Proteomics. Tissue-based map of the human proteome.
paper
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- Authors
- UhlΓ©n, Mathias; Fagerberg, Linn; HallstrΓΆm, BjΓΆrn M; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Γ sa; Kampf, Caroline; SjΓΆstedt, Evelina; Asplund, Anna; Olsson, IngMarie; Edlund, Karolina; Lundberg, Emma; Navani, Sanjay; Szigyarto, Cristina Al-Khalili; Odeberg, Jacob; Djureinovic, Dijana; Takanen, Jenny Ottosson; Hober, Sophia; Alm, Tove; Edqvist, Per-Henrik; Berling, Holger; Tegel, Hanna; Mulder, Jan; Rockberg, Johan; Nilsson, Peter; Schwenk, Jochen M; Hamsten, Marica; von Feilitzen, Kalle; Forsberg, Mattias; Persson, Lukas; Johansson, Fredric; Zwahlen, Martin; von Heijne, Gunnar; Nielsen, Jens; PontΓ©n, Fredrik
- Year
- 2015
- Journal
- Science (New York, N.Y.)
- PMID
- 25613900
- DOI
- 10.1126/science.1260419
Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
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| Active Antigen-Specific Adaptive Immune Responses Are Shared among Patients with Progressive Fibrotic Interstitial Lung Disease. | Velez TE et al. | β | 2025 | β |
| Adenylate kinase 5, a novel genetic risk factor for Alzheimer's disease, regulates microglial inflammatory activation. | Seong WJ et al. | β | 2025 | β |
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| Advances and applications of clinical proteomics in precision medicine. | Alshehri S et al. | β | 2025 | β |
| Advancing Plasma Proteomics for the Discovery of Ovarian Cancer Biomarkers. | Sarygina EV et al. | β | 2025 | β |
| A fork in the road: PADI4 citrullinates p53 to control immune-related networks. | Bhattacharjee S et al. | β | 2025 | β |
| A genetic map of human metabolism across the allele frequency spectrum. | Zoodsma M et al. | β | 2025 | β |
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| A human pan-disease blood atlas of the circulating proteome. | Γlvez MB et al. | β | 2025 | β |
| AKR1B10 as a novel prognostic biomarker linking methylation and immune escape in hepatocellular carcinoma. | Khan MN et al. | β | 2025 | β |
| A lactate related signature for predicting prognosis and tumor microenvironment in lung adenocarcinoma. | Wang Y et al. | β | 2025 | β |
| Allele-Specific Methylation Links Non-coding Variant of rs2280906 to MYOM2 Regulation in Schizophrenia. | Li Q et al. | β | 2025 | β |
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| A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer. | Zuljan E et al. | β | 2025 | β |
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| A Multiomics Study of Circulating Proteins and Kidney Stone Risk. | Zhou LT et al. | β | 2025 | β |
| Amyloid-Ξ², Tau, and Ξ±-Synuclein Protein Interactomes as Therapeutic Targets in Neurodegenerative Diseases. | Mohan Kumar D et al. | β | 2025 | β |
| Analysis of Transcript Expression and Core Promoter DNA Sequences of Brain, Adipose Tissues and Testis in Human and Fruit Fly. | Vedelek V et al. | β | 2025 | β |
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| Andrographolide alleviates type 2 diabetic nephropathy through suppressing PI3K/AKT1/RRM2-triggered oxeiptosis. | Han M et al. | β | 2025 | β |
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| A novel TRP channel-related prognostic model of glioma based on transcriptomics and single cell sequencing analysis. | Niu X et al. | β | 2025 | β |
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| An unbiased whole-genome open reading frame overexpression screen identifies B3GALT2, a novel inducer of cellular ASO activity. | Hesselmann J et al. | β | 2025 | β |
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| A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation. | Liu Y et al. | β | 2025 | β |
| A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research. | Guedes J et al. | β | 2025 | β |
| A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function. | Hong J et al. | β | 2025 | β |
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| CCN5 Drives Leydig Cell Aging and Testicular Dysfunction: Insights into Fibrosis, Lipid Dysregulation, and Therapeutic Potential. | Tan X et al. | β | 2025 | β |
| CD38-NAD(+) Axis: New Insights into Glaucoma Therapy. | Zhang W et al. | β | 2025 | β |
