Alcohol dependence and anxiety disorders: what is the relationship?
paper
Primary
Public
Unavailable
- Authors
- Schuckit, M A; Hesselbrock, V
- Year
- 1994
- Journal
- The American journal of psychiatry
- PMID
- 7977877
- DOI
- 10.1176/ajp.151.12.1723
OBJECTIVE: In this critical review the authors evaluate the literature regarding the relationship between lifelong DSM-III-R anxiety disorders and alcohol dependence. Many alcohol-dependent individuals demonstrate severe anxiety symptoms in the context of acute or protracted abstinence syndromes, but it is unclear whether these anxiety conditions are independent psychiatric disorders or temporary syndromes likely to disappear on their own. METHODS: Reports since 1975 describing the relationship between alcoholism and anxiety disorders were reviewed to determine whether 1) lifelong anxiety disorders are unusually prevalent among alcohol-dependent individuals, 2) children of alcoholics are more likely to develop anxiety disorders than comparison populations, 3) anxiety syndromes are likely to disappear with abstinence, 4) the rate of alcohol dependence among subjects with lifelong anxiety disorders is higher than normal, 5) there is familial crossover between alcohol dependence and anxiety disorders, and 6) alcoholism is often preceded by anxiety disorders in groups from the general population studied prospectively. RESULTS: The interaction between alcohol use and anxiety disorders is complex. The available data, while imperfect, do not prove a close relationship between life-long anxiety disorders and alcohol dependence. Further, prospective studies of children of alcoholics and individuals from the general population do not indicate a high rate of anxiety disorders preceding alcohol dependence. CONCLUSIONS: The high rates of comorbidity in some studies likely reflect a mixture of true anxiety disorders among alcoholics at a rate equal to or slightly higher than that for the general population, along with temporary, but at times severe, substance-induced anxiety syndromes.
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| Title | Year | PMID |
|---|---|---|
| The epigenetic landscape of alcoholism. | 2014 | 25131543 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Net Effect of Positive Changes in Alcohol Consumption on Mental Health Among South Korean Adults. | Park JS et al. | β | 2026 | β |
| A Brief Cognitive Behavioral Therapy-Based Digital Intervention for Reducing Hazardous Alcohol Use in South Korea: Development and Prospective Pilot Study. | Kwon M et al. | β | 2025 | β |
| Digital interventions for supporting alcohol abstinence in aftercare - a systematic review. | Lenzi L et al. | β | 2025 | β |
| Early alcohol abstinence symptoms and the role of cumulative adversity. | Fox HC et al. | β | 2025 | β |
| Evaluating the synergy: anxiety prevalence and alcohol consumption patterns in high-income countries using Granger causality analysis. | Senarathne B et al. | β | 2025 | β |
| Influence of tobacco smoking and alcohol drinking on anxiety in sample of 30 836 individuals in Taiwan Biobank. | Wen YT et al. | β | 2025 | β |
| Anxiety disorders among youth with substance use and associated factors in Northwest Ethiopia: A community-based study. | Melkam M et al. | β | 2024 | β |
| Behavioral and Amygdala Biochemical Damage Induced by Alternating Mild Stress and Ethanol Intoxication in Adolescent Rats: Reversal by Argan Oil Treatment? | El Mostafi H et al. | β | 2024 | β |
| Cheers to anxiety: Granger causality insights on alcohol consumption patterns across 13 South American countries. | Palliyaguru D et al. | β | 2024 | β |
| Ethno-racial variations in mental health symptoms among sexually-active gay, bisexual, and other men who have sex with men in Vancouver, Canada: a longitudinal analysis. | Bao SL et al. | β | 2024 | β |
| Genomic and Transcriptomic Analysis of Ninein Alternative Splicing Between C57BL/6J and DBA/2J Mice | Gnatowski E et al. | β | 2024 | β |
| Ninein, a candidate gene for ethanol anxiolysis, shows complex exon-specific expression and alternative splicing differences between C57BL/6J and DBA/2J mice. | Gnatowski ER et al. | β | 2024 | β |
| Assessing cross-lagged associations between depression, anxiety, and binge drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study. | McCabe CJ et al. | β | 2023 | β |
| Emotional Expression on Social Media Support Forums for Substance Cessation: Observational Study of Text-Based Reddit Posts. | Yang G et al. | β | 2023 | β |
| Evidence for an alcohol-related "harm paradox" in individuals with internalizing disorders: Test and replication in two independent community samples. | Anker JJ et al. | β | 2023 | β |
