An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings.
paper
Cited
Public
Unavailable
- Authors
- Sharpley, Christopher F; Palanisamy, Suresh K A; Glyde, Nicarla S; Dillingham, Peter W; Agnew, Linda L
- Year
- 2014
- Journal
- Behavioural brain research
- PMID
- 25078292
- DOI
- 10.1016/j.bbr.2014.07.030
In the three years since the most recent meta-analysis of the association between the serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of depression, another 27 studies have been published on this issue, which is an increase of 50% more studies than were previously reviewed. In addition, previous findings of inconsistency of results across studies argued for further exploration of this relationship. From the 81 studies identified to June 2013, the significant relationship between the short form of the 5-HTTLPR was confirmed (p=.0000009), which is stronger than the relationship reported in the most recent meta-analysis in 2011. However, nearly 26% of the 81 studies reviewed failed to show any significant association between the 5-HTTLPR, stress and depression, and four studies found opposite results to those expected. Examination of the methodologies of all studies failed to indicate any flaws in the opposite or unequivocal studies, and the latter had larger sample sizes than those studies which supported the expected association, arguing that the null results were not an outcome of insufficient statistical power. The need to consider aspects of samples and measures of depression, particularly the presence of subtypes of depression in future research is discussed.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | 2018 | 28373689 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study. | Jurczak A et al. | β | 2025 | β |
| Cognitive impairment in 'non-user' first-degree relatives of persons with cannabis dependence syndrome: A pilot, endophenotype study. | Das S et al. | β | 2024 | β |
| Neurogenetics of Brain Connectivity: Current Approaches to the Study (Review). | Proshina EA et al. | β | 2024 | β |
| Organic cation transporters in psychiatric and substance use disorders. | Honan LE et al. | β | 2024 | β |
| The role of serotonin in depression-A historical roundup and future directions. | Bremshey S et al. | β | 2024 | β |
| Addressing Emotional Dysregulation and Potential Pharmacogenetic Implication of 5-HTTLPR Genotype in Attention Deficit Hyperactivity Disorder. | Tan HX et al. | β | 2023 | β |
| Associations of the serotonin transporter gene polymorphism, 5-HTTLPR, and adverse life events with late life depression in the elderly Lithuanian population. | Simonyte S et al. | β | 2023 | β |
| Effects of red light on sleep and mood in healthy subjects and individuals with insomnia disorder. | Pan R et al. | β | 2023 | β |
| The serotonin theory of depression: a systematic umbrella review of the evidence. | Moncrieff J et al. | β | 2023 | β |
| A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility. | Homberg JR et al. | β | 2022 | β |
| The Athlete's Paradox: Adaptable Depression. | Forys WJ et al. | β | 2022 | β |
| Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process. | Delli Colli C et al. | β | 2022 | β |
| Genes, Environments, and Time: The Biology of Adversity and Resilience. | Boyce WT et al. | β | 2021 | β |
| Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region. | Ikegame T et al. | β | 2021 | β |
| Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms. | Lin X et al. | β | 2021 | β |
| Post-traumatic Stress Symptoms and Serotonin Transporter (5-HTTLPR) Polymorphism in Breast Cancer Patients. | Zerbinati L et al. | β | 2021 | β |
| Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores. | Starr LR et al. | β | 2021 | β |
| The <i>5-HTTLPR</i>-rs25531 <i>S-A-S-A</i> Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda. | Kalungi A et al. | β | 2021 | β |
| Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis. | Schiele MA et al. | β | 2021 | β |
| A multi-method and multi-informant approach to assessing post-traumatic stress disorder (PTSD) in children. | Grant BR et al. | β | 2020 | β |
| Depression and cardiovascular autonomic control: a matter of vagus and sex paradox. | Tobaldini E et al. | β | 2020 | β |
| Enrichment Environment Positively Influences Depression- and Anxiety-Like Behavior in Serotonin Transporter Knockout Rats through the Modulation of Neuroplasticity, Spine, and GABAergic Markers. | Sbrini G et al. | β | 2020 | β |