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| Challenges and Opportunities in Characterizing the Genetics of Stuttering: From Sample Acquisition to Functional Interpretation of the Genome. | Pruett DG et al. | β | 2025 | β |
| Challenges in Genomic Variant Interpretation Within Pakistani Populations due to Genomic Healthcare Inequalities. | Khalid Z et al. | β | 2025 | β |
| CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies. | Weber P et al. | β | 2025 | β |
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| Designing allosteric modulators to change GPCR G protein subtype selectivity. | Moore MN et al. | β | 2025 | β |
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| Development of Prognostic Features and Investigation of Therapeutic Insights Related to Non-Apoptotic Regulatory Cell Death in Colorectal Cancer. | Liu H et al. | β | 2025 | β |
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| Discovery of actionable drug targets to enhance T-cell infiltration and immune checkpoint blockade efficacy in pleural mesothelioma. | Genugten JHLTV et al. | β | 2025 | β |
| Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy. | Majid S et al. | β | 2025 | β |
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| Disulfidptosis-associated gene signature predicts prognosis and radioresistance in NSCLC. | Liu J et al. | β | 2025 | β |
| Diverse Roles of Tubulin Polymerization Promoting Protein 3 (TPPP3) in Human Health and Disease. | Lord JW et al. | β | 2025 | β |
| Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity. | Redeker KM et al. | β | 2025 | β |
| DKK1 Overexpression in Lung Adenocarcinoma: Prognostic Implications, Immune Microenvironment Correlates, and Regulatory Network Characterization. | Wang Y et al. | β | 2025 | β |
| DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy. | Zhao ZW et al. | β | 2025 | β |
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| Do Glioma Cells Rewire Neural Circuits through Epigenetic Changes? DNA Methylation Analysis of Genes Involved in Neuron-Glioma Communication in the Human Frontal Cortex. | Kassaeyan V et al. | β | 2025 | β |
| Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis. | da Silva EM et al. | β | 2025 | β |
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| DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma. | Chen X et al. | β | 2025 | β |
| Dynamic Network Driver Analysis Identifies Master Factors Associated with Progression of Solar Lentigines. | Cai D et al. | β | 2025 | β |
| Dysregulated immune proteins in plasma in the UK Biobank predict multiple myeloma 12 years before clinical diagnosis. | Fieggen J et al. | β | 2025 | β |
| Dysregulation of SELENOI Is Associated with TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis. | Isik FI et al. | β | 2025 | β |
| Early pandemic HIV-1 integration site preferences differ across anatomical sites. | Kohio HP et al. | β | 2025 | β |
| Effects and regulation of ACE2 and TMPRSS2 abundance in healthy humans and in patients with SARS-CoV-2. | Bach ML et al. | β | 2025 | β |
| EGA-Ploc: An Efficient Global-Local Attention Model for Multi-Label Protein Subcellular Localization Prediction on the Immunohistochemistry Images. | Wan B et al. | β | 2025 | β |
| Electroacupuncture and vagus nerve stimulation are emerging therapies for hyperemesis gravidarum management. | Zhang S et al. | β | 2025 | β |
| Elucidating the association between TLR-4 expression and the clinical course of glioblastoma leptomeningeal disease. | Lu VM et al. | β | 2025 | β |
| Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases. | Tian T et al. | β | 2025 | β |
| Emerging roles of the metabolite succinate in bone-related diseases. | Wu Z et al. | β | 2025 | β |
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| Engineering strategies and challenges in building the follicular microenvironment for a bioprosthetic ovary. | Saunders DC et al. | β | 2025 | β |
| Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion. | Montagud-Marrahi E et al. | β | 2025 | β |
| Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration. | Daniilidou M et al. | β | 2025 | β |
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| Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer. | Arroyo Villora S et al. | β | 2025 | β |
