Mendelian randomization: prospects, potentials, and limitations.
paper
Cited
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- Authors
- Smith, George Davey; Ebrahim, Shah
- Year
- 2004
- Journal
- International journal of epidemiology
- PMID
- 15075143
- DOI
- 10.1093/ije/dyh132
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Causal Relationship of Genetically Predicted Serum Micronutrients Levels With Sarcopenia: A Mendelian Randomization Study. | Sha T et al. | β | 2022 | β |
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| Association Study and Mendelian Randomization Analysis Reveal Effects of the Genetic Interaction Between <i>PtoMIR403b</i> and <i>PtoGT31B-1</i> on Wood Formation in <i>Populus tomentosa</i>. | Xiao L et al. | β | 2021 | β |
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| Gallstone Disease and Type 2 Diabetes Risk: A Mendelian Randomization Study. | Wang F et al. | β | 2019 | β |
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| Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. | Jones SE et al. | β | 2019 | β |
| Gout and the risk of Alzheimer's disease: A Mendelian randomization study. | Lee YH | β | 2019 | β |
| Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study. | Wainberg M et al. | β | 2019 | β |
| Identifying Novel Types of Irritability Using a Developmental Genetic Approach. | Riglin L et al. | β | 2019 | β |
| IMI - Myopia Genetics Report. | Tedja MS et al. | β | 2019 | β |
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| Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer. | Cornish AJ et al. | β | 2019 | β |
| Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study. | Cheng WW et al. | β | 2019 | β |
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| An epidemiological, developmental and clinical overview of cannabis use during pregnancy. | El Marroun H et al. | β | 2018 | β |
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| Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91β105 participants from the UK Biobank. | Lyall LM et al. | β | 2018 | β |
| Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis. | Skaaby T et al. | β | 2018 | β |
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| Big Data in Public Health: Terminology, Machine Learning, and Privacy. | Mooney SJ et al. | β | 2018 | β |
| Breastfeeding and the Developmental Origins of Asthma: Current Evidence, Possible Mechanisms, and Future Research Priorities. | Miliku K et al. | β | 2018 | β |
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| Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. | Rice F et al. | β | 2018 | β |
| Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method. | Liu HM et al. | β | 2018 | β |
| Increased Plasma Ferritin Concentration and Low-Grade Inflammation-A Mendelian Randomization Study. | Moen IW et al. | β | 2018 | β |
| Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data. | Burgess S et al. | β | 2018 | β |
| Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis. | Lee YH | β | 2018 | β |
| Is low level of vitamin D a marker of poor health, or a cause? | Kurmi OP | β | 2018 | β |
| Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer's disease. | Grace C et al. | β | 2018 | β |
| Lactase Persistence and Body Mass Index: The Contribution of Mendelian Randomization. | Hartwig FP et al. | β | 2018 | β |
| Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults. | Juhl CR et al. | β | 2018 | β |
| Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome. | Liu Z et al. | β | 2018 | β |
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| Perspective: Limiting Dependence on Nonrandomized Studies and Improving Randomized Trials in Human Nutrition Research: Why and How. | Trepanowski JF et al. | β | 2018 | β |
| Pleiotropy-robust Mendelian randomization. | van Kippersluis H et al. | β | 2018 | β |
| Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: an umbrella review of meta-analyses. | Belbasis L et al. | β | 2018 | β |
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| The genetics of obstructive sleep apnoea. | Mukherjee S et al. | β | 2018 | β |
| The sirtuin1 gene associates with left ventricular myocardial hypertrophy and remodeling in two chronic kidney disease cohorts: a longitudinal study. | Spoto B et al. | β | 2018 | β |
| Unraveling the Genetic and Environmental Relationship Between Well-Being and Depressive Symptoms Throughout the Lifespan. | Baselmans BML et al. | β | 2018 | β |
| Use of Mendelian <b>R</b>andomization for <b>I</b>dentifying <b>R</b>isk <b>F</b>actors for <b>B</b>rain <b>T</b>umors. | Howell AE et al. | β | 2018 | β |
| Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization. | Bae SC et al. | β | 2018 | β |
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| Bilirubin and Stroke Risk Using a Mendelian Randomization Design. | Lee SJ et al. | β | 2017 | β |
| Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. | Eriksson J et al. | β | 2017 | β |
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| Lactose Intolerance (<i>LCT</i>-13910C>T) Genotype Is Associated with Plasma 25-Hydroxyvitamin D Concentrations in Caucasians: A Mendelian Randomization Study. | Alharbi O et al. | β | 2017 | β |
| Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities. | Walker VM et al. | β | 2017 | β |
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| Mixing omics: combining genetics and metabolomics to study rheumatic diseases. | Menni C et al. | β | 2017 | β |
| Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study. | Jhun MA et al. | β | 2017 | β |
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| Relationships between sickle cell trait, malaria, and educational outcomes in Tanzania. | Croke K et al. | β | 2017 | β |
| Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants. | Burgess S et al. | β | 2017 | β |
| Serum calcium and risk of migraine: a Mendelian randomization study. | Yin P et al. | β | 2017 | β |
| Sex discordance in asthma and wheeze prevalence in two longitudinal cohorts. | Arathimos R et al. | β | 2017 | β |
| Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. | Lawlor D et al. | β | 2017 | β |
| Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General Population: A Genetic Study. | Afzal S et al. | β | 2017 | β |
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| Adding Mendelian randomization to a meta-analysis-a burgeoning opportunity. | Niu W et al. | β | 2016 | β |
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| Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association. | Tolstrup JS et al. | β | 2016 | β |
| Alcohol Intake and Serum Glucose Levels from the Perspective of a Mendelian Randomization Design: The KCPS-II Biobank. | Jee YH et al. | β | 2016 | β |
| A significant causal association between C-reactive protein levels and schizophrenia. | Inoshita M et al. | β | 2016 | β |
| Association between lifetime alcohol consumption and prostate cancer risk: A case-control study in Montreal, Canada. | Demoury C et al. | β | 2016 | β |
| Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. | Hartwig FP et al. | β | 2016 | β |
| Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors. | Burgess S et al. | β | 2016 | β |
| Blood lipids and prostate cancer: a Mendelian randomization analysis. | Bull CJ et al. | β | 2016 | β |
| Body mass index: Has epidemiology started to break down causal contributions to health and disease? | Corbin LJ et al. | β | 2016 | β |
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| Commentary: One size fits all: are there standard rules for the use of genetic instruments in Mendelian randomization? | Timpson NJ | β | 2016 | β |
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| Detection and interpretation of shared genetic influences on 42 human traits. | Pickrell JK et al. | β | 2016 | β |
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| Enhanced circulating transforming growth factor beta 1 is causally associated with an increased risk of hepatocellular carcinoma: a mendelian randomization meta-analysis. | Lu WQ et al. | β | 2016 | β |
| Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes. | Ortega Moreno L et al. | β | 2016 | β |
| Genetics: From Molecule to Society. | Nivard MG et al. | β | 2016 | β |
| Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer's disease: a Mendelian randomization study. | Kwok MK et al. | β | 2016 | β |
| High alcohol consumption causes high IgE levels but not high risk of allergic disease. | Lomholt FK et al. | β | 2016 | β |
| Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. | Prins BP et al. | β | 2016 | β |
| Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology. | Nordestgaard BG et al. | β | 2016 | β |
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| Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization. | Taylor PN et al. | β | 2016 | β |
| Response: FACEing reality: productive tensions between our epidemiological questions, methods and mission. | Krieger N et al. | β | 2016 | β |
| Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. | Swerdlow DI et al. | β | 2016 | β |
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| Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology. | Nordestgaard BG | β | 2016 | β |
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| Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. | Greco M FD et al. | β | 2015 | β |
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| Elevated plasma YKL-40, lipids and lipoproteins, and ischemic vascular disease in the general population. | Kjaergaard AD et al. | β | 2015 | β |
| Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study. | Zhao J et al. | β | 2015 | β |
| Genetically-reduced serum ACE activity might be a causal risk factor for obstructive sleep apnea syndrome: A meta-analysis. | He L et al. | β | 2015 | β |
| Genetic variants of adiponectin and risk of colorectal cancer. | Song M et al. | β | 2015 | β |
| High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study. | WinslΓΈw UC et al. | β | 2015 | β |
| Increased alcohol consumption as a cause of alcoholism, without similar evidence for depression: a Mendelian randomization study. | Wium-Andersen MK et al. | β | 2015 | β |
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| Mendelian randomisation applied to drug development in cardiovascular disease: a review. | Mokry LE et al. | β | 2015 | β |
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| Mendelian Randomization versus Path Models: Making Causal Inferences in Genetic Epidemiology. | Ziegler A et al. | β | 2015 | β |
| Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98,529 Danish adults. | Bergholdt HK et al. | β | 2015 | β |
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| Genetic association analysis of vitamin D pathway with obesity traits. | Vimaleswaran KS et al. | β | 2013 | β |
| Genetic instrumental variable studies of effects of prenatal risk factors. | Wehby GL et al. | β | 2013 | β |
| Improving causal inference. | Ebrahim S | β | 2013 | β |
| Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps. | Fu Z et al. | β | 2013 | β |
| Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? | Au Yeung SL et al. | β | 2013 | β |
| Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: a Mendelian randomisation study. | Kamstrup PR et al. | β | 2013 | β |
| Mendelian randomization analysis with multiple genetic variants using summarized data. | Burgess S et al. | β | 2013 | β |
| Meta-analysis methods for genome-wide association studies and beyond. | Evangelou E et al. | β | 2013 | β |
| Mining the human phenome using allelic scores that index biological intermediates. | Evans DM et al. | β | 2013 | β |
| Moderate alcohol use and cardiovascular disease from Mendelian randomization. | Au Yeung SL et al. | β | 2013 | β |
| Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes. | Kones R | β | 2013 | β |
| Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men. | Wong YY et al. | β | 2013 | β |
| Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies. | Harbord RM et al. | β | 2013 | β |
| Telomeres and human health. | Bojesen SE | β | 2013 | β |
| The causal effect of malaria on stunting: a Mendelian randomization and matching approach. | Kang H et al. | β | 2013 | β |
| The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach. | Binder AM et al. | β | 2013 | β |
| The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. | BjΓΈrngaard JH et al. | β | 2013 | β |
| The relevance of the association between inflammation and atrial fibrillation. | Alegret JM et al. | β | 2013 | β |
| Use of allele scores as instrumental variables for Mendelian randomization. | Burgess S et al. | β | 2013 | β |
| Association of an apolipoprotein E polymorphism with circulating cholesterols and hypertension: a meta-based Mendelian randomization analysis. | Niu W et al. | β | 2012 | β |
| Association of interleukin-6 circulating levels with coronary artery disease: a meta-analysis implementing mendelian randomization approach. | Niu W et al. | β | 2012 | β |
| Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score. | Jokela M et al. | β | 2012 | β |
| CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. | Weischer M et al. | β | 2012 | β |
| Circulating biomarkers. | Badimon L et al. | β | 2012 | β |
| C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects. | Rius-Ottenheim N et al. | β | 2012 | β |
| Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. | Glymour MM et al. | β | 2012 | β |
| Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation. | Warren LL et al. | β | 2012 | β |
| Designs combining instrumental variables with case-control: estimating principal strata causal effects. | Shinohara RT et al. | β | 2012 | β |
| Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. | Cortessis VK et al. | β | 2012 | β |
| Evaluation of moderate alcohol use and cognitive function among men using a Mendelian randomization design in the Guangzhou biobank cohort study. | Au Yeung SL et al. | β | 2012 | β |
| Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. | Lewis SJ et al. | β | 2012 | β |
| Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. | Lewis SJ et al. | β | 2012 | β |
| Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. | Staines-Urias E et al. | β | 2012 | β |
| Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis. | Kamstrup PR et al. | β | 2012 | β |
| Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry. | Hou N et al. | β | 2012 | β |
| Genomic medicine in the prevention and treatment of atherosclerotic cardiovascular disease. | Tuteja S et al. | β | 2012 | β |
| HDL and cardiovascular risk: time to call the plumber? | Hewing B et al. | β | 2012 | β |
| Improving bias and coverage in instrumental variable analysis with weak instruments for continuous and binary outcomes. | Burgess S et al. | β | 2012 | β |
| Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study. | NΓΌesch E et al. | β | 2012 | β |
| Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis. | Theodoratou E et al. | β | 2012 | β |
| Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. | Steenweg-de Graaff J et al. | β | 2012 | β |
| Mendelian randomization: application to cardiovascular disease. | Timpson NJ et al. | β | 2012 | β |
| Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. | Mechanic LE et al. | β | 2012 | β |
| Observational studies versus randomized controlled trials: avenues to causal inference in nephrology. | Kovesdy CP et al. | β | 2012 | β |
| Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. | Song Y et al. | β | 2012 | β |
| Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. | Voight BF et al. | β | 2012 | β |
| Recent insights into the relation of Ξ5 desaturase and Ξ6 desaturase activity to the development of type 2 diabetes. | KrΓΆger J et al. | β | 2012 | β |
| The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies. | Pierce BL et al. | β | 2012 | β |
| The genetics of coronary heart disease. | Swerdlow DI et al. | β | 2012 | β |
| Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps. | Fu Z et al. | β | 2012 | β |
| Using multiple genetic variants as instrumental variables for modifiable risk factors. | Palmer TM et al. | β | 2012 | β |
| Acute-phase proteins: As diagnostic tool. | Jain S et al. | β | 2011 | β |
| Alcohol ingestion and colorectal neoplasia: a meta-analysis based on a Mendelian randomization approach. | Wang J et al. | β | 2011 | β |
| A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. | Taylor PN et al. | β | 2011 | β |
| A preliminary examination of the effects of genetic variants of redox enzymes on susceptibility to oedematous malnutrition and on percentage cytotoxicity in response to oxidative stress in vitro. | Marshall KG et al. | β | 2011 | β |
| Avoiding bias from weak instruments in Mendelian randomization studies. | Burgess S et al. | β | 2011 | β |
| Bayesian inference of gene-environment interaction from incomplete data: what happens when information on environment is disjoint from data on gene and disease? | Gustafson P et al. | β | 2011 | β |
| Bias in causal estimates from Mendelian randomization studies with weak instruments. | Burgess S et al. | β | 2011 | β |
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| Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. | Davidson MH et al. | β | 2011 | β |
| C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. | Timpson NJ et al. | β | 2011 | β |
| C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study. | Ernst GD et al. | β | 2011 | β |
| C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects. | Veen G et al. | β | 2011 | β |
| Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. | Allin KH et al. | β | 2011 | β |
| Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. | KrΓΆger J et al. | β | 2011 | β |
| Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review. | van Schie MC et al. | β | 2011 | β |
| Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. | Morales E et al. | β | 2011 | β |
| Hemochromatosis genotypes and risk of iron overload--a meta-analysis. | Neghina AM et al. | β | 2011 | β |
| Lipoprotein(a) and risk of myocardial infarction--genetic epidemiologic evidence of causality. | Kamstrup PR et al. | β | 2011 | β |
| Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study. | Benn M et al. | β | 2011 | β |
| Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring. | Morales E et al. | β | 2011 | β |
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| Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. | Peden JF et al. | β | 2011 | β |
| Type II secretory phospholipase A2 and prognosis in patients with stable coronary heart disease: mendelian randomization study. | Breitling LP et al. | β | 2011 | β |
| Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. | Davey Smith G | β | 2011 | β |
| Using a genetic, observational study as a strategy to estimate the potential cost-effectiveness of pharmacological CCR5 blockade in dialysis patients. | Muntinghe FL et al. | β | 2011 | β |
| A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians. | Schumacher FR et al. | β | 2010 | β |
| Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. | Burgess S et al. | β | 2010 | β |
| Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization. | Timpson NJ et al. | β | 2010 | β |
| Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis. | Fadini GP et al. | β | 2010 | β |
| Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study. | Riancho JA et al. | β | 2010 | β |
| C-reactive protein and all-cause mortality--the Copenhagen City Heart Study. | Zacho J et al. | β | 2010 | β |
| C-reactive protein and risk of venous thromboembolism in the general population. | Zacho J et al. | β | 2010 | β |
| Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population. | Marott SC et al. | β | 2010 | β |
| Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. | Timpson NJ et al. | β | 2010 | β |
| Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population. | Frikke-Schmidt R | β | 2010 | β |
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| Lipoprotein(a) as a cardiovascular risk factor: current status. | Nordestgaard BG et al. | β | 2010 | β |
| Mendelian randomization as applied to coronary heart disease, including recent advances incorporating new technology. | Lewis SJ | β | 2010 | β |
| Mendelian Randomization for Strengthening Causal Inference in Observational Studies: Application to Gene Γ Environment Interactions. | Smith GD | β | 2010 | β |
| Mendelian randomization in the era of genomewide association studies. | Sleiman PM et al. | β | 2010 | β |
| Metabolic imbalance and prostate cancer progression. | Burton AJ et al. | β | 2010 | β |
| Metabolic imprinting, programming and epigenetics - a review of present priorities and future opportunities. | Hanley B et al. | β | 2010 | β |
| Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. | Kones R | β | 2010 | β |
| Survival benefits with vitamin D receptor activation: new insights since 2003. | Kovesdy CP | β | 2010 | β |
| The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. | Husemoen LL et al. | β | 2010 | β |
| The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease. | Yazdani-Biuki B et al. | β | 2010 | β |
| Translating genomics into improved healthcare. | Hingorani AD et al. | β | 2010 | β |
| Usefulness of Mendelian randomization in observational epidemiology. | Bochud M et al. | β | 2010 | β |
| Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels. | Conen D et al. | β | 2010 | β |
| Aspirin, salicylates, and cancer. | Elwood PC et al. | β | 2009 | β |
| A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. | Plaisier CL et al. | β | 2009 | β |
| Challenges and novel approaches in the epidemiological study of early life influences on later disease. | Davey Smith G et al. | β | 2009 | β |
| Commentary: Maziak's essay, seen from another angle. | Vandenbroucke JP | β | 2009 | β |
| C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease. | Zacho J et al. | β | 2009 | β |
| Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. | Timpson NJ et al. | β | 2009 | β |
| Do genes allow inflammation to kill or not to kill? | Kovesdy CP et al. | β | 2009 | β |
| Factor IX and deep vein thrombosis. | Lowe G | β | 2009 | β |
| Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the MalmΓΆ Diet and Cancer cohort. | Ericson U et al. | β | 2009 | β |
| Genetically elevated C-reactive protein and vascular disease. | Bubb MR | β | 2009 | β |
| Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease. | Johannsen TH et al. | β | 2009 | β |
| Intergenerational influences on health: how far back do we have to go? | Smith GD | β | 2009 | β |
| Lipids, atherosclerosis and CVD risk: is CRP an innocent bystander? | Nordestgaard BG et al. | β | 2009 | β |
| Lipoprotein(a) should be taken much more seriously. | Kamstrup PR et al. | β | 2009 | β |
| Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. | Schatzkin A et al. | β | 2009 | β |
| Mendelian randomization in nutritional epidemiology. | Qi L | β | 2009 | β |
| Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals. | Lim SC et al. | β | 2009 | β |
| Point-counterpoint. The triumph of the null hypothesis: epidemiology in an age of change. | Maziak W | β | 2009 | β |
| Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. | Ridker PM et al. | β | 2009 | β |
| Population-based genomewide genetic analysis of common clinical chemistry analytes. | Chasman DI et al. | β | 2009 | β |
| Quantitative assessment of unobserved confounding is mandatory in nonrandomized intervention studies. | Groenwold RH et al. | β | 2009 | β |
| Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii. | Nakamura Y et al. | β | 2009 | β |
| Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study. | Giltay EJ et al. | β | 2009 | β |
| The virtues of a deliberately mis-specified disease model in demonstrating a gene-environment interaction. | Burstyn I et al. | β | 2009 | β |