| Mediators and Moderators in the Co-Occurring Anxiety and Alcohol Use Relationship: Protocol for a Systematic Review and Meta-Analysis. | Guckel T et al. | β | 2023 | β |
| Racial and gender-based disparities and trends in common psychiatric conditions in liver cirrhosis hospitalizations: A ten-year United States study. | Patel P et al. | β | 2023 | β |
| Anxiety Screening among the General Population of Latvia and Associated Factors. | Vinogradova VV et al. | β | 2022 | β |
| Assessing anxiety among adolescents in Hong Kong: psychometric properties and validity of the Generalised Anxiety Disorder-7 (GAD-7) in an epidemiological community sample. | Ip H et al. | β | 2022 | β |
| Externalizing personality characteristics define clinically relevant subgroups of alcohol use disorder. | KovΓ‘cs I et al. | β | 2022 | β |
| Ketamine plus Alcohol: What We Know and What We Can Expect about This. | Kobayashi NHC et al. | β | 2022 | β |
| Associations of <i>NLRP3</i> and <i>CARD8</i> gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study. | IljeΕ‘ AP et al. | β | 2021 | β |
| Beyond 16 Sessions: Extending Manualized Treatment of Anxious Youth. | Kagan ER et al. | β | 2021 | β |
| Examining the role of fundamental psychological needs in the development of metadehumanization: A multi-population approach. | Demoulin S et al. | β | 2021 | β |
| Genetic Basis of Dual Diagnosis: A Review of Genome-Wide Association Studies (GWAS) Focusing on Patients with Mood or Anxiety Disorders and Co-Occurring Alcohol-Use Disorders. | Stoychev K et al. | β | 2021 | β |
| Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood. | Dong E et al. | β | 2021 | β |
| The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis. | Agabio R et al. | β | 2021 | β |
| Alcohol intake in Carioca High- and Low-conditioned Freezing rats. | Bezerra-Karounis MA et al. | β | 2020 | β |
| Application of the Chinese Version of the BIS/BAS Scales in Participants With a Substance Use Disorder: An Analysis of Psychometric Properties and Comparison With Community Residents. | Che Q et al. | β | 2020 | β |
| Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons. | McGinnis MM et al. | β | 2020 | β |
| Clinical and biobehavioral perspectives: Is medication overuse headache a behavior of dependence? | Lau CI et al. | β | 2020 | β |
| Getting to the Heart of Low Sensitivity to Alcohol: Context Moderates Low Cardiovascular Response to Alcohol in Persons With a Family History of Alcohol Use Disorder. | Bates ME et al. | β | 2020 | β |
| MUNC13-1 heterozygosity does not alter voluntary ethanol consumption or sensitivity in mice. | Wooden JI et al. | β | 2020 | β |
| The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder. | Caputo F et al. | β | 2020 | β |
| Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice. | Rodriguez KM et al. | β | 2020 | β |
| An Analysis of the Child Behavior Checklist Anxiety Problems Scale's Predictive Capabilities. | Knepley MJ et al. | β | 2019 | β |
| Associations of child and adolescent anxiety with later alcohol use and disorders: a systematic review and meta-analysis of prospective cohort studies. | Dyer ML et al. | β | 2019 | β |
| Elevation of Transient Receptor Potential Vanilloid 1 Function in the Lateral Habenula Mediates Aversive Behaviors in Alcohol-withdrawn Rats. | Gregor DM et al. | β | 2019 | β |
| Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. | Pucci M et al. | β | 2019 | β |
| Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study. | Domi A et al. | β | 2019 | β |
| Therapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain. | De Ternay J et al. | β | 2019 | β |
| Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. | Dong E et al. | β | 2018 | β |
| Anxiolytic effects of buspirone and MTEP in the Porsolt Forced Swim Test. | Lee KM et al. | β | 2017 | β |
| Nucleus accumbens lentiviral-mediated gain of function of the oxytocin receptor regulates anxiety- and ethanol-related behaviors in adult mice. | Bahi A et al. | β | 2016 | β |
| The role of hazardous drinking reductions in predicting depression and anxiety symptom improvement among psychiatry patients: A longitudinal study. | Bahorik AL et al. | β | 2016 | β |
| Binge alcohol drinking elicits persistent negative affect in mice. | Lee KM et al. | β | 2015 | β |
| Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice. | Barkley-Levenson AM et al. | β | 2015 | β |
| Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice. | Lopez MF et al. | β | 2015 | β |
