Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
paper
Cited
Public
Unavailable
- Authors
- Korpi, E R; Kleingoor, C; Kettenmann, H; Seeburg, P H
- Year
- 1993
- Journal
- Nature
- PMID
- 7678923
- DOI
- 10.1038/361356a0
The selectively outbred alcohol-non-tolerant (ANT) rat line is highly susceptible to impairment of postural reflexes by benzodiazepine agonists such as diazepam. ANT cerebella are generally devoid of diazepam-insensitive high-affinity binding of the benzodiazepine [3H]Ro15-4513, whereas in non-selected strains such binding marks a granule-cell-specific GABAA (gamma-aminobutyric acid) receptor containing the alpha 6 subunit. A critical determinant for diazepam insensitivity of this 'wild-type' cerebellar GABAA receptor is an arginine residue in alpha 6 position 100, where other alpha subunits carry a histidine. Here we report that the alpha 6 gene of ANT rats is expressed at wild-type levels but carries a point mutation generating an arginine-to-glutamine substitution at position 100. In consequence, alpha 6(Q100)beta 2 gamma 2 receptors show diazepam-mediated potentiation of GABA-activated currents and diazepam-sensitive binding of [3H]Ro15-4513. Our results suggest that cerebellar motor control may be a distinct behavioural correlate of the alpha 6-subunit-containing GABAA receptor subtype.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| GABAergic mechanisms in alcohol dependence. | Uusi-Oukari M et al. | β | 2024 | β |
| Diazepam-Induced Down-Regulation of the GABA<sub>A</sub> receptor Ξ±1 Subunit, as mediated by the activation of L-Type Voltage-Gated calcium Channel/Ca<sup>2+</sup>/Protein kinase a signaling cascade. | GonzΓ‘lez GΓ³mez LC et al. | β | 2023 | β |
| <i>Ξ±</i>6-Containing GABA<sub>A</sub> Receptors: Functional Roles and Therapeutic Potentials. | Sieghart W et al. | β | 2022 | β |
| Sex differences in GABA<sub>A</sub> receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver. | Ashton MK et al. | β | 2022 | β |
| GABA<sub>A</sub> receptors in GtoPdb v.2021.3. | Belelli D et al. | β | 2021 | β |
| Finnish neuroscience from past to present. | Korpi ER et al. | β | 2020 | β |
| Dopaminergic-GABAergic interplay and alcohol binge drinking. | Leggio GM et al. | β | 2019 | β |
| Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs. | Engel O et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| A Tribute to Peter H Seeburg (1944-2016): A Founding Father of Molecular Neurobiology. | Wisden W | β | 2016 | β |
| Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected? | FΓΆrstera B et al. | β | 2016 | β |
| Allosteric ligands and their binding sites define Ξ³-aminobutyric acid (GABA) type A receptor subtypes. | Olsen RW | β | 2015 | β |
| Allosteric modulation of GABAA receptors via multiple drug-binding sites. | Sieghart W | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Alcohol selectivity of Ξ²3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the Ξ±+Ξ²- subunit interface in Ξ±Ξ²3Ξ΄ GABAA receptors. | Wallner M et al. | β | 2014 | β |
| Analysis of Ξ³-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands. | Olsen RW | β | 2014 | β |
| Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. | Joensuu T et al. | β | 2014 | β |
| Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. | Olsen RW et al. | β | 2014 | β |
| A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. | Santhakumar V et al. | β | 2013 | β |
| Molecular mechanisms of antiseizure drug activity at GABAA receptors. | Greenfield LJ | β | 2013 | β |
| High-resolution gene expression atlases for adult and developing mouse brain and spinal cord. | Henry AM et al. | β | 2012 | β |
| Ethanol and vestibular stimulation reveal simple and complex aspects of cerebellar heterogeneity. | Eisenman LM | β | 2011 | β |
| Histamine and H3 receptor in alcohol-related behaviors. | Panula P et al. | β | 2011 | β |
| Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through Ξ±Ξ²Ξ³2-type GABA(A) Receptors. | Linden AM et al. | β | 2011 | β |
| The cerebellar GABAAR Ξ±6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats. | Kontturi LS et al. | β | 2011 | β |
| A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. | Radcliffe RA et al. | β | 2009 | β |