| Use of pathway information in molecular epidemiology. | Thomas DC et al. | β | 2009 | β |
| Why schizophrenia epidemiology needs neurobiology--and vice versa. | McGrath JJ et al. | β | 2009 | β |
| A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. | Bochud M et al. | β | 2008 | β |
| Assessing intrauterine influences on offspring health outcomes: can epidemiological studies yield robust findings? | Smith GD | β | 2008 | β |
| Assessment of cumulative evidence on genetic associations: interim guidelines. | Ioannidis JP et al. | β | 2008 | β |
| Bayesian meta-analysis of genetic association studies with different sets of markers. | Verzilli C et al. | β | 2008 | β |
| Best-practice interventions to reduce socioeconomic inequalities of coronary heart disease mortality in UK: a prospective occupational cohort study. | KivimΓ€ki M et al. | β | 2008 | β |
| Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density. | Verheus M et al. | β | 2008 | β |
| De testimonio: on the evidence for decisions about the use of therapeutic interventions. | Rawlins M | β | 2008 | β |
| Genetically elevated C-reactive protein and ischemic vascular disease. | Zacho J et al. | β | 2008 | β |
| Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study. | Linsel-Nitschke P et al. | β | 2008 | β |
| Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. | Danesh J et al. | β | 2008 | β |
| Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? | Ebrahim S et al. | β | 2008 | β |
| Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. | Lawlor DA et al. | β | 2008 | β |
| Meta-analysis of Mendelian randomization studies incorporating all three genotypes. | Palmer TM et al. | β | 2008 | β |
| Methodological challenges in causal research on racial and ethnic patterns of cognitive trajectories: measurement, selection, and bias. | Glymour MM et al. | β | 2008 | β |
| On the use of Mendelian randomization to infer causality in observational epidemiology. | Bochud M | β | 2008 | β |
| Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses. | Zafarmand MH et al. | β | 2008 | β |
| Recent developments in meta-analysis. | Sutton AJ et al. | β | 2008 | β |
| T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. | Zafarmand MH et al. | β | 2008 | β |
| The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. | Husemoen LL et al. | β | 2008 | β |
| The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. | Lawlor DA et al. | β | 2008 | β |
| The fat mass- and obesity-associated locus and dietary intake in children. | Timpson NJ et al. | β | 2008 | β |
| The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study. | Zafarmand MH et al. | β | 2008 | β |
| The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. | Lewis SJ et al. | β | 2008 | β |
| Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. | Ponsonby AL et al. | β | 2008 | β |
| Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase. | Beulens JW et al. | β | 2007 | β |
| An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. | Frayling TM et al. | β | 2007 | β |
| Capitalizing on Mendelian randomization to assess the effects of treatments. | Davey Smith G | β | 2007 | β |
| Coronary heart disease aetiology: associations and causality. | DucimetiΓ¨re P et al. | β | 2007 | β |
| Direct, reverse or reciprocal causation in the relation between homocysteine and ischemic heart disease. | Grassi M et al. | β | 2007 | β |
| Genetic variation and human aging: progress and prospects. | Melzer D et al. | β | 2007 | β |
| Getting to grips with complexity of disease will make genomics useful in arterial thrombosis. | AriΓ«ns RA | β | 2007 | β |
| Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. | Ellervik C et al. | β | 2007 | β |
| Mendelian randomization as an instrumental variable approach to causal inference. | Didelez V et al. | β | 2007 | β |
| Multistage sampling for latent variable models. | Thomas DC | β | 2007 | β |
| Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. | Magnussen EB et al. | β | 2007 | β |
| Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. | Thomas DC et al. | β | 2007 | β |
| Role of protein z in stroke. | Tran HA et al. | β | 2007 | β |
| Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence. | Folsom AR et al. | β | 2007 | β |
| Thrombophilia and pregnancy complications: cause or association? | Middeldorp S | β | 2007 | β |
| TNF gene polymorphism and quantitative traits related to cardiovascular disease: getting to the heart of the matter. | Mellick GD | β | 2007 | β |
| Cohort profile: The Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong-Birmingham collaboration. | Jiang C et al. | β | 2006 | β |
| Commentary: evolution of action in cells and organisms. | Weiss KM | β | 2006 | β |
| Commentary: magnetic field exposure and childhood leukaemia--moving the research agenda forward. | RΓΆΓΆsli M et al. | β | 2006 | β |