| Similar effects of intranasal oxytocin administration and acute alcohol consumption on socio-cognitions, emotions and behaviour: Implications for the mechanisms of action. | Mitchell IJ et al. | β | 2015 | β |
| Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | Sakharkar AJ et al. | β | 2014 | β |
| Neurochemical mechanisms of alcohol withdrawal. | Becker HC et al. | β | 2014 | β |
| Psychiatric co-morbidity in problem and pathological gamblers: investigating the confounding influence of alcohol use disorder. | Abdollahnejad R et al. | β | 2014 | β |
| Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats. | Acevedo MB et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| Alcohol and tobacco use disorder comorbidity in young adults and the influence of romantic partner environments. | Meacham MC et al. | β | 2013 | β |
| An investigator-blinded, randomized study to compare the efficacy of combined CBT for alcohol use disorders and social anxiety disorder versus CBT focused on alcohol alone in adults with comorbid disorders: the Combined Alcohol Social Phobia (CASP) trial protocol. | Baillie AJ et al. | β | 2013 | β |
| Comorbid Alcohol Dependence and Anxiety Disorders: A National Survey. | Pacek LR et al. | β | 2013 | β |
| Reports of drinking to self-medicate anxiety symptoms: longitudinal assessment for subgroups of individuals with alcohol dependence. | Crum RM et al. | β | 2013 | β |
| Alcohol use history and panic-relevant responding among adolescents: a test using a voluntary hyperventilation challenge. | Blumenthal H et al. | β | 2012 | β |
| Anxiety and alcohol use disorders: comorbidity and treatment considerations. | Smith JP et al. | β | 2012 | β |
| Anxiety disorders and substance use disorders: different associations by anxiety disorder. | Marmorstein NR | β | 2012 | β |
| Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. | Sakharkar AJ et al. | β | 2012 | β |
| Interrelationship of substance use and psychological distress over the life course among a cohort of urban African Americans. | Green KM et al. | β | 2012 | β |
| Prospective memory and future event simulation in individuals with alcohol dependence. | Griffiths A et al. | β | 2012 | β |
| Revisiting the concepts of risk and protective factors for understanding the etiology and development of substance use and substance use disorders: implications for prevention. | Sloboda Z et al. | β | 2012 | β |
| Stress, epigenetics, and alcoholism. | Moonat S et al. | β | 2012 | β |
| The occurrence of neurological symptoms in currently abstinent misusers of alcohol. | Khalily MT et al. | β | 2012 | β |
| Treatment and outcomes for anxiety disorders among children and adolescents: a review of coping strategies and parental behaviors. | Simpson D et al. | β | 2012 | β |
| Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala. | Cannady R et al. | β | 2011 | β |
| Anxiety Psychopathology and Alcohol Use among Adolescents: A Critical Review of the Empirical Literature and Recommendations for Future Research. | Blumenthal H et al. | β | 2011 | β |
| Assessment and treatment of anxiety disorders in children and adolescents. | Connolly SD et al. | β | 2011 | β |
| Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. | Klugmann M et al. | β | 2011 | β |
| Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice. | Lopez MF et al. | β | 2011 | β |
| Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. | Simon O'Brien E et al. | β | 2011 | β |
| GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. | Zhang LL et al. | β | 2011 | β |
| Individual vulnerability to addiction. | Swendsen J et al. | β | 2011 | β |
| Relationships between state and trait anxiety inventory and alcohol use disorder identification test scores among Korean twins and families: the healthy twin study. | Sung J et al. | β | 2011 | β |
| Sub-clinical anxiety and the onset of alcohol use disorders: longitudinal associations from the Baltimore ECA follow-up, 1981-2004. | MacDonald R et al. | β | 2011 | β |
| The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. | Moonat S et al. | β | 2011 | β |
| Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? | Heilig M et al. | β | 2010 | β |
| Comorbidity of generalized anxiety disorder and substance use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. | AlegrΓa AA et al. | β | 2010 | β |
| Decreased psychological well-being in late 'chronotypes' is mediated by smoking and alcohol consumption. | Wittmann M et al. | β | 2010 | β |
| Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey. | Swendsen J et al. | β | 2010 | β |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | β | 2010 | β |
| Person-environment interaction in the prediction of alcohol abuse and alcohol dependence in adulthood. | Hill KG et al. | β | 2010 | β |
