Co-occurrence of anxiety and bipolar disorders: clinical and therapeutic overview.
paper
Cited
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- Authors
- VΓ‘zquez, Gustavo H; Baldessarini, Ross J; Tondo, Leonardo
- Year
- 2014
- Journal
- Depression and anxiety
- PMID
- 24610817
- DOI
- 10.1002/da.22248
BACKGROUND: Anxiety commonly co-occurs with bipolar disorders (BDs), but the significance of such "co-morbidity" remains to be clarified and its optimal treatment adequately defined. METHODS: We reviewed epidemiological, clinical, and treatment studies of the co-occurrence of BD and anxiety disorder through electronic searching of Pubmed/MEDLINE and EMBASE databases. RESULTS: Nearly half of BD patients meet diagnostic criteria for an anxiety disorder at some time, and anxiety is associated with poor treatment responses, substance abuse, and disability. Reported rates of specific anxiety disorders with BD rank: panic β₯ phobias β₯ generalized anxiety β₯ posttraumatic stress β₯ obsessive-compulsive disorders. Their prevalence appears to be greater among women than men, but similar in types I and II BD. Anxiety may be more likely in depressive phases of BD, but relationships of anxiety phenomena to particular phases of BD, and their temporal distributions require clarification. Adequate treatment trials for anxiety syndromes in BD patients remain rare, and the impact on anxiety of treatments aimed at mood stabilization is not clear. Benzodiazepines are sometimes given empirically; antidepressants are employed cautiously to limit risks of mood switching and emotional destabilization; lamotrigine, valproate, and second-generation antipsychotics may be useful and relatively safe. CONCLUSIONS: Anxiety symptoms and syndromes co-occur commonly in patients with BD, but "co-morbid" phenomena may be part of the BD phenotype rather than separate illnesses.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cognitive behavioral group therapy for bipolar disorder with comorbid anxiety disorder: a mixed-methods feasibility pilot study. | Jensen RN et al. | β | 2026 | β |
| The anxious bipolar phenotype: clinical complexity and treatment response. | Singh B et al. | β | 2026 | β |
| Comorbid anxiety in depression and rTMS treatment response: A retrospective study. | Kazemi R et al. | β | 2025 | β |
| Emotion regulation difficulties are associated with psychosocial functioning via trait anxiety levels in remitted bipolar disorder patients. | Sezgin SΔ°D et al. | β | 2025 | β |
| Who transitions to bipolar disorder? A comparison of major depressive disorder, anxiety, and ADHD. | Li K et al. | β | 2025 | β |
| Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern. | Aguglia A et al. | β | 2024 | β |
| Childhood Clinical Features Preceding the Onset of Bipolar Versus Major Depressive Disorders During Adolescence. | Guidetti C et al. | β | 2024 | β |
| Anxiety in bipolar disorder: A review of publication trends. | Couillard Larocque M et al. | β | 2023 | β |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | β | 2023 | β |
| Comorbidities in Youth with Bipolar Disorder: Clinical Features and Pharmacological Management. | Sesso G et al. | β | 2023 | β |
| Comparison of Aripiprazole and Risperidone effectiveness in treating obsessive-compulsive disorder in patients with bipolar disorder: Double-blind, randomizedΒ clinical trial. | Khorshidian F et al. | β | 2023 | β |
| Status of Type II vs. Type I Bipolar Disorder: Systematic Review with Meta-Analyses. | Hernandorena CV et al. | β | 2023 | β |
| Could bipolar depressed patients respond better to rTMS than unipolar depressed patients? A naturalistic, observational study. | Gama-Chonlon L et al. | β | 2022 | β |
| Gender differences in the associations of multiple psychiatric and chronic conditions with major depressive disorder among patients with opioid use disorder. | Nwabueze C et al. | β | 2022 | β |
| The role of lithium treatment on comorbid anxiety symptoms in patients with bipolar depression. | Jones G et al. | β | 2022 | β |
| Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder: A Systematic Review of Cross-Diagnostic Studies. | MassΓ³ Rodriguez A et al. | β | 2021 | β |
| Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus. | Beyer DKE et al. | β | 2021 | β |
| Social cognition in first-degree relatives of bipolar disorder: Theory of Mind and nonverbal sensitivity. | EspinΓ³s U et al. | β | 2021 | β |
| Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset. | Galimberti C et al. | β | 2020 | β |
| How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach. | Hamidian S et al. | β | 2020 | β |
| The prevalence of anxiety and its association with the quality of life and illness severity among bipolar affective disorder patients in a developing country. | Gamage N et al. | β | 2020 | β |
| A Chinese cross-sectional study on depression and anxiety symptoms in patients with psoriasis vulgaris. | Tian Z et al. | β | 2019 | β |
| Anxiety disorders anticipate the diagnosis of bipolar disorder in comorbid patients: Findings from an Italian tertiary clinic. | Caricasole V et al. | β | 2019 | β |
| Clinical significance of neutrophil-lymphocyte and platelet-lymphocyte ratios in bipolar patients: An 18-month prospective study. | Melo MCA et al. | β | 2019 | β |
