Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
paper
Cited
Public
Unavailable
- Authors
- Potthoff, Matthew J; Kliewer, Steven A; Mangelsdorf, David J
- Year
- 2012
- Journal
- Genes & development
- PMID
- 22302876
- DOI
- 10.1101/gad.184788.111
- PMCID
- PMC3289879
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.
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| Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose. | Zhang J et al. | β | 2017 | β |
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| Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. | Chen Z et al. | β | 2017 | β |
| PKCΞ²: Expanding role in hepatic adaptation of cholesterol homeostasis to dietary fat/cholesterol. | Mehta D et al. | β | 2017 | β |
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| Emerging Role of Sensory Perception in Aging and Metabolism. | Riera CE et al. | β | 2016 | β |
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| Heme-Regulated eIF2Ξ± Kinase Modulates Hepatic FGF21 and Is Activated by PPARΞ²/Ξ΄ Deficiency. | Zarei M et al. | β | 2016 | β |
| Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression. | Girer NG et al. | β | 2016 | β |
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| Overexpression of Ξ²-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity. | Samms RJ et al. | β | 2016 | β |
| PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates. | Thompson WC et al. | β | 2016 | β |
| PPARΞ³ agonists promote differentiation of cancer stem cells by restraining YAP transcriptional activity. | Basu-Roy U et al. | β | 2016 | β |
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| Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors. | Schumacher JD et al. | β | 2016 | β |
| Review article: bile acid diarrhoea - pathogenesis, diagnosis and management. | Mottacki N et al. | β | 2016 | β |
| Skeletal muscle-specific eukaryotic translation initiation factor 2Ξ± phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism. | Miyake M et al. | β | 2016 | β |
| The Nuclear Receptor Rev-erbΞ± Regulates Adipose Tissue-specific FGF21 Signaling. | Jager J et al. | β | 2016 | β |
| Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. | Degirolamo C et al. | β | 2016 | β |
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| Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma. | Li Y et al. | β | 2016 | β |
| A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption. | Wang X et al. | β | 2015 | β |
| A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism. | Walters JR et al. | β | 2015 | β |
| Bariatric surgery: prevalence, predictors, and mechanisms of diabetes remission. | Argyropoulos G | β | 2015 | β |
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| Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin. | Schisler JC et al. | β | 2015 | β |
| Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase active L. reuteri NCIMB 30242. | Martoni CJ et al. | β | 2015 | β |
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| Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. | Katafuchi T et al. | β | 2015 | β |
| Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography. | Wang JS et al. | β | 2015 | β |
| Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation. | Wu W et al. | β | 2015 | β |
| Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer. | Hu L et al. | β | 2015 | β |
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| Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. | Helsten T et al. | β | 2015 | β |
| Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. | Patel R et al. | β | 2015 | β |
| Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. | Lawan A et al. | β | 2015 | β |
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| Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases. | Zhang F et al. | β | 2015 | β |
| New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. | Beuers U et al. | β | 2015 | β |
| Perturbations of fibroblast growth factors 19 and 21 in type 2 diabetes. | Roesch SL et al. | β | 2015 | β |
| Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and Ξ²-klotho expression decrease with fasting in northern elephant seals. | Suzuki M et al. | β | 2015 | β |
| Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. | Vaz FM et al. | β | 2015 | β |
| Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target. | Liu WY et al. | β | 2015 | β |
| The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination. | Wang Y et al. | β | 2015 | β |
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| The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics. | Ridlon JM et al. | β | 2015 | β |
| The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review. | Cole AJ et al. | β | 2015 | β |
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| A nontumorigenic variant of FGF19 treats cholestatic liver diseases. | Luo J et al. | β | 2014 | β |
| BAT thermogenesis: Linking shivering to exercise. | Virtanen KA | β | 2014 | β |
| Beyond intestinal soap--bile acids in metabolic control. | Kuipers F et al. | β | 2014 | β |
| Bile acids are nutrient signaling hormones. | Zhou H et al. | β | 2014 | β |
| Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. | Markan KR et al. | β | 2014 | β |
| Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hormones of energy balance in a TCDD-sensitive and a TCDD-resistant rat strain. | LindΓ©n J et al. | β | 2014 | β |
| Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. | Wewalka M et al. | β | 2014 | β |
| FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. | Owen BM et al. | β | 2014 | β |
| FGF21 is an endocrine signal of protein restriction. | Laeger T et al. | β | 2014 | β |
| Fibroblast growth factor 21: a new liver safeguard. | Cariello M et al. | β | 2014 | β |
| Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. | Hondares E et al. | β | 2014 | β |
| Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. | Brahma MK et al. | β | 2014 | β |
| Fibroblast growth factor 21 is regulated by the IRE1Ξ±-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. | Jiang S et al. | β | 2014 | β |
| Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions. | Ge H et al. | β | 2014 | β |
| Functional thermogenic beige adipogenesis is inducible in human neck fat. | Lee P et al. | β | 2014 | β |
