The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.
- Authors
- Warden, Anna; Erickson, Emma; Robinson, Gizelle; Harris, R Adron; Mayfield, R Dayne
- Year
- 2016
- Journal
- Pharmacogenomics
- PMID
- 27918243
- DOI
- 10.2217/pgs-2016-0062
- PMCID
- PMC5618934
Transcriptome profiling enables discovery of gene networks that are altered in alcoholic brains. This technique has revealed involvement of the brain's neuroimmune system in regulating alcohol abuse and dependence, and has provided potential therapeutic targets. In this review, we discuss Toll-like-receptor pathways, hypothesized to be key players in many stages of the alcohol addiction cycle. The growing appreciation of the neuroimmune system's involvement in alcoholism has also led to consideration of crucial roles for glial cells, including astrocytes and microglia, in the brain's response to alcohol abuse. We discuss current knowledge and hypotheses on the roles that specific neuroimmune cell types may play in addiction. Current strategies for repurposing US FDA-approved drugs for the treatment of alcohol use disorders are also discussed.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD. | Crews FT et al. | β | 2024 | β |
| Hippocampal gray matter volume in young adulthood varies with adolescent alcohol use. | Purcell JB et al. | β | 2024 | β |
| Cytokine level in patients with mood disorder, alcohol use disorder and their comorbidity. | Mednova IA et al. | β | 2023 | β |
| Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. | Wang JQ et al. | β | 2023 | β |
| The Role of Toll and Nonnuclear NF-ΞΊB Signaling in the Response to Alcohol. | Atkinson NS | β | 2023 | β |
| A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats. | Saba LM et al. | β | 2021 | β |
| Astroglia in the Vulnerability and Maintenance of Alcohol Use Disorders. | Miguel-Hidalgo JJ | β | 2021 | β |
| Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. | Socodato R et al. | β | 2020 | β |
| Single cell transcriptome profiling of the human alcohol-dependent brain. | Brenner E et al. | β | 2020 | β |
| Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior | Socodato R et al. | β | 2019 | β |
| Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. | Kapoor M et al. | β | 2019 | β |
| A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder. | Ferguson LB et al. | β | 2019 | β |
| Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders. | Melbourne JK et al. | β | 2019 | β |
| Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement. | Morel C et al. | β | 2019 | β |
| Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'. | Engel GL et al. | β | 2019 | β |
| The relationship between the morphological subtypes of microglia and Alzheimer's disease neuropathology. | Paasila PJ et al. | β | 2019 | β |
| The Toll-Like Receptor 3 Agonist Poly(I:C) Induces Rapid and Lasting Changes in Gene Expression Related to Glutamatergic Function and Increases Ethanol Self-Administration in Rats. | Randall PA et al. | β | 2019 | β |
| Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice. | Warden AS et al. | β | 2019 | β |
| Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference. | Blednov YA et al. | β | 2018 | β |
| Dynorphin and ΞΊ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. | Bazov I et al. | β | 2018 | β |
| New steps for treating alcohol use disorder. | Campbell EJ et al. | β | 2018 | β |
| Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. | Kalinin S et al. | β | 2018 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target? | Pomrenze MB et al. | β | 2017 | β |
| Inhibition of IKKΞ² Reduces Ethanol Consumption in C57BL/6J Mice. | Truitt JM et al. | β | 2016 | β |