A mouse model for Down syndrome exhibits learning and behaviour deficits.
paper
Cited
Public
Unavailable
- Authors
- Reeves, R H; Irving, N G; Moran, T H; Wohn, A; Kitt, C; Sisodia, S S; Schmidt, C; Bronson, R T; Davisson, M T
- Year
- 1995
- Journal
- Nature genetics
- PMID
- 7550346
- DOI
- 10.1038/ng1095-177
Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human beings. Mice with segmental trisomy 16 (Ts65Dn mice) are at dosage imbalance for genes corresponding to those on human chromosome 21q21-22.3--which includes the so-called DS 'critical region'. They do not show early-onset of Alzheimer disease pathology; however, Ts65Dn mice do demonstrate impaired performance in a complex learning task requiring the integration of visual and spatial information. The reproducibility of this phenotype among Ts65Dn mice indicates that dosage imbalance for a gene or genes in this region contributes to this impairment. The corresponding dosage imbalance for the human homologues of these genes may contribute to cognitive deficits in DS.
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| Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. | Mellott TJ et al. | β | 2017 | β |
| Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date. | Hart SJ et al. | β | 2017 | β |
| Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. | Nakano-Kobayashi A et al. | β | 2017 | β |
| Rodent models in Down syndrome research: impact and future opportunities. | Herault Y et al. | β | 2017 | β |
| Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome. | Caraci F et al. | β | 2017 | β |
| Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome. | Colas D et al. | β | 2017 | β |
| The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. | Contestabile A et al. | β | 2017 | β |
| The medial temporal memory system in Down syndrome: Translating animal models of hippocampal compromise. | Clark CAC et al. | β | 2017 | β |
| The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system. | Sosa LJ et al. | β | 2017 | β |
| The roles of motor activity and environmental enrichment in intellectual disability. | De Giorgio A | β | 2017 | β |
| Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models. | Do C et al. | β | 2017 | β |
| Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. | Shimohata A et al. | β | 2017 | β |
| Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders. | Rutkowski TP et al. | β | 2017 | β |
| Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life. | Fernandez F et al. | β | 2017 | β |
| Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. | Xu W et al. | β | 2016 | β |
| A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to Ξ²-Cell Mitochondrial Dysfunction in Type 2 Diabetes. | Peiris H et al. | β | 2016 | β |
| Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome. | Powers BE et al. | β | 2016 | β |
| Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. | Hamlett ED et al. | β | 2016 | β |
| Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome. | Catuara-Solarz S et al. | β | 2016 | β |
| Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model. | Abeysekera I et al. | β | 2016 | β |
| Differentially expressed miRNAs in trisomy 21 placentas. | SvobodovΓ‘ I et al. | β | 2016 | β |
| Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. | Kelley CM et al. | β | 2016 | β |
| ERP correlates of object recognition memory in Down syndrome: Do active and passive tasks measure the same thing? | Van Hoogmoed AH et al. | β | 2016 | β |
| Experience-dependent reduction of soluble Ξ²-amyloid oligomers and rescue of cognitive abilities in middle-age Ts65Dn mice, a model of Down syndrome. | Sansevero G et al. | β | 2016 | β |
| GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development. | Kuwahara K et al. | β | 2016 | β |
| Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks. | Wang Y et al. | β | 2016 | β |
| Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis. | LΓ³pez-Hidalgo R et al. | β | 2016 | β |
| Improving Memory and Cognition in Individuals with Down Syndrome. | Rafii MS | β | 2016 | β |
| Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome. | Tramutola A et al. | β | 2016 | β |
| Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. | Dorard E et al. | β | 2016 | β |
| Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome. | McElyea SD et al. | β | 2016 | β |
| Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. | Strupp BJ et al. | β | 2016 | β |
| Mouse-based genetic modeling and analysis of Down syndrome. | Xing Z et al. | β | 2016 | β |
| Mouse models of Down syndrome: gene content and consequences. | Gupta M et al. | β | 2016 | β |
| SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation. | Meraviglia V et al. | β | 2016 | β |
| Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models. | CrΓ©au N et al. | β | 2016 | β |
| Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome. | Marland JR et al. | β | 2016 | β |
| Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students. | Lepeta K et al. | β | 2016 | β |
| The Link between Alzheimer's Disease and Down Syndrome. A Historical Perspective. | Salehi A et al. | β | 2016 | β |
| The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model. | Valenti D et al. | β | 2016 | β |
| Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers. | Stern S et al. | β | 2016 | β |
| Treating trisomies: Prenatal Down's syndrome therapies explored in mice. | Kuehn BM | β | 2016 | β |
| Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. | De Toma I et al. | β | 2016 | β |
| Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. | Blazek JD et al. | β | 2015 | β |
| Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology. | Singh N et al. | β | 2015 | β |
| Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn. | HernΓ‘ndez-GonzΓ‘lez S et al. | β | 2015 | β |
| Assessing cognitive improvement in people with Down syndrome: important considerations for drug-efficacy trials. | Fernandez F et al. | β | 2015 | β |
| Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. | Mayfield J et al. | β | 2015 | β |
| Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition. | Rivero O et al. | β | 2015 | β |