| ETS Family Transcription Factors in Gastric Cancer and the Role of ELF3 in the Core Metaplasia Transcription Factor Network. | Voutsadakis IA | β | 2025 | β |
| Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from <i>Cannabis sativa</i> and <i>Piper nigrum</i> Against Malignant Glioma: An In Silico to In Vitro Approach. | Turizo Smith AD et al. | β | 2025 | β |
| Evaluation of Nanoparticle-Based Plasma Enrichment on Individuals with Primary and Metastatic Pancreatic Cancer. | Ang CS et al. | β | 2025 | β |
| Evaluation of PE5 Entries on the Human Proteome Project Target List. | Zheng C et al. | β | 2025 | β |
| Evolving stratification and biomarker discovery in cancer research with technological advancement of proteomics: 35 years and counting. | Mahajan D et al. | β | 2025 | β |
| Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle. | Katayama M et al. | β | 2025 | β |
| Expanding the Reach of Membrane Protein-Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics. | Lambos JC et al. | β | 2025 | β |
| Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches. | Wang N et al. | β | 2025 | β |
| Exploring Hippo YAP/TAZ Signaling: A Novel Avenue for Cardiovascular Disorders. | Mithaiwala A et al. | β | 2025 | β |
| Exploring OR2H1-Mediated Sperm Chemotaxis: Development and Application of a Novel Microfluidic Device. | Di Nicuolo F et al. | β | 2025 | β |
| Exploring the Clinical Implication of S100A9 in Ulcerative Colitis and Its Progression to Cancer: A Journey from Inflammation to Cancer. | Cheon J et al. | β | 2025 | β |
| Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach. | Zhou L et al. | β | 2025 | β |
| Exploring the shared genetic basis between autism spectrum disorder and gastrointestinal disorders: a bioinformatic study. | Malekpour M et al. | β | 2025 | β |
| Exploring the TRIM15 protein interaction network as a drug target using machine learning in pancreatic cancer. | Bas Topcu KS et al. | β | 2025 | β |
| Exposing the DNA methylation-responsive compartment of the leukaemic genome in T-ALL cell lines support its potential as a novel therapeutic target in T-ALL. | Bensberg M et al. | β | 2025 | β |
| Extracellular Matrix-MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC. | Llerena P et al. | β | 2025 | β |
| Extracellular matrix stiffness reduces DNA 6Β ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter. | Xie SA et al. | β | 2025 | β |
| F-box only protein (FBXO) family genes in cattle (Bos taurus): Genome-wide identification and functions in the skeletal muscle development. | Song F et al. | β | 2025 | β |
| FCGBP promotes ovarian cancer progression via activation of IL-6/JAK-STAT signaling pathway. | Fu Z et al. | β | 2025 | β |
| Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models. | Jeong K et al. | β | 2025 | β |
| Federated Deep Learning Enables Cancer Subtyping by Proteomics. | Cai Z et al. | β | 2025 | β |
| Fluorescent Probes Targeting Acyl-CoA Synthetase Long-Chain Family Member 4 for Intraoperative Imaging of Hepatocellular Carcinoma. | Tan J et al. | β | 2025 | β |
| Folate receptor Ξ² performs an immune checkpoint function in activated macrophages. | Zhang F et al. | β | 2025 | β |
| Framework Nucleic Acid Nanomaterials for Central Nervous System Therapies: Design for Barrier Penetration, Targeted Delivery, Cellular Uptake, and Endosomal Escape. | Chen X et al. | β | 2025 | β |
| From cholesterol to glucose: uncovering how statins induce Ξ²-cell dysfunction to promote type 2 diabetes. | Barrow BM et al. | β | 2025 | β |
| Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short-Chain Per- and Polyfluoroalkyl Substances (PFAS). | Collier GE et al. | β | 2025 | β |
| Functional characteristics of fresh antitumor immune interferer GDF-15 in multiple cancers. | Fang M et al. | β | 2025 | β |
| Gasdermin E in glioblastoma -pyroptosis resistance and tumor-promoting functions. | Solel E et al. | β | 2025 | β |
| Generation and characterization of a humanized <i>ACE2</i> rat model for the study of SARS-CoV-2 and COVID-19. | Olson RM et al. | β | 2025 | β |
| Generation of Leucine-Rich Repeat Kinase 2 (LRRK2) Knockout Neuroblastoma Cells SH-SY5Y by CRISPR/Cas9-Mediated Genome Editing. | Jong HL et al. | β | 2025 | β |
| Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk. | Wu Z et al. | β | 2025 | β |
| Genetic associations between serotonin receptor 1F (<i>HTR1F</i>) regulatory variation and sleep apnoea in non-obese individuals: insights from GWAS and eQTL analyses. | Strausz S et al. | β | 2025 | β |
| Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits. | Currin KW et al. | β | 2025 | β |
| Genetic Susceptibility to Periodontitis. | Richter GM et al. | β | 2025 | β |
| Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations. | Han Y et al. | β | 2025 | β |
| Genome-Wide Association Study for Milk Protein Content in Romanian Dual-Purpose Cattle. | Bratu DG et al. | β | 2025 | β |
| Genome-Wide Blood DNA Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen-Specific Immunotherapy. | Lahnsteiner A et al. | β | 2025 | β |
| Genomic analysis identifies TJP3 as a prognostic marker for radiotherapy and chemoradiotherapy in oral squamous cell carcinoma. | Kuk SK et al. | β | 2025 | β |
| Genomic insights into young stock survival in Danish Jersey cattle: A breed-specific QTL on chromosome 10 and its regulatory potential. | Bai Z et al. | β | 2025 | β |
| Genotype-phenotype correlation and management of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome: a descriptive cohort study. | Hilberath J et al. | β | 2025 | β |
| GETgene-AI: a framework for prioritizing actionable cancer drug targets. | Gu A et al. | β | 2025 | β |
| Glia maturation factor-Ξ² in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish. | Li HY et al. | β | 2025 | β |
| Global profiling of N-terminal cysteine-dependent degradation mechanisms. | Bekturova A et al. | β | 2025 | β |
| GLP1 receptor agonism alters growth and therapeutic response in prostate cancer. | Bera S et al. | β | 2025 | β |
| Glucokinase Regulatory Protein (GCKR) Links Metabolic Reprogramming With Immune Exclusion: Insights From a Pan-Cancer Analysis and Gastric Cancer Validation. | Fan S et al. | β | 2025 | β |
| Glutamate metabotropic receptor 4 in breast cancer: a potential and specific target for chimeric antigen receptor therapy. | Xu Y et al. | β | 2025 | β |
| Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation. | JÑñez Pedrayes A et al. | β | 2025 | β |
| Growth Hormone Signaling in Bladder Cancer: Transcriptomic Profiling of Patient Samples and In Vitro Evidence of Therapy Resistance via ABC Transporters and EMT Activation. | Davis E et al. | β | 2025 | β |
| Guanylate-binding protein 5: a promising biomarker and therapeutic target. | Lu J et al. | β | 2025 | β |
| Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants. | Nagaraj SK et al. | β | 2025 | β |
| HAUS6 as a potential prognostic and immunological biomarker: validation from pan-cancer analysis to hepatocellular carcinoma. | Xie H et al. | β | 2025 | β |
| HDAC5 Inhibition as a Therapeutic Strategy for Titin Deficiency-Induced Cardiac Remodeling: Insights from Human iPSC Models. | Hasan AU et al. | β | 2025 | β |
| Herpesvirus-host interactions in neurological diseases: the immunogenetic role of HLA-E. | Graninger M et al. | β | 2025 | β |
| Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk. | Bai Q et al. | β | 2025 | β |
| High-efficiency homology-directed insertion into the genome using the engineered homing endonuclease ARCUS. | Resly LC et al. | β | 2025 | β |
| High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer. | Israelsson P et al. | β | 2025 | β |
| High-Resolution Assembly of the Human Y Chromosome Identifies a Vast Landscape of Inverted Repeats Associated with Structural and Functional Genomic Features. | DobrovolnΓ‘ M et al. | β | 2025 | β |
| Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery. | Zhao F et al. | β | 2025 | β |
| Hippo in smooth muscle - a therapeutic target in vascular diseases driven by aging and hypertension. | Albinsson S et al. | β | 2025 | β |
| Histone-related gene WDR77 promotes tumor progression through cell cycle regulation in skin cutaneous melanoma. | Zhang H et al. | β | 2025 | β |
| HLA Class Ib and MICA/MICB Expression in Human Tissues and Cell Types: Reshuffling Immune Players. | Abi-Rached L et al. | β | 2025 | β |
| How diquat kills: investigation of the toxicological profiles of diquat and bromide ion concentrations in serum by LC-MS-MS and capillary electrophoresis in a suicide case. | Kusano M et al. | β | 2025 | β |
| HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission. | Simon F et al. | β | 2025 | β |
| HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations. | Wang X et al. | β | 2025 | β |
| Human brain vascular multi-omics elucidates disease-risk associations. | Reid MM et al. | β | 2025 | β |
| Identification and Analysis of the GMC Oxidoreductase Family Genes in <i>Cnaphalocrocis medinalis</i> and Their Response to Spinetoram. | Xiao C et al. | β | 2025 | β |
| Identification and Characterization of SRSF2 as a Splicing-Relevant Factor Associated with the Distribution of Membranous to Secreted PD-L1, Exemplarily Considered on Human Renal Tissue, Including Renal Cell Carcinoma. | Hohmann T et al. | β | 2025 | β |
| Identification and characterization of tissue- and stress-specific circular RNAs (circRNAs)Β of tea to generate the largest tea circRNAs data repository. | Rawal HC et al. | β | 2025 | β |
| Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis. | Scholl LS et al. | β | 2025 | β |
| Identification of a dihydroartemisinin-related prognostic signature and its contribution to cancer associated fibroblast of the tumor microenvironment of pancreatic cancer. | Lai J et al. | β | 2025 | β |
| Identification of CD320, SLC44A1 and TNFRSF13B as potential novel therapeutic targets for CAR T-cell therapy in multiple myeloma. | Garofano F et al. | β | 2025 | β |
| Identification of FANCG as a prognostic factor for prostate cancer. | Gao W et al. | β | 2025 | β |
| Identification of gene-sun exposure interactions of GWAS-identified variants in perceived facial aging progression. | Obry L et al. | β | 2025 | β |
| Identification of host cell surface proteins inhibiting furin dependent proteolytic processing of viral glycoproteins. | Williams N et al. | β | 2025 | β |
| Identification of hub genes and potential molecular mechanisms of tumor immune microenvironment-related radiotherapy sensitivity in locally advanced cervical cancer. | Zan Y et al. | β | 2025 | β |
| Identification of mitochondrial-related genes to evaluate the immune infiltration and prognosis of lung adenocarcinoma. | Ge Y et al. | β | 2025 | β |
| Identification of MRVI1-interacting proteins by biotin-based proximity labelling reveals NPM-ALK-dependent interaction dynamics. | Higashi K et al. | β | 2025 | β |
| Identification of neoantigen epitopes in cervical cancer by multi-omics analysis. | Yuan J et al. | β | 2025 | β |
| Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation study. | Wu S et al. | β | 2025 | β |
| Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers. | Zhao J et al. | β | 2025 | β |
| Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization study. | Li Y et al. | β | 2025 | β |
| Identifying potential genetic biomarkers for sperm dysfunction through whole-genome sequencing. | Khan MR et al. | β | 2025 | β |
| Identifying therapeutic targets for allergic asthma through atopic dermatitis-associated genetic mechanisms. | Pu Y et al. | β | 2025 | β |
| IDH2 lactylation promotes angiogenesis in murine diabetic myocardial infarction via blocking Cav1-eNOS interaction. | Zang G et al. | β | 2025 | β |
| IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats. | Baud A et al. | β | 2025 | β |
| IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation. | Pearson JA et al. | β | 2025 | β |
| IL-18 in atopic dermatitis-a multifaceted driver of skin inflammation. | BΓ€hler L et al. | β | 2025 | β |
| Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing. | Tampere M et al. | β | 2025 | β |
| Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma. | Zhang X et al. | β | 2025 | β |
| Immunodiagnostic profiling of SPON2 and MSMB as biomarkers in prostate cancer for nanomaterial- based detection strategies. | Ye J et al. | β | 2025 | β |
| Immunohistochemical Assessment of Cardiac Macrophages in the Aged Fischer 344 Rat. | Bloomer SA | β | 2025 | β |
| Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides. | HΓΈibΓΈ M et al. | β | 2025 | β |
| Impact of Copper Nanoparticles on Keratin 19 (KRT19) Gene Expression in Breast Cancer Subtypes: Integrating Experimental and Bioinformatics Approaches. | Taha S et al. | β | 2025 | β |
| IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope. | Ogawa-Iio A et al. | β | 2025 | β |
| Implicates of PIP5K1Ξ± in asthma-related biological processes: insights into mechanisms and therapeutic potential. | Wang SJ et al. | β | 2025 | β |
| Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment. | Sharma S et al. | β | 2025 | β |
| Increase of intracellular Zn<sup>2+</sup> concentration directly inhibits phospholipase CΞ΅ and suppresses inflammation and tumour formation in mice. | Yoshikawa Y et al. | β | 2025 | β |
| Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo. | RapΓΆhn I et al. | β | 2025 | β |
| Inhibition of PCSK9 Attenuates Liver Endothelial Cell Activation Induced by Colorectal Cancer Stem Cells During Liver Metastasis. | Martin A et al. | β | 2025 | β |
| Inhibition of Soluble Epoxide Hydrolase Prevents Docetaxel-Induced Painful Peripheral Neuropathy. | Wagner KM et al. | β | 2025 | β |
| Inhibitory Effect of Fucoidan Analogs on Highly Metastatic Gastric Cancer Cells via Galectin-4 Inhibition. | Ji S et al. | β | 2025 | β |
| Integrated bulk and single-cell transcriptomic profiling reveals NECTIN-TIGIT interaction underlies T cell exhaustion in papillary thyroid carcinoma. | Golestanifar A et al. | β | 2025 | β |
| Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia. | Lin Q et al. | β | 2025 | β |
| Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity. | Peng J et al. | β | 2025 | β |
| Integrated pan-cancer and melanoma-specific analysis of angiopoietin-2: prognostic value, immune microenvironment modulation, and ceRNA network regulation. | Ni X et al. | β | 2025 | β |
| Integrating the secretome and interactome to identify novel biomarkers and therapeutic targets in colorectal cancer. | Caxali GH et al. | β | 2025 | β |
| Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis. | Di Raimo C et al. | β | 2025 | β |
| Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders. | Koetsier J et al. | β | 2025 | β |
| Integrative bioinformatics and machine learning approaches reveal oxidative stress and glucose metabolism related genes as therapeutic targets and drug candidates in Alzheimer's disease. | Noor F et al. | β | 2025 | β |
| Integrative single-cell and spatial transcriptomics analysis reveals FLAD1 as a regulator of the immune microenvironment in hepatocellular carcinoma. | Zhu P et al. | β | 2025 | β |
| Intelligent technology leads the transformation of traditional Chinese medicine: Large models and virtual cells aid modern analysis of stroke treatment. | Meng Q et al. | β | 2025 | β |
| Interaction Between Activating Transcription Factor 4 and Interleukin 6 Dictates Osteoclast Differentiation and Activity. | Tu S et al. | β | 2025 | β |
| Interplay between acute Type A aortic dissection and pan-cancer: Clinical evidence, bioinformatics, and experimental validation. | Tan F et al. | β | 2025 | β |
| Interplay of stromal cell-derived factor 2 and endoplasmic reticulum stress in the placenta: A review. | Bevilacqua E et al. | β | 2025 | β |
| Intrinsic heterogeneity of primary cilia revealed through spatial proteomics. | Hansen JN et al. | β | 2025 | β |
| Investigating the prognostic role of citrullination-related genes in breast cancer by combining transcriptomics, single-cell analysis and verification. | He W et al. | β | 2025 | β |
| In Vitro Evaluation of Anticancer and Apoptotic Activity of Elaeagnus caudata Schltdl. With Computational Identification of a Novel HSP90 Inhibitor. | Nghakliana F et al. | β | 2025 | β |
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| Iron Regulatory Protein 2 Deficiency Is Protective Against Resistive Breathing-induced Pulmonary Inflammation. | Toumpanakis D et al. | β | 2025 | β |
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| ISENICS: a model for identifying senescent immune cells and samples and characterization of their roles in tumor microenvironment. | Tian M et al. | β | 2025 | β |
| Isoform-level profiling of m<sup>6</sup>A epitranscriptomic signatures in human brain. | Gleeson J et al. | β | 2025 | β |
| Isoform-Selective PAD2/PAD4 Substrates with Unnatural Amino Acids Enable Cellular Peptidylarginine Deiminase Activity Profiling and Reveal Vimentin Citrullination Effects in Macrophages. | GorzeΕ O et al. | β | 2025 | β |
