Whole genome expression as a quantitative trait.
paper
Cited
Public
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- Authors
- Hardy, John; Trabzuni, Danyah; Ryten, Mina
- Year
- 2009
- Journal
- Biochemical Society transactions
- PMID
- 19909261
- DOI
- 10.1042/BST0371276
Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases have shown that genetic variability in gene expression levels of deposited proteins influence disease risk. With this background, we have embarked on a comprehensive project to determine the effects of common genetic variability on whole genome gene expression.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. | Bogdan R et al. | — | 2018 | → |
| Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. | Bogdan R et al. | — | 2017 | → |
| Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. | Stevenson JM et al. | — | 2016 | → |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | — | 2015 | → |
| Using DNA methylation to understand biological consequences of genetic variability. | Hernandez DG et al. | — | 2012 | → |
| Genomic microdeletions associated with epilepsy: not a contraindication to resective surgery. | Catarino CB et al. | — | 2011 | → |
| Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies. | Trabzuni D et al. | — | 2011 | → |