Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.
paper
Cited
Public
Unavailable
- Authors
- Skol, Andrew D; Scott, Laura J; Abecasis, Gonçalo R; Boehnke, Michael
- Year
- 2006
- Journal
- Nature genetics
- PMID
- 16415888
- DOI
- 10.1038/ng1706
Genome-wide association is a promising approach to identify common genetic variants that predispose to human disease. Because of the high cost of genotyping hundreds of thousands of markers on thousands of subjects, genome-wide association studies often follow a staged design in which a proportion (pi(samples)) of the available samples are genotyped on a large number of markers in stage 1, and a proportion (pi(samples)) of these markers are later followed up by genotyping them on the remaining samples in stage 2. The standard strategy for analyzing such two-stage data is to view stage 2 as a replication study and focus on findings that reach statistical significance when stage 2 data are considered alone. We demonstrate that the alternative strategy of jointly analyzing the data from both stages almost always results in increased power to detect genetic association, despite the need to use more stringent significance levels, even when effect sizes differ between the two stages. We recommend joint analysis for all two-stage genome-wide association studies, especially when a relatively large proportion of the samples are genotyped in stage 1 (pi(samples) >or= 0.30), and a relatively large proportion of markers are selected for follow-up in stage 2 (pi(markers) >or= 0.01).
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| BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm. | Siokas V et al. | β | 2019 | β |
| CCR5-Ξ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes. | SΕomiΕski B et al. | β | 2019 | β |
| Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk? | Stamati P et al. | β | 2019 | β |
| Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury. | Dardiotis E et al. | β | 2019 | β |
| Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. | Deak JD et al. | β | 2019 | β |
| ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population. | Dardiotis E et al. | β | 2019 | β |
| Functional Polymorphism Located in the microRNA Binding Site of the Insulin Receptor (INSR) Gene Confers Risk for Type 2 Diabetes Mellitus in the Bangladeshi Population. | Parvin M et al. | β | 2019 | β |
| Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. | Laufer VA et al. | β | 2019 | β |
| Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension. | Kuehn MH et al. | β | 2019 | β |
| Gene variants of adhesion molecules predispose to MS: A case-control study. | Dardiotis E et al. | β | 2019 | β |
| Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits. | Zhao B et al. | β | 2019 | β |
| Genome-wide association study of psoriasis in an Egyptian population. | Bejaoui Y et al. | β | 2019 | β |
| Genome-wide association study of right-sided colonic diverticulosis in a Korean population. | Choe EK et al. | β | 2019 | β |
| Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B. | Radhakrishnan K et al. | β | 2019 | β |
| Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study. | LΓ³pez-MejΓas R et al. | β | 2019 | β |
| Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. | Nalls MA et al. | β | 2019 | β |
| IgG4-related disease in the Japanese population: a genome-wide association study. | Terao C et al. | β | 2019 | β |
| Influence of single nucleotide polymorphisms (SNPs) in genetic susceptibility towards periprosthetic osteolysis. | Jagga S et al. | β | 2019 | β |
| Lack of Association of the rs11655081 ARSG Gene with Blepharospasm. | Siokas V et al. | β | 2019 | β |
| Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. | Lu Y et al. | β | 2019 | β |
| Lipidomics, Atrial Conduction, and Body Mass Index. | Del Greco M F et al. | β | 2019 | β |
| Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. | de Vries PS et al. | β | 2019 | β |
| Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. | Bentley AR et al. | β | 2019 | β |
| Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. | Stevenson A et al. | β | 2019 | β |
| Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. | den Dekker HT et al. | β | 2019 | β |
| PAMAM: Power analysis in multiancestry admixture mapping. | Gautam Y et al. | β | 2019 | β |
| PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome. | Mola-Caminal M et al. | β | 2019 | β |
| Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification. | Moore CM et al. | β | 2019 | β |
| Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms. | Haug-Baltzell A et al. | β | 2019 | β |
| pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS). | Graw S et al. | β | 2019 | β |
| Rare-variant collapsing analyses for complex traits: guidelines and applications. | Povysil G et al. | β | 2019 | β |
| Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease. | Pirola CJ et al. | β | 2019 | β |
| Statistical power in genome-wide association studies and quantitative trait locus mapping. | Wang M et al. | β | 2019 | β |
| The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight. | Bandres-Ciga S et al. | β | 2019 | β |
| The genetics of human hematopoiesis and its disruption in disease. | Bao EL et al. | β | 2019 | β |
| The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects. | Leung KH et al. | β | 2019 | β |
| X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. | Zuo XY et al. | β | 2019 | β |
| A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773). | Meng W et al. | β | 2018 | β |
| A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes. | Meng W et al. | β | 2018 | β |
| A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. | Sung YJ et al. | β | 2018 | β |
| A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response. | Lyu XM et al. | β | 2018 | β |
| Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women. | Arora GP et al. | β | 2018 | β |
| Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus. | GonzΓ‘lez-Serna D et al. | β | 2018 | β |
| Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population. | Huang L et al. | β | 2018 | β |
| Association of PGC-1Ξ± gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study. | Sharma R et al. | β | 2018 | β |
| A two-stage hidden Markov model design for biomarker detection, with application to microbiome research. | Zhou YH et al. | β | 2018 | β |
| CCR5Ξ32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. | Cavalla F et al. | β | 2018 | β |
| Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy. | Leon Rodriguez DA et al. | β | 2018 | β |
| Consortium-based genome-wide meta-analysis for childhood dental caries traits. | Haworth S et al. | β | 2018 | β |
| DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain. | Pascal MMV et al. | β | 2018 | β |
| Effect of Obesity-Linked <i>FTO</i> rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women. | West NR et al. | β | 2018 | β |
| Epigenome-Wide Association Study of Dietary Fiber Intake in African American Adolescents. | Chen L et al. | β | 2018 | β |
| Frequency of Cardiovascular Genetic Risk Factors in a Calabrian Population and Their Effects on Dementia. | Maletta R et al. | β | 2018 | β |
| Genetic association study from North India to analyze association of CYP19A1 and CYP17A1 with polycystic ovary syndrome. | Kaur R et al. | β | 2018 | β |
| Genetic disease risks can be misestimated across global populations. | Kim MS et al. | β | 2018 | β |
| Genetic variations in the <i>SULF1</i> gene alter the risk of cervical cancer and precancerous lesions. | Dardiotis E et al. | β | 2018 | β |
| Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. | Teumer A et al. | β | 2018 | β |
| Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus. | Munz M et al. | β | 2018 | β |
| Genome-wide association studies of albuminuria: towards genetic stratification in diabetes? | Pattaro C | β | 2018 | β |
| Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. | Tanskanen T et al. | β | 2018 | β |
| Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. | Zheng R et al. | β | 2018 | β |
| Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. | Vojinovic D et al. | β | 2018 | β |
| Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer. | Gao B et al. | β | 2018 | β |
| Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. | Nielsen JB et al. | β | 2018 | β |
| Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer. | Scannell Bryan M et al. | β | 2018 | β |
| GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response. | Sathur Raghuraman B et al. | β | 2018 | β |
| Identification of an Amino Acid Motif in HLA-DRΞ²1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis. | Haasnoot AJW et al. | β | 2018 | β |
| Identification of rare noncoding sequence variants in gamma-aminobutyric acid A receptor, alpha 4 subunit in autism spectrum disorder. | Griswold AJ et al. | β | 2018 | β |
| Interethnic analyses of blood pressure loci in populations of East Asian and European descent. | Takeuchi F et al. | β | 2018 | β |
| Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease. | Sookoian S et al. | β | 2018 | β |
| Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. | Floyd JS et al. | β | 2018 | β |
| Machine Learning and Radiogenomics: Lessons Learned and Future Directions. | Kang J et al. | β | 2018 | β |
| Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. | Nagel M et al. | β | 2018 | β |
| New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation. | Fabbri C et al. | β | 2018 | β |
| No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children. | Bozdogan ST et al. | β | 2018 | β |
| Power and sample size calculations for high-throughput sequencing-based experiments. | Li CI et al. | β | 2018 | β |
| Power, false discovery rate and Winner's Curse in eQTL studies. | Huang QQ et al. | β | 2018 | β |
| Replication of GWAS identified miR-137 and its target gene polymorphisms in Schizophrenia of South Indian population and meta-analysis with Psychiatric Genomics Consortium. | Sudesh R et al. | β | 2018 | β |
| Strong Association of the <i>HLA-DR/DQ</i> Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. | Jia X et al. | β | 2018 | β |
| The evidential statistical paradigm in genetics. | Strug LJ | β | 2018 | β |
| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | β | 2018 | β |
| Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. | Loveday C et al. | β | 2018 | β |
| A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol. | Chang CJ et al. | β | 2017 | β |
| A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis. | Carmona FD et al. | β | 2017 | β |
| A genome-wide association study of essential hypertension in an Australian population using a DNA pooling approach. | Fowdar JY et al. | β | 2017 | β |
| A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers. | Meng W et al. | β | 2017 | β |
| A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility. | Uren C et al. | β | 2017 | β |
