New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.
paper
Cited
Public
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- Authors
- Dongre, Anushka; Weinberg, Robert A
- Year
- 2019
- Journal
- Nature reviews. Molecular cell biology
- PMID
- 30459476
- DOI
- 10.1038/s41580-018-0080-4
Epithelial-mesenchymal transition (EMT) is a cellular programme that is known to be crucial for embryogenesis, wound healing and malignant progression. During EMT, cell-cell and cell-extracellular matrix interactions are remodelled, which leads to the detachment of epithelial cells from each other and the underlying basement membrane, and a new transcriptional programme is activated to promote the mesenchymal fate. In the context of neoplasias, EMT confers on cancer cells increased tumour-initiating and metastatic potential and a greater resistance to elimination by several therapeutic regimens. In this Review, we discuss recent findings on the mechanisms and roles of EMT in normal and neoplastic tissues, and the cell-intrinsic signals that sustain expression of this programme. We also highlight how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state, which could function as cancer stem cells. In addition, we describe the contributions of the tumour microenvironment in inducing EMT and the effects of EMT on the immunobiology of carcinomas.
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| Peritoneal Immunosurgery: Immunotherapy Augmented Surgery for the Treatment of Peritoneal Cancers. | Ozcan AI et al. | — | 2025 | → |
| Peritoneal Lavage Cytology Predicts Peritoneal Metastasis and is Associated with Poor Prognosis in Patients with Stage II-III Colorectal Cancer. | Kong D et al. | — | 2025 | → |
| Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression. | Cai J et al. | — | 2025 | → |
| Pharmacological role of <i>Herba Patriniae</i> and <i>Coix</i> seed in colorectal cancer. | Zhang YX et al. | — | 2025 | → |
| Phytochemical strategies in glioblastoma therapy: Mechanisms, efficacy, and future perspectives. | Baliyan D et al. | — | 2025 | → |
| PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State. | Killarney ST et al. | — | 2025 | → |
| Platelets and platelet-derived extracellular vesicles: their role in lung cancer dissemination and premetastatic niche formation. | Locatelli C et al. | — | 2025 | → |
| Polyclonality and metabolic heterogeneity in a colorectal tumor model. | Delamotte P et al. | — | 2025 | → |
| Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma. | Marcovici I et al. | — | 2025 | → |
| Predictive biomarkers of pancreatic cancer metastasis: A comprehensive review. | Chen M et al. | — | 2025 | → |
| Predictive value of serum calcium ion level in patients with colorectal cancer: A retrospective cohort study. | Shu Y et al. | — | 2025 | → |
| Preliminary exploration of the role of fibrinogen-like protein 2 in neuroblastoma. | Qi C et al. | — | 2025 | → |
| Prognostic and immunological role of LASP2 in clear cell renal cell carcinoma. | Chen L et al. | — | 2025 | → |
| Prognostic significance of Ki-67 in assessing the risk of progression, relapse or metastasis in pheochromocytomas and paragangliomas. | Luo Z et al. | — | 2025 | → |
| Programmed death-ligand 1 regulates ameloblastoma growth and recurrence. | Zhang L et al. | — | 2025 | → |
| Promising new drugs and therapeutic approaches for treatment of ovarian cancer-targeting the hallmarks of cancer. | Hillmann J et al. | — | 2025 | → |
| Propolis: A Natural Substance with Multifaceted Properties and Activities. | Martinotti S et al. | — | 2025 | → |
| Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups. | Ji S et al. | — | 2025 | → |
| Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer. | Holt MV et al. | — | 2025 | → |
| PSMD14 promotes breast cancer progression by reducing K63-linked ubiquitination on FOXM1 and activating the PI3K/AKT/mTOR pathway. | Liu Y et al. | — | 2025 | → |
| PXDN regulated by WTAP/YTHDF1-mediated m<sup>6</sup>A modification activates PI3K/AKT signaling pathway through extracellular matrix remodeling to promote progression in nasopharyngeal carcinoma. | Li Y et al. | — | 2025 | → |
| Quantitative profiling of intratumor immune heterogeneity identifies loss of immune diversity as a hallmark of cancer progression. | Lu Q et al. | — | 2025 | → |
| Rac1 in gastric cancer: a molecular driver of invasion, EMT, and therapeutic resistance. | Li J et al. | — | 2025 | → |
| Ranunculus ternatus Thunb. alkaloids attenuate colorectal cancer metastasis through EMT suppression. | Li Y et al. | — | 2025 | → |
| Real-time assessment of circulating tumor cells refines the indication for HER2-targeted therapy in metastatic gastric cancer. | Kimura Y et al. | — | 2025 | → |
| Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches. | Aquino A et al. | — | 2025 | → |
| Reconceptualizing Endothelial-to-mesenchymal transition in atherosclerosis: Signaling pathways and prospective targeting strategies. | You N et al. | — | 2025 | → |
| Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse. | Drago-Garcia D et al. | — | 2025 | → |
| Regnases play a crucial role in guarding against cancer development. | Wawro M et al. | — | 2025 | → |
| Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway. | Li Q et al. | — | 2025 | → |
| RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53<sup>R249S</sup> Mutation and is a Potential Therapeutic Target. | Wu Z et al. | — | 2025 | → |
| Research progress on NAT10-mediated acetylation in normal development and disease. | Qin D et al. | — | 2025 | → |
| Research progress on the role of biomechanical clues in the progression of lung cancer. | Gong F et al. | — | 2025 | → |
| RNA N4-acetylcytidine modification and its role in health and diseases. | Wang Q et al. | — | 2025 | → |
| Role of EMT in drug resistance of breast cancer: molecular mechanisms and therapeutic strategies. | Luo Y et al. | — | 2025 | → |
| Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment. | Aakel N et al. | — | 2025 | → |
| Role of IL-17 cytokines in tubal fibrosis and infertility due to salpingitis. | Zhao J et al. | — | 2025 | → |
| Role of Mesenchymal Markers in Colorectal Cancer Metastasis. | Soni S et al. | — | 2025 | → |
| Role of Oral Microbes in Epithelial-Mesenchymal Transition in Cancer Progression. | Gopinath D et al. | — | 2025 | → |