| Some new directions for research on psychological interventions for comorbid anxiety and substance use disorders. | Baillie AJ et al. | β | 2010 | β |
| The association between psychopathology and substance use in young people: a review of the literature. | Saban A et al. | β | 2010 | β |
| Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. | Heilig M et al. | β | 2010 | β |
| Correlates of self-medication for anxiety disorders: results from the National Epidemiolgic Survey on Alcohol and Related Conditions. | Robinson JA et al. | β | 2009 | β |
| Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding. | Yang AR et al. | β | 2009 | β |
| Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. | Chiavegatto S et al. | β | 2009 | β |
| Health maintenance issues in cirrhosis. | Mehta G et al. | β | 2009 | β |
| Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. | Glantz MD et al. | β | 2009 | β |
| Prevalence and correlates of alcohol and other substance use disorders in young adulthood: A population-based study. | Latvala A et al. | β | 2009 | β |
| Self-medication of anxiety disorders with alcohol and drugs: Results from a nationally representative sample. | Robinson J et al. | β | 2009 | β |
| Trait anxiety and ethanol: anxiolysis in high-anxiety mice and no relation to intake behavior in an addiction model. | Correia D et al. | β | 2009 | β |
| Abstinence in patients with alcoholic liver cirrhosis: A follow-up study. | Kalaitzakis E et al. | β | 2008 | β |
| Adolescent neurological development and its implications for adolescent substance use prevention. | Lopez B et al. | β | 2008 | β |
| Brain chromatin remodeling: a novel mechanism of alcoholism. | Pandey SC et al. | β | 2008 | β |
| Interplay of psychosocial factors and the long-term course of adolescents with a substance use disorder. | Winters KC et al. | β | 2008 | β |
| Levetiracetam for the treatment of co-occurring alcohol dependence and anxiety: case series and review. | Mariani JJ et al. | β | 2008 | β |
| The effect of comorbid substance use disorders on treatment outcome for anxiety disorders. | McEvoy PM et al. | β | 2008 | β |
| Transient up-regulation of cocaine- and amphetamine-regulated transcript peptide (CART) immunoreactivity following ethanol withdrawal in rat hypothalamus. | Dandekar MP et al. | β | 2008 | β |
| Development and validation of the college drinking influences survey. | Fisher CB et al. | β | 2007 | β |
| Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). | Sparta DR et al. | β | 2007 | β |
| Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. | Connolly SD et al. | β | 2007 | β |
| The pharmacological management of childhood anxiety disorders: a review. | Reinblatt SP et al. | β | 2007 | β |
| Associations between volume of alcohol consumption and social status, intelligence, and personality in a sample of young adult Danes. | Mortensen EL et al. | β | 2006 | β |
| Chronic hydrocephalus and alcohol abuse in a young male suicide. | Montisci M et al. | β | 2006 | β |
| Comorbidity between substance use disorders and psychiatric conditions. | Schuckit MA | β | 2006 | β |
| Comorbid psychiatric disorders, sex, and methamphetamine use in adolescents: a case-control study. | Yen CF et al. | β | 2006 | β |
| Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism. | Ciccocioppo R et al. | β | 2006 | β |
| Illicit drug use and anxiety disorders: findings from two community surveys. | Sareen J et al. | β | 2006 | β |
| Lifetime posttraumatic stress disorder in Turkish alcohol-dependent inpatients: relationship with depression, anxiety and erectile dysfunction. | Evren C et al. | β | 2006 | β |
| Remission of psychiatric symptoms among drug misusers after drug dependence treatment. | Gossop M et al. | β | 2006 | β |
| The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats. | Duncan EA et al. | β | 2006 | β |
| Use of alcohol and drugs to self-medicate anxiety disorders in a nationally representative sample. | Bolton J et al. | β | 2006 | β |
| Cognitive versus behavioral treatment of concurrent alcohol dependence and agoraphobia: a pilot study. | Toneatto T | β | 2005 | β |
| Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. | Hayes DM et al. | β | 2005 | β |
| Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. | Pandey SC et al. | β | 2005 | β |
| Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats. | Da Silva GE et al. | β | 2005 | β |
| Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. | Hirani K et al. | β | 2005 | β |
| Follow-up study of anxiety disorder and alcohol dependence in comorbid alcoholism treatment patients. | Kushner MG et al. | β | 2005 | β |