| Jordan syndrome due to <i>PPP2R5D</i> gene mutation: a report of two pediatric cases and literature review. | Huang Y et al. | β | 2025 | β |
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| Ketoboronate as a Minimal Covalent-Reversible Tag for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins. | Pechalrieu D et al. | β | 2025 | β |
| Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With InΒ Vivo and InΒ Vitro Validation. | Luo Q et al. | β | 2025 | β |
| KSMoFinder-knowledge graph embedding of proteins and motifs for predicting kinases of human phosphosites. | Anandakrishnan M et al. | β | 2025 | β |
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| Literature review: CAR T-cell therapy as a promising immunotherapeutic approach for medulloblastoma. | Eksteen C et al. | β | 2025 | β |
| l-malic acid: A multifunctional metabolite at the crossroads of redox signaling, microbial symbiosis, and therapeutic innovation. | Lu J et al. | β | 2025 | β |
| LncCE: Landscape of Cellularly-elevated lncRNAs in Single Cells Across Normal and Cancer Tissues. | Xu K et al. | β | 2025 | β |
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| Long read whole genome sequencing-based discovery of structural variants and their role in aetiology of non-syndromic autism spectrum disorder in India. | Shah J et al. | β | 2025 | β |
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| Mapping the brain cell-specific regulatory architecture of migraine: a single-cell causal framework nominating inhibitory-neuronal BTBD16 and astrocytic RIMS1 as therapeutic targets. | Ye H et al. | β | 2025 | β |
| Mapping the Proteomic Landscape of Pancreatic Cancer: Prognostic Insights and Subtype Stratification. | Aref AT et al. | β | 2025 | β |
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| Matrix Metalloproteinases as Candidate Antigenic Determinants for Anti-Tumor Autoantibodies in Human Ovarian Cancer: A Post Hoc Analysis. | Markosian C et al. | β | 2025 | β |
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| MEHMO syndrome: Review and proposed classification as an eIF2-related neuroendocrinopathy. | Dang Do AN et al. | β | 2025 | β |
| Melatonin Administration Attenuates High-Fat-Diet-Induced Renal Damage in Wistar Rats. | Kalmukova O et al. | β | 2025 | β |
| Melatonin suppresses cancer cell proliferation, DNA repair and expression of the oncogene TRIP13. | Liu W et al. | β | 2025 | β |
| Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism. | Dinesh RK et al. | β | 2025 | β |
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| Metabolism-Related Genes SMOX and SUCLG2 as Immunological and Prognostic Biomarkers in Colorectal Cancer: A Pan-Cancer Analysis. | Xiong Z et al. | β | 2025 | β |
| MEX3A promotes hepatocellular carcinoma cell proliferation and migration <i>via</i> the Wnt/Ξ²-catenin and EMT pathways. | Xiao FK et al. | β | 2025 | β |
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| MICA+ Tumor Cells Modulate Macrophage Phenotype and Function via PPAR/EHHADH-Mediated Fatty Acid Metabolism in Hepatocellular Carcinoma (HCC). | Huang J et al. | β | 2025 | β |
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| Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies. | Santamaria-Castro I et al. | β | 2025 | β |
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| Molecular Subtypes and Risk Prediction Model Based on Malignant Cell Differentiation Trajectories in Breast Cancer. | Yan P et al. | β | 2025 | β |
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| Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5'-Monophosphate Deaminase Activity to Improve Glomerular Injury. | Yang Y et al. | β | 2025 | β |
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| mRNA-based immunotherapy platform targeting endometrial cancer. | Freyberg M et al. | β | 2025 | β |
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| Much ado about NAA-thing. | Funcke JB et al. | β | 2025 | β |
| Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers. | Xie L et al. | β | 2025 | β |
| Multidimensional pan cancer analysis of the sodium induced cell death gene TRPM4. | Dai Y et al. | β | 2025 | β |
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