| Role of RGD-binding Integrins in ovarian cancer progression, metastasis and response to therapy. | Ranga V et al. | — | 2025 | → |
| Roles of β-catenin protein in non-small cell lung cancer (Review). | Peng L et al. | — | 2025 | → |
| RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway. | Cheng C et al. | — | 2025 | → |
| RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness. | Vitale E et al. | — | 2025 | → |
| Schwann cell reprogramming via EMT-like program following peripheral nerve injury and during nerve regeneration. | Dai W et al. | — | 2025 | → |
| Schwann cells in regeneration and cancer. | Zhang L et al. | — | 2025 | → |
| Seabuckthorn polysaccharide alleviates renal fibrosis in a mouse model of diabetic nephropathy via p311/TGFβ1/Fstl1 signaling pathway. | Huang Q et al. | — | 2025 | → |
| SERPINI1 serves as a biomarker promoting cell proliferation and invasion in hepatocellular carcinoma. | Han Y et al. | — | 2025 | → |
| Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases. | Bastos VAF et al. | — | 2025 | → |
| Single-Cell RNA-Seq Recognized Key Genes for Metastasis and Macrophage Infiltration in Colorectal Cancer. | Shi J et al. | — | 2025 | → |
| Single-Cell RNA Sequencing Reveals LEF1 as a Prognostic Biomarker for Poor Outcomes in Oxaliplatin-Resistant Colorectal Cancer. | Huang P et al. | — | 2025 | → |
| Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients. | Guo K et al. | — | 2025 | → |
| Single-cell transcriptomic profiling reveals the heterogeneity of epithelial cells in lung adenocarcinoma lymph node metastasis and develops a prognostic signature. | Mu Q et al. | — | 2025 | → |
| SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis. | Qi C et al. | — | 2025 | → |
| Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution. | Ma H et al. | — | 2025 | → |
| Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer. | Aung TN et al. | — | 2025 | → |
| SpatialSNV: A novel method for identifying and analyzing spatially resolved SNVs in tumor microenvironments. | Liu Y et al. | — | 2025 | → |
| Spatial Transcriptomics Unveils Regional Heterogeneity and Subclonal Dynamics in the Lung Adenocarcinoma Microenvironment. | An H et al. | — | 2025 | → |
| Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies. | Chang X et al. | — | 2025 | → |
| Specific modulation of 28S_Um2402 rRNA 2'-<i>O</i>-ribose methylation as a novel epitranscriptomic marker of ZEB1-induced epithelial-mesenchymal transition in different mammary cell contexts. | Morin C et al. | — | 2025 | → |
| Spermine attenuates TGF-β-induced EMT by downregulating fibronectin. | Liu H et al. | — | 2025 | → |
| Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer. | Naro C et al. | — | 2025 | → |
| SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis. | Lu X et al. | — | 2025 | → |
| STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer. | Dong D et al. | — | 2025 | → |
| Stromal Interferon Regulatory Factor 3 Can Antagonize Human Papillomavirus Replication by Supporting Epithelial-to-Mesenchymal Transition. | Amusan OT et al. | — | 2025 | → |
| Suppression of breast cancer metastatic behavior by microRNAs targeting EMT transcription factors. A relevant participation of miR-196a-5p and miR-22-3p in ZEB1 expression. | Perez-Moreno E et al. | — | 2025 | → |
| Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system. | Chen J et al. | — | 2025 | → |
| Targeted inhibition of MDSC-derived exosomal miR-155-5p restrains epithelial-mesenchymal transition in hormone receptor-positive breast cancer by regulating SIRT1. | Chen G et al. | — | 2025 | → |
| Targeted Therapies Modulating Mesenchymal-Epithelial Transition-Linked Oncogenic Signaling in the Tumor Microenvironment: Comparative Profiling of Capmatinib, Bemcentinib, and Galunisertib. | Kawczak P et al. | — | 2025 | → |
| Targeting MED8 enhances sorafenib sensitivity in hepatocellular carcinoma by disrupting epithelial-mesenchymal transition mechanisms. | Li M et al. | — | 2025 | → |
| Targeting the Wnt/β-catenin pathway and epithelial-mesenchymal transition in gastric cancer: mechanisms, therapeutic strategies, and clinical challenges. | Shi R et al. | — | 2025 | → |
| Targeting transcription in neuroblastoma: focus on the core regulatory circuit. | Kuchur OA et al. | — | 2025 | → |
| Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer. | Liu J et al. | — | 2025 | → |
| TCN1 Drives Malignant Progression of Pancreatic Cancer Through STAT4-Mediated Transcriptional Activation of the DUOX2/ROS Signaling Axis. | Liu Z et al. | — | 2025 | → |
| TET-mediated 5hmC in breast cancer: mechanism and clinical potential. | Zhang J et al. | — | 2025 | → |
| TGF-β-mediated epithelial-mesenchymal transition of keratinocytes promotes fibrosis in secondary lymphedema. | Park HJ et al. | — | 2025 | → |
| TGF-β secreted by cancer cells-platelets interaction activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation. | Zhong C et al. | — | 2025 | → |
| TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids. | Teng YH et al. | — | 2025 | → |
| The activity of the EMT suppressor GRHL2 is regulated by SUMOylation. | Santjer S et al. | — | 2025 | → |
| The Angiofibrotic Switch in Retinal and Choroidal Vascular Diseases: Mechanistic Drivers of Angiogenesis and Endothelial-Mesenchymal Transition. | McLellan FC et al. | — | 2025 | → |
| The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer. | Qiu L et al. | — | 2025 | → |
| The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma. | Wang YF et al. | — | 2025 | → |
| The Clinical Relevance of Epithelial-to-Mesenchymal Transition Hallmarks: A Cut-Off-Based Approach in Healthy and Cancerous Cell Lines. | Rapanotti MC et al. | — | 2025 | → |
| The clinicopathological and molecular features of primary high-grade neuroendocrine tumour in the breast. | Hong R et al. | — | 2025 | → |
| The dark side of radiotherapy. | Piffkó A et al. | — | 2025 | → |
| The endocannabinoid system in cancer biology: a mini-review of mechanisms and therapeutic potential. | Salum KCR et al. | — | 2025 | → |
| The feedback loop between miR-222-3p and ZEB1 harnesses metastasis in renal cell carcinoma. | Wang F et al. | — | 2025 | → |