| Dendritic spine dysgenesis in autism related disorders. | Phillips M et al. | β | 2015 | β |
| Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region. | Liu W et al. | β | 2015 | β |
| Dissecting Alzheimer disease in Down syndrome using mouse models. | Choong XY et al. | β | 2015 | β |
| Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome. | Marechal D et al. | β | 2015 | β |
| Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. | Belichenko PV et al. | β | 2015 | β |
| DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites. | Li S et al. | β | 2015 | β |
| DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome. | Najas S et al. | β | 2015 | β |
| Early environmental therapy rescues brain development in a mouse model of Down syndrome. | Begenisic T et al. | β | 2015 | β |
| Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. | Nie X et al. | β | 2015 | β |
| Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). | Alldred MJ et al. | β | 2015 | β |
| Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. | Alldred MJ et al. | β | 2015 | β |
| GIRK Channels: A Potential Link Between Learning and Addiction. | Tipps ME et al. | β | 2015 | β |
| Glutamate synapses in human cognitive disorders. | Volk L et al. | β | 2015 | β |
| Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. | Witton J et al. | β | 2015 | β |
| Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. | Nosheny RL et al. | β | 2015 | β |
| Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. | Nizetic D et al. | β | 2015 | β |
| Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice. | Stern S et al. | β | 2015 | β |
| Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice. | Stagni F et al. | β | 2015 | β |
| Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. | Stringer M et al. | β | 2015 | β |
| Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development. | Meechan DW et al. | β | 2015 | β |
| Murine AΞ² over-production produces diffuse and compact Alzheimer-type amyloid deposits. | Xu G et al. | β | 2015 | β |
| New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. | Bartesaghi R et al. | β | 2015 | β |
| Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. | Brault V et al. | β | 2015 | β |
| Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. | Gardiner KJ | β | 2015 | β |
| Preschoolers with Down syndrome do not yet show the learning and memory impairments seen in adults with Down syndrome. | Roberts LV et al. | β | 2015 | β |
| Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome. | Catuara-Solarz S et al. | β | 2015 | β |
| Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. | Blazek JD et al. | β | 2015 | β |
| Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome. | Deidda G et al. | β | 2015 | β |
| Sleep-like behavior and 24-h rhythm disruption in the Tc1 mouse model of Down syndrome. | Heise I et al. | β | 2015 | β |
| The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. | Polk RC et al. | β | 2015 | β |
| Adaptive and pathological inhibition of neuroplasticity associated with circadian rhythms and sleep. | Heller HC et al. | β | 2014 | β |
| Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome. | Bianchi P et al. | β | 2014 | β |
| A novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21. | Miyamoto K et al. | β | 2014 | β |
| APP-dependent alteration of GSK3Ξ² activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. | Trazzi S et al. | β | 2014 | β |
| Astrocytes of the murine model for Down Syndrome Ts65Dn display reduced intracellular ionic zinc. | BallestΓn R et al. | β | 2014 | β |
| Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome. | SahΓΊn I et al. | β | 2014 | β |
| Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome. | Mouton-Liger F et al. | β | 2014 | β |
| Domains of genome-wide gene expression dysregulation in Down's syndrome. | Letourneau A et al. | β | 2014 | β |
| Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. | Sosa LJ et al. | β | 2014 | β |
| Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans. | De la Torre R et al. | β | 2014 | β |
| Epigenetics: the neglected key to minimize learning and memory deficits in Down syndrome. | Dekker AD et al. | β | 2014 | β |
| Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. | Souchet B et al. | β | 2014 | β |
| Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome. | Begenisic T et al. | β | 2014 | β |
| Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments. | King MK et al. | β | 2014 | β |
| Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. | Zhang L et al. | β | 2014 | β |
| In vivo 1H MRS study in microlitre voxels in the hippocampus of a mouse model of Down syndrome at 11.7βT. | Santin MD et al. | β | 2014 | β |
| Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. | Kelley CM et al. | β | 2014 | β |
| Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. | Ash JA et al. | β | 2014 | β |
| Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. | Yan J et al. | β | 2014 | β |
| Nerve growth factor metabolic dysfunction in Down's syndrome brains. | Iulita MF et al. | β | 2014 | β |
| Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors. | Heller HC et al. | β | 2014 | β |
| Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice. | Starbuck JM et al. | β | 2014 | β |
| Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model. | Guidi S et al. | β | 2014 | β |
| Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. | Kelley CM et al. | β | 2014 | β |
| Treating enhanced GABAergic inhibition in Down syndrome: use of GABA Ξ±5-selective inverse agonists. | MartΓnez-CuΓ© C et al. | β | 2014 | β |
| Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. | Lane AA et al. | β | 2014 | β |
| Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics. | Perluigi M et al. | β | 2014 | β |
| Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior. | Hussaini SM et al. | β | 2014 | β |
| Aging and intellectual disability: insights from mouse models of Down syndrome. | Ruparelia A et al. | β | 2013 | β |
| Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome. | Haas MA et al. | β | 2013 | β |
| Automated multi-day tracking of marked mice for the analysis of social behaviour. | Ohayon S et al. | β | 2013 | β |
| Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy. | Kuwajima M et al. | β | 2013 | β |
| Commonality in Down and fetal alcohol syndromes. | Solzak JP et al. | β | 2013 | β |
| Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. | Malinge S et al. | β | 2013 | β |
| DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels. | Tlili A et al. | β | 2013 | β |
| Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome. | Guidi S et al. | β | 2013 | β |
| Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity. | Pang TY et al. | β | 2013 | β |
| Expression of trisomic proteins in Down syndrome model systems. | Spellman C et al. | β | 2013 | β |
| Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. | Das I et al. | β | 2013 | β |
| [Identification of molecules with altered expression in the brain of mouse model for Down syndrome by comprehensive analyses]. | Ishihara K | β | 2013 | β |
| Lithium rescues synaptic plasticity and memory in Down syndrome mice. | Contestabile A et al. | β | 2013 | β |
| Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. | Kida E et al. | β | 2013 | β |
| Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. | Velazquez R et al. | β | 2013 | β |
| Modelling human disease with pluripotent stem cells. | Siller R et al. | β | 2013 | β |
| Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. | Tyler WA et al. | β | 2013 | β |
| Neuroprotective actions of perinatal choline nutrition. | Blusztajn JK et al. | β | 2013 | β |
| Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome. | Billingsley CN et al. | β | 2013 | β |
| Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. | Altafaj X et al. | β | 2013 | β |
| Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome. | Stagni F et al. | β | 2013 | β |
| Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. | Zhang G et al. | β | 2013 | β |
| Prospects for improving brain function in individuals with Down syndrome. | Costa AC et al. | β | 2013 | β |
| Reducing GABAA Ξ±5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. | MartΓnez-CuΓ© C et al. | β | 2013 | β |
| Regulation of the MIR155 host gene in physiological and pathological processes. | Elton TS et al. | β | 2013 | β |
| Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome. | Colas D et al. | β | 2013 | β |
| Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment. | Gutierrez-Castellanos N et al. | β | 2013 | β |
| The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome. | Trazzi S et al. | β | 2013 | β |
| Usp16 contributes to somatic stem-cell defects in Down's syndrome. | Adorno M et al. | β | 2013 | β |
| Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. | Szemes M et al. | β | 2013 | β |
| Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome. | Heinen M et al. | β | 2012 | β |
| Age-related neurodegeneration and memory loss in down syndrome. | Lockrow JP et al. | β | 2012 | β |
| Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn. | HernΓ‘ndez S et al. | β | 2012 | β |
| Altered synaptic marker abundance in the hippocampal stratum oriens of Ts65Dn mice is associated with exuberant expression of versican. | Howell MD et al. | β | 2012 | β |
| A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. | Currier DG et al. | β | 2012 | β |
| Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media. | Kuhn S et al. | β | 2012 | β |
| Brain phenotype of transgenic mice overexpressing cystathionine Ξ²-synthase. | RΓ©gnier V et al. | β | 2012 | β |
| Chromosomal instability and aneuploidy in cancer: from yeast to man. | Pfau SJ et al. | β | 2012 | β |
| Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. | Ruparelia A et al. | β | 2012 | β |
| Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression. | Duclot F et al. | β | 2012 | β |
| Down syndrome: the brain in trisomic mode. | Dierssen M | β | 2012 | β |
| Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression. | Fuchs C et al. | β | 2012 | β |
| Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice. | Mazur-Kolecka B et al. | β | 2012 | β |
| From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome. | Cramer N et al. | β | 2012 | β |
| Functional and biochemical characterization of soleus muscle in Down syndrome mice: insight into the muscle dysfunction seen in the human condition. | Cowley PM et al. | β | 2012 | β |
| Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease. | Ginsberg SD et al. | β | 2012 | β |
| Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. | Zhang L et al. | β | 2012 | β |
| Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population. | Li H et al. | β | 2012 | β |
| Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment. | Edgin JO et al. | β | 2012 | β |
| Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. | Usowicz MM et al. | β | 2012 | β |
| Interneuron dysfunction in psychiatric disorders. | MarΓn O | β | 2012 | β |
| Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment. | Fowler TW et al. | β | 2012 | β |
| Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. | Rachubinski AL et al. | β | 2012 | β |
| Mouse models of Alzheimer's disease. | Hall AM et al. | β | 2012 | β |
| Mouse models of aneuploidy. | Sheppard O et al. | β | 2012 | β |
| Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. | Rueda N et al. | β | 2012 | β |
| New insights into the troubles of aneuploidy. | Siegel JJ et al. | β | 2012 | β |
| Prenatal treatment prevents learning deficit in Down syndrome model. | Incerti M et al. | β | 2012 | β |
| Prospects and challenges of reprogrammed cells in hematology and oncology. | GroΓ B et al. | β | 2012 | β |
| Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1). | Kim SS et al. | β | 2012 | β |
| Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? | Smith B et al. | β | 2012 | β |
| RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit GΞ±o. | Chuang HH et al. | β | 2012 | β |
| Role of phosphoinositides at the neuronal synapse. | Frere SG et al. | β | 2012 | β |
| Synaptic pathology of Down syndrome. | Garner CC et al. | β | 2012 | β |
| The in vivo Down syndrome genomic library in mouse. | Herault Y et al. | β | 2012 | β |
| The kinesin superfamily protein KIF17: one protein with many functions. | Wong-Riley MT et al. | β | 2012 | β |
