Analysing biological pathways in genome-wide association studies.
paper
Cited
Public
Unavailable
- Authors
- Wang, Kai; Li, Mingyao; Hakonarson, Hakon
- Year
- 2010
- Journal
- Nature reviews. Genetics
- PMID
- 21085203
- DOI
- 10.1038/nrg2884
Genome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently, pathway-based approaches have been developed, which use prior biological knowledge on gene function to facilitate more powerful analysis of GWA study data sets. These approaches typically examine whether a group of related genes in the same functional pathway are jointly associated with a trait of interest. Here we review the development of pathway-based approaches for GWA studies, discuss their practical use and caveats, and suggest that pathway-based approaches may also be useful for future GWA studies with sequencing data.
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| Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. | Han S et al. | β | 2013 | β |
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| Pathways systematically associated to Hirschsprung's disease. | FernΓ‘ndez RM et al. | β | 2013 | β |
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| Interpreting noncoding genetic variation in complex traits and human disease. | Ward LD et al. | β | 2012 | β |
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| PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes. | Ried JS et al. | β | 2012 | β |
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| Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation. | Wang K et al. | β | 2011 | β |
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| Revealing the genetic basis of multiple sclerosis: are we there yet? | Baranzini SE | β | 2011 | β |
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