| An anxiety-like phenotype in mice selectively bred for aggression. | Nehrenberg DL et al. | β | 2009 | β |
| The complexity of the GABAA receptor shapes unique pharmacological profiles. | D'Hulst C et al. | β | 2009 | β |
| Comments on "Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABA(A) receptor subunit". | Otis TS | β | 2008 | β |
| Genetic approaches to addiction: genes and alcohol. | Ducci F et al. | β | 2008 | β |
| Short-chain alcohols promote accelerated membrane distention in a dynamic liposome model of exocytosis. | Wittenberg NJ et al. | β | 2008 | β |
| Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge. | SchlΓΆsser RG et al. | β | 2007 | β |
| Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous. | Korpi ER et al. | β | 2007 | β |
| Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition. | Santhakumar V et al. | β | 2007 | β |
| Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies. | Botta P et al. | β | 2007 | β |
| Tonic for what ails us? high-affinity GABAA receptors and alcohol. | Lovinger DM et al. | β | 2007 | β |
| Basis of the gabamimetic profile of ethanol. | Breese GR et al. | β | 2006 | β |
| Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. | Santhakumar V et al. | β | 2006 | β |
| Ethanol modulation of GABAergic transmission: the view from the slice. | Weiner JL et al. | β | 2006 | β |
| Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. | Hanchar HJ et al. | β | 2006 | β |
| Low dose acute alcohol effects on GABA A receptor subtypes. | Wallner M et al. | β | 2006 | β |
| Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513. | Wallner M et al. | β | 2006 | β |
| Serotonergic dysfunction: brain imaging and behavioral correlates. | Wrase J et al. | β | 2006 | β |
| Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. | Hanchar HJ et al. | β | 2005 | β |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | β | 2005 | β |
| Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats. | Saba L et al. | β | 2005 | β |
| Laboratory models of alcoholism: treatment target identification and insight into mechanisms. | Lovinger DM et al. | β | 2005 | β |
| Single-amino-acid difference in the sequence of alpha6 subunit dramatically increases the ethanol sensitivity of recombinant GABAA receptors. | Valenzuela CF et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats. | McKay PF et al. | β | 2004 | β |
| Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer? | Hanchar HJ et al. | β | 2004 | β |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | β | 2004 | β |
| Behavioral characterization of alcohol-tolerant and alcohol-nontolerant rat lines and an f(2) generation. | Radcliffe RA et al. | β | 2004 | β |
| Biological and behavioral markers of alcohol sensitivity. | Fromme K et al. | β | 2004 | β |
| Fishing for allosteric sites on GABA(A) receptors. | Olsen RW et al. | β | 2004 | β |
| gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. | Boehm SL et al. | β | 2004 | β |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | β | 2004 | β |
| Structural determinants of the pharmacological properties of the GABAA receptor alpha6 subunit. | Drafts BC et al. | β | 2004 | β |
| The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics. | Fisher JL | β | 2004 | β |
| The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP rats. | Sanna A et al. | β | 2004 | β |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | β | 2004 | β |
| AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit. | Carr LG et al. | β | 2003 | β |
| Acute alcohol administration improves skilled reaching success in intact but not 6-OHDA dopamine depleted rats: a subsystems analysis of the motoric and anxiolytic effects of alcohol. | Metz GA et al. | β | 2003 | β |
| Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP). | Sanna A et al. | β | 2003 | β |
| Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype. | Congeddu E et al. | β | 2003 | β |
| Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABA(A) receptor alterations. | Sinkkonen ST et al. | β | 2003 | β |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | β | 2003 | β |
| Reducing GABA receptors. | Burt DR | β | 2003 | β |
| The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. | Davies M | β | 2003 | β |
| Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice. | Vekovischeva O et al. | β | 2003 | β |
| Visualization of alpha5 subunit of GABAA/benzodiazepine receptor by 11C Ro15-4513 using positron emission tomography. | Maeda J et al. | β | 2003 | β |
| Amiloride inhibition of gamma-aminobutyric acid(A) receptors depends upon the alpha subunit subtype. | Fisher JL | β | 2002 | β |
| Drug interactions at GABA(A) receptors. | Korpi ER et al. | β | 2002 | β |
| Effects of ethanol on the accumbal output of dopamine, GABA and glutamate in alcohol-tolerant and alcohol-nontolerant rats. | Piepponen TP et al. | β | 2002 | β |
| GABA alpha6 receptors mediate midazolam-induced anxiolysis. | Hoffman WE et al. | β | 2002 | β |
| Low brain histamine content affects ethanol-induced motor impairment. | Lintunen M et al. | β | 2002 | β |
| Molecular structure and physiological function of chloride channels. | Jentsch TJ et al. | β | 2002 | β |
| Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. | Petrie J et al. | β | 2001 | β |
| Cation modulation of GABA(A) receptors in brain sections of AT and ANT rats. | Uusi-Oukari M et al. | β | 2001 | β |
| GABA promotes survival but not proliferation of parvalbumin-immunoreactive interneurons in rodent neostriatum: an in vivo study with stereology. | Luk KC et al. | β | 2001 | β |
| Ion channel diseases of the central nervous system. | Li M et al. | β | 2001 | β |
| The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line. | Saba L et al. | β | 2001 | β |
| The use of electrophysiology to improve understanding of drug-receptor interactions. | Connolly JG et al. | β | 2001 | β |
| A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity. | McLean PJ et al. | β | 2000 | β |
| Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats. | Firestone LL et al. | β | 2000 | β |
| Identification of a naturally occurring Pro385-Ser385 substitution in the GABA(A) receptor alpha6 subunit gene in alcoholics and healthy volunteers. | Iwata N et al. | β | 2000 | β |
| Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. | Uusi-Oukari M et al. | β | 2000 | β |
| Neonatal 6-hydroxydopamine treatment affects GABA(A) receptor subunit expression during postnatal development of the rat cerebellum. | Podkletnova I et al. | β | 2000 | β |
| Quantification of GABA(A) receptor subunit mRNAs by non-radioisotopic competitive RT-PCR utilizing plate-based EIA methodology. | Uusi-Oukari M et al. | β | 2000 | β |
| Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. | Loh EW et al. | β | 2000 | β |
| A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition. | Schmieden V et al. | β | 1999 | β |
| An update on GABAA receptors. | Mehta AK et al. | β | 1999 | β |
| Association analysis of sequence variants of GABA(A) alpha6, beta2, and gamma2 gene cluster and alcohol dependence. | Sander T et al. | β | 1999 | β |
| Cerebellar GABA(A) receptors and anxiolytic action of diazepam. | Vekovischeva OY et al. | β | 1999 | β |
| Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice. | Korpi ER et al. | β | 1999 | β |
| Differential effects of zinc on native GABA(A) receptor function in rat hippocampus and cerebellum. | Schmid G et al. | β | 1999 | β |
| Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. | Serretti A et al. | β | 1999 | β |
| Enhanced benzodiazepine and ethanol actions on cerebellar GABA(A) receptors mediating glutamate release in an alcohol-sensitive rat line. | Schmid G et al. | β | 1999 | β |
| Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats. | MΓ€kelΓ€ R et al. | β | 1999 | β |
| Modulation of mPer1 gene expression by anxiolytic drugs in mouse cerebellum. | Akiyama M et al. | β | 1999 | β |
| New perspectives in the functional role of GABA(A) channel heterogeneity. | Vicini S | β | 1999 | β |
| No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. | Serretti A et al. | β | 1999 | β |
| Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity. | Iwata N et al. | β | 1999 | β |
| Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. | Schuckit MA et al. | β | 1999 | β |
| Widespread expression of GABA(A) receptor subunits in peripheral tissues. | Akinci MK et al. | β | 1999 | β |
