Mediation of effects of the level of response to alcohol and impulsivity 15 years later in 36-year-old men: Implications for prevention efforts.
- Authors
- Schuckit, Marc A; Smith, Tom L
- Year
- 2017
- Journal
- Drug and alcohol dependence
- PMID
- 28954250
- DOI
- 10.1016/j.drugalcdep.2017.08.030
BACKGROUND: Although the prevalence of alcohol use disorders (AUDs) has increased in older individuals in the recent decade, there are few programs to mitigate that increase. The current analyses evaluate the feasibility of applying to older drinkers elements of an approach to prevent heavier drinking in young adults by focusing on mediators of effects of two risk factors for alcohol problems, low levels of response to alcohol (low LRs) and higher impulsivity. METHODS: Data were extracted from the San Diego Prospective Study (SDPS). Structural Equation Models evaluated relationships among age 36 low LRs and higher impulsivity; age 46 perceived peer drinking, alcohol expectancies, and drinking to cope; and age 51 alcohol problems, even after controlling for age 36 alcohol problems. RESULTS: Relationships of age 36 low LRs to later alcohol problems was both direct and linked to age 46 heavy drinking peers. LR also operated indirectly through peer drinking to alcohol expectancies and drinking to cope. Age 36 impulsivity had no direct path to later alcohol problems and operated primarily through mediation by alcohol expectancies and via expectancies to drinking to cope. After controlling for age 36 alcohol problems, the low LR and impulsivity results remained robust. CONCLUSIONS: Programs for mitigating increases in alcohol problems in middle-age drinkers should consider identifying individuals with low LRs and/or higher impulsivity and implementing prevention approaches similar to a program used in young adults. The approach should emphasize some different mediators for older drinkers with low LRs and those with higher impulsivity.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Evaluations of potential sex differences in alcohol use and problems in 454 offspring from the San Diego Prospective Study. | Schuckit MA et al. | — | 2025 | → |
| High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study. | Schuckit MA et al. | — | 2025 | → |
| Inter-individual divergence in thresholds for detecting opioid effects: Within-subject human laboratory evidence of a testable behavioral phenotype. | McKendrick G et al. | — | 2025 | → |
| Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype-genotype assessment. | Dunn KE et al. | — | 2024 | → |
| Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response? | Schuckit MA et al. | — | 2023 | → |
| Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli. | McKenna BS et al. | — | 2022 | → |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | — | 2021 | → |
| Getting to the Heart of Low Sensitivity to Alcohol: Context Moderates Low Cardiovascular Response to Alcohol in Persons With a Family History of Alcohol Use Disorder. | Bates ME et al. | — | 2020 | → |
| Performance of the Self-Report of the Effects of Alcohol Questionnaire Across Sexes and Generations. | Schuckit MA et al. | — | 2019 | → |
| A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism. | Schuckit MA et al. | — | 2018 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |