
| Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis. | Bousman CA et al. | β | 2013 | β |
| Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: a meta-analysis. | Tang ST et al. | β | 2013 | β |
| Evidence-based translational medicine. | Howells DW et al. | β | 2013 | β |
| Genetics of warfarin dosing--one polymorphism at a time. | Alberts MJ | β | 2013 | β |
| Genetic variants in pre-eclampsia: a meta-analysis. | Buurma AJ et al. | β | 2013 | β |
| Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis. | Li C et al. | β | 2013 | β |
| Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds. | Fowler KE et al. | β | 2013 | β |
| Genome-wide association studies in pharmacogenomics: successes and lessons. | Motsinger-Reif AA et al. | β | 2013 | β |
| Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. | Clark SL et al. | β | 2013 | β |
| Glutathione S-transferase T1 gene polymorphism and colorectal cancer risk: an updated analysis. | Qin XP et al. | β | 2013 | β |
| Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle. | Capparelli R et al. | β | 2013 | β |
| Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review. | Duff BJ et al. | β | 2013 | β |
| Immature dentate gyrus: an endophenotype of neuropsychiatric disorders. | Hagihara H et al. | β | 2013 | β |
| Increased risk of major depression by childhood abuse is not modified by CNR1 genotype. | Pearson JF et al. | β | 2013 | β |
| Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age. | Coletta RR et al. | β | 2013 | β |
| Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing. | Westbrook MJ et al. | β | 2013 | β |
| MicroRNA associated with dyslipidemia and coronary disease in humans. | Flowers E et al. | β | 2013 | β |
| Monoamine oxidase A and sudden infant death syndrome. | Klintschar M et al. | β | 2013 | β |
| Oxytocin and social salience: a call for gene-environment interaction research. | Tabak BA | β | 2013 | β |
| Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies. | Aslibekyan S et al. | β | 2013 | β |
| Polymorphism in the CHRNA4 gene is associated with rapid scene categorization performance. | Kikuno Y et al. | β | 2013 | β |
| Potential clinical utility of genetic and platelet function tests in patients on treatment with clopidogrel. | Cattaneo M | β | 2013 | β |
| Predicting the cost and pace of pharmacogenomic advances: an evidence-based study. | Arnaout R et al. | β | 2013 | β |
| Quantifying diet for nutrigenomic studies. | Tucker KL et al. | β | 2013 | β |
| Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children. | Pussegoda K et al. | β | 2013 | β |
| Reporting practices of pharmacodynamic studies involving invasive research procedures in cancer trials. | Freeman GA et al. | β | 2013 | β |
| Rethinking our public health genetics research paradigm. | El-Sayed AM et al. | β | 2013 | β |
| Review of the cost effectiveness of pharmacogenetic-guided treatment of hypercholesterolaemia. | Sorich MJ et al. | β | 2013 | β |
| The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis. | Murphy SE et al. | β | 2013 | β |
| The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches. | Haralambieva IH et al. | β | 2013 | β |
| The genomics of schizophrenia: update and implications. | Giusti-RodrΓguez P et al. | β | 2013 | β |
| The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis. | Capparelli R et al. | β | 2013 | β |
| The myeloperoxidase -463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls. | Chang C et al. | β | 2013 | β |
| The power of meta-analysis in genome-wide association studies. | Panagiotou OA et al. | β | 2013 | β |
| To replicate or not to replicate: the case of pharmacogenetic studies: Establishing validity of pharmacogenomic findings: from replication to triangulation. | Aslibekyan S et al. | β | 2013 | β |
| Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis. | Sun L et al. | β | 2013 | β |
| US studies may overestimate effect sizes in softer research. | Fanelli D et al. | β | 2013 | β |
| Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease. | Anderson JL et al. | β | 2013 | β |
| Why selective publication of statistically significant results can be effective. | de Winter J et al. | β | 2013 | β |
| Why stability is better than instability. | Hadjigeorgiou G | β | 2013 | β |
| Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population. | Caccamo D et al. | β | 2013 | β |
| A common variant in the adiponectin gene and polycystic ovary syndrome risk. | Ranjzad F et al. | β | 2012 | β |
| Ambulatory monitoring in the genetics of psychosomatic medicine. | Finan PH et al. | β | 2012 | β |
| Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia. | Galimova E et al. | β | 2012 | β |
| An association between hOGG1 Ser326Cys polymorphism and the risk of bladder cancer in non-smokers: a meta-analysis. | Ji C et al. | β | 2012 | β |
| A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study. | Zhou S et al. | β | 2012 | β |
| Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis. | Matsuda A et al. | β | 2012 | β |
| Association of DRD2 gene polymorphisms with mood disorders: a meta-analysis. | Zou YF et al. | β | 2012 | β |
| Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case-control studies. | Pan F et al. | β | 2012 | β |
| Association of KIBRA with episodic and working memory: a meta-analysis. | Milnik A et al. | β | 2012 | β |
| Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis. | Guo Y et al. | β | 2012 | β |
| Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: a meta-analysis. | Tang ST et al. | β | 2012 | β |
| A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation. | Verhagen M et al. | β | 2012 | β |
| Biological monitoring of carcinogens: current status and perspectives. | Pavanello S et al. | β | 2012 | β |
| Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. | Lee YH et al. | β | 2012 | β |
| Clinical utility of genetic variants for cardiovascular risk prediction: a futile exercise or insufficient data? | Di Angelantonio E et al. | β | 2012 | β |
| COL1A1 association and otosclerosis: a meta-analysis. | Schrauwen I et al. | β | 2012 | β |
| Consistency of genome-wide associations across major ancestral groups. | Ntzani EE et al. | β | 2012 | β |
| Convergence of genome-wide association and candidate gene studies for alcoholism. | Olfson E et al. | β | 2012 | β |
| CTLA-4 and TNF-Ξ± promoter-308 A/G polymorphisms and ANCA-associated vasculitis susceptibility: a meta-analysis. | Lee YH et al. | β | 2012 | β |
| Distinguishing science from pseudoscience in school psychology: science and scientific thinking as safeguards against human error. | Lilienfeld SO et al. | β | 2012 | β |
| Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: the role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven. | Krishna V et al. | β | 2012 | β |
| Enamel formation genes influence enamel microhardness before and after cariogenic challenge. | Shimizu T et al. | β | 2012 | β |
| Evaluating the evidence for transmission distortion in human pedigrees. | Meyer WK et al. | β | 2012 | β |
| Excess variants in AFF2 detected by massively parallel sequencing of males with autism spectrum disorder. | Mondal K et al. | β | 2012 | β |
| Framework for interpretation of genetic variations in pancreatitis patients. | Whitcomb DC | β | 2012 | β |
| Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia. | Uezato A et al. | β | 2012 | β |
| Genetic association studies in lumbar disc degeneration: a systematic review. | Eskola PJ et al. | β | 2012 | β |
| Genetic determinants of response to cardiovascular drugs. | Wells QS et al. | β | 2012 | β |
| Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. | Bevan S et al. | β | 2012 | β |
| Genetic polymorphism studies in periodontitis and FcΞ³ receptors. | Chai L et al. | β | 2012 | β |
| Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new. | Talameh JA et al. | β | 2012 | β |
| Genetic variation in myosin 1H contributes to mandibular prognathism. | Tassopoulou-Fishell M et al. | β | 2012 | β |
| Genomic research to identify novel pathways in the development of abdominal aortic aneurysm. | Harrison SC et al. | β | 2012 | β |
| Glutathione S-transferase M1 and T1 gene polymorphism and COPD risk in smokers: an updated analysis. | Xue H et al. | β | 2012 | β |
| Glutathione S-transferase T1 polymorphism contributes to bladder cancer risk: a meta-analysis involving 50 studies. | Gong M et al. | β | 2012 | β |
| Heritability of performance deficit accumulation during acute sleep deprivation in twins. | Kuna ST et al. | β | 2012 | β |
| Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. | Collins AL et al. | β | 2012 | β |
| Individual differences in cognition, affect, and performance: behavioral, neuroimaging, and molecular genetic approaches. | Parasuraman R et al. | β | 2012 | β |
| Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate. | Letra A et al. | β | 2012 | β |
| Introduction to genetic association studies. | Lewis CM et al. | β | 2012 | β |
| Knowledge translation of research findings. | Grimshaw JM et al. | β | 2012 | β |
| Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk. | Zhong DY et al. | β | 2012 | β |
| Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. | Mathieson I et al. | β | 2012 | β |
| Meta-analysis of QTL mapping experiments. | Wu XL et al. | β | 2012 | β |
| Molecular classification of breast carcinomas with particular emphasis on "basal-like" carcinoma: a critical review. | Lavasani MA et al. | β | 2012 | β |
| Most reported genetic associations with general intelligence are probably false positives. | Chabris CF et al. | β | 2012 | β |
| Multiple testing in large-scale genetic studies. | Bouaziz M et al. | β | 2012 | β |
| Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. | Morgan AA et al. | β | 2012 | β |
| Oxytocin receptor genetic variation promotes human trust behavior. | Krueger F et al. | β | 2012 | β |
| Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the taiwanese han population. | Wu CH et al. | β | 2012 | β |
| Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. | Chen B et al. | β | 2012 | β |
| Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution? | Cattaneo M | β | 2012 | β |
| Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis. | Nahon P et al. | β | 2012 | β |
| Some surprising twists on the road to discovering the contribution of rare variants to complex diseases. | Thomas DC | β | 2012 | β |
| The -4817 G>A (rs2238136) variant of the vitamin D receptor gene: a probable risk factor for colorectal cancer. | Mahmoudi T et al. | β | 2012 | β |
| The association between UGT1A7 polymorphism and cancer risk: a meta-analysis. | Han SX et al. | β | 2012 | β |
| The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects. | Cai J et al. | β | 2012 | β |
| The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. | Guerreiro RJ et al. | β | 2012 | β |
| The genetics of Alzheimer's disease. | Barber RC | β | 2012 | β |
| The influence of genetic variation on innate immune activation in an environment with high infectious pressure. | Boef AG et al. | β | 2012 | β |
| The role of laboratory monitoring in antiplatelet therapy. | Cattaneo M | β | 2012 | β |
| Tracking replicability as a method of post-publication open evaluation. | Hartshorne JK et al. | β | 2012 | β |
| Understanding cardiovascular disease: a journey through the genome (and what we found there). | Lara-Pezzi E et al. | β | 2012 | β |
| What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. | Panagiotou OA et al. | β | 2012 | β |
| Accounting for population stratification in practice: a comparison of the main strategies dedicated to genome-wide association studies. | Bouaziz M et al. | β | 2011 | β |
| A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population. | Yanagisawa S et al. | β | 2011 | β |
| APOC3 polymorphisms and non-alcoholic fatty liver disease: resolving some doubts and raising others. | Romero-GΓ³mez M | β | 2011 | β |
| A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis. | Varvarigou V et al. | β | 2011 | β |
| Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects. | Curtis J et al. | β | 2011 | β |
| Association of an IL-4 gene haplotype with Graves disease in children: experimental study and meta-analysis. | Lee YJ et al. | β | 2011 | β |
| Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women. | MunafΓ² MR et al. | β | 2011 | β |
| Association of FK506 binding protein 5 (FKBP5) gene rs4713916 polymorphism with mood disorders: a meta-analysis. | Feng XL et al. | β | 2011 | β |
| Association of leptin receptor gene Gln223Arg polymorphism with susceptibility to colorectal cancer. | Karimi K et al. | β | 2011 | β |
| Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis. | Yang Y et al. | β | 2011 | β |
| Association of study characteristics with estimates of effect size in studies of ecstasy use. | Taylor EM et al. | β | 2011 | β |
| Associations between P53 Arg72Pro and development of digestive tract cancers: a meta-analysis. | Liu L et al. | β | 2011 | β |
| Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis. | Peter I et al. | β | 2011 | β |
| BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor gene and periodontitis: a meta-analysis of 15 studies including 1338 cases and 1302 controls. | Deng H et al. | β | 2011 | β |
| Cancer evolution and individual susceptibility. | PΓ©rez-Losada J et al. | β | 2011 | β |
| Cardiovascular pharmacogenomics. | Roden DM et al. | β | 2011 | β |
| Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians. | Jabbari J et al. | β | 2011 | β |
| Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls. | Sergentanis TN et al. | β | 2011 | β |
| Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis. | Sergentanis TN et al. | β | 2011 | β |
| Delivering affordable cancer care in high-income countries. | Sullivan R et al. | β | 2011 | β |
| Developing biobanks in developing countries. | Rudan I et al. | β | 2011 | β |
| Developments in obesity genetics in the era of genome-wide association studies. | Day FR et al. | β | 2011 | β |
| Effect of genome-wide simultaneous hypotheses tests on the discovery rate. | Eyheramendy S et al. | β | 2011 | β |
| ERCC2 Lys751Gln and Asp312Asn polymorphisms and gastric cancer risk: a meta-analysis. | Chen B et al. | β | 2011 | β |
| Gene polymorphisms and periodontitis. | Zhang J et al. | β | 2011 | β |
| Genetic Association Analysis of Dopamine DRD3 Ser9Gly Polymorphism and Schizophrenia in Malay Population. | Tee S et al. | β | 2011 | β |
| Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies. | Peng S et al. | β | 2011 | β |
| Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. | Fenger M et al. | β | 2011 | β |
| Genetic susceptibility and the setting of occupational health standards. | Schulte P et al. | β | 2011 | β |
| Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. Background Document to the ESHG recommendations on genetic testing and common disorders. | Becker F et al. | β | 2011 | β |
| Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. | Zhang B et al. | β | 2011 | β |
| Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis. | Wang Y et al. | β | 2011 | β |
| Genome-wide association studies and susceptibility to infectious diseases. | Newport MJ et al. | β | 2011 | β |
| Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications. | Harrison SC et al. | β | 2011 | β |
| Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. | Sun LD et al. | β | 2011 | β |
| Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. | McClay JL et al. | β | 2011 | β |
| Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. | McClay JL et al. | β | 2011 | β |
| Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis. | Kurotaki N et al. | β | 2011 | β |
| Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. | Bauer T et al. | β | 2011 | β |
| In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes. | Skiba T et al. | β | 2011 | β |
| Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility: a meta-analysis. | Wei YG et al. | β | 2011 | β |
| Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis. | Andia DC et al. | β | 2011 | β |
| Is dietary fat associated with the risk of colorectal cancer? A meta-analysis of 13 prospective cohort studies. | Liu L et al. | β | 2011 | β |
| Lack of association of IL-10 gene polymorphisms with prostate cancer: evidence from 11,581 subjects. | Zou YF et al. | β | 2011 | β |
| Lack of replication for the association between HER2 I655V polymorphism and breast cancer risk: a systematic review and meta-analysis. | Dahabreh IJ et al. | β | 2011 | β |
| Large scale association analysis identifies three susceptibility loci for coronary artery disease. | Saade S et al. | β | 2011 | β |
| Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature. | Bagos PG | β | 2011 | β |
| Molecular Genetics and Economics. | Beauchamp JP et al. | β | 2011 | β |
| No evidence for association between DRD3 and COMT with schizophrenia in a Malay population. | Tee SF et al. | β | 2011 | β |
| No relationship between TNF-Ξ± genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis. | Veloso S et al. | β | 2011 | β |
| Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study. | Oki NO et al. | β | 2011 | β |
| p53 codon 72 polymorphism and liver cancer susceptibility: a meta-analysis of epidemiologic studies. | Chen X et al. | β | 2011 | β |
| Periodontal genetics: a decade of genetic association studies mandates better study designs. | SchΓ€fer AS et al. | β | 2011 | β |
| Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer. | Pander J et al. | β | 2011 | β |
| Pharmacogenomics: the genetics of variable drug responses. | Roden DM et al. | β | 2011 | β |
| Polymorphisms of tumor necrosis factor-alpha and hepatocellular carcinoma risk: a HuGE systematic review and meta-analysis. | Wei Y et al. | β | 2011 | β |
| PON1 Q192R and clopidogrel: a case of the winner's curse or inadequate replication? | Talameh JA et al. | β | 2011 | β |
| Recent human evolution has shaped geographical differences in susceptibility to disease. | Marigorta UM et al. | β | 2011 | β |
| Significance testing as perverse probabilistic reasoning. | Westover MB et al. | β | 2011 | β |
| Start codon FokI and intron 8 BsmI variants in the vitamin D receptor gene and susceptibility to colorectal cancer. | Mahmoudi T et al. | β | 2011 | β |
| Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis. | Grady BJ et al. | β | 2011 | β |
| The hOGG1 Ser326Cys polymorphism and prostate cancer risk: a meta-analysis of 2584 cases and 3234 controls. | Zhang H et al. | β | 2011 | β |
| The influence of three genes on whether adolescents use contraception, USA 1994-2002. | Daw J et al. | β | 2011 | β |
| The meta-analysis of genome-wide association studies. | Thompson JR et al. | β | 2011 | β |
| Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. | Breitling LP et al. | β | 2011 | β |
| Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. | Yuan J et al. | β | 2011 | β |
| Utility of genetic determinants of lipids and cardiovascular events in assessing risk. | Holmes MV et al. | β | 2011 | β |
| Validation in genetic association studies. | KΓΆnig IR | β | 2011 | β |
| Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? | Burn GL et al. | β | 2011 | β |
| A comparison of internal validation techniques for multifactor dimensionality reduction. | Winham SJ et al. | β | 2010 | β |
| A confidence-limit-based approach to the assessment of Hardy-Weinberg equilibrium. | Wellek S et al. | β | 2010 | β |
| A functional polymorphism in the pre-microRNA-196a2 and the risk of lung cancer in a Korean population. | Kim MJ et al. | β | 2010 | β |
| Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study. | MΓΆller M et al. | β | 2010 | β |
| Analysis of three functional polymorphisms in relation to osteoporosis phenotypes: replication in a Spanish cohort. | Agueda L et al. | β | 2010 | β |
| An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction. | Carlquist JF et al. | β | 2010 | β |
| Angiotensin-converting enzyme insertion/deletion polymorphism associated with acute respiratory distress syndrome among caucasians. | Hu Z et al. | β | 2010 | β |
| Antidepressant response and the serotonin transporter gene-linked polymorphic region. | Taylor MJ et al. | β | 2010 | β |
| An update on the genetics of atopic dermatitis: scratching the surface in 2009. | Barnes KC | β | 2010 | β |
| A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies. | Terry KL et al. | β | 2010 | β |
| Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. | Glubb DM et al. | β | 2010 | β |
| Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters. | Safarinejad MR et al. | β | 2010 | β |
| Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. | Campos SB et al. | β | 2010 | β |
| Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. | Clarke H et al. | β | 2010 | β |
| Association of the fatty acid-binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta-analysis in 13451 subjects. | Zhao T et al. | β | 2010 | β |
| Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli. | Kwang T et al. | β | 2010 | β |
| Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners. | Tsianos GI et al. | β | 2010 | β |
| Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. | Galvan A et al. | β | 2010 | β |
| Candidate gene association studies: successes and failures. | Pasche B et al. | β | 2010 | β |
| Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis. | Hutter CM et al. | β | 2010 | β |
| Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. | Cho MH et al. | β | 2010 | β |
| Complex gene-chemical interactions: hepatic uroporphyria as a paradigm. | Smith AG et al. | β | 2010 | β |
| Credible genetic associations? | MunafΓ² MR | β | 2010 | β |
| Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. | Weng KP et al. | β | 2010 | β |
| Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis. | Tian Y et al. | β | 2010 | β |
| Effectiveness of strategies to increase the validity of findings from association studies: size vs. replication. | Weitkunat R et al. | β | 2010 | β |
| Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. | Hwang R et al. | β | 2010 | β |
| [Endometriosis and genetics: what responsibility for the genes?]. | Borghese B et al. | β | 2010 | β |
| Estimating effect sizes in genome-wide association studies. | BukszΓ‘r J et al. | β | 2010 | β |
| Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis. | Dimou NL et al. | β | 2010 | β |
| From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders. | Wermter AK et al. | β | 2010 | β |
| Genetics of Alzheimer disease in the pre- and post-GWAS era. | Ertekin-Taner N | β | 2010 | β |
| Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? | van der Zanden LF et al. | β | 2010 | β |
| Genetic studies of IgA nephropathy: past, present, and future. | Kiryluk K et al. | β | 2010 | β |
| Genetic susceptibility factors for multiple chemical sensitivity revisited. | Berg ND et al. | β | 2010 | β |
| Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations. | Schrauwen I et al. | β | 2010 | β |
| Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. | Poynter JN et al. | β | 2010 | β |
| Genome-wide association studies of hypertension: light at the end of the tunnel. | Hastie CE et al. | β | 2010 | β |
| Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. | Panagiotou OA et al. | β | 2010 | β |
| Glutathione S-transferase M1 gene polymorphism and gastric cancer risk: an updated analysis. | Chen B et al. | β | 2010 | β |
| Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians. | Wang H et al. | β | 2010 | β |
| Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiologic studies. | Chen B et al. | β | 2010 | β |
| Heritability of body weight: moving beyond genetics. | Russo P et al. | β | 2010 | β |
| High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. | Giroux S et al. | β | 2010 | β |
| Interleukin10 -592 promoter polymorphism associated with gastric cancer among Asians: a meta-analysis of epidemiologic studies. | Zhuang W et al. | β | 2010 | β |
| Joint identification of multiple genetic variants via elastic-net variable selection in a genome-wide association analysis. | Cho S et al. | β | 2010 | β |
| Judging a plethora of p-values: how to contend with the problem of multiple testing--part 10 of a series on evaluation of scientific publications. | Victor A et al. | β | 2010 | β |
| Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population. | Liu Z et al. | β | 2010 | β |
| Lower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important? | Gruber R et al. | β | 2010 | β |
| Methodological issues of genetic association studies. | Simundic AM | β | 2010 | β |
| Methods: genetic epidemiology. | Benke KS et al. | β | 2010 | β |
| Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. | Wagner S et al. | β | 2010 | β |
| Molecular biology and genetics in clinical chemistry and laboratory medicine. | Whitfield JB | β | 2010 | β |
| Molecular genetics of attention-deficit/hyperactivity disorder: an overview. | Banaschewski T et al. | β | 2010 | β |
| MTHFR polymorphisms in relation to ovarian cancer risk. | Terry KL et al. | β | 2010 | β |
| Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention? | Reinvang I et al. | β | 2010 | β |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. | Dupuis J et al. | β | 2010 | β |
| No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. | Apicella CL et al. | β | 2010 | β |
| Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis. | Dahabreh IJ et al. | β | 2010 | β |
| Pathway genetic load allows simultaneous evaluation of multiple genetic associations. | Huebinger RM et al. | β | 2010 | β |
| Personalized medicine for depression: can we match patients with treatments? | Simon GE et al. | β | 2010 | β |
| Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17. | Li-Wan-Po A et al. | β | 2010 | β |
| Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle. | Pander J et al. | β | 2010 | β |
| Points to consider in assessing and appraising predictive genetic tests. | Rogowski WH et al. | β | 2010 | β |
| Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis. | Wang J et al. | β | 2010 | β |
| Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India. | Srivastava K et al. | β | 2010 | β |
| Polymorphisms in KCNE1 or KCNE3 are not associated with MΓ©niΓ¨re disease in the Caucasian population. | Campbell CA et al. | β | 2010 | β |
| Practical issues in building risk-predicting models for complex diseases. | Kang J et al. | β | 2010 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2010 | β |
| Race, socioeconomic status, and health: complexities, ongoing challenges, and research opportunities. | Williams DR et al. | β | 2010 | β |
| Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study. | Safarinejad MR et al. | β | 2010 | β |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | β | 2010 | β |
| Reproducible science. | Casadevall A et al. | β | 2010 | β |
| Serotonin transporter and BDNF genetic variants interact to predict cognitive reactivity in healthy adults. | Wells TT et al. | β | 2010 | β |
| Shining light on the microbial world the application of Raman microspectroscopy. | Huang WE et al. | β | 2010 | β |
| Spontaneous arterial dissection: phenotype and molecular pathogenesis. | Grond-Ginsbach C et al. | β | 2010 | β |
| The application of genetics to inherited bleeding disorders. | James P et al. | β | 2010 | β |
| The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility. | Navarro-Costa P et al. | β | 2010 | β |
| The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). | Wagner S et al. | β | 2010 | β |
| The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis. | Tsai HT et al. | β | 2010 | β |
| The end of behavioral genetics? 2008. | McGue M | β | 2010 | β |
| The genetic epidemiology of personality disorders. | Reichborn-Kjennerud T | β | 2010 | β |
| Use of quality control charts for detection of outliers and temporal trends in cumulative meta-analysis. | Kulinskaya E et al. | β | 2010 | β |
| Validation of Serbian version of the disease-specific myasthenia gravis questionnaire. | Basta I et al. | β | 2010 | β |
| Alzheimer's disease genetics current status and future perspectives. | Bertram L | β | 2009 | β |
| An empirical comparison of meta-analyses of published gene-disease associations versus consortium analyses. | Janssens AC et al. | β | 2009 | β |
| An evolutionary approach to the medical implications of the tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) gene. | Sazzini M et al. | β | 2009 | β |
| APOE gene polymorphisms and response to statin therapy. | Zintzaras E et al. | β | 2009 | β |