| A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL. | Sofer T et al. | β | 2017 | β |
| Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation. | Winkler TW et al. | β | 2017 | β |
| Association analysis identifies 65 new breast cancer risk loci. | Michailidou K et al. | β | 2017 | β |
| Association of 4p14 and 6q27 variation with Graves disease: a case-control study and a meta-analysis of available evidence. | Li FM et al. | β | 2017 | β |
| Association of a Haplotype in the NR3C2 Gene, Encoding the Mineralocorticoid Receptor, With Chronic Central Serous Chorioretinopathy. | van Dijk EHC et al. | β | 2017 | β |
| Association of Common Variants in TGFA with Increased Risk of Knee Osteoarthritis Susceptibility. | Cui G et al. | β | 2017 | β |
| Association of FCGR2A/FCGR3A variant rs2099684 with Takayasu arteritis in the Han Chinese population. | Chen S et al. | β | 2017 | β |
| Association of <i>TCN2</i> rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies. | Oussalah A et al. | β | 2017 | β |
| Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population. | Yu H et al. | β | 2017 | β |
| Dense genotyping of immune-related loci implicates host responses to microbial exposure in BehΓ§et's disease susceptibility. | Takeuchi M et al. | β | 2017 | β |
| Design Considerations for Genetic Linkage and Association Studies. | Nsengimana J et al. | β | 2017 | β |
| Discovery of susceptibility loci associated with tuberculosis in Han Chinese. | Qi H et al. | β | 2017 | β |
| Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations. | Nagy K et al. | β | 2017 | β |
| Donor Genotype and Intragraft Expression of CYP3A5 Reflect the Response to Steroid Treatment During Acute Renal Allograft Rejection. | Rekers NV et al. | β | 2017 | β |
| Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study. | Vilella M et al. | β | 2017 | β |
| Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. | Busch R et al. | β | 2017 | β |
| Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. | Kalmbach DA et al. | β | 2017 | β |
| Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study. | Siitonen A et al. | β | 2017 | β |
| Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. | Way MJ et al. | β | 2017 | β |
| Genetic variants of 20q12 contributed to non-syndromic orofacial clefts susceptibility. | Yin X et al. | β | 2017 | β |
| Genetic variation in GABRΞ²1 and the risk for developing alcohol dependence. | McCabe WA et al. | β | 2017 | β |
| Genetic variation in long noncoding RNAs and the risk of nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2017 | β |
| Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma. | Wilkins OM et al. | β | 2017 | β |
| Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. | Li Z et al. | β | 2017 | β |
| Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. | Hammerschlag AR et al. | β | 2017 | β |
| Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine. | Haralambieva IH et al. | β | 2017 | β |
| Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. | Deming Y et al. | β | 2017 | β |
| Genome-Wide Association Study of Acute Renal Graft Rejection. | Ghisdal L et al. | β | 2017 | β |
| Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. | Sud A et al. | β | 2017 | β |
| Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation. | Gondalia R et al. | β | 2017 | β |
| Genome-wide study of resistant hypertension identified from electronic health records. | Dumitrescu L et al. | β | 2017 | β |
| GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population. | Li L et al. | β | 2017 | β |
| Glutathione S-transferase P1 gene polymorphisms and susceptibility to coronary artery disease in a subgroup of north Indian population. | Bhat MA et al. | β | 2017 | β |
| High-resolution copy number variation analysis of schizophrenia in Japan. | Kushima I et al. | β | 2017 | β |
| Holy Smokes-An Interaction! | Mitchell BD | β | 2017 | β |
| <i>AdmixPower</i>: Statistical Power and Sample Size Estimation for Mapping Genetic Loci in Admixed Populations. | Gautam Y et al. | β | 2017 | β |
| Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. | Litchfield K et al. | β | 2017 | β |
| Identifying and mitigating batch effects in whole genome sequencing data. | Tom JA et al. | β | 2017 | β |
| IFN-Ξ»3, not IFN-Ξ»4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis. | Eslam M et al. | β | 2017 | β |
| Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews. | Streicher SA et al. | β | 2017 | β |
| Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children. | Schuldt K et al. | β | 2017 | β |
| Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. | Wild PS et al. | β | 2017 | β |
| Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale. | Rao DC et al. | β | 2017 | β |
| New insights into the genetic component of non-infectious uveitis through an Immunochip strategy. | MΓ‘rquez A et al. | β | 2017 | β |
| Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency. | Sookoian S et al. | β | 2017 | β |
| Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults. | Varga TV et al. | β | 2017 | β |
| Plasminogen Activator Inhibitor Type-1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetes Mellitus Type 2 and Diabetic Retinopathy. | Siokas V et al. | β | 2017 | β |
| Positive Association between <i>ANKRD55</i> Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population. | Li L et al. | β | 2017 | β |
| Prioritizing covariates in the planning of future studies in the meta-analytic framework. | Karvanen J et al. | β | 2017 | β |
| Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology: A Primer on -Omic Technologies. | WΓΌrtz P et al. | β | 2017 | β |
| Rare germline variants in ATM are associated with chronic lymphocytic leukemia. | Tiao G et al. | β | 2017 | β |
| Revisiting biomarker discovery by plasmaΒ proteomics. | Geyer PE et al. | β | 2017 | β |
| Role of 108 schizophrenia-associated loci in modulating psychopathological dimensions in schizophrenia and bipolar disorder. | Fabbri C et al. | β | 2017 | β |
| Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome. | Lorca V et al. | β | 2017 | β |
| Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population. | Chen S et al. | β | 2017 | β |
| Statistical correction of the Winner's Curse explains replication variability in quantitative trait genome-wide association studies. | Palmer C et al. | β | 2017 | β |
| The association study of nonsyndromic cleft lip with or without cleft palate identified risk variants of the GLI3 gene in a Chinese population. | Wang Y et al. | β | 2017 | β |
| The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study. | Khella MS et al. | β | 2017 | β |
| The Genetic Landscape of Renal Complications in Type 1 Diabetes. | Sandholm N et al. | β | 2017 | β |
| The SNP-set based association study identifies ITGA1 as a susceptibility gene of attention-deficit/hyperactivity disorder in Han Chinese. | Liu L et al. | β | 2017 | β |
| Two genetic loci associated with ankle injury. | Kim SK et al. | β | 2017 | β |
| A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. | Li X et al. | β | 2016 | β |
| A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. | Chang C et al. | β | 2016 | β |
| A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference. | de Toro-MartΓn J et al. | β | 2016 | β |
| A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. | de Vries PS et al. | β | 2016 | β |
| Analysis of association of FOXO3 gene with Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy. | Leon Rodriguez DA et al. | β | 2016 | β |
| A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. | Deming Y et al. | β | 2016 | β |
| Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality. | Kim J et al. | β | 2016 | β |
| A Toll-like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinean children. | Manning L et al. | β | 2016 | β |
| Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children. | Gomez-Sanchez CI et al. | β | 2016 | β |
| Beyond Endometriosis Genome-Wide Association Study: From Genomics to Phenomics to the Patient. | Zondervan KT et al. | β | 2016 | β |
| Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics. | Bandelow B et al. | β | 2016 | β |
| Breeding for resistance to gastrointestinal nematodes - the potential in low-input/output small ruminant production systems. | Zvinorova PI et al. | β | 2016 | β |
| Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits. | Golbus JR et al. | β | 2016 | β |
| Common Genetic Variant in VIT Is Associated with Human Brain Asymmetry. | Tadayon SH et al. | β | 2016 | β |
| Complement pathway biomarkers and age-related macular degeneration. | Gemenetzi M et al. | β | 2016 | β |
| CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk. | Garcia-Albeniz X et al. | β | 2016 | β |
| DNA Repair Gene (XRCC1) Polymorphism (Arg399Gln) Associated with Schizophrenia in South Indian Population: A Genotypic and Molecular Dynamics Study. | Sujitha SP et al. | β | 2016 | β |
| Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy. | Leon Rodriguez DA et al. | β | 2016 | β |
| Exome Sequencing of Familial Bipolar Disorder. | Goes FS et al. | β | 2016 | β |
| Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. | Pattaro C et al. | β | 2016 | β |
| Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study. | Pavlidou E et al. | β | 2016 | β |
| Genetics of structural connectivity and information processing in the brain. | Giddaluru S et al. | β | 2016 | β |
| Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits. | Deming Y et al. | β | 2016 | β |
| Genetic Variants Associated with Colorectal Adenoma Susceptibility. | AbulΓ A et al. | β | 2016 | β |
| Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review. | Oussalah A et al. | β | 2016 | β |
| Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. | van Rheenen W et al. | β | 2016 | β |
| Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia. | Zhang YB et al. | β | 2016 | β |
| Genome-wide association study of sporadic brain arteriovenous malformations. | Weinsheimer S et al. | β | 2016 | β |
| Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. | Reyes-Gibby CC et al. | β | 2016 | β |
| Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. | Gong J et al. | β | 2016 | β |
| IL18 Gene Variants Influence the Susceptibility to Chagas Disease. | Leon Rodriguez DA et al. | β | 2016 | β |
| Immune response genes receptors expression and polymorphisms in relation to multiple sclerosis susceptibility and response to INF-Ξ² therapy. | Karam RA et al. | β | 2016 | β |
| Influence of TNF-Ξ±-308Β G/A gene polymorphism on temporomandibular disorder. | Furquim BD et al. | β | 2016 | β |
| Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway. | LΓ³pez-Isac E et al. | β | 2016 | β |
| Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. | NINDS Stroke Genetics Network (SiGN) et al. | β | 2016 | β |
| MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C. | Thabet K et al. | β | 2016 | β |
