Platelet serotonin uptake in men with family histories of alcoholism.
paper
Cited
Public
Unavailable
- Authors
- Rausch, J L; Monteiro, M G; Schuckit, M A
- Year
- 1991
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 2025381
Platelet serotonin uptake kinetics were examined in a carefully screened group of 28 male subjects, half of whom had an alcoholic father. Paired subjects were matched for a variety of characteristics, including age, race, sex, substance use history, height/weight ratio, season, and time of day for platelet serotonin uptake assays. The family history positive group had a significantly (p = 0.01) higher mean Vmax for platelet serotonin uptake (64.1 +/- 19, SD) compared to the control group without family histories of first-degree relatives with alcoholism (53.8 +/- 19). No significant differences in the affinity constant (Km) or in the Hill constant were found between groups. The results are consistent with the possibility that a higher Vmax of platelet serotonin uptake indicates a biologic factor associated with alcoholism risk.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk. | Wang FL et al. | — | 2018 | → |
| Ethanol self-administration in serotonin transporter knockout mice: unconstrained demand and elasticity. | Lamb RJ et al. | — | 2013 | → |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | — | 2011 | → |
| Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter. | Dawes MA et al. | — | 2009 | → |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | — | 2008 | → |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | — | 2005 | → |
| Clinical features of depressed patients with or without a family history of alcoholism. | Sher L et al. | — | 2005 | → |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | — | 2004 | → |
| Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. | Crean J et al. | — | 2002 | → |
| Neurodevelopmental liabilities in alcohol dependence: central serotonin and dopamine dysfunction. | Naranjo CA et al. | — | 2002 | → |
| Neurodevelopmental liabilities of substance abuse. | Palomo T et al. | — | 2002 | → |
| The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals. | Petrakis IL et al. | — | 2002 | → |
| Tryptophan metabolism in alcoholism. | Badawy AA | — | 2002 | → |
| Fluvoxamine treatment of mixed anxiety and depression: evidence for serotonergically mediated anxiolysis. | Rausch JL et al. | — | 2001 | → |
| Serotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics. | Twitchell GR et al. | — | 2001 | → |
| Fetal alcohol exposure alters serotonin transporter sites in rat brain. | Zafar H et al. | — | 2000 | → |
| Serotonergic function, behavioral disinhibition, and negative affect in children of alcoholics: the moderating effects of puberty. | Twitchell GR et al. | — | 2000 | → |
| Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. | Schuckit MA et al. | — | 1999 | → |
| Prevalence of high serotonin uptake in lymphocytes of abstinent alcoholics. | Faraj BA et al. | — | 1997 | → |
| Serotonergic dysfunction in addiction: effects of alcohol, cigarette smoking and heroin on platelet 5-HT content. | Schmidt LG et al. | — | 1997 | → |
| Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide. | Little KY et al. | — | 1997 | → |
| Characteristics and putative mechanisms in boys at risk for drug abuse and aggression. | Pihl RO et al. | — | 1996 | → |
| Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. | Melo JA et al. | — | 1996 | → |
| Detoxified alcoholics, major depressives and tyramine sulphate excretion. | Hale AS et al. | — | 1995 | → |
| Expression of a high-affinity serotonin transporter in human lymphocytes. | Faraj BA et al. | — | 1994 | → |
| Serotonin and alcohol intake, abuse, and dependence: clinical evidence. | LeMarquand D et al. | — | 1994 | → |
| Paroxetine binding in the blood platelets of post-traumatic stress disorder patients. | Arora RC et al. | — | 1993 | → |
| Platelets 3H 5-HT uptake in descendants from alcoholic patients: a potential risk factor for alcohol dependence? | Ernouf D et al. | — | 1993 | → |