| A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. | Huffaker SJ et al. | β | 2009 | β |
| Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. | Rogers AJ et al. | β | 2009 | β |
| Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. | Perez-Martinez P et al. | β | 2009 | β |
| Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. | Song H et al. | β | 2009 | β |
| Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. | Ji GR et al. | β | 2009 | β |
| Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach. | Castro FA et al. | β | 2009 | β |
| Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese. | Shi YM et al. | β | 2009 | β |
| Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers. | Speletas M et al. | β | 2009 | β |
| Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. | Haas DW et al. | β | 2009 | β |
| A truncation in the aryl hydrocarbon receptor of the CRL:WI(Han) rat does not affect the developmental toxicity of TCDD. | Jiang T et al. | β | 2009 | β |
| Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). | Limer KL et al. | β | 2009 | β |
| Building a knowledge base on genetic variation and cancer risk through field synopses. | Yesupriya A et al. | β | 2009 | β |
| Candidate gene studies of ADHD: a meta-analytic review. | Gizer IR et al. | β | 2009 | β |
| Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. | Cunningham JM et al. | β | 2009 | β |
| Challenges of translating genetic tests into clinical and public health practice. | Rogowski WH et al. | β | 2009 | β |
| Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. | Psaty BM et al. | β | 2009 | β |
| Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men. | Marcos M et al. | β | 2009 | β |
| CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti. | Leger P et al. | β | 2009 | β |
| Endothelial NO synthase gene polymorphisms and risk of ischemic stroke: a meta-analysis. | Tao HM et al. | β | 2009 | β |
| Epistasis in sporadic Alzheimer's disease. | Combarros O et al. | β | 2009 | β |
| Estimating the posterior probability that genome-wide association findings are true or false. | BukszΓ‘r J et al. | β | 2009 | β |
| Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: a systematic review and meta-analysis focusing on gene polymorphism. | Takeuchi M et al. | β | 2009 | β |
| Evaluating the ability of tree-based methods and logistic regression for the detection of SNP-SNP interaction. | GarcΓa-MagariΓ±os M et al. | β | 2009 | β |
| Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms. | Sull JW et al. | β | 2009 | β |
| Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. | Holmes MV et al. | β | 2009 | β |
| Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology. | Bagos PG et al. | β | 2009 | β |
| Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis. | Ionita-Laza I et al. | β | 2009 | β |
| Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia. | Jugessur A et al. | β | 2009 | β |
| Genetics of chronic obstructive pulmonary disease: a succinct review, future avenues and prospective clinical applications. | BossΓ© Y | β | 2009 | β |
| Genetic variants in surfactant, pulmonary-associated protein D (SFTPD) and Japanese susceptibility to ulcerative colitis. | Tanaka M et al. | β | 2009 | β |
| Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. | Su L et al. | β | 2009 | β |
| Genoeconomics: promises and caveats for a new field. | Navarro A | β | 2009 | β |
| Genomics of type 2 diabetes mellitus: implications for the clinician. | Stolerman ES et al. | β | 2009 | β |
| Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians. | Zhou Y et al. | β | 2009 | β |
| Human genetics and resistance to parasitic infection. | Shaw MA et al. | β | 2009 | β |
| Human V-ATPase gene can protect or predispose the host to pulmonary tuberculosis. | Capparelli R et al. | β | 2009 | β |
| Impossibility of successful classification when useful features are rare and weak. | Jin J | β | 2009 | β |
| Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India. | Gangwar R et al. | β | 2009 | β |
| Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder. | TadiΔ A et al. | β | 2009 | β |
| Interaction between HNF4A polymorphisms and physical activity in relation to type 2 diabetes-related traits: results from the Quebec Family Study. | Ruchat SM et al. | β | 2009 | β |
| Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. | Salas A et al. | β | 2009 | β |
| Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial. | MunafΓ² MR et al. | β | 2009 | β |
| Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. | Nakaoka H et al. | β | 2009 | β |
| Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype. | Lambrechts D et al. | β | 2009 | β |
| Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C. | Mirandola S et al. | β | 2009 | β |
| Multiple genetic tests for susceptibility to smoking do not outperform simple family history. | Gartner CE et al. | β | 2009 | β |
| No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. | Schrauwen I et al. | β | 2009 | β |
| Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there? | Rimbach G et al. | β | 2009 | β |
| Plasminogen activator inhibitor-1 4G/5G and 5,10-methylene-tetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndrome. | Bagos PG | β | 2009 | β |
| Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. | Tewfik MA et al. | β | 2009 | β |
| Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions and gastric cancer. | Zhuang W et al. | β | 2009 | β |
| Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation. | Ambruzova Z et al. | β | 2009 | β |
| Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. | Ioannidis JP | β | 2009 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2009 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2009 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2009 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2009 | β |
| Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. | Moher D et al. | β | 2009 | β |
| Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. | Chang MH et al. | β | 2009 | β |
| Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women. | LluΓs-Ganella C et al. | β | 2009 | β |
| Quantifying and correcting for the winner's curse in genetic association studies. | Xiao R et al. | β | 2009 | β |
| Recent advances in the genetics of autoimmune disease. | Gregersen PK et al. | β | 2009 | β |
| Reliability and replicability of genetic association studies. | MunafΓ² MR | β | 2009 | β |
| Replication and heterogeneity in gene x environment interaction studies. | MunafΓ² MR et al. | β | 2009 | β |
| Replication of genes for asthma: the importance of well-designed studies. | Litonjua AA et al. | β | 2009 | β |
| Replication of genetic associations as pseudoreplication due to shared genealogy. | Rosenberg NA et al. | β | 2009 | β |
| Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations. | Ovsyannikova IG et al. | β | 2009 | β |
| Reporting and evaluating genetic association studies. | Peters SP | β | 2009 | β |
| Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | Moher D et al. | β | 2009 | β |
| Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. | Suarez-Gestal M et al. | β | 2009 | β |
| Role and therapeutic potential of VEGF in the nervous system. | Ruiz de Almodovar C et al. | β | 2009 | β |
| [Role of tyrosine kinases in tumor progression of the head and neck]. | Bergmann C et al. | β | 2009 | β |
| Shared susceptibility variations in autoimmune diseases: a brief perspective on common issues. | Seldin MF et al. | β | 2009 | β |
| Significance of apolipoprotein E in subarachnoid hemorrhage: neuronal injury, repair, and therapeutic perspectives--a review. | Lanterna LA et al. | β | 2009 | β |
| Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. | Burton PR et al. | β | 2009 | β |
| Stewardship of human biospecimens, DNA, genotype, and clinical data in the GWAS era. | O'Brien SJ | β | 2009 | β |
| Support for the involvement of the KCNK2 gene in major depressive disorder and response to antidepressant treatment. | Liou YJ et al. | β | 2009 | β |
| Systematic reviews of genetic association studies. Human Genome Epidemiology Network. | Sagoo GS et al. | β | 2009 | β |
| The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder. | Wagner S et al. | β | 2009 | β |
| The clinical utility of genetic tests. | MunafΓ² MR | β | 2009 | β |
| The cost-effectiveness of screening for hereditary hemochromatosis in Germany: a remodeling study. | Rogowski WH | β | 2009 | β |
| The genetics of acute lung injury: looking back and pointing the way forward. | Bajwa EK | β | 2009 | β |
| The genetics of human autoimmune disease. | Invernizzi P et al. | β | 2009 | β |
| The latest news from the GENOMOS study. | Uitterlinden AG | β | 2009 | β |
| The quality of meta-analyses of genetic association studies: a review with recommendations. | Minelli C et al. | β | 2009 | β |
| TLR4 as a risk factor for periodontal disease: a reappraisal. | Ozturk A et al. | β | 2009 | β |
| Transforming growth factor-alfa gene (TGFA), human tooth agenesis, and evidence of segmental uniparental isodisomy. | Callahan N et al. | β | 2009 | β |
| Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. | Hersh CP et al. | β | 2009 | β |
| Translating genomics into the clinic: moving to the post-Mendelian world. | Cho MK | β | 2009 | β |
| TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study. | Xu C et al. | β | 2009 | β |
| Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis. | Marcos M et al. | β | 2009 | β |
| Underlying genetic models of inheritance in established type 2 diabetes associations. | Salanti G et al. | β | 2009 | β |
| Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. | Pearce CL et al. | β | 2009 | β |
| Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. | Horne BD et al. | β | 2009 | β |
| Vilazodone, a novel, dual-acting antidepressant: current status, future promise and potential for individualized treatment of depression. | Rickels K et al. | β | 2009 | β |
| Which are the greatest recent discoveries and the greatest future challenges in nutrition? | Katan MB et al. | β | 2009 | β |
| Why are so many epidemiology associations inflated or wrong? Does poorly conducted animal research suggest implausible hypotheses? | Bracken MB | β | 2009 | β |
| A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. | Crawford DC et al. | β | 2008 | β |
| A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. | Janssens AC et al. | β | 2008 | β |
| A functional polymorphism in the tyrosine hydroxylase gene indicates a role of noradrenalinergic signaling in sudden infant death syndrome. | Klintschar M et al. | β | 2008 | β |
| Age-related macular degeneration is associated with the HLA-Cw*0701 Genotype and the natural killer cell receptor AA haplotype. | Goverdhan SV et al. | β | 2008 | β |
| Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis. | Fenger M et al. | β | 2008 | β |
| A network of dopaminergic gene variations implicated as risk factors for schizophrenia. | Talkowski ME et al. | β | 2008 | β |
| A pro-inflammatory genotype predisposes to Barrett's esophagus. | Moons LM et al. | β | 2008 | β |
| Are genes really important in alcoholic liver disease? | Machado M et al. | β | 2008 | β |
| Assessment of cumulative evidence on genetic associations: interim guidelines. | Ioannidis JP et al. | β | 2008 | β |
| Association of calpain-10 polymorphisms with type 2 diabetes in the Tunisian population. | Kifagi C et al. | β | 2008 | β |
| Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level. | Stefanis NC et al. | β | 2008 | β |
| Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data. | MunafΓ² MR et al. | β | 2008 | β |
| Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. | Li N et al. | β | 2008 | β |
| Associations between XPC polymorphisms and risk of cancers: A meta-analysis. | Qiu L et al. | β | 2008 | β |
| Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer. | Song H et al. | β | 2008 | β |
| Asthma genetics: from linear to multifactorial approaches. | Guerra S et al. | β | 2008 | β |
| A study on the TNF-alpha system in Caucasian Spanish patients with alcoholic liver disease. | Auguet T et al. | β | 2008 | β |
| Bias in genetic association studies: effects of research location and resources. | MunafΓ² MR et al. | β | 2008 | β |
| Calibration of credibility of agnostic genome-wide associations. | Ioannidis JP | β | 2008 | β |
| Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. | Hettema JM et al. | β | 2008 | β |
| Catmap: case-control and TDT meta-analysis package. | Nicodemus KK | β | 2008 | β |
| Chromogranin A polymorphisms are associated with hypertensive renal disease. | Salem RM et al. | β | 2008 | β |
| Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients. | Kiser JJ et al. | β | 2008 | β |
| Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis. | Mrazek F et al. | β | 2008 | β |
| Controlling false discoveries in genetic studies. | van den Oord EJ | β | 2008 | β |
| CYP17 MspA1 polymorphism and age at menarche: a meta-analysis. | Pei YF et al. | β | 2008 | β |
| Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls. | Nikolopoulos GK et al. | β | 2008 | β |
| Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery. | Hutcheson HB et al. | β | 2008 | β |
| Effect of formal statistical significance on the credibility of observational associations. | Ioannidis JP | β | 2008 | β |
| Enamel formation genes are associated with high caries experience in Turkish children. | Patir A et al. | β | 2008 | β |
| Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury. | Barber RC et al. | β | 2008 | β |
| Estimating odds ratios in genome scans: an approximate conditional likelihood approach. | Ghosh A et al. | β | 2008 | β |
| Ethical, legal, and social implications of biobanks for genetics research. | Haga SB et al. | β | 2008 | β |
| Evaluating candidate genes in common epilepsies and the nature of evidence. | Pal DK et al. | β | 2008 | β |
| Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. | Kavvoura FK et al. | β | 2008 | β |
| Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease. | Osterreicher CH et al. | β | 2008 | β |
| Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. | Knowles JW et al. | β | 2008 | β |
| False-positive results in cancer epidemiology: a plea for epistemological modesty. | Boffetta P et al. | β | 2008 | β |
| Forum: The case for gene-environment interactions in psychiatry. | Uher R | β | 2008 | β |
| From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. | Nebert DW et al. | β | 2008 | β |
| Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge. | Armstrong DL et al. | β | 2008 | β |
| Gene by social context interactions for number of sexual partners among white male youths: genetics-informed sociology. | Guo G et al. | β | 2008 | β |
| Gene-environment interactions for complex traits: definitions, methodological requirements and challenges. | Dempfle A et al. | β | 2008 | β |
| Genetic association analysis: a primer on how it works, its strengths and its weaknesses. | Rodriguez-Murillo L et al. | β | 2008 | β |
| Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review. | Ryder JJ et al. | β | 2008 | β |
| Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. | Lim JK et al. | β | 2008 | β |
| Genetic determinants of drug response in heart failure. | Lowes BD et al. | β | 2008 | β |
| Genetic developments in autoimmune thyroid disease: an evolutionary process. | Zeitlin AA et al. | β | 2008 | β |
| Genetic epidemiology of human schistosomiasis in Brazil. | Bethony JM et al. | β | 2008 | β |
| Genetic polymorphisms and endometrial cancer risk. | Meyer LA et al. | β | 2008 | β |
| Genetic polymorphisms in susceptibility to Type 1 Diabetes. | Alizadeh BZ et al. | β | 2008 | β |
| Genetic research in schizophrenia: new tools and future perspectives. | Bertram L | β | 2008 | β |
| Genetics of personality disorders. | Reichborn-Kjennerud T | β | 2008 | β |
| Genetic susceptibility loci for breast cancer by estrogen receptor status. | Garcia-Closas M et al. | β | 2008 | β |
| Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. | Dong LM et al. | β | 2008 | β |
| Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility. | Anderson JL et al. | β | 2008 | β |
| Genome-wide association studies: progress and potential for drug discovery and development. | Kingsmore SF et al. | β | 2008 | β |
| Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. | Butcher LM et al. | β | 2008 | β |
| Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. | Turner ST et al. | β | 2008 | β |
| Human genome epidemiology: reviewing the stakes. | Grace VM | β | 2008 | β |
| Identifying susceptibility to inflammatory bowel diseases: a candidate gene approach, genome-wide association studies, or both? | Pavli P et al. | β | 2008 | β |
| Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. | Hamsten A et al. | β | 2008 | β |
| IGF-I (CA) repeat polymorphisms and risk of cancer: a meta-analysis. | Chen X et al. | β | 2008 | β |
| Interleukin-10 -1082 promoter polymorphism associated with gastric cancer among Asians. | Zhou Y et al. | β | 2008 | β |
| Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. | Grundberg E et al. | β | 2008 | β |
| Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. | KΓΌry S et al. | β | 2008 | β |
| Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. | Rantala A et al. | β | 2008 | β |
| Mannose-binding lectin haplotypes influence Brucella abortus infection in the water buffalo (Bubalus bubalis). | Capparelli R et al. | β | 2008 | β |
| MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis. | Navratilova Z et al. | β | 2008 | β |
| Meta-analysis methods. | Trikalinos TA et al. | β | 2008 | β |
| Methodological quality of pharmacogenetic studies: issues of concern. | Jorgensen AL et al. | β | 2008 | β |
| Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. | Kavvoura FK et al. | β | 2008 | β |
| Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2). | Whitcomb DC et al. | β | 2008 | β |
| National Emphysema Treatment Trial state of the art: genetics of emphysema. | Hersh CP et al. | β | 2008 | β |
| Nested randomized trials in large cohorts and biobanks: studying the health effects of lifestyle factors. | Ioannidis JP et al. | β | 2008 | β |
| No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease. | Stickel F et al. | β | 2008 | β |
| NOS1AP in schizophrenia. | Brzustowicz LM | β | 2008 | β |
| On the replication of genetic associations: timing can be everything! | Lasky-Su J et al. | β | 2008 | β |
| Partial AZFc deletions and duplications: clinical correlates in the Italian population. | Giachini C et al. | β | 2008 | β |
| Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis. | Aoun E et al. | β | 2008 | β |
| Pharmacogenomics and drug development: the impact of US FDA postapproval tracking on clinical pharmacology. | Farrell E et al. | β | 2008 | β |
| Polycystic ovary syndrome is a family affair. | Azziz R | β | 2008 | β |
| Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions. | Mechanic LE et al. | β | 2008 | β |
| Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis. | Maguire JM et al. | β | 2008 | β |
| Psoriatic arthritis: genetic susceptibility and pharmacogenetics. | Rahman P et al. | β | 2008 | β |
| Replication of associations between LRP5 and ESRRA variants and bone density in premenopausal women. | Giroux S et al. | β | 2008 | β |
| Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. | van der Net JB et al. | β | 2008 | β |
| Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. | Yesupriya A et al. | β | 2008 | β |
| Required sample size and nonreplicability thresholds for heterogeneous genetic associations. | Moonesinghe R et al. | β | 2008 | β |
| Research review: DSM-V conduct disorder: research needs for an evidence base. | Moffitt TE et al. | β | 2008 | β |
| Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. | Patsopoulos NA et al. | β | 2008 | β |
| Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. | MunafΓ² MR et al. | β | 2008 | β |
| Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. | Allen NC et al. | β | 2008 | β |
| Telomeres and race: what can we learn about human biology from health differentials? | Kaufman JS et al. | β | 2008 | β |
| The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. | Le Strat Y et al. | β | 2008 | β |
| The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese children. | Huang FY et al. | β | 2008 | β |
| The association of genetic variants in KrΓΌppel-like factor 11 and Type 2 diabetes in the Japanese population. | Tanahashi T et al. | β | 2008 | β |
| The End of Behavioral Genetics? | McGue M | β | 2008 | β |
| The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. | McAteer JB et al. | β | 2008 | β |
| The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases. | Eike MC et al. | β | 2008 | β |
| The helix in the labyrinth: do we need genetic health services and policy research? | Miller FA et al. | β | 2008 | β |
| The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. | Tuo J et al. | β | 2008 | β |
| The influence of genetics on intracranial aneurysm formation and rupture: current knowledge and its possible impact on future treatment. | Krischek B et al. | β | 2008 | β |
| The search for genes contributing to endometriosis risk. | Montgomery GW et al. | β | 2008 | β |
| Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis. | Gorouhi F et al. | β | 2008 | β |
| Using genetic data in cognitive neuroscience: from growing pains to genuine insights. | Green AE et al. | β | 2008 | β |
| Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. | Li H et al. | β | 2008 | β |
| Why most discovered true associations are inflated. | Ioannidis JP | β | 2008 | β |
| XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis. | Geng J et al. | β | 2008 | β |
| A follow-up study of Nordic multiple sclerosis candidate gene regions. | Datta P et al. | β | 2007 | β |
| A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders. | Coon KD et al. | β | 2007 | β |
| Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. | Ralph DA et al. | β | 2007 | β |
| A letter to the editor in reply to "susceptibility to guillain-barre syndrome is associated to polymorphisms of CD1 genes" by Caporale et al. in the J of Neuroimmunology (2006), 177:112-118. | Bang H et al. | β | 2007 | β |
| A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. | Yang B et al. | β | 2007 | β |
| Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. | Clerget-Darpoux F et al. | β | 2007 | β |
| Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. | Levin AM et al. | β | 2007 | β |
| Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium. | Salanti G et al. | β | 2007 | β |
| Bias in association studies of systemic lupus erythematosus susceptibility due to geographical variation in the frequency of a programmed cell death 1 polymorphism across Europe. | Ferreiros-Vidal I et al. | β | 2007 | β |
| Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. | Tang F et al. | β | 2007 | β |
| Characterization of breast cancer by array comparative genomic hybridization. | Climent J et al. | β | 2007 | β |
| Commentary: rare alleles, modest genetic effects and the need for collaboration. | Campbell H et al. | β | 2007 | β |
| Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk. | Falvella FS et al. | β | 2007 | β |
| Comprehensive testing of positionally cloned asthma genes in two populations. | Hersh CP et al. | β | 2007 | β |
| Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. | Arnedo M et al. | β | 2007 | β |
| Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. | Johnson N et al. | β | 2007 | β |
| Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. | Kavvoura FK et al. | β | 2007 | β |
| Detection of gene x gene interactions in genome-wide association studies of human population data. | Musani SK et al. | β | 2007 | β |
| [Diffusion of genetic testing in oncology: what criteria for regulation?]. | Eisinger F et al. | β | 2007 | β |
| Dopamine genes and schizophrenia: case closed or evidence pending? | Talkowski ME et al. | β | 2007 | β |
| Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a cohort of Spanish HIV-1-infected subjects. | ViladΓ©s C et al. | β | 2007 | β |
| Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. | Barnett JH et al. | β | 2007 | β |
| Estimating the number and size of the main effects in genome-wide case-control association studies. | Kuo PH et al. | β | 2007 | β |
| Familial CLL: genes and environment. | Goldin LR et al. | β | 2007 | β |
| Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma. | Rogers AJ et al. | β | 2007 | β |
| Fine mapping versus replication in whole-genome association studies. | Clarke GM et al. | β | 2007 | β |
| -G308A tumor necrosis factor alpha functional polymorphism and schizophrenia risk: meta-analysis plus association study. | Sacchetti E et al. | β | 2007 | β |
| Genetic influences on outcome following traumatic brain injury. | Jordan BD | β | 2007 | β |
| Genetic predisposition to asthma and atopy. | Contopoulos-Ioannidis DG et al. | β | 2007 | β |
| Genetics of Alzheimer's disease: a centennial review. | Ertekin-Taner N | β | 2007 | β |
| Genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases. | Kingsmore SF et al. | β | 2007 | β |
| Genotype-specific weight loss treatment advice: how close are we? | Adamo KB et al. | β | 2007 | β |
| Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes. | De Cosmo S et al. | β | 2007 | β |
| G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. | Renner W et al. | β | 2007 | β |
| Heterogeneity in meta-analyses of genome-wide association investigations. | Ioannidis JP et al. | β | 2007 | β |
| Horizons in SjΓΆgren's syndrome genetics. | Williams PH et al. | β | 2007 | β |
| Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. | Crawford DC et al. | β | 2007 | β |
| Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects. | Fontana P et al. | β | 2007 | β |
| Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis. | Lee CC et al. | β | 2007 | β |
| Large-scale population-based study shows no association between common polymorphisms of the TGFB1 gene and BMD in women. | McGuigan FE et al. | β | 2007 | β |
| Large-scale zygosity testing using single nucleotide polymorphisms. | Hannelius U et al. | β | 2007 | β |
| Linkage disequilibrium mapping for complex disease genes. | DeWan A et al. | β | 2007 | β |
| Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia. | Farrer MJ et al. | β | 2007 | β |
| LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. | Francks C et al. | β | 2007 | β |
| Mechanisms of disease: The genetic basis of coronary heart disease. | Kullo IJ et al. | β | 2007 | β |
| Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. | Evangelou E et al. | β | 2007 | β |
| Meta-analysis of association between the ASPN D-repeat and osteoarthritis. | Nakamura T et al. | β | 2007 | β |
| Meta-analysis of gene-environment interactions in developmental psychopathology. | Taylor A et al. | β | 2007 | β |
| Migraine: a complex genetic disorder. | Wessman M et al. | β | 2007 | β |
| Molecular analysis of estrogen receptor alpha gene AGATA haplotype and SNP12 in European populations: potential protective effect for cryptorchidism and lack of association with male infertility. | Galan JJ et al. | β | 2007 | β |
| Molecular evidence-based medicine: evolution and integration of information in the genomic era. | Ioannidis JP | β | 2007 | β |
| Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease. | Horne BD et al. | β | 2007 | β |
| NCAM1 and neurocognition in schizophrenia. | Sullivan PF et al. | β | 2007 | β |
| Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. | Lopez VA et al. | β | 2007 | β |
| Non-replication and inconsistency in the genome-wide association setting. | Ioannidis JP | β | 2007 | β |
| Non-replication of association studies: "pseudo-failures" to replicate? | Gorroochurn P et al. | β | 2007 | β |
| Online genetic databases informing human genome epidemiology. | Frodsham AJ et al. | β | 2007 | β |
| PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. | Lee YH et al. | β | 2007 | β |
| Pharmacogenetics of the response to beta 2 agonist drugs: a systematic overview of the field. | Contopoulos-Ioannidis DG et al. | β | 2007 | β |
| Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. | Rajaraman P et al. | β | 2007 | β |
| Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma. | Lima CS et al. | β | 2007 | β |
| Polymorphisms in the 3' untranslated region of the fractalkine (CX3CL1) gene and the risk of HIV-1 infection and disease progression. | Peraire J et al. | β | 2007 | β |
| Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease. | Kooloos WM et al. | β | 2007 | β |
| Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes. | Wessel J et al. | β | 2007 | β |
| Progress in unraveling the genetics of coronary artery disease and myocardial infarction. | Anderson JL et al. | β | 2007 | β |
| Replicating genotype-phenotype associations. | NCI-NHGRI Working Group on Replication in Association Studies et al. | β | 2007 | β |
| Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. | Willer CJ et al. | β | 2007 | β |
| Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect. | Lei SF et al. | β | 2007 | β |
| Spurious genetic associations. | Sullivan PF | β | 2007 | β |
| Studying genetic predisposition among small-for-gestational-age newborns. | Infante-Rivard C | β | 2007 | β |
| Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. | Bertram L et al. | β | 2007 | β |
| The endophenotype concept in psychiatric genetics. | Flint J et al. | β | 2007 | β |
| The genetic basis of complex traits: rare variants or "common gene, common disease"? | Iyengar SK et al. | β | 2007 | β |
| The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population. | Hansen PS et al. | β | 2007 | β |
| The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism. | Grundberg E et al. | β | 2007 | β |
| The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. | Ross RJ et al. | β | 2007 | β |
| The Nramp1AA genotype confers susceptibility to Brucella abortus in water buffalo. | Capparelli R et al. | β | 2007 | β |
| The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. | Prudente S et al. | β | 2007 | β |
| The role of genetic polymorphisms in periodontitis. | Yoshie H et al. | β | 2007 | β |
| The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. | De Jager PL et al. | β | 2007 | β |
| The search for genetic variants predisposing women to endometriosis. | Di W et al. | β | 2007 | β |
| Toward a comprehensive set of asthma susceptibility genes. | BossΓ© Y et al. | β | 2007 | β |
| Toxicogenetics of antiretroviral therapy: genetic factors that contribute to metabolic complications. | Tarr PE et al. | β | 2007 | β |
| Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan. | Warren LL et al. | β | 2007 | β |
| Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study. | StengΓ₯rd JH et al. | β | 2007 | β |
| Variation in the BMP2 gene: bone mineral density and ultrasound in young adult and elderly women. | McGuigan FE et al. | β | 2007 | β |
| Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures. | Mueller JC et al. | β | 2007 | β |
| A functional polymorphism in MMP-9 is associated with childhood atopic asthma. | Nakashima K et al. | β | 2006 | β |
| A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry. | Raeder H et al. | β | 2006 | β |
| A heterogeneity-based genome search meta-analysis for autism-spectrum disorders. | Trikalinos TA et al. | β | 2006 | β |
| A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. | Zintzaras E et al. | β | 2006 | β |
| A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype. | Wallace HM | β | 2006 | β |
| An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment. | Contopoulos-Ioannidis DG et al. | β | 2006 | β |
| A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases. | Tang NL et al. | β | 2006 | β |
| A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials. | Mulert C et al. | β | 2006 | β |
| Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. | Turunen JA et al. | β | 2006 | β |
| Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. | Hettema JM et al. | β | 2006 | β |
| Association between PADI4 and rheumatoid arthritis: a meta-analysis. | Iwamoto T et al. | β | 2006 | β |
| Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review. | Vieira AR | β | 2006 | β |
| Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset. | Hadjigeorgiou GM et al. | β | 2006 | β |
| Association of endometriosis risk and genetic polymorphisms involving sex steroid biosynthesis and their receptors: a meta-analysis. | Guo SW | β | 2006 | β |
| Association of estrogen receptor alpha gene polymorphisms and lifestyle factors with calcaneal quantitative ultrasound and osteoporosis in postmenopausal Vietnamese women. | Binh TQ et al. | β | 2006 | β |
| Association of uteroglobin G38A polymorphism with IgA nephropathy: a meta-analysis. | Yong D et al. | β | 2006 | β |
| Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study. | Onnie CM et al. | β | 2006 | β |
| Association study of COL9A2 with lumbar disc disease in the Japanese population. | Seki S et al. | β | 2006 | β |
| Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. | SΓ‘nchez E et al. | β | 2006 | β |
| Asthma genetics 2006: the long and winding road to gene discovery. | Ober C et al. | β | 2006 | β |
| A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. | Freathy RM et al. | β | 2006 | β |
| A systematic review of the quality of genetic association studies in human sepsis. | Clark MF et al. | β | 2006 | β |
| Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. | Wang H et al. | β | 2006 | β |
| Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. | Wu X et al. | β | 2006 | β |
| BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study. | Medici M et al. | β | 2006 | β |
| Candidate genes for late-onset Alzheimer's disease: focus on chromosome 12. | Panza F et al. | β | 2006 | β |
| Candidate gene studies in the 21st century: meta-analysis, mediation, moderation. | MunafΓ² MR | β | 2006 | β |
| Can pharmacogenetics help smokers quit? | MunafΓ² M et al. | β | 2006 | β |
| Cardiovascular genomics. | Sabatine MS et al. | β | 2006 | β |
| Case-control genetic association studies in gastrointestinal disease: review and recommendations. | Saito YA et al. | β | 2006 | β |
| Case-control studies in the genomic era: a clinician's guide. | Healy DG | β | 2006 | β |
| CCR5 promoter polymorphisms and HIV-1 perinatal transmission in Brazilian children. | de Souza PR et al. | β | 2006 | β |
| Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. | Schmidt S et al. | β | 2006 | β |
| Clinical implications of CYP3A polymorphisms. | Wojnowski L et al. | β | 2006 | β |
| Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland. | Little J et al. | β | 2006 | β |
| Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. | Ioannidis JP | β | 2006 | β |
| Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort. | Cheng I et al. | β | 2006 | β |
| Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. | Breast Cancer Association Consortium | β | 2006 | β |
| Common susceptibility genes for cancer: search for the end of the rainbow. | Baker SG et al. | β | 2006 | β |
| COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD. | Sengupta SM et al. | β | 2006 | β |
| Concordance of functional in vitro data and epidemiological associations in complex disease genetics. | Ioannidis JP et al. | β | 2006 | β |
| Considering the nature of individual research results. | Beskow LM | β | 2006 | β |
| Contribution of regulatory and structural variations in APOE to predicting dyslipidemia. | StengΓ₯rd JH et al. | β | 2006 | β |
| Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease. | D'Introno A et al. | β | 2006 | β |
| DCNP1: a novel candidate gene for major depression. | Willis-Owen SA et al. | β | 2006 | β |
| Dissecting complex disease: the quest for the Philosopher's Stone? | Buchanan AV et al. | β | 2006 | β |
| DLG5 variants contribute to Crohn disease risk in a Canadian population. | Newman WG et al. | β | 2006 | β |
| Estrogen receptor alpha promoter polymorphism: stronger estrogen action is coupled with lower sperm count. | Guarducci E et al. | β | 2006 | β |
| Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. | Talkowski ME et al. | β | 2006 | β |
| Evolution and translation of research findings: from bench to where? | Ioannidis JP | β | 2006 | β |
| Extreme between-study homogeneity in meta-analyses could offer useful insights. | Ioannidis JP et al. | β | 2006 | β |
| Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC-Norfolk prospective population study. | Boekholdt SM et al. | β | 2006 | β |
| Gene-environment interactions in asthma. | Castro-Giner F et al. | β | 2006 | β |
| Generalist genes and cognitive neuroscience. | Butcher LM et al. | β | 2006 | β |
| Genetic basis of rheumatoid arthritis. | Orozco G et al. | β | 2006 | β |
| Genetic dissection of the common epilepsies. | Tan NC et al. | β | 2006 | β |
| Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis). | Borriello G et al. | β | 2006 | β |
| Genetics of autoimmune diseases--disorders of immune homeostasis. | Gregersen PK et al. | β | 2006 | β |
| Genetics of disc degeneration. | Chan D et al. | β | 2006 | β |
| Genetics of osteoporosis. | Huang QY et al. | β | 2006 | β |
| Genetic variability in the extracellular matrix protein as a determinant of risk for developing HTLV-I-associated neurological disease. | Nobuhara Y et al. | β | 2006 | β |
| Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study. | Kuningas M et al. | β | 2006 | β |
| Genetic variation and the assessment of risk in septic patients. | Suffredini AF et al. | β | 2006 | β |
| Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. | Crawford DC et al. | β | 2006 | β |
| Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. | Wu X et al. | β | 2006 | β |
| Genome-based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design. | White TJ et al. | β | 2006 | β |
| Genomic analyses: a neonatology perspective. | Cotten CM et al. | β | 2006 | β |
| Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain. | Kogevinas M et al. | β | 2006 | β |