| Alcohol and benzodiazepines: recent mechanistic studies. | Harris RA et al. | β | 1998 | β |
| Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. | Kang MH et al. | β | 1998 | β |
| Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands. | Schaerer MT et al. | β | 1998 | β |
| Anomalous rectifying properties of 'diazepam-insensitive' GABA(A) receptors. | Granja R et al. | β | 1998 | β |
| Benzodiazepine receptor antagonists modulate the actions of ethanol in alcohol-preferring and -nonpreferring rats. | June HL et al. | β | 1998 | β |
| Decreased expression of GABAA receptor alpha6 and beta3 subunits in stargazer mutant mice: a possible role for brain-derived neurotrophic factor in the regulation of cerebellar GABAA receptor expression? | Thompson CL et al. | β | 1998 | β |
| Ethanol: Novel Actions on Nerve Cell Physiology Explain Impaired Functions. | Korpi ER et al. | β | 1998 | β |
| Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice. | Homanics GE et al. | β | 1998 | β |
| GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats. | June HL et al. | β | 1998 | β |
| Genetic dissection of the molecular target(s) of anesthetics with the gene knockout approach in mice. | Homanics GE et al. | β | 1998 | β |
| Heritable mutations in the glycine, GABAA, and nicotinic acetylcholine receptors provide new insights into the ligand-gated ion channel receptor superfamily. | Vafa B et al. | β | 1998 | β |
| Search for mutations near the alternatively spliced 8-amino-acid exon in the GABAA receptor gamma 2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan. | Hsu YP et al. | β | 1998 | β |
| The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. | Hevers W et al. | β | 1998 | β |
| Adenosine A1 receptor antisense infused in striatum of rats: actions on alcohol-induced locomotor impairment, blood alcohol, and body temperature. | Biggs TA et al. | β | 1997 | β |
| A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor. | Wilke K et al. | β | 1997 | β |
| A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. | Buhr A et al. | β | 1997 | β |
| Behavioral sensitivity and ethanol potentiation of the N-methyl-D-aspartate receptor antagonist MK-801 in a rat line selected for high ethanol sensitivity. | Toropainen M et al. | β | 1997 | β |
| Blockade of behavioral effects of bretazenil by flumazenil and ZK 93,426 in pigeons. | Witkin JM et al. | β | 1997 | β |
| Candidate gene study of eight GABAA receptor subunits in panic disorder. | Crowe RR et al. | β | 1997 | β |
| Chloride channels: an emerging molecular picture. | Jentsch TJ et al. | β | 1997 | β |
| Chloride channels cough up. | Thakker RV | β | 1997 | β |
| Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. | Homanics GE et al. | β | 1997 | β |
| Genetic approaches to CNS disorders with particular reference to GABAA-receptor mutations. | Mohler H | β | 1997 | β |
| Localization and pharmacological characterization of pigeon diazepam-insensitive GABAA receptors. | Acri JB et al. | β | 1997 | β |
| Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. | Homanics GE et al. | β | 1997 | β |
| Polymorphisms and intron sequences flanking the alternatively spliced 8-amino-acid exon of gamma2 subunit gene for GABAA receptors. | Cheng AT et al. | β | 1997 | β |
| Propofol-induced ataxia and hypnosis in rat lines selected for differential alcohol sensitivity. | Yildirim Y et al. | β | 1997 | β |
| Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands. | Buhr A et al. | β | 1997 | β |
| Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site. | Buhr A et al. | β | 1997 | β |
| Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. | Hill-Venning C et al. | β | 1997 | β |
| The GABAA receptor alpha 6 subunit gene (Gabra6) is tightly linked to the alpha 1-gamma 2 subunit cluster on mouse chromosome 11. | Garrett KM et al. | β | 1997 | β |
| Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas. | Pesold C et al. | β | 1997 | β |
| Benzodiazepines on trial: a research strategy for their rehabilitation. | Costa E et al. | β | 1996 | β |
| Blunted furosemide action on cerebellar GABAA receptors in ANT rats selectively bred for high alcohol sensitivity. | MΓ€kelΓ€ R et al. | β | 1996 | β |