| The function of microRNA related to cancer-associated fibroblasts in pancreatic ductal adenocarcinoma. | Fang Y et al. | — | 2025 | → |
| The impact of METTL3 on bladder cancer through m<sup>6</sup>A modification: a potential therapeutic target and prognostic biomarker. | Wen D et al. | — | 2025 | → |
| The integrated stress response drives MET oncogene overexpression in cancers. | Cerqua M et al. | — | 2025 | → |
| The JAK1/STAT3 pathway mediates the effects of SERPINH1 on glioma EMT. | Wang S et al. | — | 2025 | → |
| The key role of cellular plasticity in the development of colorectal cancer. | Lou L et al. | — | 2025 | → |
| The lncRNA MIR22HG suppresses prostate cancer cell proliferation, migration, and epithelial-mesenchymal transition via the miR-4428/PCDH9 axis. | Li A et al. | — | 2025 | → |
| The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness. | Montemurro M et al. | — | 2025 | → |
| The metastatic cascade through the lens of therapeutic inhibition. | Miranda I et al. | — | 2025 | → |
| The Mevalonate Pathway in the Radiation Response of Cancer. | Azizi L et al. | — | 2025 | → |
| The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond. | Yu S et al. | — | 2025 | → |
| The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications. | Wei X et al. | — | 2025 | → |
| The PI3K-AKT-mTOR signaling pathway mediates epithelial mesenchymal transition and cytoskeletal architecture changes induce to renal fibrosis after Bisphenol S exposure. | Zhang Z et al. | — | 2025 | → |
| The pro-tumorigenic roles of granzyme B: mechanisms and therapeutic implications. | Zhang Y et al. | — | 2025 | → |
| Therapeutic limitations of oncolytic VSVd51-mediated miR-199a-5p delivery in triple negative breast cancer models. | St-Cyr G et al. | — | 2025 | → |
| Therapy resistance: Modulating evolutionarily conserved heat shock protein machinery in cancer. | Skrabalak I et al. | — | 2025 | → |
| The regulatory effect of CoL10A1 to the intracranial vascular invasion and cell proliferation in breast cancer via EMT pathway. | Wang X et al. | — | 2025 | → |
| The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies. | Zhao R et al. | — | 2025 | → |
| The role and clinical significance of tumor-associated macrophages in the epithelial-mesenchymal transition of lung cancer. | Liao L et al. | — | 2025 | → |
| The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer. | Song Y et al. | — | 2025 | → |
| The role and regulation of integrins in cell migration and invasion. | Chastney MR et al. | — | 2025 | → |
| The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development. | Zhao B et al. | — | 2025 | → |
| The Role of Epithelial-Mesenchymal Transition in Malignant Pleural Mesothelioma: From Pathogenesis to Diagnosis and Treatment. | Magouliotis DE et al. | — | 2025 | → |
| The Role of lncRNA <i>FEZF1-AS1</i> in Colorectal Cancer Progression Via the <i>P53</i> Signaling Pathway. | Ding M et al. | — | 2025 | → |
| The role of SUMOylation in epithelial-mesenchymal transition. | Li S et al. | — | 2025 | → |
| The Therapeutic Effect of EZH2 Inhibitors in Targeting Human Papillomavirus Associated Cervical Cancer. | Vidalina D et al. | — | 2025 | → |
| The Uptake of Metallic Nanoparticles in Breast Cancer Cell Lines is Modulated by the Hyaluronan-CD44 Axis. | Hullo M et al. | — | 2025 | → |
| The WT1 protein molecule drives the proliferation and metastasis of anaplastic thyroid carcinoma through the EMT process. | Zheng J et al. | — | 2025 | → |
| TOE1 deadenylase inhibits gastric cancer cell proliferation by regulating cell cycle progression. | Sun XL et al. | — | 2025 | → |
| Training and experimental validation a novel anoikis- and epithelial‒mesenchymal transition-related signature for evaluating prognosis and predicting immunotherapy efficacy in gastric cancer. | Zeng C et al. | — | 2025 | → |
| Transcription factor Yin Yang 1 enhances epithelial-mesenchymal transition, migration, and stemness of non-small cell lung cancer cells by targeting sonic hedgehog. | Huang T et al. | — | 2025 | → |
| Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment. | Liu L et al. | — | 2025 | → |
| Tregs With High CD29 Expression Promote Cell Adhesion and Contribute to the Malignant Transformation of MASLD. | Lu Y et al. | — | 2025 | → |
| Triaptosis and Cancer: Next Hope? | Li ZZ et al. | — | 2025 | → |
| TRIB1 facilitates the proliferation and migration of ovarian cancer cells by inducing EMT progression. | Shi G et al. | — | 2025 | → |
| Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through <i>BRD4</i>/<i>c-Myc</i> endoplasmic reticulum-stress pathway. | Chen YM et al. | — | 2025 | → |
| Triple-Negative Breast Cancer Progression and Drug Resistance in the Context of Epithelial-Mesenchymal Transition. | Błaszczak E et al. | — | 2025 | → |
| Tumor-adipose assembloids reveal cell-fate-transition-triggered multistage collective invasions. | Lei M et al. | — | 2025 | → |
| Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions. | Sun S et al. | — | 2025 | → |
| Tumor-infiltrating lymphocytes and tumor-associated macrophages in cancer immunoediting: a targetable therapeutic axis. | Mukherjee S et al. | — | 2025 | → |
| Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations. | Parker HN et al. | — | 2025 | → |
| Ubiquitination in hepatocellular carcinoma immunity. | Zhao J et al. | — | 2025 | → |
| Ubiquitin E3 ligase KPC1 governs mesenchymal metastatic melanoma reprogramming via proteasomal degradation of ZEB1. | Nakano Y et al. | — | 2025 | → |
| UCHL1 stabilizes Twist1 via K11/K63-linked deubiquitination to drive tumor metastasis in non-small cell lung cancer. | Feng Q et al. | — | 2025 | → |
| Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification. | Mao Q et al. | — | 2025 | → |
| Understanding cancer cell plasticity: EMT, respecialisation, and therapeutic opportunities. | Morel AP et al. | — | 2025 | → |
| "Undruggable KRAS": druggable after all. | Cox AD et al. | — | 2025 | → |
| Unravelling the molecular crosstalk between Epithelial-Mesenchymal transition and human papillomavirus in oral cancer. | Bhattacharya S et al. | — | 2025 | → |
| Unveiling the complex double-edged sword role of exosomes in nasopharyngeal carcinoma. | Huang X et al. | — | 2025 | → |