| High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. | Amos CI et al. | β | 2006 | β |
| ICAM gene cluster SNPs and prostate cancer risk in African Americans. | Chen H et al. | β | 2006 | β |
| Identification of atherosclerosis-modifying genes: pathogenic insights and therapeutic potential. | Smith JD et al. | β | 2006 | β |
| Identifying susceptibility genes for immunological disorders: patterns, power, and proof. | Plenge R et al. | β | 2006 | β |
| Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. | Trikalinos TA et al. | β | 2006 | β |
| Implications of genetic polymorphisms in drug transporters for pharmacotherapy. | Kerb R | β | 2006 | β |
| Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. | Ioannidis JP et al. | β | 2006 | β |
| Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk. | Fletcher O et al. | β | 2006 | β |
| Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. | Kamangar F et al. | β | 2006 | β |
| Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. | Casas JP et al. | β | 2006 | β |
| Lack of association of VEGF promoter polymorphisms with sporadic ALS. | Chen W et al. | β | 2006 | β |
| Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. | Ralston SH et al. | β | 2006 | β |
| Long QT syndrome: reduced repolarization reserve and the genetic link. | Roden DM | β | 2006 | β |
| Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. | Weidinger S et al. | β | 2006 | β |
| MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. | Kim-Cohen J et al. | β | 2006 | β |
| Mapping genes and pathways in autoimmune disease. | Spurkland A et al. | β | 2006 | β |
| Meta-analysis of vitamin D receptor polymorphisms and type 1 diabetes: a HuGE review of genetic association studies. | Guo SW et al. | β | 2006 | β |
| Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. | Motsinger AA et al. | β | 2006 | β |
| Multiple hypothesis testing strategies for genetic case-control association studies. | Rosenberg PS et al. | β | 2006 | β |
| No association of single nucleotide polymorphisms in the micro-opioid receptor subunit gene with idiopathic generalized epilepsy. | Barratt C et al. | β | 2006 | β |
| NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach. | Healy DG et al. | β | 2006 | β |
| Oestrogen receptor genetics: a needle that cuts through many haystacks? | Shearman AM | β | 2006 | β |
| Paraoxonase cluster polymorphisms are associated with sporadic ALS. | Saeed M et al. | β | 2006 | β |
| Pharmacogenomics: challenges and opportunities. | Roden DM et al. | β | 2006 | β |
| Policy implications of genetic information on regulation under the Clean Air Act: the case of particulate matter and asthmatics. | Kramer CB et al. | β | 2006 | β |
| Polygenetic traits in pancreatic disorders. | Whitcomb DC | β | 2006 | β |
| Polymorphisms of the FCRL3 gene in a Spanish population of systemic lupus erythematosus patients. | Sanchez E et al. | β | 2006 | β |
| Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa. | Lotery AJ et al. | β | 2006 | β |
| Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. | Rodriguez-Lopez J et al. | β | 2006 | β |
| Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. | Wessels JA et al. | β | 2006 | β |
| Replication of association of the D-repeat polymorphism in asporin with osteoarthritis. | Ikegawa S et al. | β | 2006 | β |
| Resampling-based multiple hypothesis testing procedures for genetic case-control association studies. | Chen BE et al. | β | 2006 | β |
| Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. | Newman WG et al. | β | 2006 | β |
| RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis. | Li H et al. | β | 2006 | β |
| Significant association between the genetic variations in the 5' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia. | Zhao X et al. | β | 2006 | β |
| Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. | Tang J et al. | β | 2006 | β |
| Study of a functional polymorphism in the p53 gene in systemic lupus erythematosus: lack of replication in a Spanish population. | SΓ‘nchez E et al. | β | 2006 | β |
| Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. | Ikari K et al. | β | 2006 | β |
| Tackling the genetic bases of metabolic syndrome: a realistic objective? | Siani A et al. | β | 2006 | β |
| TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. | Florez JC et al. | β | 2006 | β |
| Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. | Kaunisto MA et al. | β | 2006 | β |
| The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. | Waldman ID et al. | β | 2006 | β |
| The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. | Uitterlinden AG et al. | β | 2006 | β |
| The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: a systematic review. | Guo SW | β | 2006 | β |
| The balance between heritable and environmental aetiology of human disease. | Hemminki K et al. | β | 2006 | β |
| The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis. | Sharp L et al. | β | 2006 | β |
| The genetics of attention deficit hyperactivity disorder. | Waldman ID et al. | β | 2006 | β |
| The host or the virus? Impact of genetic factors on the outcome of hepatitis C virus infection. | Ferenci P | β | 2006 | β |
| The KrΓΌppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people. | Florez JC et al. | β | 2006 | β |
| The publication process itself was the major cause of publication bias in genetic epidemiology. | Calnan M et al. | β | 2006 | β |
| The response of lipoproteins to dietary fat and cholesterol in lean and obese persons. | Katan MB | β | 2006 | β |
| The role of genetic polymorphisms in alcoholic liver disease. | Stickel F et al. | β | 2006 | β |
| The serotonin transporter gene polymorphism is not associated with smoking behavior. | Trummer O et al. | β | 2006 | β |
| Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. | Cui J et al. | β | 2006 | β |
| TNFalpha polymorphisms and risk of psoriatic arthritis. | Rahman P et al. | β | 2006 | β |
| Towards compendia of negative genetic association studies: an example for Alzheimer disease. | Blomqvist ME et al. | β | 2006 | β |
| Translating genomic biomarkers into clinically useful diagnostics. | Ginsburg GS et al. | β | 2006 | β |
| Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet). | Brenchley PE et al. | β | 2006 | β |
| Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate. | Kremeyer B et al. | β | 2006 | β |
| UCHL-1 is not a Parkinson's disease susceptibility gene. | Healy DG et al. | β | 2006 | β |
| Understanding the molecular basis of celiac disease: what genetic studies reveal. | Monsuur AJ et al. | β | 2006 | β |
| Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis. | Barile S et al. | β | 2006 | β |
| Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. | Fang Y et al. | β | 2006 | β |
| What role for public health in genetics and vice versa? | Holtzman NA | β | 2006 | β |
| Workgroup report: Implementing a national occupational reproductive research agenda--decade one and beyond. | Lawson CC et al. | β | 2006 | β |
| ADAM33: a newly identified gene in the pathogenesis of asthma. | Holgate ST et al. | β | 2005 | β |
| Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. | Lenzen KP et al. | β | 2005 | β |
| Association of the TSHR gene with Graves' disease: the first disease specific locus. | Dechairo BM et al. | β | 2005 | β |
| Deletion allele of angiotensin-converting enzyme is associated with increased risk and severity of bronchopulmonary dysplasia. | Kazzi SN et al. | β | 2005 | β |
| Eating disorders: from twin studies to candidate genes and beyond. | Slof-Op 't Landt MC et al. | β | 2005 | β |
| Eliminating the improbable: Sherlock Holmes and standards of evidence in the genomic age. | Herrington D | β | 2005 | β |
| Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology. | Whitcomb DC et al. | β | 2005 | β |
| Framework for a fully powered risk engine. | β | β | 2005 | β |
| Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. | Bertram L et al. | β | 2005 | β |
| Gearing up for genome-wide gene-association studies. | Farrall M et al. | β | 2005 | β |
| Genetic epidemiology and public health: hope, hype, and future prospects. | Davey Smith G et al. | β | 2005 | β |
| Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. | Noso S et al. | β | 2005 | β |
| Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years. | Vidal F et al. | β | 2005 | β |
| Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. | Pan Z et al. | β | 2005 | β |
| Mammalian G proteins and their cell type specific functions. | Wettschureck N et al. | β | 2005 | β |
| Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. | Fan JB et al. | β | 2005 | β |
| Reliability of statistical associations between genes and disease. | Manly KF | β | 2005 | β |
| Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. | Plenge RM et al. | β | 2005 | β |
| Shaking the tree: mapping complex disease genes with linkage disequilibrium. | Palmer LJ et al. | β | 2005 | β |
| Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. | Greenwood PM et al. | β | 2005 | β |
| The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population. | Cermakova Z et al. | β | 2005 | β |
| The response of lipoproteins to dietary fat and cholesterol in lean and obese persons. | Katan MB | β | 2005 | β |
| The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4. | Talmud PJ et al. | β | 2005 | β |
| Tumour necrosis factor gene polymorphisms and childhood wheezing. | Bilolikar H et al. | β | 2005 | β |
| What makes a good genetic association study? | Hattersley AT et al. | β | 2005 | β |