Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa.
- Authors
- Kiezebrink, Kirsty; Mann, Evleen T; Bujac, Sarah R; Stubbins, Michael J; Campbell, David A; Blundell, John E
- Year
- 2010
- Journal
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- PMID
- 20545463
- DOI
- 10.3109/15622975.2010.484550
OBJECTIVES: There is mixed evidence of association of serotoninergic genes with anorexia nervosa (AN), but substantial evidence for the involvement of serotonergic mechanisms in appetite control. This study was designed to investigate possible associations between the two subtypes of AN (Restricting-RAN, and Binge-purging-BPAN) and polymorphisms within five genes encoding for proteins involved in the serotoninergic system. METHODS: In order to carry out this investigation we have conducted a case-control association study on 226 females meeting the criteria for AN, and 678 matched healthy females. RESULTS: Our data show a significant association between polymorphisms with the gene encoding HTR2A with both AN subtypes, an association between polymorphisms within the genes encoding HTR1D and HTR1B with RAN, and an association between polymorphisms within the gene encoding HTR2C with BPAN. No associations were found for any polymorphisms of the serotonin transporter gene. This outcome indicates a substantial and complex inter-relationship between serotoninergic genes and AN. CONCLUSIONS: Given these data we hypothesis that the expression or control of expression of several genes of the serotoninergic system, and interactions between these genes, could exert considerable influence over the specific symptomatology of the subtypes of AN.
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External
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| Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review. | Monserrat Hernández M et al. | — | 2024 | → |
| Contemporary views on the genetics of anorexia nervosa. | Shih PA et al. | — | 2016 | → |
| Genetics and Epigenetics of Eating Disorders. | Yilmaz Z et al. | — | 2015 | → |
| Preliminary evidence for the role of HTR2A variants in binge eating in young women. | Koren R et al. | — | 2014 | → |
| [Role of Serotonin Transporter Gene in Eating Disorders]. | Hernández-Muñoz S et al. | — | 2014 | → |
| The genetics of eating disorders. | Trace SE et al. | — | 2013 | → |
| Antipsychotic agents in the treatment of anorexia nervosa: neuropsychopharmacologic rationale and evidence from controlled trials. | Brewerton TD | — | 2012 | → |
| Epigenetics and eating disorders. | Pjetri E et al. | — | 2012 | → |
| Examining associations between disordered eating and serotonin transporter gene polymorphisms. | Munn-Chernoff MA et al. | — | 2012 | → |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | — | 2012 | → |
| The genetics of eating disorders. | Helder SG et al. | — | 2011 | → |