Delta-9-tetrahydrocannabinol: localization in body fat.
paper
Cited
Public
Unavailable
- Authors
- Kreuz, D S; Axelrod, J
- Year
- 1973
- Journal
- Science (New York, N.Y.)
- PMID
- 4682965
- DOI
- 10.1126/science.179.4071.391
[(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Delta(9)THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Delta(9)THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Delta(9)THC and its metabolites accumulated in fat and brain.
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