| Long-term use of benzodiazepines in participants with comorbid anxiety and alcohol use disorders. | Mueller TI et al. | β | 2005 | β |
| Psychopharmacologic treatment of pediatric anxiety disorders. | Reinblatt SP et al. | β | 2005 | β |
| The relationship between social anxiety disorder and alcohol use disorders: a critical review. | Morris EP et al. | β | 2005 | β |
| A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. | Thiele TE et al. | β | 2004 | β |
| CO(2) hypersensitivity in recently abstinent alcohol dependent individuals:; A possible mechanism underlying the high risk for anxiety disorder among alcoholics. | Rassovsky Y et al. | β | 2004 | β |
| Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients. | Terra MB et al. | β | 2004 | β |
| Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation. | Fee JR et al. | β | 2004 | β |
| The epidemiology of dual diagnosis. | Kessler RC | β | 2004 | β |
| The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. | Pandey SC | β | 2004 | β |
| Alcohol expectancies, alcohol consumption, and problem drinking: the moderating role of family history. | Conway KP et al. | β | 2003 | β |
| Alcoholism in 274 patients with panic disorder in Spain, one of the main producers of wine worldwide. | MΓ‘rquez M et al. | β | 2003 | β |
| Alcohol use disorders and psychological distress: a prospective state-trait analysis. | Jackson KM et al. | β | 2003 | β |
| Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene. | Pandey SC | β | 2003 | β |
| Medication dependence and anxiety. | von Moltke LL et al. | β | 2003 | β |
| Psychological stress and cortisol secretion in anhedonic alcoholic men. | Marra D et al. | β | 2003 | β |
| The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats. | Pandey SC et al. | β | 2003 | β |
| A prospective study of mortality among drug misusers during a 4-year period after seeking treatment. | Gossop M et al. | β | 2002 | β |
| Are personality traits familial risk factors for substance use disorders? Results of a controlled family study. | Swendsen JD et al. | β | 2002 | β |
| Measuring risks and outcomes in substance use disorders prevention research. | Clark DB et al. | β | 2002 | β |
| Mood and anxiety symptoms among 140 children from alcoholic and control families. | Preuss UW et al. | β | 2002 | β |
| Opposite effects of ethanol and ketamine in the elevated plus-maze test in Wistar rats undergoing a chronic oral voluntary consumption procedure. | Silvestre JS et al. | β | 2002 | β |
| Patterns of association between alcohol consumption and symptoms of depression and anxiety in young adults. | Caldwell TM et al. | β | 2002 | β |
| Self-administration of alcohol before and after a public speaking challenge by individuals with social phobia. | Abrams K et al. | β | 2002 | β |
| Syndrome profiles in alcoholism and panic disorder with or without agoraphobia: an explorative family study. | Davids E et al. | β | 2002 | β |
| Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependency. | Hahesy AL et al. | β | 2002 | β |
| The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach. | Heilig M et al. | β | 2002 | β |
| A therapeutic approach to children and adolescents with anxiety disorders and associated comorbid conditions. | Manassis K et al. | β | 2001 | β |
| Co-morbidity of personality disorders in individuals with substance use disorders. | Verheul R | β | 2001 | β |
| Comorbidity of phobic disorders with alcoholism in a Canadian community sample. | Sareen J et al. | β | 2001 | β |
| Comorbidity of psychiatric and substance use disorders in late adolescence: a cluster analytic approach. | Beitchman JH et al. | β | 2001 | β |
| Management of anxiety disorders: the added challenge of comorbidity. | Dunner DL | β | 2001 | β |
| Natural course of alcohol use disorders from adolescence to young adulthood. | Rohde P et al. | β | 2001 | β |
| No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. | Eriksson M et al. | β | 2001 | β |
| Out-patient behaviour therapy in alcoholism: impact of personality disorders and cognitive impairments. | WΓΆlwer W et al. | β | 2001 | β |
| Risk of heavy drinking and alcohol use disorders in social phobia: a prospective analysis. | Crum RM et al. | β | 2001 | β |
| The long-term treatment outcomes of depression and anxiety comorbid with substance abuse. | Bovasso G | β | 2001 | β |
| A controlled trial of cognitive behavioral treatment of panic in alcoholic inpatients with comorbid panic disorder. | Bowen RC et al. | β | 2000 | β |
| Acoustic startle and fear-potentiated startle in alcohol-preferring (P) and -nonpreferring (NP) lines of rats. | Mckinzie DL et al. | β | 2000 | β |