| Interactions of childhood maltreatment and genetic variations in adult depression: A systematic review. | Li M et al. | β | 2020 | β |
| Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia. | Ikegame T et al. | β | 2020 | β |
| Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. | Thystrup CK et al. | β | 2020 | β |
| The interplay of polygenic plasticity and adrenocortical activity as sources of variability in pathways among family adversity, youth emotional reactivity, and psychological problems. | Davies PT et al. | β | 2020 | β |
| The role of 5-HTTLPR in autism spectrum disorder: New evidence and a meta-analysis of this polymorphism in Latin American population with psychiatric disorders. | NuΓ±ez-Rios DL et al. | β | 2020 | β |
| 5-HTTLPR polymorphism is associated with nostalgia proneness: The role of neuroticism. | Luo YLL et al. | β | 2019 | β |
| Advance in Stress for Depressive Disorder. | Ding Y et al. | β | 2019 | β |
| Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model. | Thibodeau EL et al. | β | 2019 | β |
| Cognitive and attentional vulnerability to depression in youth: A review. | Kertz SJ et al. | β | 2019 | β |
| EEG cross-frequency correlations as a marker of predisposition to affective disorders. | Knyazev GG et al. | β | 2019 | β |
| Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience. | Elbau IG et al. | β | 2019 | β |
| Genetic variants in major depressive disorder: From pathophysiology to therapy. | Gonda X et al. | β | 2019 | β |
| Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. | Araos P et al. | β | 2019 | β |
| Serotonin transporter-linked polymorphic region genotypes in relation to stress conditions among patients with papillary thyroid carcinoma. | Chen FX et al. | β | 2019 | β |
| Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression. | Little K et al. | β | 2019 | β |
| Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health. | Heim CM et al. | β | 2019 | β |
| When Distress Becomes Somatic: Dementia Family Caregivers' Distress and Genetic Vulnerability to Pain and Sleep Problems. | Wilson SJ et al. | β | 2019 | β |
| Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians. | Sharpley CF et al. | β | 2018 | β |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | β | 2018 | β |
| Depression During and After the Perimenopause: Impact of Hormones, Genetics, and Environmental Determinants of Disease. | Bromberger JT et al. | β | 2018 | β |
| Gene-environment interaction and psychiatric disorders: Review and future directions. | Assary E et al. | β | 2018 | β |
| Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions. | Nilsson KW et al. | β | 2018 | β |
| Harsh Parenting and Serotonin Transporter and BDNF Val66Met Polymorphisms as Predictors of Adolescent Depressive Symptoms. | Koss KJ et al. | β | 2018 | β |
| High anxiety trait: A vulnerable phenotype for stress-induced depression. | Weger M et al. | β | 2018 | β |
| Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples. | Γ slund C et al. | β | 2018 | β |
| Mechanisms underlying the association between insomnia, anxiety, and depression in adolescence: Implications for behavioral sleep interventions. | Blake MJ et al. | β | 2018 | β |
| Parental Serotonin Transporter Polymorphism (5-HTTLPR) Moderates Associations of Stress and Child Behavior With Parenting Behavior. | Morgan JE et al. | β | 2018 | β |
| Relationship Between the Incidence of Road Traffic Accidents, Psychological Characteristics, and Genotype in Bus Drivers in a Chinese Population. | Wang X et al. | β | 2018 | β |
| The Association between Epidermal Growth Factor Receptor (<i>EGFR</i>) Gene Polymorphisms and Lung Cancer Risk. | Bashir NA et al. | β | 2018 | β |
| The effect of interactions between genetics and cannabis use on neurocognition. A review. | Cosker E et al. | β | 2018 | β |
| An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR. | Palma-Gudiel H et al. | β | 2017 | β |
| Anxiety disorders. | Craske MG et al. | β | 2017 | β |
| Association of 5-HTTLPR Polymorphism with the Nursing Diagnoses and the Achievement of Nursing Outcomes in Patients with Major Depression. | Prokofieva M et al. | β | 2017 | β |
| Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation. | Valderrama J et al. | β | 2017 | β |