| Unveiling the material basis of Shenshuaifu granule and its therapeutic mechanism in chronic renal failure: a combined approach of high-resolution mass spectrometry and <i>in silico</i> technology. | Huang Q et al. | — | 2025 | → |
| Unveiling the therapeutic potential of silibinin in head and neck squamous cell carcinoma via network pharmacology. | Zheng Y et al. | — | 2025 | → |
| Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance. | Toledano-Fonseca M et al. | — | 2025 | → |
| XPD Regulates MIAT/miR-29a-3p/COL4A1 Axis to Impede Hepatocellular Carcinoma Development. | Wang Q et al. | — | 2025 | → |
| Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in <i>Helicobacter pylori</i>-induced gastric cancer progression. | Chen JW et al. | — | 2025 | → |
| ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer. | Xie X et al. | — | 2025 | → |
| β-Lapachone sensitizes glioblastoma to Temozolomide by inhibiting NF-κB signaling. | Quan C et al. | — | 2025 | → |
| 5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential. | Fenech K et al. | — | 2024 | → |
| A 69 long noncoding RNA signature predicts relapse and acts as independent prognostic factor in pediatric AML. | Ren Z et al. | — | 2024 | → |
| Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model. | Frame G et al. | — | 2024 | → |
| A comprehensive exploration of twist1 to identify a biomarker for tumor immunity and prognosis in pan-cancer. | Wang Y et al. | — | 2024 | → |
| Actin Cytoskeleton Remodeling Accompanied by Redistribution of Adhesion Proteins Drives Migration of Cells in Different EMT States. | Ilnitskaya AS et al. | — | 2024 | → |
| ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-β1 activation in lung adenocarcinoma. | Xiao L et al. | — | 2024 | → |
| ADAMTS Proteases: Their Multifaceted Role in the Regulation of Cancer Metastasis. | Bacchetti R et al. | — | 2024 | → |
| Adherens junctions as molecular regulators of emergent tissue mechanics. | Campàs O et al. | — | 2024 | → |
| Adipocytes promote metastasis of breast cancer by attenuating the FOXO1 effects and regulating copper homeostasis. | Chen X et al. | — | 2024 | → |
| Adipose-Derived Stromal Cells and Cancer-Associated Fibroblasts: Interactions and Implications in Tumor Progression. | El Alaa RSA et al. | — | 2024 | → |
| Advances and challenges in the use of liquid biopsy in gynaecological oncology. | Zhang Y et al. | — | 2024 | → |
| Advances in sequencing and omics studies in prostate cancer: unveiling molecular pathogenesis and clinical applications. | Lu B et al. | — | 2024 | → |
| Advances in systemic immune inflammatory indices in non-small cell lung cancer: A review. | Mao KY et al. | — | 2024 | → |
| Advances in the role of GPX3 in ovarian cancer (Review). | Geng D et al. | — | 2024 | → |
| A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial-mesenchymal plasticity. | Rea M et al. | — | 2024 | → |
| A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma. | Liu J et al. | — | 2024 | → |
| Agrimonolide Inhibits the Malignant Progression of Non-small Cell Lung Cancer and Induces Ferroptosis through the mTOR Signaling Pathway. | Zhang X et al. | — | 2024 | → |
| AKR1C3 mediates gastric cancer cell invasion and metastasis via the AKT and JNK/p-NF-κB signaling pathways. | Lin L et al. | — | 2024 | → |
| ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT. | Gao L et al. | — | 2024 | → |
| Alveolar type 2 cells marker gene <i>SFTPC</i> inhibits epithelial-to-mesenchymal transition by upregulating <i>SOX7</i> and suppressing WNT/β-catenin pathway in non-small cell lung cancer. | Zhang Q et al. | — | 2024 | → |
| Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis. | Jian HY et al. | — | 2024 | → |
| A milestone in epithelial-mesenchymal transition. | Sun Y et al. | — | 2024 | → |
| Analysis of the role of dihydromyricetin derived from vine tea (<i>Ampelopsis grossedentata</i>) on multiple myeloma by activating STAT1/RIG-I axis. | Jiang W et al. | — | 2024 | → |
| An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. | Yang F et al. | — | 2024 | → |
| A novel bioinformatic approach reveals cooperation between Cancer/Testis genes in basal-like breast tumors. | Laisné M et al. | — | 2024 | → |
| A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer. | Lin WD et al. | — | 2024 | → |
| Anti-tumor effect and hepatotoxicity mechanisms of psoralen. | Meng D et al. | — | 2024 | → |
| Apelin-13 alleviates intrauterine adhesion by inhibiting epithelial-mesenchymal transition of endometrial epithelial cells and promoting angiogenesis. | Zhao Q et al. | — | 2024 | → |
| A perspective on tumor radiation resistance following high-LET radiation treatment. | Rajpurohit YS et al. | — | 2024 | → |
| A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | Mohamedali A et al. | — | 2024 | → |
| ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer. | Taniguchi H et al. | — | 2024 | → |
| Axillary nodal staging in breast cancer: what have we learned? | Schwartz TL | — | 2024 | → |
| Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells. | Wang Z et al. | — | 2024 | → |
| Beta-elemene: A phytochemical with promise as a drug candidate for tumor therapy and adjuvant tumor therapy. | Feng Y et al. | — | 2024 | → |
| Biological Functions and Potential Therapeutic Significance of O-GlcNAcylation in Hepatic Cellular Stress and Liver Diseases. | Mao Z et al. | — | 2024 | → |
| Biomarkers of epithelial-mesenchymal transition: E-cadherin and beta-catenin in malignant transformation of oral lesions. | Yim IS et al. | — | 2024 | → |
| Biomimetic Hydrogel-Mediated Mechano-Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery. | Dong Y et al. | — | 2024 | → |
| Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment. | Li J et al. | — | 2024 | → |
| CAB39 modulates epithelial-mesenchymal transition through NF-κB signaling activation, enhancing invasion, and metastasis in bladder cancer. | Huang J et al. | — | 2024 | → |
| Cadherin adhesion complexes direct cell aggregation in the epithelial transition of Wnt-induced nephron progenitor cells. | Der B et al. | — | 2024 | → |
| CADM2 participates in endometriosis development by influencing the epithelial-mesenchymal transition. | Wang Z et al. | — | 2024 | → |
| Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter. | Feng S et al. | — | 2024 | → |
| Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma. | Lorenzo-Sanz L et al. | — | 2024 | → |
| Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors. | Tirosh I et al. | — | 2024 | → |
| Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer. | Zhong D et al. | — | 2024 | → |
| Cancer spreading patterns based on epithelial-mesenchymal plasticity. | Wang R et al. | — | 2024 | → |
| Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia. | Wang Y et al. | — | 2024 | → |
| Case report: Two cases of prostate adenocarcinoma progressing to rare sarcomatoid carcinoma with normal PSA levels following endocrine therapy. | Dai Z et al. | — | 2024 | → |
| Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers. | Kuchinski K et al. | — | 2024 | → |
| CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer. | Guan Y et al. | — | 2024 | → |
| CD146, a therapeutic target involved in cell plasticity. | Wu Z et al. | — | 2024 | → |
| CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming. | Liu S et al. | — | 2024 | → |
| Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium. | Faust D et al. | — | 2024 | → |
| Cell-intrinsic and microenvironmental determinants of metastatic colonization. | Lambert AW et al. | — | 2024 | → |
| Cell of Origin of Pancreatic cancer: Novel Findings and Current Understanding. | Zheng C et al. | — | 2024 | → |
| Cetuximab chemotherapy resistance: Insight into the homeostatic evolution of head and neck cancer (Review). | Diniz CHP et al. | — | 2024 | → |
| Characteristics and transcriptional regulators of spontaneous epithelial-mesenchymal transition in genetically unperturbed patient-derived non-spindled breast carcinoma. | Lien HC et al. | — | 2024 | → |
| Characterization of polyamine metabolism predicts prognosis, immune profile, and therapeutic efficacy in lung adenocarcinoma patients. | Li Z et al. | — | 2024 | → |
| Chromosomal instability drives immunosuppression and metastatic dissemination. | Vitale I et al. | — | 2024 | → |
| Circ_0070203 Promotes Epithelial-mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis. | Tang Q et al. | — | 2024 | → |
| Circadian rhythms and breast cancer: from molecular level to therapeutic advancements. | Li DD et al. | — | 2024 | → |
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| CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions. | Xerez MC et al. | — | 2024 | → |
| Clinical application of liquid biopsy in colorectal cancer: detection, prediction, and treatment monitoring. | Tao XY et al. | — | 2024 | → |
| Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis. | Del Puerto HL et al. | — | 2024 | → |
| Co-Expression Network Analysis Unveiled lncRNA-mRNA Links Correlated to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance and/or Intermediate Epithelial-to-Mesenchymal Transition Phenotypes in a Human Non-Small Cell Lung Cancer Cellular Model System. | Fustaino V et al. | — | 2024 | → |
| Combination of miR-99b-5p and Enzalutamide or Abiraterone Synergizes the Suppression of EMT-Mediated Metastasis in Prostate Cancer. | Waseem M et al. | — | 2024 | → |
| Combinatorial Biosynthesis Creates a Novel Aglycone Polyether with High Potency and Low Side Effects Against Bladder Cancer. | Yan P et al. | — | 2024 | → |
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| Comprehensive pan-cancer analysis reveals prognostic implications of TMEM92 in the tumor immune microenvironment. | Wu Z et al. | — | 2024 | → |
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| CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells. | Wang K et al. | — | 2024 | → |
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| Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition. | Zhang H et al. | — | 2024 | → |
| Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression. | Feng X et al. | — | 2024 | → |
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| Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer. | Heß L et al. | — | 2024 | → |
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| Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition. | Liu K et al. | — | 2024 | → |
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| Expression of Epithelial-Mesenchymal Transition Markers in Epidermal Layer of Atopic Dermatitis. | Kitazawa K et al. | — | 2024 | → |
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| Extracellular vesicle-derived non-coding RNAs in remodeling melanoma. | Zhan Y et al. | — | 2024 | → |
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| Extrachromosomal circular DNA-related SPOCK1 contributes to development and enzalutamide resistance of prostate cancer by regulating epithelial mesenchymal transition. | Yao Y et al. | — | 2024 | → |
| EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells. | Gallardo A et al. | — | 2024 | → |
| F2RL3 Regulates Epithelial-Mesenchymal Transition and Angiogenesis in Gastric Cancer through the Rap1/MAPK Signaling Pathway. | Ma J et al. | — | 2024 | → |
| FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma. | Liao Z et al. | — | 2024 | → |
| Farrerol suppresses epithelial-mesenchymal transition in hepatocellular carcinoma via suppression of TGF-β1/Smad2/3 signaling. | Hao Y et al. | — | 2024 | → |
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| First Use of AXL Targeting in Metastatic, Refractory, Adenoid Cystic Carcinoma: A Case Report. | Hoff CO et al. | — | 2024 | → |
| Flow cytometry of non-hematopoietic cells in canine effusions. | Sini F et al. | — | 2024 | → |
| Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation. | Chullo G et al. | — | 2024 | → |
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| FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation. | Xu X et al. | — | 2024 | → |
| Fullerene Derivatives for Tumor Treatment: Mechanisms and Application. | Hou W et al. | — | 2024 | → |
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| FUT4 promotes the progression of Cholangiocarcinoma by modulating epithelial-mesenchymal transition. | Liu E et al. | — | 2024 | → |
| FUT6 Suppresses the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells via the Epidermal Growth Factor Receptor/Extracellular Signal-Regulated Kinase Signaling Pathway. | Lao J et al. | — | 2024 | → |
| Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response. | Ye Y et al. | — | 2024 | → |
| Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment. | Chen C et al. | — | 2024 | → |
| Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling-Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors. | Wang D et al. | — | 2024 | → |
| Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis. | Perez-Moreno E et al. | — | 2024 | → |
| Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation. | Yu J et al. | — | 2024 | → |
| GDF-15 Attenuates the Epithelium-Mesenchymal Transition and Alleviates TGFβ2-Induced Lens Opacity. | Wang S et al. | — | 2024 | → |
| Genetic and phenotypic profiling of single living circulating tumor cells from patients with microfluidics. | Dong Z et al. | — | 2024 | → |
| GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells. | Ito F et al. | — | 2024 | → |
| Growth Hormone Upregulates Melanoma Drug Resistance and Migration via Melanoma-Derived Exosomes. | Kulkarni P et al. | — | 2024 | → |
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| Harnessing atomic force microscopy-based single-cell analysis to advance physical oncology. | Li M | — | 2024 | → |
| Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis. | Mendoza-Rodríguez MG et al. | — | 2024 | → |
| High aggressiveness of papillary thyroid cancer: from clinical evidence to regulatory cellular networks. | Zhang J et al. | — | 2024 | → |
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| How much do we know about the metastatic process? | Rodriguez-Tirado C et al. | — | 2024 | → |
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| Hypermethylated RASAL1's promotive role in chemoresistance and tumorigenesis of choriocarcinoma was regulated by TET2 but not DNMTs. | Zeng X et al. | — | 2024 | → |
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| Imbalance between Actin Isoforms Contributes to Tumour Progression in Taxol-Resistant Triple-Negative Breast Cancer Cells. | Dugina V et al. | — | 2024 | → |
| <i>microRNA-141-3p</i> Suppressed the Progression of the Clear Cell Renal Cell Carcinoma by Targeting <i>Transforming Growth Factor Beta 2</i> Gene Expression. | Hu X et al. | — | 2024 | → |
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| Inhibitor of PD-1/PD-L1: a new approach may be beneficial for the treatment of idiopathic pulmonary fibrosis. | Tan J et al. | — | 2024 | → |
| Inhibitory effect of recombinant tyrosine‑sulfated madanin‑1, a thrombin inhibitor, on the behavior of MDA‑MB‑231 and SKOV3 cells <i>in vitro</i>. | Jo GH et al. | — | 2024 | → |
| <i>NRXN1</i> as a Prognostic Biomarker: Linking Copy Number Variation to EMT and Survival in Colon Cancer. | Bang HJ et al. | — | 2024 | → |
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| Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma. | Liu H et al. | — | 2024 | → |
| Intermediate Filaments in Breast Cancer Progression, and Potential Biomarker for Cancer Therapy: A Narrative Review. | Shalannandia WA et al. | — | 2024 | → |
| Intracellular Pathogens: Infection, Immunity, and Intervention. | Martens-Koop A et al. | — | 2024 | → |
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| Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high. | Cai J et al. | — | 2024 | → |
| Isogarcinol inhibits nasopharyngeal carcinoma growth through mitochondria-mediated autophagic cell death. | Li J et al. | — | 2024 | → |
| KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer. | Cong S et al. | — | 2024 | → |
| Klebsiella aerogenes exacerbates colon tumorigenesis in the AOM/DSS-induced C57BL/6J mouse. | Wang X et al. | — | 2024 | → |
| KLF5 inhibition initiates epithelial-mesenchymal transition in non-transformed human squamous epithelial cells. | Bhargava D et al. | — | 2024 | → |
| Knockdown of EPS8 expression attenuates the proliferation of enzalutamide-resistant prostate cancer cells. | Huang WL et al. | — | 2024 | → |
| Kv3.4 regulates cell migration and invasion through TGF-β-induced epithelial-mesenchymal transition in A549 cells. | Sim HJ et al. | — | 2024 | → |
| Lack of basic rationale in epithelial-mesenchymal transition and its related concepts. | Cao Y | — | 2024 | → |
| Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice. | Song S et al. | — | 2024 | → |
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| Lineage Plasticity: The New Cancer Hallmark on the Block. | Mehta A et al. | — | 2024 | → |
| Lipid droplets' functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia. | Chen XJ et al. | — | 2024 | → |
| Lipid droplets provide metabolic flexibility for cancer progression. | Safi R et al. | — | 2024 | → |
| LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis. | Wang L et al. | — | 2024 | → |
| Long noncoding RNA <i>GPRC5D-AS1</i> in renal cell carcinoma: a molecular mechanism study. | Jia M et al. | — | 2024 | → |
| Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis. | Tucci FA et al. | — | 2024 | → |
| Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer. | Sharma S et al. | — | 2024 | → |
| Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma. | Zhang Y et al. | — | 2024 | → |
| Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation. | Wang J et al. | — | 2024 | → |
| LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling. | Yu S et al. | — | 2024 | → |
| LOXL2-induced PEAR1 Ser891 phosphorylation suppresses CD44 degradation and promotes triple-negative breast cancer metastasis. | Shen Y et al. | — | 2024 | → |
| LSD1 inhibits the invasion and migration of breast cancer through exosomes. | Zhang N et al. | — | 2024 | → |
| Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy. | Hu S et al. | — | 2024 | → |
| Luteolin alleviates airway remodeling in asthma by inhibiting the epithelial-mesenchymal transition via β-catenin regulation. | Quan J et al. | — | 2024 | → |
| Machine-learning developed an iron, copper, and sulfur-metabolism associated signature predicts lung adenocarcinoma prognosis and therapy response. | Zhang L et al. | — | 2024 | → |
| Magnetically Stimulated Integrin Binding Alters Cell Polarity and Affects Epithelial-Mesenchymal Plasticity in Metastatic Cancer Cells. | Kim YJ et al. | — | 2024 | → |
| Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis. | Li T et al. | — | 2024 | → |
| Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors. | Buriak I et al. | — | 2024 | → |
