The Netherlands Twin Register biobank: a resource for genetic epidemiological studies.
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- Authors
- Willemsen, Gonneke; de Geus, Eco J C; Bartels, Meike; van Beijsterveldt, C E M Toos; Brooks, Andy I; Estourgie-van Burk, G Frederique; Fugman, Douglas A; Hoekstra, Chantal; Hottenga, Jouke-Jan; Kluft, Kees; Meijer, Piet; Montgomery, Grant W; Rizzu, Patrizia; Sondervan, David; Smit, August B; Spijker, Sabine; Suchiman, H Eka D; Tischfield, Jay A; Lehner, Thomas; Slagboom, P Eline; Boomsma, Dorret I
- Year
- 2010
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 20477721
- DOI
- 10.1375/twin.13.3.231
In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am, fasting blood and morning urine samples were collected. Fertile women were bled on day 2-4 of the menstrual cycle, or in their pill-free week. Biological samples were collected for DNA isolation, gene expression studies, creation of cell lines and for biomarker assessment. At the time of blood sampling, additional phenotypic information concerning health, medication use, body composition and smoking was collected. Of the participants contacted, 69% participated. Blood and urine samples were collected in 9,530 participants (63% female, average age 44.4 (SD 15.5) years) from 3,477 families. Lipid profile, glucose, insulin, HbA1c, haematology, CRP, fibrinogen, liver enzymes and creatinine have been assessed. Longitudinal survey data on health, personality and lifestyle are currently available for 90% of all participants. Genome-wide SNP data are available for 3,524 participants, with additional genotyping ongoing. The NTR biobank, combined with the extensive phenotypic information available within the NTR, provides a valuable resource for the study of genetic determinants of individual differences in mental and physical health. It offers opportunities for DNA-based and gene expression studies as well as for future metabolomic and proteomic projects.
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|---|---|---|---|---|
| DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease. | Sinke L et al. | β | 2026 | β |
| Epigenome-wide association study of circulating interleukin-6 connects DNA methylation to immunometabolic and inflammatory health. | Sinke L et al. | β | 2026 | β |
| Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects. | Zhang X et al. | β | 2026 | β |
| Serum NfL, GFAP, and p-tau217 in adults with drug-resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury. | Kwetsie H et al. | β | 2026 | β |
| Blood-Based EWAS of Asthma Polygenic Burden in The Netherlands Twin Register. | Van Asselt AJ et al. | β | 2025 | β |
| Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration. | Sant'Anna Barbosa Ferreira P et al. | β | 2025 | β |
| Genetic and environmental contributions to variation in plasma phosphorylated tau 217. | Rousset RZ et al. | β | 2025 | β |
| Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry. | Gui A et al. | β | 2025 | β |
| Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design. | Rousset RZ et al. | β | 2025 | β |
| Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks. | Graham AC et al. | β | 2025 | β |
| Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register. | Gonggrijp BMA et al. | β | 2025 | β |
| Nutritional associations with decelerated epigenetic aging: vegan diet in a Dutch population. | Janssens GE et al. | β | 2025 | β |
| The association between metabolite concentrations and wellbeing in adults. | Azcona-Granada N et al. | β | 2025 | β |
| Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins. | Hubers N et al. | β | 2025 | β |
| Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation. | Singh M et al. | β | 2025 | β |
| Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort. | Pelt DHM et al. | β | 2024 | β |
| Causal relationships between gut microbiome and aplastic anemia: a Mendelian randomization analysis. | Liu J et al. | β | 2024 | β |
| Cognitively healthy centenarians are genetically protected against Alzheimer's disease. | Tesi N et al. | β | 2024 | β |
| Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers. | Van Asselt AJ et al. | β | 2024 | β |
| Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study. | Demirkan A et al. | β | 2024 | β |
| Transcriptomic and Metabolomic analyses in Monozygotic and Dizygotic twins | Hubers N et al. | β | 2024 | β |
| Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs. | van Dongen J et al. | β | 2023 | β |
| Genome-Wide DNA Methylation Profiles in Whole-Blood and Buccal Samples-Cross-Sectional, Longitudinal, and across Platforms. | Van Asselt AJ et al. | β | 2023 | β |
| Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins. | Drouard G et al. | β | 2023 | β |
| Plasma biomarkers predict amyloid pathology in cognitively normal monozygotic twins after 10 years. | den Braber A et al. | β | 2023 | β |
| DNA methylation in peripheral tissues and left-handedness. | Odintsova VV et al. | β | 2022 | β |
| Fat metabolism is associated with telomere length in six population-based studies. | van der Spek A et al. | β | 2022 | β |
| Impact of long-term exposure to PM<sub>2.5</sub> on peripheral blood gene expression pathways involved in cell signaling and immune response. | Vlaanderen J et al. | β | 2022 | β |
| Intergenerational transmission of body mass index and associations with educational attainment. | Alrouh H et al. | β | 2022 | β |
| Limited evidence for blood eQTLs in human sexual dimorphism. | Porcu E et al. | β | 2022 | β |
| Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system. | Barbu MC et al. | β | 2022 | β |