| Familial risk for alcoholism and self-reported psychopathology. | Alterman AI et al. | β | 2000 | β |
| Social phobia. Epidemiology and cost of illness. | Lipsitz JD et al. | β | 2000 | β |
| The influence of maternal drinking and drug use on the quality of the home environment of school-aged children. | Jester JM et al. | β | 2000 | β |
| Why take social anxiety disorder seriously? | LΓ©pine JP et al. | β | 2000 | β |
| Anxiety disorders among abstinent alcohol-dependent patients. | Roberts MC et al. | β | 1999 | β |
| Association of low-voltage alpha EEG with a subtype of alcohol use disorders. | Enoch MA et al. | β | 1999 | β |
| Experimental anxiety and the reinforcing effects of ethanol in rats. | Blatt SL et al. | β | 1999 | β |
| Prospective analysis of the relation between DSM-III anxiety disorders and alcohol use disorders. | Kushner MG et al. | β | 1999 | β |
| Sleep, anxiety, and depression in abstinent and drinking alcoholics. | Mackenzie A et al. | β | 1999 | β |
| A direct-interview family study of generalized social phobia. | Stein MB et al. | β | 1998 | β |
| A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal. | Rosenthal RN et al. | β | 1998 | β |
| Axis I and axis II comorbidity in alcohol dependence and the two types of alcoholism. | Driessen M et al. | β | 1998 | β |
| First-incidence anxiety in the Lundby Study: course and predictors of outcome. | GrΓ€sbeck A et al. | β | 1998 | β |
| Psychiatric comorbidity in pathological gambling: a critical review. | Crockford DN et al. | β | 1998 | β |
| Social phobia and alcoholism: a complex relationship. | LΓ©pine JP et al. | β | 1998 | β |
| The comorbidity of alcoholism with anxiety and depressive disorders in four geographic communities. | Swendsen JD et al. | β | 1998 | β |
| Adulthood functioning: the joint effects of parental alcoholism, gender and childhood socio-economic stress. | Hill EM et al. | β | 1997 | β |
| Association of prenatal alcohol exposure with behavioral and learning problems in early adolescence. | Olson HC et al. | β | 1997 | β |
| Attention deficit hyperactivity disorder (ADHD) is associated with early onset substance use disorders. | Wilens TE et al. | β | 1997 | β |
| Clinical characteristics of psychiatrically referred adolescent outpatients with substance use disorder. | Wilens TE et al. | β | 1997 | β |
| D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze. | Moraes Ferreira VM et al. | β | 1997 | β |
| Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. | MΓΆller C et al. | β | 1997 | β |
| Decreased measures of experimental anxiety in rats bred for high alcohol preference. | MΓΆller C et al. | β | 1997 | β |
| Dual diagnosis in primary care. Detecting and treating both the addiction and mental illness. | Ziedonis D et al. | β | 1997 | β |
| Effect of alcoholism on the incidence of lactate-induced panic attacks. | George DT et al. | β | 1997 | β |
| Gender and comorbid psychopathology in adolescents with alcohol dependence. | Clark DB et al. | β | 1997 | β |
| Genetic and environmental contributions to the correlation between alcohol consumption and symptoms of anxiety and depression. Results from a bivariate analysis of Norwegian twin data. | Tambs K et al. | β | 1997 | β |
| Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder: an association study. | Steinlein OK et al. | β | 1997 | β |
| Risk factors for alcohol dependence: a questionnaire survey. | Poikolainen K | β | 1997 | β |
| The 2-year course following detoxification treatment of substance abuse: the possible influence of psychiatric comorbidity. | TΓ³masson K et al. | β | 1997 | β |
| The life-time rates of three major mood disorders and four major anxiety disorders in alcoholics and controls. | Schuckit MA et al. | β | 1997 | β |
| Alcohol, Anxiety, and Depressive Disorders. | Schuckit MA | β | 1996 | β |
| Comorbidity of Alcoholism and Anxiety Disorders: The Role of Family Studies. | Merikangas KR et al. | β | 1996 | β |
| Do specific anxiety disorders show specific drug problems? | Page AC et al. | β | 1996 | β |
| Effects of long-term abstinence on psychological functioning: a prospective longitudinal analysis comparing alcohol-dependent patients and healthy volunteers. | Voltaire-Carlsson A et al. | β | 1996 | β |
| Reliability of the SANS. | Phillips MR | β | 1996 | β |
| Substance abuse, comorbidity, and sensation seeking: gender differences. | Scourfield J et al. | β | 1996 | β |
| Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. | Spanagel R et al. | β | 1995 | β |
| Genetic animal models of alcohol and drug abuse. | Crabbe JC et al. | β | 1994 | β |