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| Mechanism study of serum extracellular nano-vesicles miR-412-3p targeting regulation of TEAD1 in promoting malignant biological behavior of sub-centimeter lung nodules. | Deng Y et al. | — | 2024 | → |
| Meroterpenoids from Marine Sponge <i>Hyrtios</i> sp. and Their Anticancer Activity against Human Colorectal Cancer Cells. | Wang J et al. | — | 2024 | → |
| Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration. | Hansman DS et al. | — | 2024 | → |
| Metaplastic Breast Carcinoma and Mesenchymal Features of Other Breast Malignancies. | Dean PB | — | 2024 | → |
| Metformin: From diabetes to cancer to prolongation of life. | Sirtori CR et al. | — | 2024 | → |
| Metformin Inhibits the Progression of Pancreatic Cancer Through Regulating miR-378a-3p/VEGFA/RGC-32 Axis. | He J et al. | — | 2024 | → |
| METTL3-dependent m6A modification facilitates decreased endometrial decidualization via attenuation of MET in endometriosis. | Xiong W et al. | — | 2024 | → |
| METTL3-mediated m<sup>6</sup>A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I. | Li B et al. | — | 2024 | → |
| METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis. | Ouyang P et al. | — | 2024 | → |
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| Micafungin exerts antitumor effect on breast cancer and osteosarcoma through preventing EMT in tumor cells in an USP7/AKT/GSK-3β pathway-dependent manner. | Wang QL et al. | — | 2024 | → |
| Microenvironmental entropy dynamics analysis reveals novel insights into Notch-Delta-Jagged decision-making mechanism. | Pujar AA et al. | — | 2024 | → |
| MicroRNA-145-5p Regulates the Epithelial-Mesenchymal Transition in Nasal Polyps by Targeting Smad3. | Zhang M et al. | — | 2024 | → |
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| Nicotine downregulates miR-375-3p via neurotrophic tyrosine receptor kinase 2 to enhance the malignant behaviors of laryngopharyngeal squamous epithelial cells. | Shen YJ et al. | — | 2024 | → |
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| Novel Epigenetic Modifiers of Histones Presenting Potent Inhibitory Effects on Adenoid Cystic Carcinoma Stemness and Invasive Properties. | Pina PSS et al. | — | 2024 | → |
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| Overexpression of FERM Domain Containing Kindlin 2 (FERMT2) in Fibroblasts Correlates with EMT and Immunosuppression in Gastric Cancer. | Yin SY et al. | — | 2024 | → |
| Overexpression of REST Represses the Epithelial-Mesenchymal Transition Process and Decreases the Aggressiveness of Prostate Cancer Cells. | Indo S et al. | — | 2024 | → |
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| Plasma-Activated Medium Inhibited the Proliferation and Migration of Non-Small Cell Lung Cancer A549 Cells in 3D Culture. | Sun Z et al. | — | 2024 | → |
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| Poly (Adp-Ribose) Polymerase-1 (PARP-1) Is a Good Prognostic Marker for Pancreatic/Periampullary Cancers. | Yim K et al. | — | 2024 | → |
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| Putative epithelial-mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations. | Kim RT et al. | — | 2024 | → |
| Quercetin-induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis. | Huang C et al. | — | 2024 | → |
| RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway. | Takeda T et al. | — | 2024 | → |
| RARRES2 is involved in the "lock-and-key" interactions between osteosarcoma stem cells and tumor-associated macrophages. | Ma J et al. | — | 2024 | → |
| Recent advances in hematopoietic cell kinase in cancer progression: Mechanisms and inhibitors. | Zeng Q et al. | — | 2024 | → |
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| Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management. | Kumar A et al. | — | 2024 | → |
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| Revealing Cellular Heterogeneity and Key Regulatory Factors of Triple-Negative Breast Cancer through Single-Cell RNA Sequencing. | Zhang H et al. | — | 2024 | → |
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| Role of AMIGO2 in cancer progression: Novel insights (Review). | Tian Z et al. | — | 2024 | → |
| Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: Implications for proliferative vitreoretinopathy. | Zou W et al. | — | 2024 | → |
| Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential. | Roberts BK et al. | — | 2024 | → |
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| RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells. | Lv F et al. | — | 2024 | → |
| Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysis. | Yu G et al. | — | 2024 | → |
| Screening for the presence of aberrantly expressed ACTR2 in osteosarcoma and analyzing its mechanism of action through an online database. | Yi M et al. | — | 2024 | → |
| SERPINA1 promotes the invasion, metastasis, and proliferation of pancreatic ductal adenocarcinoma via the PI3K/Akt/NF-κB pathway. | Xiubing C et al. | — | 2024 | → |
| Serum from Hypertensive Patients Induces Cancer-Supporting Phenotype of Vascular Endothelium In Vitro. | Uruski P et al. | — | 2024 | → |
| SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells. | Jing LP et al. | — | 2024 | → |
| Signaling dynamics in coexisting monoclonal cell subpopulations unveil mechanisms of resistance to anti-cancer compounds. | Blanchard CE et al. | — | 2024 | → |
| Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner. | Chen Y et al. | — | 2024 | → |
| Single-cell and spatial omics unravel the spatiotemporal biology of tumour border invasion and haematogenous metastasis. | Cheng X et al. | — | 2024 | → |
| Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer. | Yang S et al. | — | 2024 | → |
| Single-cell atlas of healthy vocal folds and cellular function in the endothelial-to-mesenchymal transition. | Liu D et al. | — | 2024 | → |
| Single-cell EpiChem jointly measures drug-chromatin binding and multimodal epigenome. | Dong C et al. | — | 2024 | → |
| Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis. | Cai J et al. | — | 2024 | → |
| Small Cell Lung Cancer Plasticity Enables NFIB-Independent Metastasis. | Ko JH et al. | — | 2024 | → |
| SNAI1: a key modulator of survival in lung squamous cell carcinoma and its association with metastasis. | Li B et al. | — | 2024 | → |