| The use of mouse models for understanding the biology of down syndrome and aging. | Vacano GN et al. | β | 2012 | β |
| Trisomy 21 and early brain development. | Haydar TF et al. | β | 2012 | β |
| Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice. | Cooper A et al. | β | 2012 | β |
| Working memory in the aged Ts65Dn mouse, a model for Down syndrome. | Whitney KN et al. | β | 2012 | β |
| Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes. | Keck-Wherley J et al. | β | 2011 | β |
| Animal models of intellectual disability: towards a translational approach. | Scorza CA et al. | β | 2011 | β |
| APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. | Trazzi S et al. | β | 2011 | β |
| Bone density phenotypes in mice aneuploid for the Down syndrome critical region. | Olson LE et al. | β | 2011 | β |
| Cardiovascular development and survival during gestation in the Ts65Dn mouse model for Down syndrome. | Lorandeau CG et al. | β | 2011 | β |
| Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. | Brault V et al. | β | 2011 | β |
| Chronic Treatment with a Promnesiant GABA-A Ξ±5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. | Braudeau J et al. | β | 2011 | β |
| Cognitive deficits in Down syndrome: narrowing 'Down' to Olig1 and Olig2. | Wong B | β | 2011 | β |
| Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of Ξ²1-adrenergic receptor by xamoterol as a potential cognitive enhancer. | Faizi M et al. | β | 2011 | β |
| Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress. | Lorenzo LP et al. | β | 2011 | β |
| Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice. | Blazek JD et al. | β | 2011 | β |
| Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. | Lockrow J et al. | β | 2011 | β |
| Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome. | Begenisic T et al. | β | 2011 | β |
| Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome. | Chakrabarti L et al. | β | 2011 | β |
| Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine. | Scott-McKean JJ et al. | β | 2011 | β |
| Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. | de Souza FM et al. | β | 2011 | β |
| Genetic analysis of Down syndrome-associated heart defects in mice. | Liu C et al. | β | 2011 | β |
| G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model. | Baamonde C et al. | β | 2011 | β |
| Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome. | Duchon A et al. | β | 2011 | β |
| Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. | Yang A et al. | β | 2011 | β |
| Investigating monogenic and complex diseases with pluripotent stem cells. | Zhu H et al. | β | 2011 | β |
| Is it possible to improve neurodevelopmental abnormalities in Down syndrome? | Bartesaghi R et al. | β | 2011 | β |
| Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. | Vilardell M et al. | β | 2011 | β |
| Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. | Reinholdt LG et al. | β | 2011 | β |
| Mouse models for Down syndrome-associated developmental cognitive disabilities. | Liu C et al. | β | 2011 | β |
| Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. | Kern DS et al. | β | 2011 | β |
| Prevention of learning deficit in a Down syndrome model. | Incerti M et al. | β | 2011 | β |
| Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome. | Blanchard J et al. | β | 2011 | β |
| Specific targeting of the GABA-A receptor Ξ±5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice. | Braudeau J et al. | β | 2011 | β |
| Striatum-hippocampus balance: from physiological behavior to interneuronal pathology. | Ghiglieri V et al. | β | 2011 | β |
| The contribution of GABAergic dysfunction to neurodevelopmental disorders. | Ramamoorthi K et al. | β | 2011 | β |
| The Down syndrome critical region regulates retinogeniculate refinement. | Blank M et al. | β | 2011 | β |
| The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway. | Kim SS et al. | β | 2011 | β |
| The role of DYRK1A in neurodegenerative diseases. | Wegiel J et al. | β | 2011 | β |
| The use of mouse models to understand and improve cognitive deficits in Down syndrome. | Das I et al. | β | 2011 | β |
| Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome. | Popov VI et al. | β | 2011 | β |
| Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome. | PΓ©rez-Cremades D et al. | β | 2010 | β |
| A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes. | De Cegli R et al. | β | 2010 | β |
| A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. | Yu T et al. | β | 2010 | β |
| Animal models of amyloid-beta-related pathologies in Alzheimer's disease. | Philipson O et al. | β | 2010 | β |
| Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). | Costa AC et al. | β | 2010 | β |
| Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. | Kuhn DE et al. | β | 2010 | β |
| Circadian locomotor rhythms are normal in Ts65Dn "Down syndrome" mice and unaffected by pentylenetetrazole. | Ruby NF et al. | β | 2010 | β |
| Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome. | Contestabile A et al. | β | 2010 | β |
| Controlled somatic and germline copy number variation in the mouse model. | HΓ©rault Y et al. | β | 2010 | β |
| Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. | Ruparelia A et al. | β | 2010 | β |
| Down syndrome: from understanding the neurobiology to therapy. | Gardiner K et al. | β | 2010 | β |
| Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. | Bianchi P et al. | β | 2010 | β |
| Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. | Yu T et al. | β | 2010 | β |
| Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome. | Llorens-MartΓn MV et al. | β | 2010 | β |
| Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome. | Blazek JD et al. | β | 2010 | β |
| Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. | LΓΌscher C et al. | β | 2010 | β |
| Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. | Ishihara K et al. | β | 2010 | β |
| GABAB-GIRK2-mediated signaling in Down syndrome. | Cramer NP et al. | β | 2010 | β |
| Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome. | Di Filippo M et al. | β | 2010 | β |
| Increased male reproductive success in Ts65Dn "Down syndrome" mice. | Moore CS et al. | β | 2010 | β |
| Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. | Bianchi P et al. | β | 2010 | β |
| Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. | Netzer WJ et al. | β | 2010 | β |
| Mouse models of cognitive disabilities in trisomy 21 (Down syndrome). | Roubertoux PL et al. | β | 2010 | β |
| Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. | Chakrabarti L et al. | β | 2010 | β |
| PCR prescreen for genotyping the Ts65Dn mouse model of Down syndrome. | Lorenzi H et al. | β | 2010 | β |
| Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome. | Moon J et al. | β | 2010 | β |
| [Relevance of animal models in the study of human pathologies: a mouse model of Down syndrome]. | Morice E | β | 2010 | β |
| The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. | Scott-McKean JJ et al. | β | 2010 | β |
| Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins. | Elton TS et al. | β | 2010 | β |
| Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). | Seo SR et al. | β | 2009 | β |
| Adult reversal of cognitive phenotypes in neurodevelopmental disorders. | Silva AJ et al. | β | 2009 | β |
| Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. | Choi JH et al. | β | 2009 | β |
| Aneuploidy: from a physiological mechanism of variance to Down syndrome. | Dierssen M et al. | β | 2009 | β |
| A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. | Roper RJ et al. | β | 2009 | β |
| A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. | Pereira PL et al. | β | 2009 | β |
| Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. | Contestabile A et al. | β | 2009 | β |
| Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. | Lockrow J et al. | β | 2009 | β |
| Chromosome engineering in ES cells. | van der Weyden L et al. | β | 2009 | β |
| Cognitive enhancement therapy for a model of Down syndrome. | Wiseman FK | β | 2009 | β |
| Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. | Peng S et al. | β | 2009 | β |
| Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for Down syndrome, change as they age? | Sanders NC et al. | β | 2009 | β |
| Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. | Baek KH et al. | β | 2009 | β |
| DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. | Noll C et al. | β | 2009 | β |
| Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. | Belichenko PV et al. | β | 2009 | β |
| Function and regulation of Dyrk1A: towards understanding Down syndrome. | Park J et al. | β | 2009 | β |
| Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. | Lyle R et al. | β | 2009 | β |
| Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. | Guedj F et al. | β | 2009 | β |
| Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. | Galante M et al. | β | 2009 | β |
| Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. | Malinge S et al. | β | 2009 | β |
| In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. | Chen Y et al. | β | 2009 | β |
| Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome. | Reinholdt LG et al. | β | 2009 | β |
| Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome. | Fernandez F et al. | β | 2009 | β |
| Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors. | Vink J et al. | β | 2009 | β |
| Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. | Wang Y et al. | β | 2009 | β |
| Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. | Levine S et al. | β | 2009 | β |
| Technical challenges in using human induced pluripotent stem cells to model disease. | Saha K et al. | β | 2009 | β |
| The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. | Belichenko NP et al. | β | 2009 | β |
| The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. | Ooms LM et al. | β | 2009 | β |
| Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain. | Ramakrishna N et al. | β | 2009 | β |
| Video imaging system for automated shaping and analysis of complex locomotory behavior. | Publicover NG et al. | β | 2009 | β |
| Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. | Contestabile A et al. | β | 2009 | β |
| Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. | Pollonini G et al. | β | 2008 | β |
| Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. | Chang Q et al. | β | 2008 | β |
| Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model. | Roberson R et al. | β | 2008 | β |
| Alzheimer disease models and human neuropathology: similarities and differences. | Duyckaerts C et al. | β | 2008 | β |
| Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse. | Necchi D et al. | β | 2008 | β |
| Characterization of the cardiac phenotype in neonatal Ts65Dn mice. | Williams AD et al. | β | 2008 | β |
| Down's syndrome: paradox of a tumour repressor. | Threadgill DW | β | 2008 | β |
| DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. | Canzonetta C et al. | β | 2008 | β |
| Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. | Rueda N et al. | β | 2008 | β |
| Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. | Fernandez F et al. | β | 2008 | β |
| GATA1-related leukaemias. | Shimizu R et al. | β | 2008 | β |
| Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. | Kirsammer G et al. | β | 2008 | β |
| Increased levels of carbonic anhydrase II in the developing Down syndrome brain. | Palminiello S et al. | β | 2008 | β |
| Jugular lymphatic sacs in the first trimester of pregnancy: the prevalence and the potential value in screening for chromosomal abnormalities. | van Heesch PN et al. | β | 2008 | β |
| Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways. | Rachidi M et al. | β | 2008 | β |
| Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. | Seah C et al. | β | 2008 | β |
| Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. | Morice E et al. | β | 2008 | β |
| Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate. | Xie W et al. | β | 2008 | β |
| Reversing neurodevelopmental disorders in adults. | Ehninger D et al. | β | 2008 | β |
| Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. | Voronov SV et al. | β | 2008 | β |
| The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases. | Contestabile A et al. | β | 2008 | β |
| Trisomy 21 and Down syndrome: a short review. | Sommer C et al. | β | 2008 | β |
| Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. | Sussan TE et al. | β | 2008 | β |
| A year of unprecedented progress in Down syndrome basic research. | Reeves RH et al. | β | 2007 | β |
| Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistry. | Hill JM et al. | β | 2007 | β |
| Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. | Contestabile A et al. | β | 2007 | β |
| Cre/loxP-mediated chromosome engineering of the mouse genome. | Brault V et al. | β | 2007 | β |
| Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. | Chakrabarti L et al. | β | 2007 | β |
| Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. | Aldridge K et al. | β | 2007 | β |
| Effects of aneuploidy on skull growth in a mouse model of Down syndrome. | Hill CA et al. | β | 2007 | β |
| Gene expression variation in Down's syndrome mice allows prioritization of candidate genes. | Sultan M et al. | β | 2007 | β |
| Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. | Sethupathy P et al. | β | 2007 | β |
| Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders. | Takao K et al. | β | 2007 | β |
| Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. | Bearer EL et al. | β | 2007 | β |
| Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. | Rachidi M et al. | β | 2007 | β |
| Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: a clinical report series. | Spiridigliozzi GA et al. | β | 2007 | β |
| Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. | Belichenko PV et al. | β | 2007 | β |
| The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. | Hanson JE et al. | β | 2007 | β |
| The power of comparative and developmental studies for mouse models of Down syndrome. | Moore CS et al. | β | 2007 | β |
| Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. | Olson LE et al. | β | 2007 | β |
| Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. | Best TK et al. | β | 2007 | β |
| Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. | Harashima C et al. | β | 2006 | β |
| Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome. | Siarey RJ et al. | β | 2006 | β |
| Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. | MartΓnez-CuΓ© C et al. | β | 2006 | β |
| C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down syndrome. | Rachidi M et al. | β | 2006 | β |
| Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. | Contestabile A et al. | β | 2006 | β |
| Current perspectives on Down syndrome: selected medical and social issues. | Crissman BG et al. | β | 2006 | β |
| Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. | Roper RJ et al. | β | 2006 | β |
| DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. | Ahn KJ et al. | β | 2006 | β |
| Expression profiling of drug response--from genes to pathways. | Herwig R et al. | β | 2006 | β |
| Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. | Clark S et al. | β | 2006 | β |
| Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. | Lorenzi HA et al. | β | 2006 | β |
| Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. | Shukkur EA et al. | β | 2006 | β |
| MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins. | Adayev T et al. | β | 2006 | β |
| Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization. | Brault V et al. | β | 2006 | β |
| Mouse chromosome engineering for modeling human disease. | van der Weyden L et al. | β | 2006 | β |
| Mouse models of cognitive disorders in trisomy 21: a review. | SΓ©rΓ©gaza Z et al. | β | 2006 | β |
| Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation. | Sahir N et al. | β | 2006 | β |
| New techniques to understand chromosome dosage: mouse models of aneuploidy. | Tybulewicz VL et al. | β | 2006 | β |
| NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. | Arron JR et al. | β | 2006 | β |
| Perinatal loss of Ts65Dn Down syndrome mice. | Roper RJ et al. | β | 2006 | β |
| Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. | Moore CS | β | 2006 | β |
| The challenge of Down syndrome. | Antonarakis SE et al. | β | 2006 | β |
| The cholinergic system in Down's syndrome. | Fodale V et al. | β | 2006 | β |
| The growth capacity of bone marrow CD34 positive cells in culture is drastically reduced in a murine model of Down syndrome. | Jablonska B et al. | β | 2006 | β |
| Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development. | Potier MC et al. | β | 2006 | β |
| Working memory in the Ts65Dn mouse, a model for Down syndrome. | Dowdy-Sanders NC et al. | β | 2006 | β |
| Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. | Seo H et al. | β | 2005 | β |
| Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. | Siarey RJ et al. | β | 2005 | β |
| Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation. | Haydar TF | β | 2005 | β |
| An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. | O'Doherty A et al. | β | 2005 | β |
| Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. | MartΓnez-CuΓ© C et al. | β | 2005 | β |
| Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. | Costa AC et al. | β | 2005 | β |
| Down syndrome and genetics - a case of linked histories. | Patterson D et al. | β | 2005 | β |
| DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes? | Kluetzman KS et al. | β | 2005 | β |
| Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. | Villar AJ et al. | β | 2005 | β |
| Neuroimaging and human genetics. | Winterer G et al. | β | 2005 | β |
| Notch signaling, brain development, and human disease. | Lasky JL et al. | β | 2005 | β |
| Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. | Mao R et al. | β | 2005 | β |
| Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. | VacΓk T et al. | β | 2005 | β |
| The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome. | Dauphinot L et al. | β | 2005 | β |
| Transcriptional consequences of autosomal trisomy: primary gene dosage with complex downstream effects. | FitzPatrick DR | β | 2005 | β |
| Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. | Gotti S et al. | β | 2004 | β |
| Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. | Hunter CL et al. | β | 2004 | β |
| Chromosome 21 and down syndrome: from genomics to pathophysiology. | Antonarakis SE et al. | β | 2004 | β |