| Correction for both common and rare cell types in blood is important to identify genes that correlate with age. | Pellegrino-Coppola D et al. | β | 2021 | β |
| Defining functional variants associated with Alzheimer's disease in the induced immune response. | Harwood JC et al. | β | 2021 | β |
| Identical twins carry a persistent epigenetic signature of early genome programming. | van Dongen J et al. | β | 2021 | β |
| Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. | Bos MM et al. | β | 2021 | β |
| Ketone body 3-hydroxybutyrate as a biomarker of aggression. | Whipp AM et al. | β | 2021 | β |
| Male microchimerism in females: a quantitative study of twin pedigrees to investigate mechanisms. | Johnson BN et al. | β | 2021 | β |
| Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. | Pistis G et al. | β | 2021 | β |
| Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum. | Tesi N et al. | β | 2021 | β |
| Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles. | Odintsova VV et al. | β | 2021 | β |
| The Effect of Alzheimer's Disease-Associated Genetic Variants on Longevity. | Tesi N et al. | β | 2021 | β |
| A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. | Ouwens KG et al. | β | 2020 | β |
| Deconvolution of bulk blood eQTL effects into immune cell subpopulations. | Aguirre-Gamboa R et al. | β | 2020 | β |
| Empirical comparisons of multiple Mendelian randomization approaches in the presence of assortative mating. | MinicΔ CC et al. | β | 2020 | β |
| Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. | Pool R et al. | β | 2020 | β |
| Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. | Hagenbeek FA et al. | β | 2020 | β |
| Substance use: Interplay between polygenic risk and neighborhood environment. | Pasman JA et al. | β | 2020 | β |
| Association Between rs1051730 and Smoking During Pregnancy in Dutch Women. | Mbarek H et al. | β | 2019 | β |
| Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism. | Abdellaoui A et al. | β | 2019 | β |
| Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. | Evans DM et al. | β | 2019 | β |
| Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci. | Gupta R et al. | β | 2019 | β |
| Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use. | Allegrini AG et al. | β | 2019 | β |
| The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. | Ligthart L et al. | β | 2019 | β |
| Bidirectional Prospective Associations Between Cardiac Autonomic Activity and Inflammatory Markers. | Hu MX et al. | β | 2018 | β |
| Brain reward responses to food stimuli among female monozygotic twins discordant for BMI. | Doornweerd S et al. | β | 2018 | β |
| Cohort profile: the Geoscience and Health Cohort Consortium (GECCO) in the Netherlands. | Timmermans EJ et al. | β | 2018 | β |
| DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort. | Sandanger TM et al. | β | 2018 | β |
| DNA methylation signatures of educational attainment. | van Dongen J et al. | β | 2018 | β |
| Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs. | van Dongen J et al. | β | 2018 | β |
| Genome-wide association study of offspring birth weight in 86β577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. | Beaumont RN et al. | β | 2018 | β |
| Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study. | Molnos S et al. | β | 2018 | β |
| Metataxonomic Analysis of Individuals at BMI Extremes and Monozygotic Twins Discordant for BMI. | Finnicum CT et al. | β | 2018 | β |
| Predicting loneliness with polygenic scores of social, psychological and psychiatric traits. | Abdellaoui A et al. | β | 2018 | β |
| Testing Familial Transmission of Smoking With Two Different Research Designs. | Treur JL et al. | β | 2018 | β |
| The EMIF-AD PreclinAD study: study design and baseline cohort overview. | Konijnenberg E et al. | β | 2018 | β |
| 2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio. | Lin BD et al. | β | 2017 | β |
| Dietary effects of Bacillus subtilis fmbj on the antioxidant capacity of broilers at an early age. | Zhang L et al. | β | 2017 | β |
| Differential gene expression patterns between smokers and non-smokers: cause or consequence? | Vink JM et al. | β | 2017 | β |
| Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. | Lin BD et al. | β | 2017 | β |
| Interaction between the <i>FTO</i> gene, body mass index and depression: meta-analysis of 13701 individuals. | Rivera M et al. | β | 2017 | β |
| Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype. | Hillger JM et al. | β | 2017 | β |
| Relative Telomere Repeat Mass in Buccal and Leukocyte-Derived DNA. | Finnicum CT et al. | β | 2017 | β |
| Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. | Ferreira MA et al. | β | 2017 | β |
| Smoking and caffeine consumption: a genetic analysis of their association. | Treur JL et al. | β | 2017 | β |
| Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile. | McArtor DB et al. | β | 2017 | β |
| Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study. | Lin BD et al. | β | 2016 | β |
| Detection of gene-environment interaction in pedigree data using genome-wide genotypes. | Nivard MG et al. | β | 2016 | β |
| Genetic and environmental influences interact with age and sex in shaping the human methylome. | van Dongen J et al. | β | 2016 | β |
| Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. | Mbarek H et al. | β | 2016 | β |
| Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs. | Roos L et al. | β | 2016 | β |
| Physical activity and dietary intake in BMI discordant identical twins. | Doornweerd S et al. | β | 2016 | β |
