PPAR agonists as therapeutics for CNS trauma and neurological diseases.

paper Cited Public

Authors: Mandrekar-Colucci, Shweta; Sauerbeck, Andrew; Popovich, Phillip G; McTigue, Dana M
Year: 2013
Journal: ASN neuro
PMID: 24215544
DOI: 10.1042/AN20130030
PMCID: PMC3866683

#	Section	Preview
40	PPARs AND MITOCHONDRIAL BIOENERGETICS	In addition to driving gene transcription, some PPAR agonists interact directly with mitochondria…
41	RXRs AS A MEANS TO TARGET PPARs	RXRs are essential for PPAR signaling. Specifically, RXRs heterodimerize with PPARs, creating…
42	RXRs AS A MEANS TO TARGET PPARs	Activation of RXR elicits a response similar to that observed after PPAR activation. For instance,…
43	RXRs AS A MEANS TO TARGET PPARs	Moreover, due to the promiscuous nature of RXR heterodimer activation, PPAR signaling pathways may…
44	NON-TRADITIONAL ACTIONS OF PPARs	PPAR agonists can influence pathological processes through mechanisms that are independent of their…
45	NON-TRADITIONAL ACTIONS OF PPARs	explained by immune cells expressing both PPARγ and PPARδ receptors and each receptor having…
46	CONCLUSIONS	The beneficial effects of PPAR activation have been independently reproduced in many rodent models…

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In this knowledge base

Title	Year	PMID
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.	2015	25516156

External

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Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study.	Eldahshan W et al.	—	2019	→
Peroxisome Proliferator-Activated Receptor γ Agonist Rosiglitazone Protects Blood-Brain Barrier Integrity Following Diffuse Axonal Injury by Decreasing the Levels of Inflammatory Mediators Through a Caveolin-1-Dependent Pathway.	Zhao Y et al.	—	2019	→
PPAR-γ agonist GL516 reduces oxidative stress and apoptosis occurrence in a rat astrocyte cell line.	Giampietro L et al.	—	2019	→
Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion.	Serra MP et al.	—	2019	→
The Medical Management of Cerebral Edema: Past, Present, and Future Therapies.	Halstead MR et al.	—	2019	→
A Precision Medicine Approach to Cerebral Edema and Intracranial Hypertension after Severe Traumatic Brain Injury: Quo Vadis?	Jha RM et al.	—	2018	→
Cell death after traumatic brain injury: Detrimental role of anoikis in healing.	Sater AP et al.	—	2018	→
Emerging Therapeutic Role of PPAR-α in Cognition and Emotions.	Nisbett KE et al.	—	2018	→
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair.	Cai W et al.	—	2018	→
Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice.	Wen L et al.	—	2018	→
PPARβ/δ: Linking Metabolism to Regeneration.	Magadum A et al.	—	2018	→
Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion.	Carta G et al.	—	2018	→
Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation.	Villapol S	—	2018	→
Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-<i>γ</i> Impairs Glucose Metabolism and Estrous Cycling in Female Mice.	Fernandez MO et al.	—	2017	→
Changes in PPARδ expression in a rat model of stress-induced depression.	Liu KF et al.	—	2017	→
Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease.	Srinivasan M et al.	—	2017	→
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.	Zhu Y et al.	—	2017	→
Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics.	Pearn ML et al.	—	2017	→
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.	Ji J et al.	—	2017	→
Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy.	Simeone TA et al.	—	2017	→
The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury.	Stivers NS et al.	—	2017	→
Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation.	Avila-Martin G et al.	—	2017	→
Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish.	Ashikawa Y et al.	—	2016	→
Evidence that activation of nuclear peroxisome proliferator-activated receptor alpha (PPARα) modulates sleep homeostasis in rats.	Murillo-Rodríguez E et al.	—	2016	→
Protective features of peripheral monocytes/macrophages in stroke.	Gliem M et al.	—	2016	→
Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats.	Liu H et al.	—	2016	→
Activation of central PPAR-γ attenuates angiotensin II-induced hypertension.	Yu Y et al.	—	2015	→
Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders.	Demeestere D et al.	—	2015	→
Complex role of peroxisome proliferator activator receptors (PPARs) in nociception.	Giniatullin R et al.	—	2015	→
Macrophage activation and its role in repair and pathology after spinal cord injury.	Gensel JC et al.	—	2015	→
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.	Blednov YA et al.	—	2015	→
Fetal alcohol spectrum disorders and neuroimmune changes.	Drew PD et al.	—	2014	→
Role of PPAR γ in the Differentiation and Function of Neurons.	Quintanilla RA et al.	—	2014	→