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| Head over hepatocytes for FGF21. | Potthoff MJ et al. | β | 2014 | β |
| Hepatic FGF21 production is increased in late pregnancy in the mouse. | Cui Y et al. | β | 2014 | β |
| Hepatic IRE1Ξ± regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARΞ± axis signalling. | Shao M et al. | β | 2014 | β |
| How sweet it is to activate FXR. | Jansen PL et al. | β | 2014 | β |
| Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. | Burrin DG et al. | β | 2014 | β |
| Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer. | Matsuda Y et al. | β | 2014 | β |
| Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors. | CortΓ©s VA et al. | β | 2014 | β |
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| Lysosome: regulator of lipid degradation pathways. | Settembre C et al. | β | 2014 | β |
| Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. | Yousef H et al. | β | 2014 | β |
| Metabolic function of the CTRP family of hormones. | Seldin MM et al. | β | 2014 | β |
| Mix 'n' match estrogens. | Uhlenhaut NH | β | 2014 | β |
| Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. | Chen W et al. | β | 2014 | β |
| Nuclear Receptors, RXR, and the Big Bang. | Evans RM et al. | β | 2014 | β |
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| Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. | Kahn SE et al. | β | 2014 | β |
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| Role of fibroblast growth factors in elicitation of cell responses. | Laestander C et al. | β | 2014 | β |
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| The adipokine/ceramide axis: key aspects of insulin sensitization. | Xia JY et al. | β | 2014 | β |
| The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. | Wang GX et al. | β | 2014 | β |
| The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. | Labialle S et al. | β | 2014 | β |
| The PPARΞ±-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. | Vernia S et al. | β | 2014 | β |
| The role of bile acids in functional GI disorders. | Appleby RN et al. | β | 2014 | β |
| The single nucleotide polymorphism rs499765 is associated with fibroblast growth factor 21 and nonalcoholic fatty liver disease in a Chinese population with normal glucose tolerance. | Jiang S et al. | β | 2014 | β |
| Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. | Dogan SA et al. | β | 2014 | β |
| Transcriptional regulation of fibroblast growth factor 21 expression. | Bae KH et al. | β | 2014 | β |
| What we talk about when we talk about fat. | Rosen ED et al. | β | 2014 | β |
| Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. | Lin Z et al. | β | 2013 | β |
| An endocrine role for brown adipose tissue? | Villarroya J et al. | β | 2013 | β |
| An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. | Holland WL et al. | β | 2013 | β |
| A novel approach to improve the function of FGF21. | Smith R et al. | β | 2013 | β |
| Bone marrow mesenchymal stem cells: fat on and blast off by FGF21. | Wan Y | β | 2013 | β |
| Cholecystectomy and NAFLD: does gallbladder removal have metabolic consequences? | Nervi F et al. | β | 2013 | β |
| Digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways. | Burrin D et al. | β | 2013 | β |
| Emerging combinatorial hormone therapies for the treatment of obesity and T2DM. | Sadry SA et al. | β | 2013 | β |
| Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis. | Romain G et al. | β | 2013 | β |
| Exploring mechanisms of FGF signalling through the lens of structural biology. | Goetz R et al. | β | 2013 | β |
| FGF-21, a newcomer in the field of hypertension research. | Eto K | β | 2013 | β |
| FGF21 contributes to neuroendocrine control of female reproduction. | Owen BM et al. | β | 2013 | β |
| FGF21 mimetic shows therapeutic promise. | Reitman ML | β | 2013 | β |
| FGF21 regulates metabolism and circadian behavior by acting on the nervous system. | Bookout AL et al. | β | 2013 | β |
| FGF23 associated bone diseases. | Liao E | β | 2013 | β |
| Fibroblast growth factor 19 entry into brain. | Hsuchou H et al. | β | 2013 | β |
| Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. | Hu MC et al. | β | 2013 | β |
| Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. | Sun LY et al. | β | 2013 | β |
| Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. | Kuro-o M | β | 2013 | β |
| Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. | Nelson BT et al. | β | 2013 | β |
| Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. | Lee P et al. | β | 2013 | β |
| Mouse models for liver cancer. | Bakiri L et al. | β | 2013 | β |
| Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver. | Staudinger JL et al. | β | 2013 | β |
| Pharmacological and nutritional agents promoting browning of white adipose tissue. | Bonet ML et al. | β | 2013 | β |
| Pleiotropic roles of bile acids in metabolism. | de Aguiar Vallim TQ et al. | β | 2013 | β |
| Recent progress on the role of ChREBP in glucose and lipid metabolism. | Iizuka K | β | 2013 | β |
| Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: association with insulin resistance, adiponectin, and polycystic ovary syndrome history. | Wang D et al. | β | 2013 | β |
| Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels. | Fang Q et al. | β | 2013 | β |
| Stress heats up the adipocyte. | Fisher FM et al. | β | 2013 | β |
| The role of hepatokines in metabolism. | Stefan N et al. | β | 2013 | β |
| Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver. | Cicione C et al. | β | 2012 | β |
| Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling. | Kuribayashi H et al. | β | 2012 | β |
| FGF21 requires Ξ²klotho to act in vivo. | Adams AC et al. | β | 2012 | β |
| Metabolic actions of fibroblast growth factor 21. | Cuevas-Ramos D et al. | β | 2012 | β |
| Role of fibroblast growth factor 19 in the control of glucose homeostasis. | Schaap FG | β | 2012 | β |
| The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. | Zhang Y et al. | β | 2012 | β |
| Treating diabetes and obesity with an FGF21-mimetic antibody activating the Ξ²Klotho/FGFR1c receptor complex. | Foltz IN et al. | β | 2012 | β |
| Ξ²Klotho is required for fibroblast growth factor 21 effects on growth and metabolism. | Ding X et al. | β | 2012 | β |