| Comorbid anxiety in bipolar CHOICE: Insights from the bipolar inventory of symptoms scale. | Kinrys G et al. | β | 2019 | β |
| Comorbidity of bipolar and anxiety disorders: An overview of trends in research. | Spoorthy MS et al. | β | 2019 | β |
| Familial Aggregation and Coaggregation of Suicide Attempts and Comorbid Mental Disorders in Adults. | Ballard ED et al. | β | 2019 | β |
| Predictors of psychosocial outcome of bipolar disorder: data from the Stanley Foundation Bipolar Network. | Bennett F et al. | β | 2019 | β |
| The validity of daily patient-reported anxiety measured using smartphones and the association with stress, quality of life and functioning in patients with bipolar disorder. | Faurholt-Jepsen M et al. | β | 2019 | β |
| Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. | Yatham LN et al. | β | 2018 | β |
| Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial. | Sampaio-Junior B et al. | β | 2018 | β |
| Hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders. A systematic review. | Fischer S et al. | β | 2018 | β |
| Is Internet Addiction a Clinical Symptom or a Psychiatric Disorder? A Comparison With Bipolar Disorder. | Caldiroli A et al. | β | 2018 | β |
| Modelling mood disorders: An ACE solution? | Malhi GS et al. | β | 2018 | β |
| Obsessive-compulsive Disorder with Comorbid Bipolar Disorders: Clinical Features and Treatment Implications. | Mucci F et al. | β | 2018 | β |
| Reducing relapse and suicide in bipolar disorder: practical clinical approaches to identifying risk, reducing harm and engaging service users in planning and delivery of care β the PARADES (Psychoeducation, Anxiety, Relapse, Advance Directive Evaluation and Suicidality) programme | Jones S et al. | β | 2018 | β |
| The perils of being too stable: mood regulation in bipolar disorder | Ortiz A et al. | β | 2018 | β |
| The role of lifetime anxiety history in the course of bipolar spectrum disorders. | Titone MK et al. | β | 2018 | β |
| Treatment of anxiety disorders in patients with comorbid bipolar disorder. | Ott CA | β | 2018 | β |
| A 10-year evaluation on adolescents with anxiety disorders: are they at risk of bipolarity? | Aguglia A et al. | β | 2017 | β |
| American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence. | Dell'Osso B et al. | β | 2017 | β |
| Antidepressant-induced hypomania/mania in patients with major depression: Evidence from the BRIDGE-II-MIX study. | Barbuti M et al. | β | 2017 | β |
| Associations among Substance Use, Mental Health Disorders, and Self-Harm in a Prison Population: Examining Group Risk for Suicide Attempt. | Gates ML et al. | β | 2017 | β |
| Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms. | Pantazopoulos H et al. | β | 2017 | β |
| Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis. | Pavlova B et al. | β | 2017 | β |
| Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial. | Ellard KK et al. | β | 2017 | β |
| Attention-deficit hyperactivity disorder, its pharmacotherapy, and the risk of developing bipolar disorder: A nationwide population-based study in Taiwan. | Wang LJ et al. | β | 2016 | β |
| Bipolar I and II Disorders; A Systematic Review and Meta-Analysis on Differences in Comorbid Obsessive-Compulsive Disorder. | Amerio A et al. | β | 2016 | β |
| Considerations for MRI study design and implementation in pediatric and clinical populations. | Greene DJ et al. | β | 2016 | β |
| Management of obsessive-compulsive disorder comorbid with bipolar disorder. | Kazhungil F et al. | β | 2016 | β |
| The influence of comorbid disorders on the episodicity of bipolar disorder in youth. | Yen S et al. | β | 2016 | β |
| A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder. | Ashbrook DG et al. | β | 2015 | β |
| Bipolar disorder and anxiety: a comorbidity needing better treatments. | Mitchell PB | β | 2015 | β |
| Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States. | Holtzman JN et al. | β | 2015 | β |
| Co-morbidity of bipolar disorder and borderline personality disorder: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. | McDermid J et al. | β | 2015 | β |
| Effects of comorbid anxiety disorders on the course of bipolar disorder-I. | Buturak SV et al. | β | 2015 | β |
| Features preceding diagnosis of bipolar versus major depressive disorders. | Serra G et al. | β | 2015 | β |
| Pharmacological Approaches for Treatment-resistant Bipolar Disorder. | Hui Poon S et al. | β | 2015 | β |
| Predictors of long-term work disability among patients with type I and II bipolar disorder: a prospective 18-month follow-up study. | Arvilommi P et al. | β | 2015 | β |
| Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. | Stratford HJ et al. | β | 2015 | β |
| The importance of anxiety states in bipolar disorder. | Goes FS | β | 2015 | β |
| The prevalence and predictors of comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review and meta-analysis. | Amerio A et al. | β | 2015 | β |
| The relationship between bipolar disorders, anxiety, and trauma - implications for clinical practice. | Kuiper S et al. | β | 2015 | β |
| [Affective disorders and anxiety comorbidities]. | Kaladjian A et al. | β | 2014 | β |
| Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. | Angoa-PΓ©rez M et al. | β | 2014 | β |
| The impact of psychopharmacology on contemporary clinical psychiatry. | VΓ‘zquez GH | β | 2014 | β |