Adrenocortical responses and family history of alcoholism.
- Authors
- Wand, G S; Mangold, D; Ali, M; Giggey, P
- Year
- 1999
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 10443984
BACKGROUND: This study was designed to assess whether nonalcoholic offspring from families with a high density of alcohol-dependent individuals have altered hypothalamic-pituitary-adrenal (HPA) axis dynamics compared with nonalcoholic subjects without a family history of alcohol dependence. METHODS: Seventy-eight nonalcoholic subjects aged 18 to 25 were enrolled in the protocol. Thirty-nine subjects were offspring from families with a high density of alcohol dependence and were designated as family history-positive (FHP) subjects. Thirty-nine subjects were biological offspring of nonalcohol-dependent parents and were designated as family history-negative (FHN) subjects. Subjects received naloxone hydrochloride (0 and 125 microg/kg) and cosyntropin (0, 0.25 microg, and 250 microg) in double-blind, randomized order and cortisol was monitored. A subset of subjects (11 FHP, 11 FHN) was admitted to the General Clinical Research Center to measure serum cortisol levels every 30 min for 24 hr. RESULTS: FHP subjects had an increased cortisol response to opioid receptor blockade induced by naloxone. However, no group differences in cortisol were uncovered during administration of cosyntropin or during monitoring of the cortisol circadian profile. CONCLUSION: These observations suggest that differences in the cortisol dynamics between FHP and FHN subjects are unmasked by opioid receptor blockade directed at the hypothalamus, but not when cortisol levels are directly provoked at the level of the adrenal gland. In addition, unprovoked cortisol secretion monitored over a 24-hr interval cannot distinguish FHP from FHN subjects.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Line- and sex-dependent effects of juvenile stress on contextual fear- and anxiety-related behavior in high- and low-alcohol-preferring mouse lines. | Mukadam AA et al. | — | 2024 | → |
| A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade. | Daubenmier J et al. | — | 2014 | → |
| Effects of alcohol on the endocrine system. | Rachdaoui N et al. | — | 2013 | → |
| Clinical laboratory stressors used to study alcohol-stress relationships. | Thomas S et al. | — | 2012 | → |
| Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. | Lovallo WR et al. | — | 2012 | → |
| Stress and the HPA axis: role of glucocorticoids in alcohol dependence. | Stephens MA et al. | — | 2012 | → |
| The limbic-hypothalamic-pituitary-adrenal axis and the development of alcohol use disorders in youth. | Schepis TS et al. | — | 2011 | → |
| High risk groups often have higher levels of alcohol response than low risk: the other side of the coin. | Newlin DB et al. | — | 2010 | → |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | — | 2010 | → |
| Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior. | Pratt WM et al. | — | 2009 | → |
| Stress, alcohol and drug interaction: an update of human research. | Uhart M et al. | — | 2009 | → |
| Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. | Weerts EM et al. | — | 2008 | → |
| Family history of alcoholism does not influence adrenocortical hyporesponsiveness in abstinent alcohol-dependent men. | Hardin E et al. | — | 2008 | → |
| Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. | Goletiani NV et al. | — | 2007 | → |
| How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. | Zimmermann US et al. | — | 2007 | → |
| Association of the kappa-opioid system with alcohol dependence. | Xuei X et al. | — | 2006 | → |
| Different effects of stress on alcohol drinking behaviour in male and female mice selectively bred for high alcohol preference. | Chester JA et al. | — | 2006 | → |
| Hormonal responses to psychological stress and family history of alcoholism. | Uhart M et al. | — | 2006 | → |
| Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. | Dai X et al. | — | 2005 | → |
| Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness. | Adinoff B et al. | — | 2005 | → |
| Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholism. | Gianoulakis C et al. | — | 2005 | → |
| Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. | Oswald LM et al. | — | 2005 | → |
| Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects. | Haddad JJ | — | 2004 | → |
| Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report. | Oswald LM et al. | — | 2004 | → |
| Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. | Zimmermann U et al. | — | 2004 | → |
| Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. | Bencherif B et al. | — | 2004 | → |
| Opioids and alcoholism. | Oswald LM et al. | — | 2004 | → |
| Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1). | Hernandez-Avila CA et al. | — | 2003 | → |
| Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism. | Hernandez-Avila CA et al. | — | 2002 | → |
| Cortisol dysregulation and cognitive impairment in abstinent male alcoholics. | Errico AL et al. | — | 2002 | → |
| Confirmation that offspring from families with alcohol-dependent individuals have greater hypothalamic-pituitary-adrenal axis activation induced by naloxone compared with offspring without a family history of alcohol dependence. | Wand G et al. | — | 2001 | → |
| Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls. | Anthenelli RM et al. | — | 2001 | → |