| Solute carrier family 4 member 4 (SLC4A4) is associated with cell proliferation, migration and immune cell infiltration in colon cancer. | Yu C et al. | — | 2024 | → |
| SOX2 control activation of dormant prostate cancer cells in bone metastases by promoting CCNE2 gene expression. | Deng M et al. | — | 2024 | → |
| Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development. | Takano Y et al. | — | 2024 | → |
| Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis-Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment. | Zhi Y et al. | — | 2024 | → |
| SQSTM1/p62 promotes the progression of gastric cancer through epithelial-mesenchymal transition. | Xu Y et al. | — | 2024 | → |
| Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds? | Chiappara G et al. | — | 2024 | → |
| Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition. | Gorji-Bahri G et al. | — | 2024 | → |
| Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma <i>via</i> Regulation of the Wnt/β-catenin Signaling Pathway. | Zhu M et al. | — | 2024 | → |
| Studies on Human Cultured Fibroblasts and Cutaneous Squamous Cell Carcinomas Suggest That Overexpression of Histone Variant H2A.J Promotes Radioresistance and Oncogenic Transformation. | Freyter BM et al. | — | 2024 | → |
| Survivin inhibition attenuates EGF-induced epithelial mesenchymal transformation of human RPE cells via the EGFR/MAPK pathway. | Zhu Y et al. | — | 2024 | → |
| SVIL promotes ovarian cancer progression and epithelial-mesenchymal transition under hypoxic conditions through the TGF-β/Smad pathway. | Dai D et al. | — | 2024 | → |
| Synthesis of Novel Nilotinib Analogues and Biological Evaluation of Their Antiplatelet Activity and Functionality towards Cancer Cell Proliferation In Vitro. | Pechlivani L et al. | — | 2024 | → |
| Systematic Analysis of Disulfidptosis-Related lncRNAs in Hepatocellular Carcinoma with Vascular Invasion Revealed That AC131009.1 Can Promote HCC Invasion and Metastasis through Epithelial-Mesenchymal Transition. | Gu X et al. | — | 2024 | → |
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| Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer. | Zhang GQ et al. | — | 2024 | → |
| Targeting HSP47 for cancer treatment. | Shi R et al. | — | 2024 | → |
| Targeting LRP6: A new strategy for cancer therapy. | Xue W et al. | — | 2024 | → |
| Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor. | Seeneevassen L et al. | — | 2024 | → |
| Targeting neutrophil elastase is a promising direction for future cancer treatment. | Jia W et al. | — | 2024 | → |
| Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors. | Runa F et al. | — | 2024 | → |
| Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions. | Amormino C et al. | — | 2024 | → |
| Targeting the autophagy-miRNA axis in prostate cancer: toward novel diagnostic and therapeutic strategies. | Syed RU et al. | — | 2024 | → |
| Targeting the GTPase RAN by liposome delivery for tackling cancer stemness-emanated therapeutic resistance. | Wang K et al. | — | 2024 | → |
| Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals. | Fakhri S et al. | — | 2024 | → |
| Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity. | Li C et al. | — | 2024 | → |
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| TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m<sup>6</sup>A modification. | Wu Z et al. | — | 2024 | → |
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| TGF-β and RAS jointly unmask primed enhancers to drive metastasis. | Lee JH et al. | — | 2024 | → |
| TGFβ family signaling in human stem cell self-renewal and differentiation. | Liu S et al. | — | 2024 | → |
| TGF-β-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization. | Huang L et al. | — | 2024 | → |
| TGF-β Isoforms and Local Environments Greatly Modulate Biological Nature of Human Retinal Pigment Epithelium Cells. | Nishikiori N et al. | — | 2024 | → |
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| The Different Gene Expression Profile in the Eutopic and Ectopic Endometrium Sheds New Light on the Endometrial Seed in Endometriosis. | Riaz MA et al. | — | 2024 | → |
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| The Role of Hypoxia-inducible Factor-1 in Bladder Cancer. | Chai J et al. | — | 2024 | → |
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| TMEM176B Promotes EMT via FGFR/JNK Signalling in Development and Tumourigenesis of Lung Adenocarcinoma. | Sun PH et al. | — | 2024 | → |
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| Transcriptomics Reveals the Mechanism of Platycodin D Targeting TGFβ for Anti-Lung Cancer Activity. | Feng M et al. | — | 2024 | → |
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| Tumor-associated macrophages affect the treatment of lung cancer. | Yu Z et al. | — | 2024 | → |
| Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment. | Krishnamohan M et al. | — | 2024 | → |
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| Understanding the autophagic functions in cancer stem cell maintenance and therapy resistance. | Niharika et al. | — | 2024 | → |
| Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin. | Patrícia Gonçalves Tenório L et al. | — | 2024 | → |
| Variable effects of periprostatic adipose tissue on prostate cancer cells: Role of adipose tissue lipid composition and cancer cells related factors. | Cancel M et al. | — | 2024 | → |
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| XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT. | Zhao R et al. | — | 2024 | → |
| YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1. | Kwon JH et al. | — | 2024 | → |
| ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma. | Wang Y et al. | — | 2024 | → |
| Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. | Schwab A et al. | — | 2024 | → |
| α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation. | Abdullah KM et al. | — | 2024 | → |
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| High Expression of THY1 in Intestinal Gastric Cancer as a Key Factor in Tumor Biology: A Poor Prognosis-Independent Marker Related to the Epithelial-Mesenchymal Transition Profile. | Rohan P et al. | — | 2023 | → |
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