| Mendelian randomisation suggests no beneficial effect of moderate alcohol consumption on the severity of nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2016 | β |
| Meta-analysis of genome-wide association from genomic prediction models. | Bernal Rubio YL et al. | β | 2016 | β |
| Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. | Kerns SL et al. | β | 2016 | β |
| Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome. | Sinisalo J et al. | β | 2016 | β |
| On Sample Size and Power Calculation for Variant Set-Based Association Tests. | Wu B et al. | β | 2016 | β |
| Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity. | Crocco P et al. | β | 2016 | β |
| Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis. | Bowker N et al. | β | 2016 | β |
| Positive association of genetic variations in the phospholipase C-like 1 gene with dermatomyositis in Chinese Han. | Wang Q et al. | β | 2016 | β |
| Possible association of CCDC62 rs12817488 polymorphism and Parkinson's disease risk in Chinese population: a meta-analysis. | Lu Y et al. | β | 2016 | β |
| PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients. | Gallego-Fabrega C et al. | β | 2016 | β |
| Reclassification of genetic-based risk predictions as GWAS data accumulate. | Krier J et al. | β | 2016 | β |
| Relationship between MTHFR C677T and A1298C gene polymorphisms and complications of type 2 diabetes mellitus in an Emirati population. | El Hajj Chehadeh SW et al. | β | 2016 | β |
| Separating the wheat from the chaff: systematic identification of functionally relevant noncoding variants in ADHD. | Tong JH et al. | β | 2016 | β |
| Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates. | Lochner C et al. | β | 2016 | β |
| The genomic landscape of testicular germ cell tumours: from susceptibility to treatment. | Litchfield K et al. | β | 2016 | β |
| The Human MSI2 Gene is Associated with Schizophrenia in the Chinese Han Population. | Luan Z et al. | β | 2016 | β |
| Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol. | Cotlarciuc I et al. | β | 2016 | β |
| Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations. | Wang HZ et al. | β | 2016 | β |
| 15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers. | Leng S et al. | β | 2015 | β |
| A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. | Bossini-Castillo L et al. | β | 2015 | β |
| A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain. | Meng W et al. | β | 2015 | β |
| A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain. | Meng W et al. | β | 2015 | β |
| A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility. | Carmona FD et al. | β | 2015 | β |
| Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. | Nan H et al. | β | 2015 | β |
| Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension. | Leu HB et al. | β | 2015 | β |
| Association of gene variants with susceptibility to type 2 diabetes among Omanis. | Al-Sinani S et al. | β | 2015 | β |
| Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. | Salie M et al. | β | 2015 | β |
| Association of Transforming Growth Factor Beta-1 (TGF-Ξ²1) Genetic Variation with Type 2 Diabetes and End Stage Renal Disease in Two Large Population Samples from North India. | Raina P et al. | β | 2015 | β |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | β | 2015 | β |
| Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. | SΓ‘nchez-Mora C et al. | β | 2015 | β |
| Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi-ethnic cohort. | Abdullah N et al. | β | 2015 | β |
| Contribution of common and rare variants of the PTCHD1 gene to autism spectrum disorders and intellectual disability. | Torrico B et al. | β | 2015 | β |
| COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. | Lin CH et al. | β | 2015 | β |
| DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection. | Everson TM et al. | β | 2015 | β |
| Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. | Pirola CJ et al. | β | 2015 | β |
| Evaluation of a two-step iterative resampling procedure for internal validation of genome-wide association studies. | Kang G et al. | β | 2015 | β |
| F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease. | Tosto G et al. | β | 2015 | β |
| Genetic contributions to urgency urinary incontinence in women. | Richter HE et al. | β | 2015 | β |
| Genetic loci associated with circulating levels of very long-chain saturated fatty acids. | Lemaitre RN et al. | β | 2015 | β |
| Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise. | Grondin Y et al. | β | 2015 | β |
| Genetic study of intracranial aneurysms. | Yan J et al. | β | 2015 | β |
| Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. | MacInnes SJ et al. | β | 2015 | β |
| Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity. | Sookoian S et al. | β | 2015 | β |
| Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. | Evans DS et al. | β | 2015 | β |
| Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. | Ghesquieres H et al. | β | 2015 | β |
| Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). | Wojczynski MK et al. | β | 2015 | β |
| Hierarchical Bayesian model for rare variant association analysis integrating genotype uncertainty in human sequence data. | He L et al. | β | 2015 | β |
| Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population. | Wei JC et al. | β | 2015 | β |
| Lessons learned in the analysis of high-dimensional data in vaccinomics. | Oberg AL et al. | β | 2015 | β |
| Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome. | Almawi WY et al. | β | 2015 | β |
| Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis. | Onodera K et al. | β | 2015 | β |
| Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. | Germain M et al. | β | 2015 | β |
| Metabolomics in the developmental origins of obesity and its cardiometabolic consequences. | Hivert MF et al. | β | 2015 | β |
| Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds. | Shin DH et al. | β | 2015 | β |
| Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies. | Zhang W et al. | β | 2015 | β |
| P < 5 Γ 10(-8) has emerged as a standard of statistical significance for genome-wide association studies. | Jannot AS et al. | β | 2015 | β |
| Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults. | Hochner H et al. | β | 2015 | β |
| Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. | Huffman JE et al. | β | 2015 | β |
| Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma. | Chen W et al. | β | 2015 | β |
| Robust Association Tests for the Replication of Genome-Wide Association Studies. | Joo J et al. | β | 2015 | β |
| Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population. | Chen S et al. | β | 2015 | β |
| Solving the genetic puzzle of systemic lupus erythematosus. | Yang W et al. | β | 2015 | β |
| TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection. | Cavalla F et al. | β | 2015 | β |
| Testing for polygenic effects in genome-wide association studies. | Pan W et al. | β | 2015 | β |
| Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation. | Dessing MC et al. | β | 2015 | β |
| UGMDR: a unified conceptual framework for detection of multifactor interactions underlying complex traits. | Lou XY | β | 2015 | β |
| 8q24 risk alleles and prostate cancer in African-Barbadian men. | Cropp CD et al. | β | 2014 | β |
| A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. | LΓ³pez-Isac E et al. | β | 2014 | β |
| A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA. | Awata T et al. | β | 2014 | β |
| A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study. | Schmit SL et al. | β | 2014 | β |
| A novel SNP associated with nighttime pulse pressure in young-onset hypertension patients could be a genetic prognostic factor for cardiovascular events in a general cohort in Taiwan. | Leu HB et al. | β | 2014 | β |
| Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect. | Takahashi H et al. | β | 2014 | β |
| A recessive genetic model and runs of homozygosity in major depressive disorder. | Power RA et al. | β | 2014 | β |
| Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study. | Marr N et al. | β | 2014 | β |
| Assessment of Parkinson's disease risk loci in Greece. | Kara E et al. | β | 2014 | β |
| Association mapping of disease resistance traits in rainbow trout using restriction site associated DNA sequencing. | Campbell NR et al. | β | 2014 | β |
| Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in Taiwan. | Lin CH et al. | β | 2014 | β |
| Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. | Loomis SJ et al. | β | 2014 | β |
| Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population. | Ando T et al. | β | 2014 | β |
| Association of Toll-like receptor polymorphisms with HIV status in North Americans. | Willie B et al. | β | 2014 | β |
| A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. | Fachal L et al. | β | 2014 | β |
| Censored Rank Independence Screening for High-dimensional Survival Data. | Song R et al. | β | 2014 | β |
| Common and rare variant analysis in early-onset bipolar disorder vulnerability. | Jamain S et al. | β | 2014 | β |
| Complex pedigrees in the sequencing era: to track transmissions or decorrelate? | Li D et al. | β | 2014 | β |
| Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. | Kiryluk K et al. | β | 2014 | β |
| Effect of genetic variants associated with plasma homocysteine levels on stroke risk. | Cotlarciuc I et al. | β | 2014 | β |
| Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children. | Schuldt K et al. | β | 2014 | β |
| Environmental risk score as a new tool to examine multi-pollutants in epidemiologic research: an example from the NHANES study using serum lipid levels. | Park SK et al. | β | 2014 | β |
| Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. | Chen GB et al. | β | 2014 | β |
| Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women. | Lee HS et al. | β | 2014 | β |
| Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. | Palmer ND et al. | β | 2014 | β |
| Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3. | Rye MS et al. | β | 2014 | β |
| Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population. | Chen S et al. | β | 2014 | β |
| Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. | Ma X et al. | β | 2014 | β |
| Genetic variation modifies risk for neurodegeneration based on biomarker status. | Hohman TJ et al. | β | 2014 | β |
| Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children. | Sharma N et al. | β | 2014 | β |
| Genomewide association study in cervical dystonia demonstrates possible association with sodium leak channel. | Mok KY et al. | β | 2014 | β |
| Genome-wide diet-gene interaction analyses for risk of colorectal cancer. | Figueiredo JC et al. | β | 2014 | β |
| Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. | BΓΈrglum AD et al. | β | 2014 | β |
| ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease. | Barresi V et al. | β | 2014 | β |
| Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. | Mayes MD et al. | β | 2014 | β |
| Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism. | Bruzelius M et al. | β | 2014 | β |
| Investigation of maternal genotype effects in autism by genome-wide association. | Yuan H et al. | β | 2014 | β |
| Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study. | Ferreiro-Iglesias A et al. | β | 2014 | β |
| Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. | Ng MC et al. | β | 2014 | β |
| Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair. | Yee Ko JM et al. | β | 2014 | β |
| No large-effect low-frequency coding variation found for myocardial infarction. | Holmen OL et al. | β | 2014 | β |
| No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia. | Kishi T et al. | β | 2014 | β |
| PLA2R-associated membranous glomerulopathy is modulated by common variants in PLA2R1 and HLA-DQA1 genes. | Saeed M et al. | β | 2014 | β |
| Polymorphisms in immune mediators associate with risk of cervical cancer. | Zhang Z et al. | β | 2014 | β |
| Polymorphisms in TNC and COL5A1 genes are associated with risk of superficial digital flexor tendinopathy in National Hunt Thoroughbred racehorses. | Tully LJ et al. | β | 2014 | β |
| Power analysis and sample size estimation for sequence-based association studies. | Wang GT et al. | β | 2014 | β |
| Predicting non return to work after orthopaedic trauma: the Wallis Occupational Rehabilitation RisK (WORRK) model. | Luthi F et al. | β | 2014 | β |
| Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. | Kim DS et al. | β | 2014 | β |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. | Cho MH et al. | β | 2014 | β |
| SCN1A variations and response to multiple antiepileptic drugs. | Yip TS et al. | β | 2014 | β |
| The validity of circulating microRNAs in oncology: five years of challenges and contradictions. | Jarry J et al. | β | 2014 | β |
| Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study. | Thompson CM et al. | β | 2014 | β |
| Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population. | Lin CH et al. | β | 2014 | β |
| A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder. | Fernandes CP et al. | β | 2013 | β |
| A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. | Allen EK et al. | β | 2013 | β |
| A genome-wide association study of total serum and mite-specific IgEs in asthma patients. | Kim JH et al. | β | 2013 | β |
| A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication. | Hein R et al. | β | 2013 | β |
| A novel method for analyzing genetic association with longitudinal phenotypes. | Londono D et al. | β | 2013 | β |
| Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. | Qi L et al. | β | 2013 | β |
| Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population. | Liu H et al. | β | 2013 | β |
| Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. | Teruel M et al. | β | 2013 | β |
| Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population. | Wang X et al. | β | 2013 | β |
| Association study of CRP gene polymorphism and hypertension in Han Chinese population. | Zhao Y et al. | β | 2013 | β |
| A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. | Martin JE et al. | β | 2013 | β |
| BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations. | Fernandez-Rozadilla C et al. | β | 2013 | β |
| CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients. | GarcΓa-BermΓΊdez M et al. | β | 2013 | β |
| Challenges in reproducibility of genetic association studies: lessons learned from the obesity field. | Li A et al. | β | 2013 | β |
| Characterizing vaccine responses using host genomic and transcriptomic analysis. | O'Connor D et al. | β | 2013 | β |
| Chiari malformation type I: a case-control association study of 58 developmental genes. | Urbizu A et al. | β | 2013 | β |
| Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance. | Tellechea ML et al. | β | 2013 | β |
| Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. | Bossini-Castillo L et al. | β | 2013 | β |
| C-reactive protein +Β 1059 G>C polymorphism in type 2 diabetes and coronary artery disease patients. | Kaur R et al. | β | 2013 | β |
| Development and validation of a predicting model of all-cause mortality in patients with type 2 diabetes. | De Cosmo S et al. | β | 2013 | β |
| Early antidepressant efficacy modulation by glutamatergic gene variants in the STAR*D. | Fabbri C et al. | β | 2013 | β |
| Emerging paradigms in genomics-based crop improvement. | Bohra A | β | 2013 | β |
| Ethnic differences in CAPN10 SNP-19 in type 2 diabetes: a North-West Indian case control study and evidence from meta-analysis. | Sharma R et al. | β | 2013 | β |
| Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. | Albrechtsen A et al. | β | 2013 | β |
| Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. | Swaminathan B et al. | β | 2013 | β |
| Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | Sun X et al. | β | 2013 | β |
| Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. | Hutter CM et al. | β | 2013 | β |
| Genetic analysis of candidate SNPs for metabolic syndrome in obstructive sleep apnea (OSA). | Grilo A et al. | β | 2013 | β |
| Genetic analysis of the FUS/TLS gene in essential tremor. | Parmalee N et al. | β | 2013 | β |
| Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. | Helmstaedter C et al. | β | 2013 | β |
| Genetic variations in EGFR and ERBB4 increase susceptibility to cervical cancer. | Ma D et al. | β | 2013 | β |
| Genome-wide analysis of blood pressure variability and ischemic stroke. | Yadav S et al. | β | 2013 | β |
| Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. | Germain M et al. | β | 2013 | β |
| Genome-wide association studies. | Yang TH et al. | β | 2013 | β |
| Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. | Chen DT et al. | β | 2013 | β |
| Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. | Duggal P et al. | β | 2013 | β |
| Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. | Weissglas-Volkov D et al. | β | 2013 | β |
| Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. | Popanda O et al. | β | 2013 | β |
| High trans-ethnic replicability of GWAS results implies common causal variants. | Marigorta UM et al. | β | 2013 | β |
| ICD-9 tobacco use codes are effective identifiers of smoking status. | Wiley LK et al. | β | 2013 | β |
| Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data. | Takahashi H et al. | β | 2013 | β |
| Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. | Diaz-Gallo LM et al. | β | 2013 | β |
| Inherited variants in regulatory T cell genes and outcome of ovarian cancer. | Goode EL et al. | β | 2013 | β |
| Investigation of juvenile idiopathic arthritis susceptibility loci: results from a Greek population. | Dimopoulou DG et al. | β | 2013 | β |
| Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm. | Zheng HF et al. | β | 2013 | β |
| Neurotransmitter systems and neurotrophic factors in autism: association study of 37 genes suggests involvement of DDC. | Toma C et al. | β | 2013 | β |
| New insight on the Xq28 association with systemic sclerosis. | Carmona FD et al. | β | 2013 | β |
| New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. | Postula M et al. | β | 2013 | β |
| Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration. | Fernandez-Rozadilla C et al. | β | 2013 | β |
| Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach. | Hennings JM et al. | β | 2013 | β |
| Prediction of a time-to-event trait using genome wide SNP data. | Kim J et al. | β | 2013 | β |
| Replication and fine mapping of asthma-associated loci in individuals of African ancestry. | Kantor DB et al. | β | 2013 | β |
| Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population. | Sundqvist J et al. | β | 2013 | β |
| Robust joint analysis with data fusion in two-stage quantitative trait genome-wide association studies. | Pan DD et al. | β | 2013 | β |
| Seven new loci associated with age-related macular degeneration. | Fritsche LG et al. | β | 2013 | β |
| Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. | Nakano R et al. | β | 2013 | β |
| The -521 C/T variant in the dopamine-4-receptor gene (DRD4) is associated with skiing and snowboarding behavior. | Thomson CJ et al. | β | 2013 | β |
| The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium as a model of collaborative science. | Psaty BM et al. | β | 2013 | β |
| The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies. | Lindquist KJ et al. | β | 2013 | β |
| The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia. | Ohi K et al. | β | 2013 | β |
| The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. | Rask-Andersen M et al. | β | 2013 | β |
| The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. | Carmona FD et al. | β | 2013 | β |
| To replicate or not to replicate: the case of pharmacogenetic studies: Establishing validity of pharmacogenomic findings: from replication to triangulation. | Aslibekyan S et al. | β | 2013 | β |
| Two-phase and family-based designs for next-generation sequencing studies. | Thomas DC et al. | β | 2013 | β |
| Utilizing twins as controls for non-twin case-materials in genome wide association studies. | Ganna A et al. | β | 2013 | β |
| A candidate gene approach to genetic contributors to the development of IgA nephropathy. | Yamamoto R et al. | β | 2012 | β |
| A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis. | Vandenbroeck K et al. | β | 2012 | β |
| A flexible likelihood framework for detecting associations with secondary phenotypes in genetic studies using selected samples: application to sequence data. | Liu DJ et al. | β | 2012 | β |
| A general framework for two-stage analysis of genome-wide association studies and its application to case-control studies. | Wason JM et al. | β | 2012 | β |
| A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. | Manning AK et al. | β | 2012 | β |
| A genome-wide association study of gestational diabetes mellitus in Korean women. | Kwak SH et al. | β | 2012 | β |
| A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. | Heit JA et al. | β | 2012 | β |
| A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. | Bossini-Castillo L et al. | β | 2012 | β |
| A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis. | Bossini-Castillo L et al. | β | 2012 | β |
| Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis. | Falconer H et al. | β | 2012 | β |
| Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. | Teruel M et al. | β | 2012 | β |
| Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis. | Lopez de Lapuente A et al. | β | 2012 | β |
| Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis. | GarcΓa-BermΓΊdez M et al. | β | 2012 | β |
| An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. | Xu FH et al. | β | 2012 | β |
| A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival. | Willis JA et al. | β | 2012 | β |