| Comparative psychology is still alive but may be losing relevance. | Denenberg VH | β | 2004 | β |
| Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. | Kurt MA et al. | β | 2004 | β |
| Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. | Amano K et al. | β | 2004 | β |
| Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. | Olson LE et al. | β | 2004 | β |
| Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. | Stasko MR et al. | β | 2004 | β |
| Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1). | Chabert C et al. | β | 2004 | β |
| Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. | Lyle R et al. | β | 2004 | β |
| Genetics. The critical region in trisomy 21. | Nelson DL et al. | β | 2004 | β |
| Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. | Kleschevnikov AM et al. | β | 2004 | β |
| Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. | Kazuki Y et al. | β | 2004 | β |
| Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. | Marubio LM et al. | β | 2004 | β |
| Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. | Driscoll LL et al. | β | 2004 | β |
| Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. | Hunter CL et al. | β | 2004 | β |
| Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. | MartΓnez de LagrΓ‘n M et al. | β | 2004 | β |
| Operant conditioning in the Ts65Dn mouse: learning. | Wenger GR et al. | β | 2004 | β |
| Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. | Belichenko PV et al. | β | 2004 | β |
| Trafficking the NGF signal: implications for normal and degenerating neurons. | Delcroix JD et al. | β | 2004 | β |
| Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. | Kahlem P et al. | β | 2004 | β |
| Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. | Bambrick LL et al. | β | 2003 | β |
| App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. | Cataldo AM et al. | β | 2003 | β |
| Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. | Hunter CL et al. | β | 2003 | β |
| Down's syndrome. | Roizen NJ et al. | β | 2003 | β |
| Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. | Granholm AC et al. | β | 2003 | β |
| Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. | Bimonte-Nelson HA et al. | β | 2003 | β |
| Genetics of human prefrontal function. | Winterer G et al. | β | 2003 | β |
| Human neural stem cells: a new tool for studying cortical development in Down's syndrome. | Bhattacharyya A et al. | β | 2003 | β |
| Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. | Hunter CL et al. | β | 2003 | β |
| Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. | Salehi A et al. | β | 2003 | β |
| Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. | Galdzicki Z et al. | β | 2003 | β |
| Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. | Hill JM et al. | β | 2003 | β |
| 2001 William Allan Award Address. From Down syndrome to the "human" in "human genetics". | Epstein CJ | β | 2002 | β |
| A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. | Mural RJ et al. | β | 2002 | β |
| A dorsal root ganglia cell line derived from trisomy 16 fetal mice, a model for Down syndrome. | Allen DD et al. | β | 2002 | β |
| Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. | Auld DS et al. | β | 2002 | β |
| An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. | Nishigaki R et al. | β | 2002 | β |
| Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region. | Toyoda A et al. | β | 2002 | β |
| Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate-specific genes. | Vitale L et al. | β | 2002 | β |
| Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. | MartΓnez-CuΓ© C et al. | β | 2002 | β |
| Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome. | CΓ‘rdenas AM et al. | β | 2002 | β |
| Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. | Granholm AC et al. | β | 2002 | β |
| Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome. | Frederikse PH et al. | β | 2002 | β |
| Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum? | Barlow GM et al. | β | 2002 | β |
| Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. | Hyde LA et al. | β | 2002 | β |
| The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. | Moran TH et al. | β | 2002 | β |
| Tools for targeted manipulation of the mouse genome. | van der Weyden L et al. | β | 2002 | β |
| Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. | Hyde LA et al. | β | 2001 | β |
| Alteration of gene expression in Down's syndrome (DS) brains: its significance in neurodegeneration. | Sawa A | β | 2001 | β |
| Applications of the Morris water maze in the study of learning and memory. | D'Hooge R et al. | β | 2001 | β |
| Chromosome 21: from sequence to applications. | Antonarakis SE | β | 2001 | β |
| Differential gene expression studies to explore the molecular pathophysiology of Down syndrome. | Antonarakis SE et al. | β | 2001 | β |
| Down syndrome: advances in molecular biology and the neurosciences. | Capone GT | β | 2001 | β |
| Engineering chromosomal rearrangements in mice. | Yu Y et al. | β | 2001 | β |
| Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. | Cooper JD et al. | β | 2001 | β |
| Functional genomics of Down syndrome: a multidisciplinary approach. | Dierssen M et al. | β | 2001 | β |
| Motor learning in Ts65Dn mice, a model for Down syndrome. | Hyde LA et al. | β | 2001 | β |
| Murine models for Down syndrome. | Dierssen M et al. | β | 2001 | β |
| On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. | Galdzicki Z et al. | β | 2001 | β |
| Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. | Ruiz de AzΓΊa I et al. | β | 2001 | β |
| Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice. | Turner CA et al. | β | 2001 | β |
| Too much of a good thing: mechanisms of gene action in Down syndrome. | Reeves RH et al. | β | 2001 | β |
| Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. | Hyde LA et al. | β | 2001 | β |
| Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. | Pletcher MT et al. | β | 2001 | β |
| C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning. | Guipponi M et al. | β | 2000 | β |
| Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. | Bartoloni L et al. | β | 2000 | β |
| Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. | Sago H et al. | β | 2000 | β |
| Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. | Michaud J et al. | β | 2000 | β |
| Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. | Granholm AC et al. | β | 2000 | β |
| Oestrogen and nerve growth factor - neuroprotection and repair in Alzheimer's disease. | Granholm AC | β | 2000 | β |
| Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. | Richtsmeier JT et al. | β | 2000 | β |
| Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21. | Inoue T et al. | β | 2000 | β |
| Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. | Kurt MA et al. | β | 2000 | β |
| The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. | Chrast R et al. | β | 2000 | β |
| The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes. | Strippoli P et al. | β | 2000 | β |
| The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. | Wang J et al. | β | 2000 | β |
| Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. | Shetty HU et al. | β | 2000 | β |
| Gene expression relevant to Down syndrome: problems and approaches. | Tassone F et al. | β | 1999 | β |
| Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart. | O'Brien SJ et al. | β | 1999 | β |
| Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. | Siarey RJ et al. | β | 1999 | β |
| Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16. | Moore CS et al. | β | 1999 | β |
| Isolation and characterization of the mouse Aire gene. | Mittaz L et al. | β | 1999 | β |
| Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. | Ema M et al. | β | 1999 | β |
| Mouse autosomal trisomy: two's company, three's a crowd. | Hernandez D et al. | β | 1999 | β |
| Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. | Wiltshire T et al. | β | 1999 | β |
| Recent advances in the genetics of epilepsy: insights from human and animal studies. | Prasad AN et al. | β | 1999 | β |
| The promise of comparative genomics in mammals. | O'Brien SJ et al. | β | 1999 | β |
| Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21. | Hernandez D et al. | β | 1999 | β |
| Transgenic animals relevant to Alzheimer's disease. | Seabrook GR et al. | β | 1999 | β |
| 10 years of Genomics, chromosome 21, and Down syndrome. | Antonarakis SE | β | 1998 | β |
| Down syndrome and mouse models. | Kola I et al. | β | 1998 | β |
| Event-related brain potentials during an extended visual recognition memory task depict delayed development of cerebral inhibitory processes among 6-month-old infants with Down syndrome. | Karrer JH et al. | β | 1998 | β |
| Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. | Insausti AM et al. | β | 1998 | β |
| Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. | Escorihuela RM et al. | β | 1998 | β |
| Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. | Demas GE et al. | β | 1998 | β |
| Phenotype analysis in neurological models of human disease. | Martin JE et al. | β | 1998 | β |
| Physical and comparative mapping of distal mouse chromosome 16. 5 p5. | Cabin DE et al. | β | 1998 | β |
| PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C. | Berthelsen J et al. | β | 1998 | β |
| Stch maps to mouse chromosome 16, extending the conserved synteny with human chromosome 21. | Reeves RH et al. | β | 1998 | β |
| The fragile X syndrome and other fragile site disorders. | Kooy RF et al. | β | 1998 | β |
| The Mouse Gene Map. | Davisson MT et al. | β | 1998 | β |
| Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. | Sago H et al. | β | 1998 | β |
| Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon. | Guipponi M et al. | β | 1998 | β |
| Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. | Dierssen M et al. | β | 1997 | β |
| Assignment of three human markers in chromosome 21q11 to mouse chromosome 16. | Yu J et al. | β | 1997 | β |
| Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2. | Eki T et al. | β | 1997 | β |
| Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. | Mittaz L et al. | β | 1997 | β |
| Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3. | Chen H et al. | β | 1997 | β |
| Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. | Paoloni-Giacobino A et al. | β | 1997 | β |
| Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. | Paoloni-Giacobino A et al. | β | 1997 | β |
| Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. | Chrast R et al. | β | 1997 | β |
| Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. | Smith DJ et al. | β | 1997 | β |
| High-resolution recombinational map of mouse chromosome 16. | Reeves RH et al. | β | 1997 | β |
| Map location, genomic organization and expression patterns of the human RED1 RNA editase. | Villard L et al. | β | 1997 | β |
| Mental retardation: a review of the past 10 years. Part I. | King BH et al. | β | 1997 | β |
| Murine models of brain aging and age-related neurodegenerative diseases. | Jucker M et al. | β | 1997 | β |
| Optimizing the mouse to sift sequence for function. | Rubin EM et al. | β | 1997 | β |
| Phenotypic analysis--making the most of your mouse. | Martin JE et al. | β | 1997 | β |
| Simple minded mice from 'in vivo' libraries. | Kola I | β | 1997 | β |
| Single-minded--two genes, three chromosomes. | Michaud J et al. | β | 1997 | β |
| The contribution of the mouse to advances in human genetics. | Fisher EM | β | 1997 | β |
| The trefoil gene maps to mouse chromosome 17. | Burmeister M et al. | β | 1997 | β |
| Ain't misbehavin'--it's genetic! | Moran TH et al. | β | 1996 | β |
| Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. | Klein SL et al. | β | 1996 | β |
| Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. | Holtzman DM et al. | β | 1996 | β |
| Down syndrome genetics: unravelling a multifactorial disorder. | Hernandez D et al. | β | 1996 | β |
| Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model. | Dierssen M et al. | β | 1996 | β |
| Molecular genetic characterization and comparative mapping of the human PCP4 gene. | Cabin DE et al. | β | 1996 | β |
| Spatial memory deficits in segmental trisomic Ts65Dn mice. | Demas GE et al. | β | 1996 | β |
| Mental modelling. | Korenberg JR | β | 1995 | β |
| Tune into the weaver channel. | Goldowitz D et al. | β | 1995 | β |