| Gene Γ Environment Interactions: From Molecular Mechanisms to Behavior. | Halldorsdottir T et al. | β | 2017 | β |
| Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis. | Suppli NP et al. | β | 2017 | β |
| Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression. | Ancelin ML et al. | β | 2017 | β |
| Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR. | Chen FR et al. | β | 2017 | β |
| Is daily replication necessary when sampling cortisol concentrations in association studies of children with autism spectrum disorder? A systematic review and discussion paper. | Sharpley CF et al. | β | 2017 | β |
| Letter to the Editor: Bias in the measurement of bias. Letter regarding 'Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression'. | Vrshek-Schallhorn S et al. | β | 2017 | β |
| Letter to the Editor: Moving science forward by increasing awareness of reporting and citation biases: a reply to Vrshek-Schallhorn et al. (2016). | de Vries YA et al. | β | 2017 | β |
| Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders. | Perry LM et al. | β | 2017 | β |
| Suppression mediates the effect of 5-HTTLPR by stress interaction onΒ depression. | Knyazev GG et al. | β | 2017 | β |
| The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by <i>5-HTTLPR</i> genotype. | Ancelin ML et al. | β | 2017 | β |
| The interaction between 5-HTTLPR genotype and ruminative thinking on BMI. | Schepers R et al. | β | 2017 | β |
| The Serotonin Transporter and Early Life Stress: Translational Perspectives. | Houwing DJ et al. | β | 2017 | β |
| The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain. | Hooten WM et al. | β | 2017 | β |
| Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR. | Igata N et al. | β | 2017 | β |
| Why is depression more common among women than among men? | Kuehner C | β | 2017 | β |
| Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5-HTTLPR-S/Lg polymorphisms. | Ramasubbu R et al. | β | 2016 | β |
| Association between the 5-HTTLPR Genotype and Childhood Characteristics in Mood Disorders. | Eun TK et al. | β | 2016 | β |
| Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression. | de Vries YA et al. | β | 2016 | β |
| Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. | Arpawong TE et al. | β | 2016 | β |
| Gene-environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions. | Ellenbroek BA et al. | β | 2016 | β |
| Genetic Moderation of Stress Effects on Corticolimbic Circuitry. | Bogdan R et al. | β | 2016 | β |
| Infectious diseases, IL6 -174G>C polymorphism, and human development. | Napolioni V et al. | β | 2016 | β |
| Psychosocial mechanisms of serotonin transporter's genetic polymorphism in susceptibility to major depressive disorder: mediated by trait coping styles and interacted with life events. | Wang Y et al. | β | 2016 | β |
| RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders. | Montalvo-Ortiz JL et al. | β | 2016 | β |
| Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants. | Iurescia S et al. | β | 2016 | β |
| Sensory processing sensitivity and serotonin gene variance: Insights into mechanisms shaping environmental sensitivity. | Homberg JR et al. | β | 2016 | β |
| The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders. | Smoller JW | β | 2016 | β |
| 5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer. | Suppli NP et al. | β | 2015 | β |
| A Pontine Region is a Neural Correlate of the Human Affective Processing Network. | Lee TM et al. | β | 2015 | β |
| Biological determinants of depression following bereavement. | Assareh AA et al. | β | 2015 | β |
| Epigenetic variation in the serotonin transporter gene predicts resting state functional connectivity strength within the salience-network. | Muehlhan M et al. | β | 2015 | β |
| Gene-environment interaction in major depression: focus on experience-dependent biological systems. | Lopizzo N et al. | β | 2015 | β |
| Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C. | Porcelli P et al. | β | 2015 | β |
| Interaction of the 5-HTTLPR and childhood trauma influences memory bias in healthy individuals. | Vrijsen JN et al. | β | 2015 | β |
| Shame and Guilt-Proneness in Adolescents: Gene-Environment Interactions. | SzentΓ‘gotai-TΔtar A et al. | β | 2015 | β |
| The Involvement of Genes in Adolescent Depression: A Systematic Review. | Xia L et al. | β | 2015 | β |