| Association analysis of single nucleotide polymorphisms at five loci: comparison between atopic dermatitis and asthma in the Chinese Han population. | Tang HY et al. | β | 2012 | β |
| Association between peroxisomal biogenesis factor 7 and autism spectrum disorders in a Korean population. | Ro M et al. | β | 2012 | β |
| Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. | Chan M et al. | β | 2012 | β |
| Association of haplotype combination of serotonin transporter gene polymorphisms with monthly headache days in MOH patients. | Terrazzino S et al. | β | 2012 | β |
| Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. | Rask-Andersen M et al. | β | 2012 | β |
| Association study of IL10 and IL23R-IL12RB2 in Iranian patients with BehΓ§et's disease. | Xavier JM et al. | β | 2012 | β |
| Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent population. | SΓ‘nchez E et al. | β | 2012 | β |
| Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. | Carrera N et al. | β | 2012 | β |
| A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits. | Bhattacharjee S et al. | β | 2012 | β |
| Bio-repository of DNA in stroke: a study protocol of three ancestral populations. | Cotlarciuc I et al. | β | 2012 | β |
| Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. | Whitcomb DC et al. | β | 2012 | β |
| Convergence of genome-wide association and candidate gene studies for alcoholism. | Olfson E et al. | β | 2012 | β |
| Cumulative meta-analysis for genetic association: when is a new study worthwhile? | Rotondi MA et al. | β | 2012 | β |
| Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer. | Meng S et al. | β | 2012 | β |
| Design considerations for genetic linkage and association studies. | Nsengimana J et al. | β | 2012 | β |
| Evaluating rare variants under two-stage design. | Li Q et al. | β | 2012 | β |
| Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. | Pangilinan F et al. | β | 2012 | β |
| Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. | Anaya JM et al. | β | 2012 | β |
| Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis. | Manetti M et al. | β | 2012 | β |
| Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy. | Heinzen EL et al. | β | 2012 | β |
| Familial and large-scale case-control studies identify genes associated with nasopharyngeal carcinoma. | Bei JX et al. | β | 2012 | β |
| Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. | Hamilton G et al. | β | 2012 | β |
| Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. | Ohi K et al. | β | 2012 | β |
| Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients. | van Eerde AM et al. | β | 2012 | β |
| Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. | Tansey KE et al. | β | 2012 | β |
| Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. | Crosslin DR et al. | β | 2012 | β |
| Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children. | Jacobsson JA et al. | β | 2012 | β |
| Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria. | Cornejo-GarcΓa JA et al. | β | 2012 | β |
| Genome wide assessment of young onset Parkinson's disease from Finland. | Hernandez DG et al. | β | 2012 | β |
| Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. | EPICURE Consortium et al. | β | 2012 | β |
| Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. | Christie JD et al. | β | 2012 | β |
| Genome-wide association study of coronary artery disease in the Japanese. | Takeuchi F et al. | β | 2012 | β |
| Genome-wide search for gene-gene interactions in colorectal cancer. | Jiao S et al. | β | 2012 | β |
| GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder. | Kishi T et al. | β | 2012 | β |
| Improved minimum cost and maximum power two stage genome-wide association study designs. | Stanhope SA et al. | β | 2012 | β |
| Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study. | O'Mahony DS et al. | β | 2012 | β |
| Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome. | Thomas DC et al. | β | 2012 | β |
| Invited commentary: more surprises from a gene desert. | Wacholder S et al. | β | 2012 | β |
| KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. | Bossini-Castillo L et al. | β | 2012 | β |
| Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis. | GarcΓa-BermΓΊdez M et al. | β | 2012 | β |
| Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study. | Teruel M et al. | β | 2012 | β |
| Lack of association of non-synonymous FUT2 and ALPL polymorphisms with venous thrombosis. | Tregouet DA et al. | β | 2012 | β |
| Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. | Olszewski PK et al. | β | 2012 | β |
| No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese. | Ando T et al. | β | 2012 | β |
| No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis. | CΓ©nit MC et al. | β | 2012 | β |
| Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. | Teruel M et al. | β | 2012 | β |
| Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis. | Carmona FD et al. | β | 2012 | β |
| Nutrient-wide association studies: another road to the same destination. | Forman JP et al. | β | 2012 | β |
| On the covariance of two correlated log-odds ratios. | Bagos PG | β | 2012 | β |
| Possible involvement of the E-cadherin gene in genetic susceptibility to endometriosis. | Yoshida K et al. | β | 2012 | β |
| Power and sample size calculations for SNP association studies with censored time-to-event outcomes. | Owzar K et al. | β | 2012 | β |
| Replication study for reported SNP associations with breast cancer survival. | Beeghly-Fadiel A et al. | β | 2012 | β |
| Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. | Kushima I et al. | β | 2012 | β |
| Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis. | Kishi T et al. | β | 2012 | β |
| Single-variant and multi-variant trend tests for genetic association with next-generation sequencing that are robust to sequencing error. | Kim W et al. | β | 2012 | β |
| Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. | GarcΓa-BermΓΊdez M et al. | β | 2012 | β |
| Susceptibility genes for osteoporotic fracture in postmenopausal Chinese women. | Wang C et al. | β | 2012 | β |
| Systematic association analysis of microRNA machinery genes with schizophrenia informs further study. | Zhang F et al. | β | 2012 | β |
| The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. | Martin JE et al. | β | 2012 | β |
| The functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predicts improved renal transplant outcome. | Eikmans M et al. | β | 2012 | β |
| The genetics of coronary artery disease. | Roberts R et al. | β | 2012 | β |
| The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children. | Rask-Andersen M et al. | β | 2012 | β |
| The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits. | Ohi K et al. | β | 2012 | β |
| The use of chronic gingivitis as reference status increases the power and odds of periodontitis genetic studies: a proposal based in the exposure concept and clearer resistance and susceptibility phenotypes definition. | Garlet GP et al. | β | 2012 | β |
| Two-phase stratified sampling designs for regional sequencing. | Chen Z et al. | β | 2012 | β |
| Two-stage extreme phenotype sequencing design for discovering and testing common and rare genetic variants: efficiency and power. | Kang G et al. | β | 2012 | β |
| Use of germline polymorphisms in predicting concurrent chemoradiotherapy response in esophageal cancer. | Chen PC et al. | β | 2012 | β |
| A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. | Banno M et al. | β | 2011 | β |
| A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. | Cui B et al. | β | 2011 | β |
| Analysis of an extended chromosome locus 2p14-21 for replication of the 2p16.3 association with glaucoma susceptibility. | Kim K et al. | β | 2011 | β |
| Analysis of single nucleotide polymorphisms in case-control studies. | Li Y et al. | β | 2011 | β |
| A new expectation-maximization statistical test for case-control association studies considering rare variants obtained by high-throughput sequencing. | Gordon D et al. | β | 2011 | β |
| A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study. | Wang J et al. | β | 2011 | β |
| A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. | Bossini-Castillo L et al. | β | 2011 | β |
| A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. | Kanetsky PA et al. | β | 2011 | β |
| Assessing and managing risk when sharing aggregate genetic variant data. | Craig DW et al. | β | 2011 | β |
| Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. | Teruel M et al. | β | 2011 | β |
| Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. | Faruque MU et al. | β | 2011 | β |
| Association of common variants in JAK2 gene with reduced risk of metabolic syndrome and related disorders. | Penas-Steinhardt A et al. | β | 2011 | β |
| Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus. | Vieira SM et al. | β | 2011 | β |
| Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population. | Li P et al. | β | 2011 | β |
| Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data. | Pierce BL et al. | β | 2011 | β |
| A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22. | AbulΓ A et al. | β | 2011 | β |
| Basic statistical analysis in genetic case-control studies. | Clarke GM et al. | β | 2011 | β |
| Blood pressure loci identified with a gene-centric array. | Johnson T et al. | β | 2011 | β |
| Capitalizing on admixture in genome-wide association studies: a two-stage testing procedure and application to height in African-Americans. | Kang G et al. | β | 2011 | β |
| Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. | AbulΓ A et al. | β | 2011 | β |
| Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk. | Yang TH et al. | β | 2011 | β |
| Common polymorphisms in FMO1 are associated with nicotine dependence. | Hinrichs AL et al. | β | 2011 | β |
| Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. | Naj AC et al. | β | 2011 | β |
| Common variants of the thyroglobulin gene are associated with differentiated thyroid cancer risk. | Akdi A et al. | β | 2011 | β |
| Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. | Takeuchi F et al. | β | 2011 | β |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | β | 2011 | β |
| Defining the power limits of genome-wide association scan meta-analyses. | Chapman K et al. | β | 2011 | β |
| Design considerations for massively parallel sequencing studies of complex human disease. | Feng BJ et al. | β | 2011 | β |
| Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly. | Jacobsson JA et al. | β | 2011 | β |
| Disease-driven detection of differential inherited SNP modules from SNP network. | Li C et al. | β | 2011 | β |
| Estimates of array and pool-construction variance for planning efficient DNA-pooling genome wide association studies. | Earp MA et al. | β | 2011 | β |
| Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction. | Deshmukh HA et al. | β | 2011 | β |
| Evidence of association with type 1 diabetes in the SLC11A1 gene region. | Yang JH et al. | β | 2011 | β |
