Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.
- Authors
- Schwab, Sibylle G; Kusumawardhani, Agung A A A; Dai, Nan; Qin, WenWen; Wildenauer, Mutiara D B; Agiananda, Feranindhya; Amir, Nurmiati; Antoni, Ronald; Arsianti, Tiana; Asmarahadi, Asmarahadi; Diatri, Hervita; Djatmiko, Prianto; Irmansyah, Irmansyah; Khalimah, Siti; Kusumadewi, Irmia; Kusumaningrum, Profitasari; Lukman, Petrin R; Mustar, Lukman; Nasrun, Martina W; Naswati, Safyuni; Prasetiyawan, Prasetiyawan; Semen, Gerald M; Siste, Kristiana; Tobing, Heriani; Widiasih, Natalia; Wiguna, Tjhin; Wulandari, Widayanti Dewi; Indonesian Schizophrenia Genetics Consortium; Benyamin, Beben; Wildenauer, Dieter B
- Year
- 2013
- Journal
- Schizophrenia research
- PMID
- 23590871
- DOI
- 10.1016/j.schres.2013.03.022
BACKGROUND: Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background. METHODS: We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes. RESULTS: We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P=0.019, OR=1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706. CONCLUSION: We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Schizophrenia-Like Deficits and Impaired Glutamate/Gamma-aminobutyric acid Homeostasis in Zfp804a Conditional Knockout Mice. | Zhang QX et al. | — | 2024 | → |
| Polymorphism in the ZNF804A Gene and Variation in D<sub>1</sub> and D<sub>2</sub>/D<sub>3</sub> Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study. | Hegarty CE et al. | — | 2023 | → |
| Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis. | Yang L et al. | — | 2021 | → |
| Ethnicity-dependent effects of Zinc finger 804A variant on schizophrenia: a systematic review and meta-analysis. | Wang D et al. | — | 2021 | → |
| <i>ZNF804A</i> Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders. | Calabrò M et al. | — | 2020 | → |
| Control of CNS functions by RNA-binding proteins in neurological diseases. | Zhou Y et al. | — | 2018 | → |
| Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach. | Falola O et al. | — | 2017 | → |
| Association between the zinc finger protein 804A (ZNF804A) gene and the risk of schizophrenia and bipolar I disorder across diagnostic boundaries. | Baek JH et al. | — | 2017 | → |
| Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations. | Rao S et al. | — | 2017 | → |
| The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. | Chang H et al. | — | 2017 | → |
| The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. | Ou J et al. | — | 2017 | → |
| A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations. | Huang L et al. | — | 2016 | → |
| Genome-wide discovered psychosis-risk gene ZNF804A impacts on white matter microstructure in health, schizophrenia and bipolar disorder. | Mallas EJ et al. | — | 2016 | → |
| No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese. | Wang J et al. | — | 2016 | → |
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| Replication of ZNF804A gene variant associations with risk of heroin addiction. | Hancock DB et al. | — | 2015 | → |
| ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects. | Nenadic I et al. | — | 2015 | → |
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| Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. | Schwab SG et al. | — | 2013 | → |