| What Potential Donors in Research Biobanking Want to Know: A Large Population Study of the Italian Twin Registry. | Toccaceli V et al. | β | 2016 | β |
| Ambulatory measurement of the ECG T-wave amplitude. | van Lien R et al. | β | 2015 | β |
| A twin-sibling study on early growth and hormone levels in adolescents. | Estourgie-van Burk GF et al. | β | 2015 | β |
| CNV Concordance in 1,097 MZ Twin Pairs. | Abdellaoui A et al. | β | 2015 | β |
| DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins. | Tsai PC et al. | β | 2015 | β |
| Educational attainment influences levels of homozygosity through migration and assortative mating. | Abdellaoui A et al. | β | 2015 | β |
| Effect of genome and environment on metabolic and inflammatory profiles. | Sirota M et al. | β | 2015 | β |
| Epigenome-Wide Association Study of Aggressive Behavior. | van Dongen J et al. | β | 2015 | β |
| Epigenome-Wide Association Study of Tic Disorders. | ZilhΓ£o NR et al. | β | 2015 | β |
| Epigenome-Wide Association Study of Wellbeing. | Baselmans BM et al. | β | 2015 | β |
| Heritability of liver enzyme levels estimated from genome-wide SNP data. | van Beek JH et al. | β | 2015 | β |
| Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset. | MinicΔ CC et al. | β | 2015 | β |
| Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins. | van Dongen J et al. | β | 2015 | β |
| Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life. | Strohmaier J et al. | β | 2015 | β |
| Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. | Power RA et al. | β | 2015 | β |
| Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort. | Toulopoulou T et al. | β | 2015 | β |
| Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines. | Hillger JM et al. | β | 2015 | β |
| Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells. | van Dongen J et al. | β | 2014 | β |
| Further confirmation of the association between anxiety and CTNND2: replication in humans. | Nivard MG et al. | β | 2014 | β |
| Heritability and genomics of gene expression in peripheral blood. | Wright FA et al. | β | 2014 | β |
| Integrating metabolomics profiling measurements across multiple biobanks. | Dane AD et al. | β | 2014 | β |
| Polygenic risk scores for smoking: predictors for alcohol and cannabis use? | Vink JM et al. | β | 2014 | β |
| Sex differences in the human peripheral blood transcriptome. | Jansen R et al. | β | 2014 | β |
| The association of alcohol intake with Ξ³-glutamyl transferase (GGT) levels: evidence for correlated genetic effects. | van Beek JHDA et al. | β | 2014 | β |
| The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels. | van Dongen J et al. | β | 2014 | β |
| The Genome of the Netherlands: design, and project goals. | Boomsma DI et al. | β | 2014 | β |
| Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs. | Ye K et al. | β | 2013 | β |
| Association between autozygosity and major depression: stratification due to religious assortment. | Abdellaoui A et al. | β | 2013 | β |
| DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. | Zhernakova DV et al. | β | 2013 | β |
| Estimated preejection period (PEP) based on the detection of the R-wave and dZ/dt-min peaks does not adequately reflect the actual PEP across a wide range of laboratory and ambulatory conditions. | van Lien R et al. | β | 2013 | β |
| Exposure to secondhand smoke and depression and anxiety: a report from two studies in the Netherlands. | Bot M et al. | β | 2013 | β |
| Familial resemblance for serum metabolite concentrations. | Draisma HH et al. | β | 2013 | β |
| Genetic and environmental stability in attention problems across the lifespan: evidence from the Netherlands twin register. | Kan KJ et al. | β | 2013 | β |
| Genetic architecture of the pro-inflammatory state in an extended twin-family design. | Neijts M et al. | β | 2013 | β |
| Heritability of metabolic syndrome traits in a large population-based sample. | van Dongen J et al. | β | 2013 | β |
| Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families. | Draisma HH et al. | β | 2013 | β |
| Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. | Broer L et al. | β | 2013 | β |
| The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. | Willemsen G et al. | β | 2013 | β |
| The genetic architecture of liver enzyme levels: GGT, ALT and AST. | van Beek JH et al. | β | 2013 | β |
| The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification. | MinicΔ CC et al. | β | 2013 | β |
| De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems. | Ehli EA et al. | β | 2012 | β |
| Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. | Talens RP et al. | β | 2012 | β |
| Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. | Lubke GH et al. | β | 2012 | β |
| Loci affecting gamma-glutamyl transferase in adults and adolescents show age Γ SNP interaction and cardiometabolic disease associations. | Middelberg RP et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | β | 2012 | β |
| Sex differences in genetic architecture of complex phenotypes? | Vink JM et al. | β | 2012 | β |
| Twins, tissue, and time: an assessment of SNPs and CNVs. | Scheet P et al. | β | 2012 | β |
| LPAR1 and ITGA4 regulate peripheral blood monocyte counts. | Maugeri N et al. | β | 2011 | β |
| Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. | Terracciano A et al. | β | 2011 | β |
| Why are monozygotic twins different? | Silva S et al. | β | 2011 | β |
| Genetic association in multivariate phenotypic data: power in five models. | Minica CC et al. | β | 2010 | β |
| Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. | Boomsma DI et al. | β | 2010 | β |