Serotonergic ethanol effects and auditory evoked dipole activity in alcoholic and healthy subjects.
- Authors
- Hegerl, U; Juckel, G; Schmidt, L G; Rommelspacher, H
- Year
- 1996
- Journal
- Psychiatry research
- PMID
- 8832773
- DOI
- 10.1016/0165-1781(96)02796-5
Ethanol has central serotonergic effects that may be of pathogenetic importance in a subgroup of alcohol-dependent patients with a central serotonergic hypofunction. Recent results indicate that pronounced amplitude increases of auditory evoked responses (tangential dipoles, N1/P2 component) with increasing stimulus intensity (loudness) may be an indicator of such a low serotonergic neurotransmission. Because of its serotonin-agonistic effects, ethanol can be expected to decrease this intensity dependence. Twenty-eight alcoholic patients were studied both in the intoxication phase and after 1 week of withdrawal. A reduced intensity dependence of the tangential dipole activity was observed in the intoxicated state. Correspondingly, a reduction of this parameter was found in 14 healthy subjects after an ethanol load (1 g/kg, p.o.).
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Effects of intensity and order of stimuli presentation on AEPs: an analysis of the consistency of EP augmenting/reducing in the auditory modality. | Carrillo-de-la-Peña MT | — | 1999 | → |
| Repeatability of the intensity dependence of cortical auditory evoked potentials in the assessment of cortical information processing. | Sándor PS et al. | — | 1999 | → |