| C-reactive protein and cardiovascular disease risk: still an unknown quantity? | Davey Smith G et al. | β | 2006 | β |
| Dissecting complex disease: the quest for the Philosopher's Stone? | Buchanan AV et al. | β | 2006 | β |
| Estimation of bias in nongenetic observational studies using "mendelian triangulation". | Bautista LE et al. | β | 2006 | β |
| Genetic association studies in cancer: good, bad or no longer ugly? | Savage SA et al. | β | 2006 | β |
| Instrumental variables: application and limitations. | Martens EP et al. | β | 2006 | β |
| Make it HuGE: human genome epidemiology reviews, population health, and the IJE. | Smith GD et al. | β | 2006 | β |
| Mensuration, Mendel, and a 19th century public health justification for US imperialism. | Smith GD | β | 2006 | β |
| Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. | Lewis SJ et al. | β | 2006 | β |
| MTHFR polymorphism and bone mineral density: meta-analysis of published studies. | Riancho JA et al. | β | 2006 | β |
| PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample. | Meigs JB et al. | β | 2006 | β |
| Place of genotyping and phenotyping in understanding and potentially modifying outcomes in peritoneal dialysis patients. | Axelsson J et al. | β | 2006 | β |
| Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. | Agudo A et al. | β | 2006 | β |
| Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study. | Van Guelpen BR et al. | β | 2006 | β |
| Randomised by (your) god: robust inference from an observational study design. | Smith GD | β | 2006 | β |
| Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study. | Wootton PT et al. | β | 2006 | β |
| The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy? | Husemoen LL et al. | β | 2006 | β |
| The eco- in eco-epidemiology. | March D et al. | β | 2006 | β |
| The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT). | Tai ES et al. | β | 2006 | β |
| Adult chronic disease and childhood obesity: a life course approach in developing countries? | Kabir Z | β | 2005 | β |
| Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. | Lewis SJ et al. | β | 2005 | β |
| Aspirin for everyone older than 50? For. | Elwood P et al. | β | 2005 | β |
| Association of C-reactive protein with blood pressure. | Bautista LE | β | 2005 | β |
| Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. | Davey Smith G et al. | β | 2005 | β |
| Avoiding milk is associated with a reduced risk of insulin resistance and the metabolic syndrome: findings from the British Women's Heart and Health Study. | Lawlor DA et al. | β | 2005 | β |
| Commentary: incubation of coronary heart disease--recent developments. | McCarron P et al. | β | 2005 | β |
| C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus. | D'Aiuto F et al. | β | 2005 | β |
| C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. | Timpson NJ et al. | β | 2005 | β |
| Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies. | Smith GD et al. | β | 2005 | β |
| Do we need genomic research for the prevention of common diseases with environmental causes? | Khoury MJ et al. | β | 2005 | β |
| Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study. | Vineis P et al. | β | 2005 | β |
| Genetic epidemiology and public health: hope, hype, and future prospects. | Davey Smith G et al. | β | 2005 | β |
| Homocysteine and stroke. | Hankey GJ et al. | β | 2005 | β |
| Homocysteine and stroke: evidence on a causal link from mendelian randomisation. | Casas JP et al. | β | 2005 | β |
| How many genes underlie the occurrence of common complex diseases in the population? | Yang Q et al. | β | 2005 | β |
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| Key concepts in genetic epidemiology. | Burton PR et al. | β | 2005 | β |
| Preventing pregnancy-induced hypertension: are there regional differences for this global problem? | LΓ³pez-Jaramillo P et al. | β | 2005 | β |
| Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. | Staton J et al. | β | 2005 | β |
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| TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. | Timpson NJ et al. | β | 2005 | β |
| The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease. | Testa A et al. | β | 2005 | β |
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| Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers? | Rossi GP et al. | β | 2004 | β |
| Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. | Serrano NC et al. | β | 2004 | β |
| Psychological and social sequelae of cannabis and other illicit drug use by young people: a systematic review of longitudinal, general population studies. | Macleod J et al. | β | 2004 | β |
| The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. | Lawlor DA et al. | β | 2004 | β |