| False-Negative-Rate Based Approach for Selecting Top Single-Nucleotide Polymorphisms in the First Stage of a Two-Stage Genome-Wide Association Study. | Huang Z et al. | β | 2011 | β |
| Genetic analysis of adult-onset autoimmune diabetes. | Howson JM et al. | β | 2011 | β |
| Genetics of venous thrombosis: insights from a new genome wide association study. | Germain M et al. | β | 2011 | β |
| Genetic variants and susceptibility to neurological complications following West Nile virus infection. | Loeb M et al. | β | 2011 | β |
| Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. | Wright FA et al. | β | 2011 | β |
| Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer. | FitzGerald LM et al. | β | 2011 | β |
| Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. | Nan H et al. | β | 2011 | β |
| Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. | Winkelmann J et al. | β | 2011 | β |
| Genome-wide association study identifies PERLD1 as asthma candidate gene. | Anantharaman R et al. | β | 2011 | β |
| Genome-wide association study identifies susceptibility loci for IgA nephropathy. | Gharavi AG et al. | β | 2011 | β |
| Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. | Purdue MP et al. | β | 2011 | β |
| Genome-wide Association study using pooled DNA to identify candidate markers mediating susceptibility to postoperative nausea and vomiting. | Janicki PK et al. | β | 2011 | β |
| Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases. | Liu Y et al. | β | 2011 | β |
| Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. | Guo T et al. | β | 2011 | β |
| GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits. | Feng S et al. | β | 2011 | β |
| Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. | Reilly MP et al. | β | 2011 | β |
| Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. | HΓΆglinger GU et al. | β | 2011 | β |
| Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. | Gorlova O et al. | β | 2011 | β |
| Joint analysis for genome-wide association studies in family-based designs. | Sha Q et al. | β | 2011 | β |
| KNG1 Ile581Thr and susceptibility to venous thrombosis. | Morange PE et al. | β | 2011 | β |
| Lack of replication in polymorphisms reported to be associated with atrial fibrillation. | Sinner MF et al. | β | 2011 | β |
| Liver X receptor Ξ± gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study. | Price ET et al. | β | 2011 | β |
| Low-coverage sequencing: implications for design of complex trait association studies. | Li Y et al. | β | 2011 | β |
| MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease. | Schormair B et al. | β | 2011 | β |
| Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients. | Zhang AM et al. | β | 2011 | β |
| Multilocus association testing with penalized regression. | Basu S et al. | β | 2011 | β |
| No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. | Hashimoto R et al. | β | 2011 | β |
| No evidence of association of the KLF12 gene with rheumatoid arthritis in Spanish and Dutch cohorts and a meta-analysis of published data. | GarcΓa-BermΓΊdez M et al. | β | 2011 | β |
| Novel genetic variation in exon 28 of FBN1 gene is associated with essential hypertension. | Shen C et al. | β | 2011 | β |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | β | 2011 | β |
| Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes. | Bu L et al. | β | 2011 | β |
| Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk. | Seibold P et al. | β | 2011 | β |
| Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. | Sehrawat B et al. | β | 2011 | β |
| Quality control procedures for genome-wide association studies. | Turner S et al. | β | 2011 | β |
| Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population. | Zhong H et al. | β | 2011 | β |
| Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort. | Gouveia LO et al. | β | 2011 | β |
| Robust joint analysis allowing for model uncertainty in two-stage genetic association studies. | Pan D et al. | β | 2011 | β |
| The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. | Rizzi TS et al. | β | 2011 | β |
| The CLOCK gene and mood disorders: a case-control study and meta-analysis. | Kishi T et al. | β | 2011 | β |
| The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA. | Chiang CW et al. | β | 2011 | β |
| The meta-analysis of genome-wide association studies. | Thompson JR et al. | β | 2011 | β |
| Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. | Peden JF et al. | β | 2011 | β |
| Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. | Janse M et al. | β | 2011 | β |
| TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. | Erhardt A et al. | β | 2011 | β |
| Two-stage analyses of sequence variants in association with quantitative traits. | Barrett JH et al. | β | 2011 | β |
| Two-stage design of sequencing studies for testing association with rare variants. | Yang F et al. | β | 2011 | β |
| Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. | Swartz MD et al. | β | 2011 | β |
| Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. | Li D et al. | β | 2011 | β |
| Variants of the RELA gene are associated with schizophrenia and their startle responses. | Hashimoto R et al. | β | 2011 | β |
| Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. | Goode EL et al. | β | 2011 | β |
| Accounting for multiple comparisons in a genome-wide association study (GWAS). | Johnson RC et al. | β | 2010 | β |
| A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. | Arcos-Burgos M et al. | β | 2010 | β |
| A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. | Morange PE et al. | β | 2010 | β |
| A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. | Wieczorek S et al. | β | 2010 | β |
| A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. | Tan W et al. | β | 2010 | β |
| A genome-wide association study identifies multiple loci associated with mathematics ability and disability. | Docherty SJ et al. | β | 2010 | β |
| A genome-wide association study using selective DNA pooling identifies candidate markers for fertility in Holstein cattle. | Huang W et al. | β | 2010 | β |
| A mixed two-stage method for detecting interactions in genomewide association studies. | Zuo Y et al. | β | 2010 | β |
| An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. | Hsu YH et al. | β | 2010 | β |
| An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population. | Kitsios GD et al. | β | 2010 | β |
| A pure likelihood approach to the analysis of genetic association data: an alternative to Bayesian and frequentist analysis. | Strug LJ et al. | β | 2010 | β |
| Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. | Kushima I et al. | β | 2010 | β |
| Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity. | von Spiczak S et al. | β | 2010 | β |
| A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. | Koide T et al. | β | 2010 | β |
| Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia. | Prasad KM et al. | β | 2010 | β |
| Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study. | Palmer ND et al. | β | 2010 | β |
| Common genetic determinants of vitamin D insufficiency: a genome-wide association study. | Wang TJ et al. | β | 2010 | β |
| Common germ-line polymorphism of C1QA and breast cancer survival. | Azzato EM et al. | β | 2010 | β |
| Common variants in the gene for the serotonin receptor 6 (HTR6) do not contribute to obesity. | Peeters AV et al. | β | 2010 | β |
| Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus. | Maiti AK et al. | β | 2010 | β |
| Design of association studies with pooled or un-pooled next-generation sequencing data. | Kim SY et al. | β | 2010 | β |
| Designs for linkage analysis and association studies of complex diseases. | Cui Y et al. | β | 2010 | β |
| "Does replication groups scoring reduce false positive rate in SNP interaction discovery? Response". | GayΓ‘n J et al. | β | 2010 | β |
| Effectiveness of strategies to increase the validity of findings from association studies: size vs. replication. | Weitkunat R et al. | β | 2010 | β |
| Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". | Johnatty SE et al. | β | 2010 | β |
| Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis. | Niewold TB et al. | β | 2010 | β |
| Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. | Aleksic B et al. | β | 2010 | β |
| Genetics of autistic disorders: review and clinical implications. | Freitag CM et al. | β | 2010 | β |
| Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. | Salloum R et al. | β | 2010 | β |
| Genome-wide association scan for five major dimensions of personality. | Terracciano A et al. | β | 2010 | β |
| Genome-wide association studies and beyond. | Witte JS | β | 2010 | β |
| Genome-wide association studies and large-scale collaborations in epidemiology. | Psaty BM et al. | β | 2010 | β |
| Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. | Akiyama K et al. | β | 2010 | β |
| Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas. | Fu YP et al. | β | 2010 | β |
| Inborn variation in metabolism. | Mootha VK et al. | β | 2010 | β |
| Lack of association of the CIITA -168AβG promoter SNP with myasthenia gravis and its role in autoimmunity. | Ramanujam R et al. | β | 2010 | β |
| Leveraging genetic variability across populations for the identification of causal variants. | Zaitlen N et al. | β | 2010 | β |
| Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. | Liu Y et al. | β | 2010 | β |
| Meta-analysis of genetic association studies and adjustment for multiple testing of correlated SNPs and traits. | Conneely KN et al. | β | 2010 | β |
| Methods: genetic epidemiology. | Benke KS et al. | β | 2010 | β |
| No association between chromosome 12p13 single nucleotide polymorphisms and early-onset ischemic stroke. | Lotta LA et al. | β | 2010 | β |
| Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. | Maiti AK et al. | β | 2010 | β |
| Power analysis for case-control association studies of samples with known family histories. | Peng B et al. | β | 2010 | β |
| Role of 2 common variants of 5HT2A gene in medication overuse headache. | Terrazzino S et al. | β | 2010 | β |
| Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis. | Muhle H et al. | β | 2010 | β |
| Screen and clean: a tool for identifying interactions in genome-wide association studies. | Wu J et al. | β | 2010 | β |
| Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. | FernΓ‘ndez-Rozadilla C et al. | β | 2010 | β |
| Statistical methods for pathway analysis of genome-wide data for association with complex genetic traits. | Holmans P | β | 2010 | β |
| The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity. | Ramanujam R et al. | β | 2010 | β |
| The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. | Ohi K et al. | β | 2010 | β |
| The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. | Baune BT et al. | β | 2010 | β |
| The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2010 | β |
| The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size. | Ackerman CM et al. | β | 2010 | β |
| Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traits. | Mirea L et al. | β | 2010 | β |
| Using public control genotype data to increase power and decrease cost of case-control genetic association studies. | Ho LA et al. | β | 2010 | β |
| Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain. | Swaminathan B et al. | β | 2010 | β |
| Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke. | Manso H et al. | β | 2010 | β |
| Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients. | Lou T et al. | β | 2010 | β |
| Voxelwise genome-wide association study (vGWAS). | Stein JL et al. | β | 2010 | β |
| A common variant in DRD3 receptor is associated with autism spectrum disorder. | de Krom M et al. | β | 2009 | β |
| A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population. | Liu Q et al. | β | 2009 | β |
| A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. | Ising M et al. | β | 2009 | β |
| Allelic association: linkage disequilibrium structure and gene mapping. | Collins A | β | 2009 | β |
| A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). | Thomas G et al. | β | 2009 | β |
| An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population. | Clarke TK et al. | β | 2009 | β |
| A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS). | Castro-Giner F et al. | β | 2009 | β |
| Approaches to the identification of susceptibility genes. | Collins A | β | 2009 | β |
| A robust genome-wide scan statistic of the Wellcome Trust Case-Control Consortium. | Joo J et al. | β | 2009 | β |
| A robust test for two-stage design in genome-wide association studies. | Kwak M et al. | β | 2009 | β |
| Association analysis between schizophrenia and the AP-3 complex genes. | Hashimoto R et al. | β | 2009 | β |
| Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. | Newton-Cheh C et al. | β | 2009 | β |
| Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. | Burkhardt J et al. | β | 2009 | β |
| Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. | Ohi K et al. | β | 2009 | β |
| A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. | ChiΓ² A et al. | β | 2009 | β |
| Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci. | Peacock M et al. | β | 2009 | β |
| Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations. | Konings A et al. | β | 2009 | β |
| Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. | Psaty BM et al. | β | 2009 | β |
| Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. | Udler MS et al. | β | 2009 | β |
| Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. | Abraham JE et al. | β | 2009 | β |
| Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. | TrΓ©gouΓ«t DA et al. | β | 2009 | β |
| Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. | Weersma RK et al. | β | 2009 | β |
| Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group. | Bromley CM et al. | β | 2009 | β |
| Discovery properties of genome-wide association signals from cumulatively combined data sets. | Pereira TV et al. | β | 2009 | β |
| Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population. | Shen C et al. | β | 2009 | β |
| Flexible designs for genomewide association studies. | Scherag A et al. | β | 2009 | β |
| Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. | Cui R et al. | β | 2009 | β |
| Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment. | Li Q et al. | β | 2009 | β |
| Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. | Kim H et al. | β | 2009 | β |
| Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. | Andreassen CN et al. | β | 2009 | β |
| Genetic variants in surfactant, pulmonary-associated protein D (SFTPD) and Japanese susceptibility to ulcerative colitis. | Tanaka M et al. | β | 2009 | β |
| Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. | Iatan I et al. | β | 2009 | β |
| Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. | Baranzini SE et al. | β | 2009 | β |
| Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. | He C et al. | β | 2009 | β |
| Genome-wide association studies of cardiovascular risk factors: design, conduct and interpretation. | Bis JC et al. | β | 2009 | β |
| Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study. | Norris JM et al. | β | 2009 | β |
| Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. | Satake W et al. | β | 2009 | β |
| Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. | Amundadottir L et al. | β | 2009 | β |
| Genome-wide association study in humans. | Smith JG et al. | β | 2009 | β |
| Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. | Knauff EA et al. | β | 2009 | β |
| Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. | Yang HC et al. | β | 2009 | β |
| Genome-Wide Significance Levels and Weighted Hypothesis Testing. | Roeder K et al. | β | 2009 | β |
| Genotypic association analysis using discordant-relative-pairs. | Yan T et al. | β | 2009 | β |
| IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients. | Couturier N et al. | β | 2009 | β |
| IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. | Suppiah V et al. | β | 2009 | β |
| Incorporating multiple-marker information to detect risk loci for rheumatoid arthritis. | Wang X et al. | β | 2009 | β |
| Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. | Bowes JD et al. | β | 2009 | β |
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| Multistage analysis strategies for genome-wide association studies: summary of group 3 contributions to Genetic Analysis Workshop 16. | Neuman RJ et al. | β | 2009 | β |
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| Population-based genomewide genetic analysis of common clinical chemistry analytes. | Chasman DI et al. | β | 2009 | β |
| Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. | Yang W et al. | β | 2009 | β |
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| Quantifying and correcting for the winner's curse in genetic association studies. | Xiao R et al. | β | 2009 | β |
| Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. | Landers JE et al. | β | 2009 | β |
| Replication in genome-wide association studies. | Kraft P et al. | β | 2009 | β |
| Replication of genetic associations as pseudoreplication due to shared genealogy. | Rosenberg NA et al. | β | 2009 | β |
| Screening for replication of genome-wide SNP associations in sporadic ALS. | Cronin S et al. | β | 2009 | β |
| Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. | Gschwendtner A et al. | β | 2009 | β |
| Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. | Cha PC et al. | β | 2009 | β |
| Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. | Silverberg MS et al. | β | 2009 | β |
| Validating, augmenting and refining genome-wide association signals. | Ioannidis JP et al. | β | 2009 | β |
| Xylosyltransferase gene variants and their role in essential hypertension. | PΓΆnighaus C et al. | β | 2009 | β |
| A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. | Tomlinson IP et al. | β | 2008 | β |
| An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. | Jungerius BJ et al. | β | 2008 | β |
| An entropy-based approach for testing genetic epistasis underlying complex diseases. | Kang G et al. | β | 2008 | β |
| A network of dopaminergic gene variations implicated as risk factors for schizophrenia. | Talkowski ME et al. | β | 2008 | β |
| A polygenic model with common variants may predict lung adenocarcinoma risk in humans. | Galvan A et al. | β | 2008 | β |
| ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. | Litonjua AA et al. | β | 2008 | β |
| Assessment of cumulative evidence on genetic associations: interim guidelines. | Ioannidis JP et al. | β | 2008 | β |
| Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan. | Nakayama R et al. | β | 2008 | β |
| Association of SIRT1 gene variation with visceral obesity. | Peeters AV et al. | β | 2008 | β |
| Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. | Sookoian S et al. | β | 2008 | β |
| Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies. | Zhong H et al. | β | 2008 | β |
| Calibrating the performance of SNP arrays for whole-genome association studies. | Hao K et al. | β | 2008 | β |
| Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. | Hettema JM et al. | β | 2008 | β |
| Circulating P-, L- and E-selectins in pseudoxanthoma elasticum patients. | GΓΆtting C et al. | β | 2008 | β |
| Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. | Teo YY | β | 2008 | β |
| Common variants in the GDF5-UQCC region are associated with variation in human height. | Sanna S et al. | β | 2008 | β |
| Comparison of two-phase analyses for case-control genetic association studies. | Zheng G et al. | β | 2008 | β |
| Complement factor H variant p.Y402H in pseudoxanthoma elasticum patients. | GΓΆtting C et al. | β | 2008 | β |
| Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis. | Stock CJ et al. | β | 2008 | β |
| Consortium analysis of 7 candidate SNPs for ovarian cancer. | Ramus SJ et al. | β | 2008 | β |
| Controlling false discoveries in genetic studies. | van den Oord EJ | β | 2008 | β |
| Current and future directions in genomics of amyotrophic lateral sclerosis. | Ravits J et al. | β | 2008 | β |
| Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. | Azzato EM et al. | β | 2008 | β |
| Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies. | Li Q et al. | β | 2008 | β |
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| Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. | Persico M et al. | β | 2008 | β |
| Elevated serum levels of intercellular adhesion molecule ICAM-1 in Pseudoxanthoma elasticum. | Hendig D et al. | β | 2008 | β |
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| Evaluating cost efficiency of SNP chips in genome-wide association studies. | Li C et al. | β | 2008 | β |
| Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. | Li Y et al. | β | 2008 | β |
| Examining the statistical properties of fine-scale mapping in large-scale association studies. | Wiltshire S et al. | β | 2008 | β |
| Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. | Wanic K et al. | β | 2008 | β |
| Gene-centric genomewide association study via entropy. | Cui Y et al. | β | 2008 | β |
| Gene-environment interactions in chronic obstructive pulmonary disease. | Molfino NA et al. | β | 2008 | β |
| Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. | Sookoian S et al. | β | 2008 | β |
| Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. | van Es MA et al. | β | 2008 | β |
| Genomewide association for schizophrenia in the CATIE study: results of stage 1. | Sullivan PF et al. | β | 2008 | β |
| Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. | Tenesa A et al. | β | 2008 | β |
| Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. | Amos CI et al. | β | 2008 | β |