| Brain regional pharmacology of GABA(A) receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. | Wong G et al. | β | 1996 | β |
| Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. | Tia S et al. | β | 1996 | β |
| Diazepam-insensitive GABAA receptors in rat cerebellum and thalamus. | Huh KH et al. | β | 1996 | β |
| Functional evidence for two native GABAA receptor subtypes in adult rat hippocampus and cerebellum. | Schmid G et al. | β | 1996 | β |
| Hereditary spastic paraplegia linked to chromosome 15q: Analysis of candidate genes. | Fink JK et al. | β | 1996 | β |
| Inhibition of GABAA ligand-gated Cl- channels by zinc in adult rat brain: a regional study. | Ito Y et al. | β | 1996 | β |
| Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol. | Wong G et al. | β | 1996 | β |
| Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors. | Gunnersen D et al. | β | 1996 | β |
| The cerebellum: a model system for studying GABAA receptor diversity. | Wisden W et al. | β | 1996 | β |
| [3H]MK-801 binding in various brain regions of rat lines selected for differential alcohol sensitivity. | NΓ€kki R et al. | β | 1995 | β |
| Antagonism of ethanol by pretreatment or posttreatment with RO 15-4513 and indomethacin alone or in combination. | Elmer GI et al. | β | 1995 | β |
| Biological function of GABAA/benzodiazepine receptor heterogeneity. | LΓΌddens H et al. | β | 1995 | β |
| Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors. | Wong G et al. | β | 1995 | β |
| Effects of ethanol on recombinant rat GABAA receptors: [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding study. | Korpi ER et al. | β | 1995 | β |
| Evaluating genetic models of cognitive evolution and behaviour. | Wahlsten D | β | 1995 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| Functional domains of GABAA receptors. | Smith GB et al. | β | 1995 | β |
| GABAA/benzodiazepine receptor heterogeneity: neurophysiological implications. | LΓΌddens H et al. | β | 1995 | β |
| Modulation of recombinant alpha 6 beta 2 gamma 2 GABAA receptors by neuroactive steroids. | Hauser CA et al. | β | 1995 | β |
| Solid-phase technology: magnetic heads to improve nucleic acid detection and analysis. | Lundeberg J et al. | β | 1995 | β |
| Structure and distribution of multiple GABAA receptor subunits with special reference to the cerebellum. | Wisden W | β | 1995 | β |
| Subtype specificity of gamma-aminobutyric acid type A receptor antagonism by clozapine. | Korpi ER et al. | β | 1995 | β |
| The GABAA receptors. | Stephenson FA | β | 1995 | β |
| Different functional effect of Ro 15-4513 and Ro 19-4603 on synaptic responses of Purkinje cells in the rat cerebellar slice. | Pringle AK et al. | β | 1994 | β |
| Differential expression of GABAA receptor subunit mRNAs in ethanol-naive withdrawal seizure resistant (WSR) vs. withdrawal seizure prone (WSP) mouse brain. | Keir WJ et al. | β | 1994 | β |
| Functional diversity of GABA-activated Cl- currents in Purkinje versus granule neurons in rat cerebellar slices. | Puia G et al. | β | 1994 | β |
| GABAA/benzodiazepine receptor alpha 6 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice. | Varecka L et al. | β | 1994 | β |
| Modulation by chronic morphine administration of single-stranded cAMP response element (ssCRE) binding proteins in the mouse cerebellum. | Osugi T et al. | β | 1994 | β |
| Molecular neurobiology of the GABAA receptor. | Dunn SM et al. | β | 1994 | β |
| Molecular physiology of anion channels. | Jentsch TJ | β | 1994 | β |
| Phenotypic characterization of second generation offspring of alcohol-sensitive ANT and alcohol-insensitive AT rat lines. | Tuominen K et al. | β | 1994 | β |
| Phenotypic consequences of deletion of the gamma 3, alpha 5, or beta 3 subunit of the type A gamma-aminobutyric acid receptor in mice. | Culiat CT et al. | β | 1994 | β |
| Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. | Peoples RW et al. | β | 1994 | β |
| A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. | Nakatsu Y et al. | β | 1993 | β |
| Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels. | Devillers-ThiΓ©ry A et al. | β | 1993 | β |
| GABA receptors, granule cells and genes. | Farrant M et al. | β | 1993 | β |
| Recombinant GABAA receptor function and ethanol. | Sigel E et al. | β | 1993 | β |