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| Identification of a xylosyltransferase II gene haplotype marker for diabetic nephropathy in type 1 diabetes. | Hendig D et al. | β | 2008 | β |
| Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. | Meulenbelt I et al. | β | 2008 | β |
| Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. | Hamsten A et al. | β | 2008 | β |
| Increasing the power of identifying gene x gene interactions in genome-wide association studies. | Kooperberg C et al. | β | 2008 | β |
| Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. | AlarcΓ³n M et al. | β | 2008 | β |
| Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. | COGENT Study et al. | β | 2008 | β |
| Methods for handling multiple testing. | Rice TK et al. | β | 2008 | β |
| Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. | Kavvoura FK et al. | β | 2008 | β |
| Multiple loci identified in a genome-wide association study of prostate cancer. | Thomas G et al. | β | 2008 | β |
| Newly identified genetic risk variants for celiac disease related to the immune response. | Hunt KA et al. | β | 2008 | β |
| No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population. | Aleksic B et al. | β | 2008 | β |
| Optimal screening for promising genes in 2-stage designs. | Moerkerke B et al. | β | 2008 | β |
| Optimal two-stage design for case-control association analysis incorporating genotyping errors. | Zuo Y et al. | β | 2008 | β |
| Optimal two-stage testing for family-based genome-wide association studies. | Macgregor S | β | 2008 | β |
| PGA: power calculator for case-control genetic association analyses. | Menashe I et al. | β | 2008 | β |
| Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. | Lekman M et al. | β | 2008 | β |
| Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease. | Wang L et al. | β | 2008 | β |
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| Prioritize and select SNPs for association studies with multi-stage designs. | Li J | β | 2008 | β |
| Probability that a two-stage genome-wide association study will detect a disease-associated snp and implications for multistage designs. | Gail MH et al. | β | 2008 | β |
| Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes. | Kitamura N et al. | β | 2008 | β |
| Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. | Murphy A et al. | β | 2008 | β |
| Sequence variants in the PLEKHH2 region are associated with diabetic nephropathy in the GoKinD study population. | Greene CN et al. | β | 2008 | β |
| SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. | Unoki H et al. | β | 2008 | β |
| Statistical methods for examining genetic influences of resistance to anti-epileptic drugs. | Baksh MF et al. | β | 2008 | β |
| Study designs for genome-wide association studies. | Kraft P et al. | β | 2008 | β |
| Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults. | Gianotti TF et al. | β | 2008 | β |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | β | 2008 | β |
| The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab. | Jais JP et al. | β | 2008 | β |
| The new genetics and chronic obstructive pulmonary disease. | Kalsheker N et al. | β | 2008 | β |
| The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG). | Sinner MF et al. | β | 2008 | β |
| The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction. | Amisten S et al. | β | 2008 | β |
| The positives, protocols, and perils of genome-wide association. | Neale BM et al. | β | 2008 | β |
| The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. | Kelley-Hedgepeth A et al. | β | 2008 | β |
| Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood. | Wise CA et al. | β | 2008 | β |
| Variable selection in logistic regression for detecting SNP-SNP interactions: the rheumatoid arthritis example. | Lin HY et al. | β | 2008 | β |
| Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases. | Yang HH et al. | β | 2008 | β |
| WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. | Lee JC et al. | β | 2008 | β |
| Xylosyltransferase I variants and their impact on abdominal aortic aneurysms. | GΓΆtting C et al. | β | 2008 | β |
| A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. | Florez JC et al. | β | 2007 | β |
| Adaptive two-stage analysis of genetic association in case-control designs. | Zheng G et al. | β | 2007 | β |
| A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. | Kathiresan S et al. | β | 2007 | β |
| A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. | Murabito JM et al. | β | 2007 | β |
| A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. | MatarΓn M et al. | β | 2007 | β |
| A grid-search algorithm for optimal allocation of sample size in two-stage association studies. | Wen SH et al. | β | 2007 | β |
| A new era in psychiatric genetics? | Insel TR et al. | β | 2007 | β |
| An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. | Shen GQ et al. | β | 2007 | β |
| [A review of power and sample size estimation in genomewide association studies]. | Park AK et al. | β | 2007 | β |
| A second major histocompatibility complex susceptibility locus for multiple sclerosis. | Yeo TW et al. | β | 2007 | β |
| Association of kallikrein gene polymorphisms with intracranial aneurysms. | Weinsheimer S et al. | β | 2007 | β |
| Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. | Horne BD et al. | β | 2007 | β |
| A two-step multiple-marker strategy for genome-wide association studies. | Aschard H et al. | β | 2007 | β |
| A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. | Steinthorsdottir V et al. | β | 2007 | β |
| Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. | Hamilton G et al. | β | 2007 | β |
| Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. | Aarnoudse AJ et al. | β | 2007 | β |
| Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. | Spirin V et al. | β | 2007 | β |
| Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. | Stacey SN et al. | β | 2007 | β |
| Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia. | Hoppe C et al. | β | 2007 | β |
| Current thinking on genetics of chronic obstructive pulmonary disease. | Molfino NA | β | 2007 | β |
| Designing candidate gene and genome-wide case-control association studies. | Zondervan KT et al. | β | 2007 | β |
| Dopamine genes and schizophrenia: case closed or evidence pending? | Talkowski ME et al. | β | 2007 | β |
| Entropy-based joint analysis for two-stage genome-wide association studies. | Kang G et al. | β | 2007 | β |
| Epidemiologic methods developments: a look forward to the year 2032. | Prentice RL | β | 2007 | β |
| Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. | Grupe A et al. | β | 2007 | β |
| Family-based association tests for genomewide association scans. | Chen WM et al. | β | 2007 | β |
| Fine mapping versus replication in whole-genome association studies. | Clarke GM et al. | β | 2007 | β |
| Flexible design for following up positive findings. | Yu K et al. | β | 2007 | β |
| Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. | Larson MG et al. | β | 2007 | β |
| Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population. | Takata Y et al. | β | 2007 | β |
| Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. | Knowles JW et al. | β | 2007 | β |
| Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. | O'Donnell CJ et al. | β | 2007 | β |
| Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. | Newton-Cheh C et al. | β | 2007 | β |
| Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. | Winkelmann J et al. | β | 2007 | β |
| Genome-wide association with diabetes-related traits in the Framingham Heart Study. | Meigs JB et al. | β | 2007 | β |
| Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis. | Steer S et al. | β | 2007 | β |
| Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. | Lewinger JP et al. | β | 2007 | β |
| IL-7Ralpha and multiple sclerosis risk. | Harley JB | β | 2007 | β |
| Improving power in genome-wide association studies: weights tip the scale. | Roeder K et al. | β | 2007 | β |
| Including sampling and phenotyping costs into the optimization of two stage designs for genomewide association studies. | MΓΌller HH et al. | β | 2007 | β |
| Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling. | Ji F et al. | β | 2007 | β |
| Introduction to genetic association studies. | Tsao H et al. | β | 2007 | β |
| ITGA4 polymorphisms and susceptibility to multiple sclerosis. | O'Doherty C et al. | β | 2007 | β |
| Joint analysis of case-parents trio and unrelated case-control designs in large scale association studies. | Joo J et al. | β | 2007 | β |
| Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error. | Gordon D et al. | β | 2007 | β |
| Linking antisocial behavior, substance use, and personality: an integrative quantitative model of the adult externalizing spectrum. | Krueger RF et al. | β | 2007 | β |
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| Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario. | Briollais L et al. | β | 2007 | β |
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| Non-replication and inconsistency in the genome-wide association setting. | Ioannidis JP | β | 2007 | β |
| Novel genes identified in a high-density genome wide association study for nicotine dependence. | Bierut LJ et al. | β | 2007 | β |
| One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies. | Rohlfs RV et al. | β | 2007 | β |
| Optimal designs for two-stage genome-wide association studies. | Skol AD et al. | β | 2007 | β |
| Optimal selection of markers for validation or replication from genome-wide association studies. | Greenwood CM et al. | β | 2007 | β |
| Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. | Wang L et al. | β | 2007 | β |
| Power analysis for genome-wide association studies. | Klein RJ | β | 2007 | β |
| Replicating genotype-phenotype associations. | NCI-NHGRI Working Group on Replication in Association Studies et al. | β | 2007 | β |
| Robust ranks of true associations in genome-wide case-control association studies. | Zheng G et al. | β | 2007 | β |
| Scanning the horizon: what is the future of genome-wide association studies in accelerating discoveries in cancer etiology and prevention? | Hunter DJ et al. | β | 2007 | β |
| Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. | Willer CJ et al. | β | 2007 | β |
| Sequential quantitative trait locus mapping in experimental crosses. | Satagopan JM et al. | β | 2007 | β |
| SPP1 promoter polymorphisms: identification of the first modifier gene for pseudoxanthoma elasticum. | Hendig D et al. | β | 2007 | β |
| Successful design and conduct of genome-wide association studies. | Amos CI | β | 2007 | β |
| Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. | Gayther SA et al. | β | 2007 | β |
| Testing association for markers on the X chromosome. | Zheng G et al. | β | 2007 | β |
| Two-stage designs applying methods differing in costs. | Goll A et al. | β | 2007 | β |
| Upward bias in odds ratio estimates from genome-wide association studies. | Garner C | β | 2007 | β |